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JOSEPHINE FERREON

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza
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    Collapse Research 
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    R01GM122763     (FERREON, JOSEPHINE CHU)Jan 1, 2018 - May 31, 2027
    NIH
    Structure and Functionof Nanog in Stem Cell Pluripotency
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Griffin P, Mann M, Wang M, Ferreon J, Suess M, Jain A, Malovannaya A, Alvarez RV, Pascal B, Kumar R, Edwards D, Griffin P, Mann M, Wang M, Ferreon J, Suess M, Jain A, Malovannaya A, Alvarez RV, Pascal B, Kumar R, Edwards D. Structural proteomics defines a sequential priming mechanism for the progesterone receptor. Res Sq. 2024 Nov 14. PMID: 39606477; PMCID: PMC11601812.
      Citations:    
    2. Mann MD, Wang M, Ferreon JC, Suess MP, Jain A, Malovannaya A, Alvarez RV, Pascal BD, Kumar R, Edwards DP, Griffin PR. Structural proteomics defines a sequential priming mechanism for the progesterone receptor. bioRxiv. 2024 Oct 03. PMID: 39282295; PMCID: PMC11398526.
      Citations:    
    3. Ferreon JC, Kongchan N, Tsoi PS, Choi KJ, Kenrick S, Neilson J, Ferreon ACM. Multivalent Protein-Nucleic Acid Interactions Probed by Composition-Gradient Multiangle Light Scattering. ACS Omega. 2024 Oct 01; 9(39):41003-41010. PMID: 39371993; PMCID: PMC11447847.
      Citations:    
    4. Tsoi PS, Ferreon JC, Ferreon ACM. Initiation of hnRNPA1 Low-Complexity Domain Condensation Monitored by Dynamic Light Scattering. Int J Mol Sci. 2024 Jun 21; 25(13). PMID: 38999934; PMCID: PMC11241569.
      Citations:    Fields:    Translation:HumansCells
    5. Ferreon JC, Ta HM, Yun H, Choi KJ, Quan MD, Tsoi PS, Kim C, Lee CW, Ferreon ACM. Stereospecific NANOG PEST Stabilization by Pin1. Biochemistry. 2024 05 07; 63(9):1067-1074. PMID: 38619104.
      Citations:    Fields:    Translation:HumansCells
    6. Quan MD, Ferreon JC, Ferreon ACM. Micropolarized to the core. Nat Chem Biol. 2024 Apr; 20(4):399-400. PMID: 38326412.
      Citations: 1     Fields:    
    7. Tsoi PS, Quan MD, Ferreon JC, Ferreon ACM. Aggregation of Disordered Proteins Associated with Neurodegeneration. Int J Mol Sci. 2023 Feb 08; 24(4). PMID: 36834792; PMCID: PMC9966039.
      Citations: 1     Fields:    Translation:Humans
    8. Quan MD, Liao SJ, Ferreon JC, Ferreon ACM. Fluorescence Lifetime Imaging Microscopy of Biomolecular Condensates. Methods Mol Biol. 2023; 2563:135-148. PMID: 36227471; PMCID: PMC10321152.
      Citations:    Fields:    Translation:Cells
    9. Choi KJ, Quan MD, Qi C, Lee JH, Tsoi PS, Zahabiyon M, Bajic A, Hu L, Prasad BVV, Liao SJ, Li W, Ferreon ACM, Ferreon JC. NANOG prion-like assembly mediates DNA bridging to facilitate chromatin reorganization and activation of pluripotency. Nat Cell Biol. 2022 05; 24(5):737-747. PMID: 35484250; PMCID: PMC9106587.
      Citations:    Fields:    Translation:HumansCells
    10. Sharma R, Choi KJ, Quan MD, Sharma S, Sankaran B, Park H, LaGrone A, Kim JJ, MacKenzie KR, Ferreon ACM, Kim C, Ferreon JC. Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nat Commun. 2021 09 22; 12(1):5579. PMID: 34552088; PMCID: PMC8458463.
      Citations: 3     Fields:    Translation:HumansCells
    11. Lee JH, Wang R, Xiong F, Krakowiak J, Liao Z, Nguyen PT, Moroz-Omori EV, Shao J, Zhu X, Bolt MJ, Wu H, Singh PK, Bi M, Shi CJ, Jamal N, Li G, Mistry R, Jung SY, Tsai KL, Ferreon JC, Stossi F, Caflisch A, Liu Z, Mancini MA, Li W. Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation. Mol Cell. 2021 08 19; 81(16):3368-3385.e9. PMID: 34375583; PMCID: PMC8383322.
      Citations: 21     Fields:    Translation:HumansCells
    12. Tsoi PS, Quan MD, Choi KJ, Dao KM, Ferreon JC, Ferreon ACM. Electrostatic modulation of hnRNPA1 low-complexity domain liquid-liquid phase separation and aggregation. Protein Sci. 2021 07; 30(7):1408-1417. PMID: 33982369; PMCID: PMC8197420.
