Ataxia Telangiectasia Mutated Proteins
"Ataxia Telangiectasia Mutated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of PROTEIN-SERINE-THREONINE KINASES which activate critical signaling cascades in double strand breaks, APOPTOSIS, and GENOTOXIC STRESS such as ionizing ultraviolet A light, thereby acting as a DNA damage sensor. These proteins play a role in a wide range of signaling mechanisms in cell cycle control.
| Descriptor ID |
D064007
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.097 D12.776.157.687.125 D12.776.660.720.125
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Ataxia Telangiectasia Mutated Proteins".
Below are MeSH descriptors whose meaning is more specific than "Ataxia Telangiectasia Mutated Proteins".
This graph shows the total number of publications written about "Ataxia Telangiectasia Mutated Proteins" by people in this website by year, and whether "Ataxia Telangiectasia Mutated Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 3 | 3 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 9 | 9 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 10 | 10 |
| 2004 | 0 | 10 | 10 |
| 2005 | 0 | 9 | 9 |
| 2006 | 0 | 9 | 9 |
| 2007 | 0 | 10 | 10 |
| 2008 | 0 | 10 | 10 |
| 2009 | 0 | 11 | 11 |
| 2010 | 0 | 13 | 13 |
| 2011 | 0 | 14 | 14 |
| 2012 | 0 | 12 | 12 |
| 2013 | 3 | 5 | 8 |
| 2014 | 5 | 8 | 13 |
| 2015 | 2 | 8 | 10 |
| 2016 | 5 | 3 | 8 |
| 2017 | 1 | 5 | 6 |
| 2018 | 2 | 2 | 4 |
| 2019 | 3 | 5 | 8 |
| 2020 | 5 | 5 | 10 |
| 2021 | 9 | 9 | 18 |
| 2022 | 0 | 3 | 3 |
| 2023 | 1 | 6 | 7 |
| 2024 | 5 | 3 | 8 |
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Below are the most recent publications written about "Ataxia Telangiectasia Mutated Proteins" by people in Profiles.
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ATR inhibition radiosensitizes cells through augmented DNA damage and G2 cell cycle arrest abrogation. JCI Insight. 2024 Oct 08; 9(19).
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Correlative Analysis of ATM, RB1, ERCC2, and FANCC Mutations and Pathologic Complete Response After Neoadjuvant Chemotherapy in Patients with Muscle-invasive Bladder Cancer: Results from the SWOG S1314 Trial. Eur Urol. 2024 Oct; 86(4):297-300.
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Olaparib for childhood tumors harboring defects in DNA damage repair genes: arm H of the NCI-COG Pediatric MATCH trial. Oncologist. 2024 Jul 05; 29(7):638-e952.
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ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma. Nat Commun. 2024 Jun 21; 15(1):5294.
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Ataxia-Telangiectasia Mutated Loss-of-Function Displays Variant and Tissue-Specific Differences across Tumor Types. Clin Cancer Res. 2024 May 15; 30(10):2121-2139.
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REV7-p53 interaction inhibits ATM-mediated DNA damage signaling. Cell Cycle. 2024 Feb; 23(4):339-352.
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Targeting ATR in patients with cancer. Nat Rev Clin Oncol. 2024 Apr; 21(4):278-293.
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Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. Sci Transl Med. 2024 Feb 14; 16(734):eadj5962.
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ATM Mutations Associate with Distinct Co-Mutational Patterns and Therapeutic Vulnerabilities in NSCLC. Clin Cancer Res. 2023 12 01; 29(23):4958-4972.
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SETD2 Loss and ATR Inhibition Synergize to Promote cGAS Signaling and Immunotherapy Response in Renal Cell Carcinoma. Clin Cancer Res. 2023 10 02; 29(19):4002-4015.