Intrinsically Disordered Proteins
"Intrinsically Disordered Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Functional proteins that do not have unique, stable, folded, three-dimensional native structures or that possess non-ordered regions under physiological conditions. They are characterized by extraordinary structural flexibility and plasticity, which enable them to adopt different conformations in response to different stimuli or different interactions.
| Descriptor ID |
D064267
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| MeSH Number(s) |
D12.776.481
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Intrinsically Disordered Proteins".
Below are MeSH descriptors whose meaning is more specific than "Intrinsically Disordered Proteins".
This graph shows the total number of publications written about "Intrinsically Disordered Proteins" by people in this website by year, and whether "Intrinsically Disordered Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2017 | 2 | 1 | 3 |
| 2018 | 2 | 2 | 4 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 1 | 1 |
| 2021 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
| 2023 | 2 | 0 | 2 |
| 2024 | 2 | 0 | 2 |
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Below are the most recent publications written about "Intrinsically Disordered Proteins" by people in Profiles.
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How hydrophobicity, side chains, and salt affect the dimensions of disordered proteins. Protein Sci. 2024 May; 33(5):e4986.
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Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing. Nat Cell Biol. 2024 Apr; 26(4):593-603.
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Aggregation of Disordered Proteins Associated with Neurodegeneration. Int J Mol Sci. 2023 Feb 08; 24(4).
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Interaction modules that impart specificity to disordered protein. Trends Biochem Sci. 2023 05; 48(5):477-490.
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The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems. Nat Commun. 2022 09 26; 13(1):5643.
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A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science. 2021 Nov 26; 374(6571):1113-1121.
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Electrostatic modulation of hnRNPA1 low-complexity domain liquid-liquid phase separation and aggregation. Protein Sci. 2021 07; 30(7):1408-1417.
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Dihydroquinazolines enhance 20S proteasome activity and induce degradation of a-synuclein, an intrinsically disordered protein associated with neurodegeneration. Bioorg Med Chem Lett. 2021 03 15; 36:127821.
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Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization. Cell. 2020 04 16; 181(2):306-324.e28.
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Single-molecule fluorescence studies of intrinsically disordered proteins and liquid phase separation. Biochim Biophys Acta Proteins Proteom. 2019 10; 1867(10):980-987.