"Prions" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small proteinaceous infectious particles which resist inactivation by procedures that modify NUCLEIC ACIDS and contain an abnormal isoform of a cellular protein which is a major and necessary component. The abnormal (scrapie) isoform is PrPSc (PRPSC PROTEINS) and the cellular isoform PrPC (PRPC PROTEINS). The primary amino acid sequence of the two isoforms is identical. Human diseases caused by prions include CREUTZFELDT-JAKOB SYNDROME; GERSTMANN-STRAUSSLER SYNDROME; and INSOMNIA, FATAL FAMILIAL.
| Descriptor ID |
D011328
|
| MeSH Number(s) |
D12.776.785
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| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Prions".
Below are MeSH descriptors whose meaning is more specific than "Prions".
This graph shows the total number of publications written about "Prions" by people in this website by year, and whether "Prions" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 2 | 0 | 2 |
| 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Prions" by people in Profiles.
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Effects of the pathological E200K mutation on human prion protein: A computational screening and molecular dynamics approach. J Cell Biochem. 2023 02; 124(2):254-265.
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NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency. Nat Cell Biol. 2022 05; 24(5):737-747.
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Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology. J Biol Chem. 2022 03; 298(3):101720.
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A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation. Cell. 2021 08 05; 184(16):4284-4298.e27.
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Supercharging Prions via Amyloid-Selective Lysine Acetylation. Angew Chem Int Ed Engl. 2021 06 25; 60(27):15069-15079.
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Axons Gonna Ride 'til They Can't No More. Neuron. 2019 10 23; 104(2):179-181.
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Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo. Cell. 2019 09 05; 178(6):1403-1420.e21.
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Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70). J Biol Chem. 2019 09 13; 294(37):13619-13628.
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Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure. Oncotarget. 2015 Sep 15; 6(27):24178-91.
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Amyloid-? oligomers as a template for secondary amyloidosis in Alzheimer's disease. Neurobiol Dis. 2014 Nov; 71:14-23.