Proto-Oncogene Proteins c-akt
"Proto-Oncogene Proteins c-akt" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein-serine-threonine kinases that contain PLECKSTRIN HOMOLOGY DOMAINS and are activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. They play a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
| Descriptor ID |
D051057
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.755 D12.776.476.565 D12.776.624.664.700.168
|
| Concept/Terms |
Proto-Oncogene Proteins c-akt- Proto-Oncogene Proteins c-akt
- Proto Oncogene Proteins c akt
- c-akt, Proto-Oncogene Proteins
- Protein Kinase B
- Proto-Oncogene Protein RAC
- Proto Oncogene Protein RAC
- RAC, Proto-Oncogene Protein
- Proto-Oncogene Protein Akt
- Akt, Proto-Oncogene Protein
- Proto Oncogene Protein Akt
- Rac Protein Kinase
- akt Proto-Oncogene Protein
- Protein, akt Proto-Oncogene
- Proto-Oncogene Protein, akt
- akt Proto Oncogene Protein
- RAC-PK Protein
- RAC PK Protein
- Related to A and C-Protein
- Related to A and C Protein
- c-akt Proto-Oncogene Protein
- Protein, c-akt Proto-Oncogene
- Proto-Oncogene Protein, c-akt
- c akt Proto Oncogene Protein
- c-akt Protein
- Protein-Serine-Threonine Kinase (Rac)
Proto-Oncogene Proteins c-akt1- Proto-Oncogene Proteins c-akt1
- Proteins c-akt1, Proto-Oncogene
- Proto Oncogene Proteins c akt1
- c-akt1, Proto-Oncogene Proteins
- AKT1 Protein Kinase
- Rac-PK alpha Protein
- Rac PK alpha Protein
- alpha Protein, Rac-PK
- Protein Kinase B alpha
- Akt-alpha Protein
- Akt alpha Protein
Proto-Oncogene Proteins c-akt2- Proto-Oncogene Proteins c-akt2
- Proteins c-akt2, Proto-Oncogene
- Proto Oncogene Proteins c akt2
- c-akt2, Proto-Oncogene Proteins
- Protein Kinase B beta
- Rac-PK beta Protein
- Rac PK beta Protein
- AKT2 Protein Kinase
- Akt-beta Protein
- Akt beta Protein
Proto-Oncogene Proteins c-akt3- Proto-Oncogene Proteins c-akt3
- Proteins c-akt3, Proto-Oncogene
- Proto Oncogene Proteins c akt3
- c-akt3, Proto-Oncogene Proteins
- Akt-gamma Protein
- Akt gamma Protein
- AKT3 Protein Kinase
- Protein Kinase B gamma
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-akt".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-akt".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-akt" by people in this website by year, and whether "Proto-Oncogene Proteins c-akt" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 9 | 9 |
| 2001 | 0 | 11 | 11 |
| 2002 | 0 | 23 | 23 |
| 2003 | 0 | 30 | 30 |
| 2004 | 1 | 39 | 40 |
| 2005 | 7 | 39 | 46 |
| 2006 | 31 | 30 | 61 |
| 2007 | 23 | 35 | 58 |
| 2008 | 19 | 34 | 53 |
| 2009 | 23 | 25 | 48 |
| 2010 | 17 | 40 | 57 |
| 2011 | 29 | 31 | 60 |
| 2012 | 21 | 39 | 60 |
| 2013 | 22 | 39 | 61 |
| 2014 | 18 | 43 | 61 |
| 2015 | 18 | 30 | 48 |
| 2016 | 8 | 23 | 31 |
| 2017 | 20 | 33 | 53 |
| 2018 | 7 | 19 | 26 |
| 2019 | 9 | 15 | 24 |
| 2020 | 5 | 19 | 24 |
| 2021 | 12 | 10 | 22 |
| 2022 | 2 | 13 | 15 |
| 2023 | 2 | 12 | 14 |
| 2024 | 5 | 5 | 10 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-akt" by people in Profiles.
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IFN-treated macrophage-derived exosomes prevents HBV-HCC migration and invasion via regulating miR-106b-3p/PCGF3/PI3K/AKT signaling axis. Front Cell Infect Microbiol. 2024; 14:1421195.
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Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies. Blood Adv. 2024 10 22; 8(20):5279-5289.
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Germline mutations in a G protein identify signaling cross-talk in T cells. Science. 2024 Sep 20; 385(6715):eadd8947.
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A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling. Nat Cardiovasc Res. 2024 Jul; 3(7):785-798.
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Paediatric strategy forum for medicinal product development of PI3-K, mTOR, AKT and GSK3? inhibitors in children and adolescents with cancer. Eur J Cancer. 2024 Aug; 207:114145.
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Inhibition of glycolysis and Src/Akt signaling reduces Caveolin-1-enhanced metastasis. Biomed Pharmacother. 2024 Jul; 176:116841.
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Novel non-invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non-coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway. Cancer Med. 2024 Jun; 13(11):e7309.
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Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype. Genes Dev. 2024 04 17; 38(5-6):273-288.
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Quantitative Assessment of Preanalytic Variables on Clinical Evaluation of PI3/AKT/mTOR Signaling Activity in Diffuse Glioma. Mod Pathol. 2024 Jun; 37(6):100488.
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Phase I Study of mTORC1/2 Inhibitor Sapanisertib (CB-228/TAK-228) in Combination with Metformin in Patients with mTOR/AKT/PI3K Pathway Alterations and Advanced Solid Malignancies. Cancer Res Commun. 2024 02 12; 4(2):378-387.