Methyl-CpG-Binding Protein 2
"Methyl-CpG-Binding Protein 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A DNA-binding protein that interacts with methylated CPG ISLANDS. It plays a role in repressing GENETIC TRANSCRIPTION and is frequently mutated in RETT SYNDROME.
| Descriptor ID |
D051783
|
| MeSH Number(s) |
D12.776.260.536 D12.776.660.235.550 D12.776.664.235.700
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Methyl-CpG-Binding Protein 2".
Below are MeSH descriptors whose meaning is more specific than "Methyl-CpG-Binding Protein 2".
This graph shows the total number of publications written about "Methyl-CpG-Binding Protein 2" by people in this website by year, and whether "Methyl-CpG-Binding Protein 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 2 | 2 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 3 | 3 |
| 2002 | 0 | 5 | 5 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 5 | 5 |
| 2005 | 2 | 0 | 2 |
| 2006 | 3 | 2 | 5 |
| 2007 | 4 | 0 | 4 |
| 2008 | 7 | 1 | 8 |
| 2009 | 6 | 4 | 10 |
| 2010 | 5 | 3 | 8 |
| 2011 | 3 | 3 | 6 |
| 2012 | 7 | 1 | 8 |
| 2013 | 3 | 4 | 7 |
| 2014 | 4 | 2 | 6 |
| 2015 | 12 | 3 | 15 |
| 2016 | 9 | 3 | 12 |
| 2017 | 2 | 0 | 2 |
| 2018 | 6 | 3 | 9 |
| 2019 | 1 | 4 | 5 |
| 2020 | 6 | 0 | 6 |
| 2021 | 4 | 2 | 6 |
| 2022 | 1 | 2 | 3 |
| 2023 | 1 | 6 | 7 |
| 2024 | 2 | 2 | 4 |
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Below are the most recent publications written about "Methyl-CpG-Binding Protein 2" by people in Profiles.
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Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels. Hum Mol Genet. 2024 11 08; 33(22):1986-2001.
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Clinical Features and Disease Progression in Older Individuals with Rett Syndrome. Genes (Basel). 2024 Aug 22; 15(8).
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Autoimmune and neuropsychiatric phenotypes in a Mecp2 transgenic mouse model on C57BL/6 background. Front Immunol. 2024; 15:1370254.
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Sensory experiences questionnaire unravels differences in sensory profiles between MECP2-related disorders. Autism Res. 2024 04; 17(4):775-784.
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Generation of five induced pluripotent stem cell lines from patients with MECP2 Duplication Syndrome. Stem Cell Res. 2024 02; 74:103292.
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A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels. Genes Dev. 2023 10 01; 37(19-20):883-900.
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Parental age effects and Rett syndrome. Am J Med Genet A. 2024 02; 194(2):160-173.
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Exploring gastrointestinal health in MECP2 duplication syndrome. Neurogastroenterol Motil. 2023 08; 35(8):e14601.
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A Comprehensive and Integrative Approach to MeCP2 Disease Transcriptomics. Int J Mol Sci. 2023 Mar 07; 24(6).
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MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function. Elife. 2023 02 27; 12.