Hepatocyte Nuclear Factor 1-beta
"Hepatocyte Nuclear Factor 1-beta" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hepatocyte nuclear factor that is closely related to HEPATOCYTE NUCLEAR FACTOR 1-ALPHA but is only weakly expressed in the LIVER. Mutations in hepatocyte nuclear factor 1-beta are associated with renal CYSTS and MATURITY-ONSET DIABETES MELLITUS type 5.
| Descriptor ID |
D051539
|
| MeSH Number(s) |
D12.776.260.262.500.750 D12.776.260.400.218.750 D12.776.660.352.500.750 D12.776.930.318.500.750
|
| Concept/Terms |
Hepatocyte Nuclear Factor 1-beta- Hepatocyte Nuclear Factor 1-beta
- Hepatocyte Nuclear Factor 1 beta
- Liver Specific Transcription Factor LF-B3
- Liver Specific Transcription Factor LF B3
- Variant Hepatic Nuclear Factor 1
- HNF-1beta
- HNF 1beta
- Hepatocyte Nuclear Factor-1beta
- Hepatocyte Nuclear Factor 1beta
|
Below are MeSH descriptors whose meaning is more general than "Hepatocyte Nuclear Factor 1-beta".
Below are MeSH descriptors whose meaning is more specific than "Hepatocyte Nuclear Factor 1-beta".
This graph shows the total number of publications written about "Hepatocyte Nuclear Factor 1-beta" by people in this website by year, and whether "Hepatocyte Nuclear Factor 1-beta" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hepatocyte Nuclear Factor 1-beta" by people in Profiles.
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Mst1/2 kinases restrain transformation in a novel transgenic model of Ras driven non-small cell lung cancer. Oncogene. 2020 01; 39(5):1152-1164.
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HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas. Cancer Res. 2017 10 01; 77(19):5313-5326.
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Whole-exome sequencing in the molecular diagnosis of individuals with congenital anomalies of the kidney and urinary tract and identification of a new causative gene. Genet Med. 2017 04; 19(4):412-420.
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Gene-specific function prediction for non-synonymous mutations in monogenic diabetes genes. PLoS One. 2014; 9(8):e104452.
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Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun. 2013; 4:1628.
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Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. PLoS One. 2010 May 28; 5(5):e10858.
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Clinical spectrum associated with recurrent genomic rearrangements in chromosome 17q12. Eur J Hum Genet. 2010 Mar; 18(3):278-84.
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A-beta-subtype of ketosis-prone diabetes is not predominantly a monogenic diabetic syndrome. Diabetes Care. 2009 May; 32(5):873-7.
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Regulation of hepatocyte nuclear factor 1 activity by wild-type and mutant hepatitis B virus X proteins. J Virol. 2002 Jun; 76(12):5875-81.
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The transcription factor HNF1 acts with C/EBP alpha to synergistically activate the human albumin promoter through a novel domain. J Biol Chem. 1994 Jan 14; 269(2):1177-82.