"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Descriptor ID |
D034741
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MeSH Number(s) |
D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
|
Concept/Terms |
RNA, Small Interfering- RNA, Small Interfering
- Interfering RNA, Small
- Short Interfering RNA
- Interfering RNA, Short
- RNA, Short Interfering
- Small Interfering RNA
- siRNA
Piwi-Interacting RNA- Piwi-Interacting RNA
- Piwi Interacting RNA
- RNA, Piwi-Interacting
- RNA, Piwi Interacting
- piRNA
Short Hairpin RNA- Short Hairpin RNA
- Hairpin RNA, Short
- RNA, Short Hairpin
- Small Hairpin RNA
- Hairpin RNA, Small
- RNA, Small Hairpin
- shRNA
Repeat-Associated siRNA- Repeat-Associated siRNA
- Repeat Associated siRNA
- siRNA, Repeat-Associated
- siRNA, Repeat Associated
Scan RNA- Scan RNA
- scnRNA
- Small Scan RNA
- RNA, Small Scan
- Scan RNA, Small
- RNA, Scan
Trans-Acting siRNA- Trans-Acting siRNA
- Trans Acting siRNA
- tasiRNA
- siRNA, Trans-Acting
- siRNA, Trans Acting
|
Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".
Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".
This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 |
2002 | 1 | 2 | 3 |
2003 | 4 | 15 | 19 |
2004 | 3 | 40 | 43 |
2005 | 8 | 66 | 74 |
2006 | 6 | 58 | 64 |
2007 | 3 | 75 | 78 |
2008 | 11 | 87 | 98 |
2009 | 8 | 72 | 80 |
2010 | 12 | 99 | 111 |
2011 | 12 | 77 | 89 |
2012 | 7 | 83 | 90 |
2013 | 5 | 74 | 79 |
2014 | 8 | 62 | 70 |
2015 | 4 | 57 | 61 |
2016 | 5 | 47 | 52 |
2017 | 7 | 31 | 38 |
2018 | 6 | 35 | 41 |
2019 | 4 | 28 | 32 |
2020 | 0 | 15 | 15 |
2021 | 3 | 12 | 15 |
2022 | 0 | 10 | 10 |
2023 | 0 | 7 | 7 |
2024 | 4 | 4 | 8 |
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Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.
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Expression levels of core spliceosomal proteins modulate the MBNL-mediated spliceopathy in DM1. Hum Mol Genet. 2024 11 05; 33(21):1873-1886.
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Bone-targeted ultrasound-responsive nanobubbles for siRNA delivery to treat osteoporosis in mice. Biomater Adv. 2025 Jan; 166:214078.
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Pachytene piRNAs control discrete meiotic events during spermatogenesis and restrict gene expression in space and time. Sci Adv. 2024 Oct 04; 10(40):eadp0466.
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Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA). Gastroenterology. 2024 Oct; 167(5):1008-1018.e5.
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A First-in-Human Phase 1 Study of a Tumor-Directed RNA-Interference Drug against HIF2a in Patients with Advanced Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2024 Jun 03; 30(11):2402-2411.
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Zodasiran, an RNAi Therapeutic Targeting ANGPTL3, for Mixed Hyperlipidemia. N Engl J Med. 2024 Sep 12; 391(10):913-925.
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Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia. N Engl J Med. 2024 Sep 12; 391(10):899-912.
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Analyzing efficiency of a lentiviral shRNA knockdown system in human enteroids using western blot and flow cytometry. STAR Protoc. 2024 Jun 21; 5(2):103082.
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Myotubularin-related protein 6 is an ion channel-associated pro-leishmanial phosphatase. Int Immunopharmacol. 2024 Mar 10; 129:111644.
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Inclisiran: Where Are We on Safety, Efficacy, and Clinical Effectiveness of?siRNA Therapies for Prevention? J Am Coll Cardiol. 2023 12 12; 82(24):2262-2264.