Methyl-CpG-Binding Protein 2
"Methyl-CpG-Binding Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-binding protein that interacts with methylated CPG ISLANDS. It plays a role in repressing GENETIC TRANSCRIPTION and is frequently mutated in RETT SYNDROME.
Descriptor ID |
D051783
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MeSH Number(s) |
D12.776.260.536 D12.776.660.235.550 D12.776.664.235.700
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Methyl-CpG-Binding Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Methyl-CpG-Binding Protein 2".
This graph shows the total number of publications written about "Methyl-CpG-Binding Protein 2" by people in this website by year, and whether "Methyl-CpG-Binding Protein 2" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1999 | 0 | 1 | 1 |
2000 | 0 | 1 | 1 |
2001 | 0 | 1 | 1 |
2002 | 0 | 5 | 5 |
2003 | 0 | 3 | 3 |
2004 | 0 | 8 | 8 |
2005 | 2 | 0 | 2 |
2006 | 3 | 2 | 5 |
2007 | 4 | 0 | 4 |
2008 | 7 | 1 | 8 |
2009 | 6 | 4 | 10 |
2010 | 5 | 3 | 8 |
2011 | 4 | 3 | 7 |
2012 | 7 | 1 | 8 |
2013 | 3 | 4 | 7 |
2014 | 4 | 2 | 6 |
2015 | 12 | 3 | 15 |
2016 | 9 | 3 | 12 |
2017 | 2 | 0 | 2 |
2018 | 5 | 3 | 8 |
2019 | 1 | 4 | 5 |
2020 | 6 | 0 | 6 |
2021 | 4 | 2 | 6 |
2022 | 1 | 3 | 4 |
2023 | 1 | 6 | 7 |
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Below are the most recent publications written about "Methyl-CpG-Binding Protein 2" by people in Profiles.
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Generation of five induced pluripotent stem cell lines from patients with MECP2 Duplication Syndrome. Stem Cell Res. 2024 02; 74:103292.
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A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels. Genes Dev. 2023 10 01; 37(19-20):883-900.
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Parental age effects and Rett syndrome. Am J Med Genet A. 2024 Feb; 194(2):160-173.
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Exploring gastrointestinal health in MECP2 duplication syndrome. Neurogastroenterol Motil. 2023 08; 35(8):e14601.
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A Comprehensive and Integrative Approach to MeCP2 Disease Transcriptomics. Int J Mol Sci. 2023 Mar 07; 24(6).
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MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function. Elife. 2023 02 27; 12.
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Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation. Cell Rep. 2023 01 31; 42(1):111942.
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Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism. J Neurosci. 2022 08 17; 42(33):6469-6482.
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Improving clinical trial readiness to accelerate development of new therapeutics for Rett syndrome. Orphanet J Rare Dis. 2022 03 04; 17(1):108.
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Disruption of MeCP2-TCF20 complex underlies distinct neurodevelopmental disorders. Proc Natl Acad Sci U S A. 2022 01 25; 119(4).