"MicroRNAs" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
| Descriptor ID |
D035683
|
| MeSH Number(s) |
D13.150.650.319 D13.444.735.150.319 D13.444.735.790.552.500
|
| Concept/Terms |
MicroRNAs- MicroRNAs
- MicroRNA
- miRNAs
- Micro RNA
- RNA, Micro
- miRNA
Primary MicroRNA- Primary MicroRNA
- MicroRNA, Primary
- Primary miRNA
- miRNA, Primary
- pri-miRNA
- pri miRNA
|
Below are MeSH descriptors whose meaning is more general than "MicroRNAs".
Below are MeSH descriptors whose meaning is more specific than "MicroRNAs".
This graph shows the total number of publications written about "MicroRNAs" by people in this website by year, and whether "MicroRNAs" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 2 | 0 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 7 | 1 | 8 |
| 2008 | 9 | 6 | 15 |
| 2009 | 17 | 5 | 22 |
| 2010 | 27 | 6 | 33 |
| 2011 | 27 | 12 | 39 |
| 2012 | 22 | 6 | 28 |
| 2013 | 42 | 9 | 51 |
| 2014 | 31 | 5 | 36 |
| 2015 | 42 | 7 | 49 |
| 2016 | 30 | 7 | 37 |
| 2017 | 28 | 9 | 37 |
| 2018 | 24 | 10 | 34 |
| 2019 | 19 | 9 | 28 |
| 2020 | 29 | 10 | 39 |
| 2021 | 18 | 12 | 30 |
| 2022 | 13 | 0 | 13 |
| 2023 | 21 | 0 | 21 |
| 2024 | 13 | 4 | 17 |
| 2025 | 6 | 1 | 7 |
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Below are the most recent publications written about "MicroRNAs" by people in Profiles.
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Rooted in regulation: MicroRNAs as gardeners of the Purkinje cell dendritic arbor. Neuron. 2025 May 21; 113(10):1463-1465.
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A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase. Nat Commun. 2025 May 17; 16(1):4588.
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Let-7 restrains an epigenetic circuit in AT2 cells to prevent fibrogenic intermediates in pulmonary fibrosis. Nat Commun. 2025 May 10; 16(1):4353.
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Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition. Clin Cancer Res. 2025 Apr 14; 31(8):1491-1503.
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The miR-290 and miR-302 clusters are essential for reprogramming of fibroblasts to induced pluripotent stem cells. Stem Cells. 2025 Feb 12; 43(2).
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miR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma. Cell Rep. 2025 01 28; 44(1):115171.
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Aptamer-conjugated gold nanoparticles enable oligonucleotide delivery into muscle stem cells to promote regeneration of dystrophic muscles. Nat Commun. 2025 Jan 10; 16(1):577.
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Inhibition of microRNA-660-5p decreases breast cancer progression through direct targeting of TMEM41B. Hereditas. 2024 Dec 21; 161(1):53.
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Hsa-miR-214-3p inhibits breast cancer cell growth and improves the tumor immune microenvironment by downregulating B7H3. Oncol Res. 2025; 33(1):103-121.
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Lung Tissue Multilayer Network Analysis Uncovers the Molecular Heterogeneity of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2024 Nov 15; 210(10):1219-1229.