"Host Cell Factor C1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cellular transcriptional coactivator that contains N-terminal KELCH REPEATS and N- and C-terminal FIBRONECTIN TYPE III DOMAINS. It functions as a transcription factor for a number of genes and in the assembly of IMMEDIATE-EARLY PROTEINS of the HERPES SIMPLEX VIRUS. Mutations in the HCFC1 gene are associated with cases of X-LINKED MENTAL RETARDATION.
| Descriptor ID |
D051863
|
| MeSH Number(s) |
D12.776.660.478 D12.776.930.325
|
| Concept/Terms |
Host Cell Factor C1- Host Cell Factor C1
- Cell Proliferation Factor HCF
- HCFC1 Protein
- C1 Host Cell Factor
|
Below are MeSH descriptors whose meaning is more general than "Host Cell Factor C1".
Below are MeSH descriptors whose meaning is more specific than "Host Cell Factor C1".
This graph shows the total number of publications written about "Host Cell Factor C1" by people in this website by year, and whether "Host Cell Factor C1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Host Cell Factor C1" by people in Profiles.
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Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Nat Commun. 2022 01 10; 13(1):134.
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Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs. Cell Rep. 2017 Nov 07; 21(6):1562-1573.
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Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Jul 13; 28(1):114-28.
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An X-linked cobalamin disorder caused by mutations in transcriptional coregulator HCFC1. Am J Hum Genet. 2013 Sep 05; 93(3):506-14.
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Loss of the tumor suppressor BAP1 causes myeloid transformation. Science. 2012 Sep 21; 337(6101):1541-6.
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Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. Genes Dev. 2010 Jul 15; 24(14):1479-84.
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Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell. 2008 Jun 27; 133(7):1162-74.
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Sequence variants in host cell factor C1 are associated with M?ni?re's disease. Otol Neurotol. 2008 Jun; 29(4):561-6.
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Hepatocyte nuclear factor 3 relieves chromatin-mediated repression of the alpha-fetoprotein gene. J Biol Chem. 1999 Aug 27; 274(35):25113-20.
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Acquisition of cellular resistance to 9-nitro-camptothecin correlates with suppression of transcription factor NF-kappa B activation and potentiation of cytotoxicity by tumor necrosis factor in human histiocytic lymphoma U-937 cells. Anticancer Drugs. 1998 Sep; 9(8):703-14.