"Lim Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serine protein kinases involved in the regulation of ACTIN polymerization and MICROTUBULE disassembly. Their activity is regulated by phosphorylation of a threonine residue within the activation loop by intracellular signaling kinases such as P21-ACTIVATED KINASES and by RHO KINASE.
| Descriptor ID |
D054461
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.542 D12.644.360.390 D12.776.476.396 D12.776.512.124
|
| Concept/Terms |
Lim Kinases- Lim Kinases
- Kinases, Lim
- LIM Motif-Containing Protein Kinases
- LIM Motif Containing Protein Kinases
- LIM-Kinase
- LIM Kinase
- Kinase, LIM
|
Below are MeSH descriptors whose meaning is more general than "Lim Kinases".
Below are MeSH descriptors whose meaning is more specific than "Lim Kinases".
This graph shows the total number of publications written about "Lim Kinases" by people in this website by year, and whether "Lim Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
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Below are the most recent publications written about "Lim Kinases" by people in Profiles.
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Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway. Cancer Lett. 2020 11 01; 492:136-146.
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Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma. Oncogene. 2020 10; 39(40):6286-6299.
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Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer. Oncotarget. 2016 Mar 01; 7(9):10498-512.
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miRNA-17 members that target Bmpr2 influence signaling mechanisms important for embryonic stem cell differentiation in vitro and gastrulation in embryos. Stem Cells Dev. 2015 Feb 01; 24(3):354-71.
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Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway. Oncotarget. 2014 Oct 15; 5(19):9382-95.
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Rho associated coiled-coil kinase-1 regulates collagen-induced phosphatidylserine exposure in platelets. PLoS One. 2013; 8(12):e84649.
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Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. J Natl Cancer Inst. 2011 Oct 19; 103(20):1513-28.
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LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system. Int J Cancer. 2006 Jun 01; 118(11):2703-10.
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p120 catenin is required for morphogenetic movements involved in the formation of the eyes and the craniofacial skeleton in Xenopus. J Cell Sci. 2004 Aug 15; 117(Pt 18):4325-39.