Methyl-CpG-Binding Protein 2
"Methyl-CpG-Binding Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-binding protein that interacts with methylated CPG ISLANDS. It plays a role in repressing GENETIC TRANSCRIPTION and is frequently mutated in RETT SYNDROME.
| Descriptor ID |
D051783
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| MeSH Number(s) |
D12.776.260.536 D12.776.660.235.550 D12.776.664.235.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Methyl-CpG-Binding Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Methyl-CpG-Binding Protein 2".
This graph shows the total number of publications written about "Methyl-CpG-Binding Protein 2" by people in this website by year, and whether "Methyl-CpG-Binding Protein 2" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 4 | 4 |
| 2005 | 2 | 0 | 2 |
| 2006 | 3 | 2 | 5 |
| 2007 | 3 | 0 | 3 |
| 2008 | 6 | 0 | 6 |
| 2009 | 5 | 2 | 7 |
| 2010 | 2 | 0 | 2 |
| 2011 | 3 | 1 | 4 |
| 2012 | 6 | 0 | 6 |
| 2013 | 2 | 3 | 5 |
| 2014 | 3 | 1 | 4 |
| 2015 | 10 | 3 | 13 |
| 2016 | 7 | 2 | 9 |
| 2017 | 1 | 0 | 1 |
| 2018 | 5 | 2 | 7 |
| 2019 | 2 | 1 | 3 |
| 2020 | 4 | 0 | 4 |
| 2021 | 4 | 2 | 6 |
| 2022 | 1 | 1 | 2 |
| 2023 | 1 | 5 | 6 |
| 2024 | 5 | 2 | 7 |
| 2025 | 3 | 0 | 3 |
| 2026 | 2 | 2 | 4 |
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Below are the most recent publications written about "Methyl-CpG-Binding Protein 2" by people in Profiles.
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Forniceal deep brain stimulation improves memory in Rett syndrome mice by promoting the maturation of newborn hippocampal neurons. Proc Natl Acad Sci U S A. 2026 Nov 03; 123(44):e2535887123.
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Translational reading frame predicts the pathogenicity of C-terminal frameshift deletions in MeCP2. Elife. 2026 Aug 10; 14.
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Structural variant allelic heterogeneity in MECP2 duplication syndrome provides insight into clinical severity and variability of disease expression. Genome Med. 2024 12 18; 16(1):146.
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Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis. Neuron. 2025 Feb 05; 113(3):380-395.e8.
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Sensory experiences questionnaire unravels differences in sensory profiles between MECP2-related disorders. Autism Res. 2024 04; 17(4):775-784.
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A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels. Genes Dev. 2023 10 01; 37(19-20):883-900.
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Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation. Cell Rep. 2023 01 31; 42(1):111942.
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Antisense oligonucleotide therapy in a humanized mouse model of MECP2 duplication syndrome. Sci Transl Med. 2021 03 03; 13(583).
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The array of clinical phenotypes of males with mutations in Methyl-CpG binding protein 2. Am J Med Genet B Neuropsychiatr Genet. 2019 01; 180(1):55-67.
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Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations. Nat Commun. 2018 08 13; 9(1):3225.