MAP Kinase Kinase Kinases
"MAP Kinase Kinase Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Mitogen-activated protein kinase kinase kinases (MAPKKKs) are serine-threonine protein kinases that initiate protein kinase signaling cascades. They phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES; (MAPKKs) which in turn phosphorylate MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs).
| Descriptor ID |
D020930
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.559 D12.644.360.400 D12.776.476.400
|
| Concept/Terms |
MAP Kinase Kinase Kinases- MAP Kinase Kinase Kinases
- Mitogen-Activated Protein Kinase Kinase Kinases
- Mitogen Activated Protein Kinase Kinase Kinases
- Kinases, MAP Kinase Kinase
- MAP3 Kinases
- Kinases, MAP3
- MAP Kinase Kinase Kinase
- MAPKKKs
MAPK-ERK Kinase Kinases- MAPK-ERK Kinase Kinases
- Kinase Kinases, MAPK-ERK
- Kinases, MAPK-ERK Kinase
- MAPK ERK Kinase Kinases
- MEK Kinases
- Kinases, MEK
- MEKKs
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase Kinases".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase Kinases".
This graph shows the total number of publications written about "MAP Kinase Kinase Kinases" by people in this website by year, and whether "MAP Kinase Kinase Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 2 | 1 | 3 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 0 | 2 | 2 |
| 2006 | 1 | 1 | 2 |
| 2008 | 2 | 1 | 3 |
| 2011 | 1 | 2 | 3 |
| 2013 | 3 | 0 | 3 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 2 | 2 | 4 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 3 | 4 |
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Below are the most recent publications written about "MAP Kinase Kinase Kinases" by people in Profiles.
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DLK-dependent axonal mitochondrial fission drives degeneration after axotomy. Nat Commun. 2024 Dec 30; 15(1):10806.
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Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity. Nat Cardiovasc Res. 2024 Dec; 3(12):1568-1583.
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Remyelination protects neurons from DLK-mediated neurodegeneration. Nat Commun. 2024 Oct 23; 15(1):9148.
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Heterozygous MAP3K20 variants cause ectodermal dysplasia, craniosynostosis, sensorineural hearing loss, and limb anomalies. Hum Genet. 2024 Mar; 143(3):279-291.
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DLK-MAPK Signaling Coupled with DNA Damage Promotes Intrinsic Neurotoxicity Associated with Non-Mutated Tau. Mol Neurobiol. 2024 May; 61(5):2978-2995.
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Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J Med Chem. 2023 07 27; 66(14):9954-9971.
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Triple blockade of Ido-1, PD-L1 and MEK as a potential therapeutic strategy in NSCLC. J Transl Med. 2022 11 22; 20(1):541.
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Human genetics uncovers MAP3K15 as an obesity-independent therapeutic target for diabetes. Sci Adv. 2022 11 18; 8(46):eadd5430.
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The MAP3Ks DLK and LZK Direct Diverse Responses to Axon Damage in Zebrafish Peripheral Neurons. J Neurosci. 2022 08 10; 42(32):6195-6210.
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Protein Phosphatase 4 Promotes Hepatocyte Lipoapoptosis by Regulating RAC1/MLK3/JNK Pathway. Oxid Med Cell Longev. 2021; 2021:5550498.