"Kruppel-Like Factor 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A Kruppel-like transcription factor that contains three C-terminal CYS2-HIS2 ZINC FINGERS and binds to GC RICH SEQUENCE (GC box) in upstream gene promoters. It functions as a transcriptional activator, tumor suppressor, and may regulate growth and development of B-cells.
| Descriptor ID |
D000075723
|
| MeSH Number(s) |
D12.776.260.522.563 D12.776.260.755.050 D12.776.624.664.700.120 D12.776.930.375.563
|
| Concept/Terms |
Kruppel-Like Factor 6- Kruppel-Like Factor 6
- Kruppel Like Factor 6
- CPBP Protein
- Core Promoter Element Binding Protein
- COPEB Protein
|
Below are MeSH descriptors whose meaning is more general than "Kruppel-Like Factor 6".
Below are MeSH descriptors whose meaning is more specific than "Kruppel-Like Factor 6".
This graph shows the total number of publications written about "Kruppel-Like Factor 6" by people in this website by year, and whether "Kruppel-Like Factor 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Kruppel-Like Factor 6" by people in Profiles.
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Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma. J Clin Invest. 2015 Aug 03; 125(8):2965-78.
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Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation. J Hepatol. 2007 Apr; 46(4):645-54.
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Assignment of the human B-cell-derived (BCD1) proto-oncogene to 10p14-p15. Genomics. 1997 Aug 01; 43(3):395-7.