"Elongin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterotrimeric protein complex composed of 110 kDa elongin A, 18 kDa elongin B, and 15 kDa elongin C subunits. It functions as a positive regulator of RNA POLYMERASE II, increasing its rate of transcriptional elongation by suppressing transient pausing along the DNA template. Elongin A is the transcriptionally active component; elongins B and C enhance its activity.
| Descriptor ID |
D000075065
|
| MeSH Number(s) |
D12.776.260.197 D12.776.930.215
|
| Concept/Terms |
Elongin- Elongin
- SIII Elongation Factor
- Elongation Factor, SIII
- TF-SIII
- Transcription Factor SIII
- SIII, Transcription Factor
- Elongin Complex
- Complex, Elongin
|
Below are MeSH descriptors whose meaning is more general than "Elongin".
Below are MeSH descriptors whose meaning is more specific than "Elongin".
This graph shows the total number of publications written about "Elongin" by people in this website by year, and whether "Elongin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Elongin" by people in Profiles.
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The TFIIS N-terminal domain (TND): a transcription assembly module at the interface of order and disorder. Biochem Soc Trans. 2023 02 27; 51(1):125-135.
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Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014 Jun 01; 74(11):3127-36.
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Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res. 2011 May; 21(5):754-69.
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Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. Structure. 2007 Nov; 15(11):1493-504.
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von Hippel-Lindau protein induces hypoxia-regulated arrest of tyrosine hydroxylase transcript elongation in pheochromocytoma cells. J Biol Chem. 1999 Oct 15; 274(42):30109-14.
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Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science. 1999 Apr 23; 284(5414):657-61.