MDS1 and EVI1 Complex Locus Protein
"MDS1 and EVI1 Complex Locus Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA binding protein, transcriptional regulator, and proto-oncogene protein that contains 10 CYS2-HIS2 ZINC FINGERS. It functions as a positive or negative regulator of expression for target genes involved in organism development.
| Descriptor ID |
D000074008
|
| MeSH Number(s) |
D12.776.260.534 D12.776.624.664.700.129 D12.776.930.419
|
| Concept/Terms |
MDS1 and EVI1 Complex Locus Protein- MDS1 and EVI1 Complex Locus Protein
- Ecotropic Virus Integration Site 1 Protein Homolog
- Zinc Finger Protein Evi1
- MECOM Protein
- Myelodysplasia Syndrome-Associated Protein 1
- Myelodysplasia Syndrome Associated Protein 1
|
Below are MeSH descriptors whose meaning is more general than "MDS1 and EVI1 Complex Locus Protein".
Below are MeSH descriptors whose meaning is more specific than "MDS1 and EVI1 Complex Locus Protein".
This graph shows the total number of publications written about "MDS1 and EVI1 Complex Locus Protein" by people in this website by year, and whether "MDS1 and EVI1 Complex Locus Protein" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "MDS1 and EVI1 Complex Locus Protein" by people in Profiles.
-
Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML. Nat Commun. 2024 Jun 04; 15(1):4739.
-
Preclinical efficacy of targeting epigenetic mechanisms in AML with 3q26 lesions and EVI1 overexpression. Leukemia. 2024 03; 38(3):545-556.
-
Expanded phenotypic and hematologic abnormalities beyond bone marrow failure in MECOM-associated syndromes. Am J Med Genet A. 2023 07; 191(7):1826-1835.
-
Newly designed breakapart FISH probe helps to identify cases with true MECOM rearrangement in myeloid malignancies. Cancer Genet. 2022 04; 262-263:23-29.
-
EVI1 dysregulation: impact on biology and therapy of myeloid malignancies. Blood Cancer J. 2021 03 22; 11(3):64.
-
Deciphering the complexities of MECOM rearrangement-driven chromosomal aberrations. Cancer Genet. 2019 04; 233-234:21-31.
-
t(3;8)(q26.2;q24) Often Leads to MECOM/MYC Rearrangement and Is Commonly Associated with Therapy-Related Myeloid Neoplasms and/or Disease Progression. J Mol Diagn. 2019 03; 21(2):343-351.
-
3q26/EVI1 rearrangement in myelodysplastic/myeloproliferative neoplasms: An early event associated with a poor prognosis. Leuk Res. 2018 02; 65:25-28.
-
Functional features of EVI1 and EVI1?324 isoforms of MECOM gene in genome-wide transcription regulation and oncogenicity. Oncogene. 2016 05 05; 35(18):2311-21.
-
Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One. 2014; 9(2):e89397.