Methyl-CpG-Binding Protein 2
"Methyl-CpG-Binding Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-binding protein that interacts with methylated CPG ISLANDS. It plays a role in repressing GENETIC TRANSCRIPTION and is frequently mutated in RETT SYNDROME.
| Descriptor ID |
D051783
|
| MeSH Number(s) |
D12.776.260.536 D12.776.660.235.550 D12.776.664.235.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Methyl-CpG-Binding Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Methyl-CpG-Binding Protein 2".
This graph shows the total number of publications written about "Methyl-CpG-Binding Protein 2" by people in this website by year, and whether "Methyl-CpG-Binding Protein 2" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 4 | 4 |
| 2005 | 2 | 0 | 2 |
| 2006 | 3 | 2 | 5 |
| 2007 | 3 | 0 | 3 |
| 2008 | 6 | 0 | 6 |
| 2009 | 5 | 2 | 7 |
| 2010 | 2 | 0 | 2 |
| 2011 | 3 | 1 | 4 |
| 2012 | 6 | 0 | 6 |
| 2013 | 2 | 3 | 5 |
| 2014 | 3 | 1 | 4 |
| 2015 | 10 | 3 | 13 |
| 2016 | 7 | 2 | 9 |
| 2017 | 1 | 0 | 1 |
| 2018 | 5 | 2 | 7 |
| 2019 | 2 | 1 | 3 |
| 2020 | 4 | 0 | 4 |
| 2021 | 4 | 2 | 6 |
| 2022 | 1 | 1 | 2 |
| 2023 | 1 | 5 | 6 |
| 2024 | 5 | 2 | 7 |
| 2025 | 3 | 0 | 3 |
| 2026 | 1 | 1 | 2 |
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Below are the most recent publications written about "Methyl-CpG-Binding Protein 2" by people in Profiles.
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Modulating alternative splicing of MECP2 is a potential therapeutic strategy for Rett syndrome. Sci Transl Med. 2026 Mar 04; 18(839):eadq4529.
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Using the linear references from the pangenome to discover missing autism variants. Nat Commun. 2026 Jan 23; 17(1):1681.
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MeCP2 interacts with the super elongation complex to regulate transcription. Sci Adv. 2025 Nov 28; 11(48):eadt5937.
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Immunomodulation of behavior impairment via spleen-specific targeting lipid nanoparticles in a MeCP2 transgenic mouse model. Sci Rep. 2025 Oct 31; 15(1):38135.
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Comprehensive assessment reveals numerous clinical and neurophysiological differences between MECP2-allelic disorders. Ann Clin Transl Neurol. 2025 Feb; 12(2):433-447.
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Structural variant allelic heterogeneity in MECP2 duplication syndrome provides insight into clinical severity and variability of disease expression. Genome Med. 2024 12 18; 16(1):146.
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Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis. Neuron. 2025 Feb 05; 113(3):380-395.e8.
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Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels. Hum Mol Genet. 2024 11 08; 33(22):1986-2001.
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MECP2 Variants in Males: More Common than Previously Appreciated. Pediatr Neurol. 2024 Dec; 161:263-267.
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Clinical Features and Disease Progression in Older Individuals with Rett Syndrome. Genes (Basel). 2024 Aug 22; 15(8).