Otx Transcription Factors
"Otx Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of VERTEBRATE homeodomain proteins that share homology with orthodenticle protein, Drosophila. They regulate GENETIC TRANSCRIPTION and play an important role in EMBRYONIC DEVELOPMENT of the BRAIN.
| Descriptor ID |
D051857
|
| MeSH Number(s) |
D12.776.260.400.718 D12.776.930.650
|
| Concept/Terms |
Otx Transcription Factors- Otx Transcription Factors
- Transcription Factors, Otx
- Otx Homeodomain Proteins
- Homeodomain Proteins, Otx
- Orthodenticle Homolog Homeodomain Proteins
|
Below are MeSH descriptors whose meaning is more general than "Otx Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "Otx Transcription Factors".
This graph shows the total number of publications written about "Otx Transcription Factors" by people in this website by year, and whether "Otx Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2022 | 0 | 1 | 1 |
| 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Otx Transcription Factors" by people in Profiles.
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Identification of an early subset of cerebellar nuclei neurons in mice. Elife. 2024 Dec 16; 13.
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A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing. Nat Cell Biol. 2024 08; 26(8):1233-1246.
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Failure of human rhombic lip differentiation underlies medulloblastoma formation. Nature. 2022 09; 609(7929):1021-1028.
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An OTX2-PAX3 signaling axis regulates Group 3 medulloblastoma cell fate. Nat Commun. 2020 07 20; 11(1):3627.
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Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells. J Clin Invest. 2020 02 03; 130(2):641-654.
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Characterization of a novel OTX2-driven stem cell program in Group 3 and Group 4 medulloblastoma. Mol Oncol. 2018 04; 12(4):495-513.
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Genitourinary defects associated with genomic deletions in 2p15 encompassing OTX1. PLoS One. 2014; 9(9):e107028.
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Ectopic Mitf in the embryonic chick retina by co-transfection of ?-catenin and Otx2. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5328-35.
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COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis. Development. 2010 Mar; 137(5):725-34.
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OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas. Cancer Res. 2010 Jan 01; 70(1):181-91.