"p21-Activated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of serine-threonine kinases that bind to and are activated by MONOMERIC GTP-BINDING PROTEINS such as RAC GTP-BINDING PROTEINS and CDC42 GTP-BINDING PROTEIN. They are intracellular signaling kinases that play a role the regulation of cytoskeletal organization.
| Descriptor ID |
D054462
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.596 D12.644.360.552 D12.776.476.548
|
| Concept/Terms |
p21-Activated Kinases- p21-Activated Kinases
- Kinases, p21-Activated
- p21 Activated Kinases
- PAK Kinases
- Kinases, PAK
p21-Activated Kinase 2- p21-Activated Kinase 2
- p21 Activated Kinase 2
- p65(PAK)
- p65PAK Protein
- PAK-2 Kinase
- PAK 2 Kinase
- PAK2 Kinase
- PAK65
- gamma-PAK
- gamma PAK
p21-Activated Kinase 1- p21-Activated Kinase 1
- p21 Activated Kinase 1
- Serine-Threonine-Protein Kinase PAK 1
- Serine Threonine Protein Kinase PAK 1
- alpha p21-Activated Kinase
- alpha p21 Activated Kinase
- alpha-PAK
- PAK1 Kinase
- PAK-1 Kinase
- PAK 1 Kinase
p21-Activated Kinase 3- p21-Activated Kinase 3
- p21 Activated Kinase 3
- Oligophrenin-3
- Oligophrenin 3
- Serine-Threonine-Protein Kinase PAK 3
- Serine Threonine Protein Kinase PAK 3
- PAK3 Kinase
- beta p21-Activated Kinase
- beta p21 Activated Kinase
- p21-Activated Kinase, beta
- beta-PAK
|
Below are MeSH descriptors whose meaning is more general than "p21-Activated Kinases".
Below are MeSH descriptors whose meaning is more specific than "p21-Activated Kinases".
This graph shows the total number of publications written about "p21-Activated Kinases" by people in this website by year, and whether "p21-Activated Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 2 | 3 | 5 |
| 2018 | 1 | 1 | 2 |
| 2020 | 2 | 0 | 2 |
| 2021 | 2 | 0 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "p21-Activated Kinases" by people in Profiles.
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PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy. Diabetes. 2024 Nov 01; 73(11):1805-1820.
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Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors. Cell. 2023 12 07; 186(25):5620-5637.e16.
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Anticancer Efficacy of KRASG12C Inhibitors Is Potentiated by PAK4 Inhibitor KPT9274 in Preclinical Models of KRASG12C-Mutant Pancreatic and Lung Cancers. Mol Cancer Ther. 2023 Dec 01; 22(12):1422-1433.
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PAK1 c.1409?T?>?a (p. Leu470Gln) de novo variant affects the protein kinase domain, leading to epilepsy, macrocephaly, spastic quadriplegia, and hydrocephalus: Case report and review of the literature. Am J Med Genet A. 2023 06; 191(6):1619-1625.
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Loss of Smad4 promotes aggressive lung cancer metastasis by de-repression of PAK3 via miRNA regulation. Nat Commun. 2021 08 11; 12(1):4853.
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p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma. Oncogene. 2021 02; 40(6):1176-1190.
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Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma. Cancer Res. 2021 01 01; 81(1):199-212.
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Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway. Cancer Lett. 2020 11 01; 492:136-146.
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Mislocalized cytoplasmic p27 activates PAK1-mediated metastasis and is a prognostic factor in osteosarcoma. Mol Oncol. 2020 04; 14(4):846-864.
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DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E11978-E11987.