Proto-Oncogene Proteins c-pim-1
"Proto-Oncogene Proteins c-pim-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serine-threonine protein kinases that relay signals from CYTOKINE RECEPTORS and are involved in control of CELL GROWTH PROCESSES; CELL DIFFERENTIATION; and APOPTOSIS.
| Descriptor ID |
D051573
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| MeSH Number(s) |
D08.811.913.696.620.682.700.776 D12.776.624.664.700.191
|
| Concept/Terms |
Proto-Oncogene Proteins c-pim-1- Proto-Oncogene Proteins c-pim-1
- Proto Oncogene Proteins c pim 1
- c-pim-1, Proto-Oncogene Proteins
- Pim-1 Kinase
- Kinase, Pim-1
- Pim 1 Kinase
- Proto-Oncogene Protein c-pim-1
- Proto Oncogene Protein c pim 1
- c-pim-1, Proto-Oncogene Protein
- Proto-Oncogene Protein pim-1
- Proto Oncogene Protein pim 1
- pim-1, Proto-Oncogene Protein
- c-pim-1 Protein
- c pim 1 Protein
- pim-1 Proto-Oncogene Protein
- pim 1 Proto Oncogene Protein
|
Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-pim-1".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-pim-1".
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-pim-1" by people in this website by year, and whether "Proto-Oncogene Proteins c-pim-1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2009 | 3 | 0 | 3 |
| 2010 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
| 2013 | 2 | 0 | 2 |
| 2014 | 2 | 0 | 2 |
| 2015 | 2 | 1 | 3 |
| 2016 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Proto-Oncogene Proteins c-pim-1" by people in Profiles.
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Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies. Cancer Res. 2021 12 01; 81(23):6029-6043.
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The first-in-human study of the pan-PIM kinase inhibitor PIM447 in patients with relapsed and/or refractory multiple myeloma. Leukemia. 2019 12; 33(12):2924-2933.
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Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks. Apoptosis. 2016 11; 21(11):1203-1213.
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Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia. Leuk Lymphoma. 2016 12; 57(12):2863-2873.
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The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget. 2015 Nov 10; 6(35):37930-47.
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Smac mimetic with TNF-a targets Pim-1 isoforms and reactive oxygen species production to abrogate transformation from blebbishields. Biochem J. 2016 Jan 01; 473(1):99-107.
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Ribosomal Biogenesis and Translational Flux Inhibition by the Selective Inhibitor of Nuclear Export (SINE) XPO1 Antagonist KPT-185. PLoS One. 2015; 10(9):e0137210.
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A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas. Neoplasia. 2014 May; 16(5):403-12.
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The Pim-1 protein kinase is an important regulator of MET receptor tyrosine kinase levels and signaling. Mol Cell Biol. 2014 Jul; 34(13):2517-32.
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Mechanism-based combinations with Pim kinase inhibitors in cancer treatments. Curr Pharm Des. 2014; 20(42):6670-81.