"Myotonin-Protein Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Serine/threonine protein kinase responsible for various SKELETAL MUSCLE functions; HEART CONDUCTION SYSTEM activity; calcium HOMEOSTASIS; calcium uptake by SARCOPLASMIC RETICULUM and SYNAPTIC PLASTICITY. It is encoded by the DMPK gene and its abnormal EXPANDED TRINUCLEOTIDE REPEAT of CTG in the 3'-UTR is associated with MYOTONIC DYSTROPHY 1.
| Descriptor ID |
D065636
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.576
|
| Concept/Terms |
Myotonin-Protein Kinase- Myotonin-Protein Kinase
- Kinase, Myotonin-Protein
- Myotonin Protein Kinase
- DM-Kinase
- DM Kinase
- Myotonic Dystrophy Protein Kinase
- DMPK Protein
- Protein, DMPK
- MDGP Protein
- Protein, MDGP
- MDPK Protein
- Protein, MDPK
- DM Protein Kinase
- Kinase, DM Protein
- Protein Kinase, DM
- DM1PK Protein
- Protein, DM1PK
|
Below are MeSH descriptors whose meaning is more general than "Myotonin-Protein Kinase".
Below are MeSH descriptors whose meaning is more specific than "Myotonin-Protein Kinase".
This graph shows the total number of publications written about "Myotonin-Protein Kinase" by people in this website by year, and whether "Myotonin-Protein Kinase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 3 | 3 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 3 | 3 |
| 2025 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Myotonin-Protein Kinase" by people in Profiles.
-
MBNL loss of function in smooth muscle as a model for myotonic dystrophy associated gastrointestinal dysmotility. Proc Natl Acad Sci U S A. 2025 Dec 16; 122(50):e2522788122.
-
Expression levels of core spliceosomal proteins modulate the MBNL-mediated spliceopathy in DM1. Hum Mol Genet. 2024 11 05; 33(21):1873-1886.
-
Rescue of Scn5a mis-splicing does not improve the structural and functional heart defects of a DM1 heart mouse model. Hum Mol Genet. 2024 10 07; 33(20):1789-1799.
-
Combinatorial effects of ion channel mis-splicing as a cause of myopathy in myotonic dystrophy. J Clin Invest. 2024 01 02; 134(1).
-
Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial. Lancet Neurol. 2023 03; 22(3):218-228.
-
Reversible cardiac disease features in an inducible CUG repeat RNA-expressing mouse model of myotonic dystrophy. JCI Insight. 2021 03 08; 6(5).
-
Towards development of a statistical framework to evaluate myotonic dystrophy type 1 mRNA biomarkers in the context of a clinical trial. PLoS One. 2020; 15(4):e0231000.
-
De novo heterozygous missense and loss-of-function variants in CDC42BPB are associated with a neurodevelopmental phenotype. Am J Med Genet A. 2020 05; 182(5):962-973.
-
Therapeutic Genome Editing for Myotonic Dystrophy Type 1?Using CRISPR/Cas9. Mol Ther. 2018 Nov 07; 26(11):2617-2630.
-
Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1. Hum Mol Genet. 2018 08 15; 27(16):2789-2804.