"I-kappa B Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus.
| Descriptor ID |
D020672
|
| MeSH Number(s) |
D12.644.360.365 D12.776.260.420 D12.776.476.381 D12.776.930.326
|
| Concept/Terms |
I-kappa B Proteins- I-kappa B Proteins
- I kappa B Proteins
- I kappa B
- IkB DNA-Binding Proteins
- IkB DNA Binding Proteins
- I-kappa B
|
Below are MeSH descriptors whose meaning is more general than "I-kappa B Proteins".
Below are MeSH descriptors whose meaning is more specific than "I-kappa B Proteins".
This graph shows the total number of publications written about "I-kappa B Proteins" by people in this website by year, and whether "I-kappa B Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 0 | 2 |
| 1995 | 2 | 0 | 2 |
| 1996 | 4 | 0 | 4 |
| 1997 | 5 | 0 | 5 |
| 1998 | 2 | 1 | 3 |
| 1999 | 3 | 1 | 4 |
| 2000 | 5 | 2 | 7 |
| 2001 | 8 | 2 | 10 |
| 2002 | 6 | 4 | 10 |
| 2003 | 1 | 10 | 11 |
| 2004 | 2 | 8 | 10 |
| 2005 | 2 | 7 | 9 |
| 2006 | 1 | 2 | 3 |
| 2007 | 2 | 3 | 5 |
| 2008 | 0 | 5 | 5 |
| 2009 | 1 | 4 | 5 |
| 2010 | 1 | 4 | 5 |
| 2011 | 1 | 3 | 4 |
| 2012 | 3 | 5 | 8 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "I-kappa B Proteins" by people in Profiles.
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Autoantibodies against type I IFNs in humans with alternative NF-?B pathway deficiency. Nature. 2023 Nov; 623(7988):803-813.
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Preventing abnormal NF-?B activation and autoimmunity by Otub1-mediated p100 stabilization. Cell Res. 2019 06; 29(6):474-485.
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Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia: Regulates pro-inflammatory mediators through inhibition of NF-?B and Erk1/2 signaling pathways in LPS-induced Raw264.7 cells. J Ethnopharmacol. 2018 Jan 10; 210:95-106.
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Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease. J Neurosci. 2016 Jan 13; 36(2):577-89.
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Baicalein alleviates doxorubicin-induced cardiotoxicity via suppression of myocardial oxidative stress and apoptosis in mice. Life Sci. 2016 Jan 01; 144:8-18.
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Targeted nuclear factor-kappaB suppression enhances gemcitabine response in human pancreatic tumor cell line murine xenografts. Surgery. 2015 Oct; 158(4):881-8; discussion 888-9.
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a-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-?B signalling. Nat Cell Biol. 2014 Mar; 16(3):245-54.
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XIAP downregulation promotes caspase-dependent inhibition of proteasome activity in AML cells. Leuk Res. 2013 Aug; 37(8):974-9.
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Silent information regulator (Sir)T1 inhibits NF-?B signaling to maintain normal skeletal remodeling. J Bone Miner Res. 2013 Apr; 28(4):960-9.
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Activation of nuclear factor-?B in acinar cells increases the severity of pancreatitis in mice. Gastroenterology. 2013 Jan; 144(1):202-10.