      Citations: 4     Fields:    Translation:HumansCells
    13. Nie S, Yao Y, Wu F, Wu X, Zhao J, Hua Y, Wu J, Huo T, Lin YL, Kneubehl AR, Vogt MB, Ferreon J, Rico-Hesse R, Song Y. Synthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J Med Chem. 2021 03 11; 64(5):2777-2800. PMID: 33596380; PMCID: PMC8052950.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    14. Nguyen TM, Kabotyanski EB, Reineke LC, Shao J, Xiong F, Lee JH, Dubrulle J, Johnson H, Stossi F, Tsoi PS, Choi KJ, Ellis AG, Zhao N, Cao J, Adewunmi O, Ferreon JC, Ferreon ACM, Neilson JR, Mancini MA, Chen X, Li W, Rosen JM, Kim J, Ma L. The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020 03 18; 48(5):2621-2642. PMID: 31863590; PMCID: PMC7049706.
      Citations: 25     Fields:    Translation:HumansCells
    15. Mitra S, Kumar D, Hu L, Sankaran B, Moosa MM, Rice AP, Ferreon JC, Ferreon ACM, Prasad BVV. Influenza A Virus Protein NS1 Exhibits Strain-Independent Conformational Plasticity. J Virol. 2019 11 01; 93(21). PMID: 31375595; PMCID: PMC6803261.
      Citations: 7     Fields:    Translation:Cells
    16. Moosa MM, Ferreon JC, Ferreon ACM. Single-Molecule FRET Detection of Early-Stage Conformations in a-Synuclein Aggregation. Methods Mol Biol. 2019; 1948:221-233. PMID: 30771181.
      Citations: 1     Fields:    Translation:Cells
    17. Choi KJ, Tsoi PS, Moosa MM, Paulucci-Holthauzen A, Liao SJ, Ferreon JC, Ferreon ACM. A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation. Biochemistry. 2018 12 18; 57(50):6822-6826. PMID: 30520303; PMCID: PMC6555487.
      Citations: 16     Fields:    Translation:HumansCells
    18. Moosa MM, Tsoi PS, Choi KJ, Ferreon ACM, Ferreon JC. Direct Single-Molecule Observation of Sequential DNA Bending Transitions by the Sox2 HMG Box. Int J Mol Sci. 2018 Dec 04; 19(12). PMID: 30518054; PMCID: PMC6321608.
      Citations: 3     Fields:    Translation:Cells
    19. Ramani S, Stewart CJ, Laucirica DR, Ajami NJ, Robertson B, Autran CA, Shinge D, Rani S, Anandan S, Hu L, Ferreon JC, Kuruvilla KA, Petrosino JF, Venkataram Prasad BV, Bode L, Kang G, Estes MK. Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection. Nat Commun. 2018 11 27; 9(1):5010. PMID: 30479342; PMCID: PMC6258677.
      Citations: 59     Fields:    Translation:HumansCells
    20. Hu L, Sankaran B, Laucirica DR, Patil K, Salmen W, Ferreon ACM, Tsoi PS, Lasanajak Y, Smith DF, Ramani S, Atmar RL, Estes MK, Ferreon JC, Prasad BVV. Glycan recognition in globally dominant human rotaviruses. Nat Commun. 2018 07 06; 9(1):2631. PMID: 29980685; PMCID: PMC6035239.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    21. Moosa MM, Ferreon JC, Ferreon ACM. Ligand interactions and the protein order-disorder energetic continuum. Semin Cell Dev Biol. 2020 03; 99:78-85. PMID: 29753880.
      Citations: 4     Fields:    Translation:HumansCells
    22. Ferreon JC, Jain A, Choi KJ, Tsoi PS, MacKenzie KR, Jung SY, Ferreon AC. Acetylation Disfavors Tau Phase Separation. Int J Mol Sci. 2018 May 04; 19(5). PMID: 29734651; PMCID: PMC5983838.
      Citations: 45     Fields:    Translation:HumansCells
    23. Moosa MM, Goodman AZ, Ferreon JC, Lee CW, Ferreon ACM, Deniz AA. Denaturant-specific effects on the structural energetics of a protein-denatured ensemble. Eur Biophys J. 2018 Jan; 47(1):89-94. PMID: 29080139; PMCID: PMC6588398.
      Citations: 1     Fields:    Translation:Cells
    24. Tsoi PS, Choi KJ, Leonard PG, Sizovs A, Moosa MM, MacKenzie KR, Ferreon JC, Ferreon ACM. The N-Terminal Domain of ALS-Linked TDP-43 Assembles without Misfolding. Angew Chem Int Ed Engl. 2017 10 02; 56(41):12590-12593. PMID: 28833982.
      Citations: 23     Fields:    Translation:HumansCells
    25. Krois AS, Ferreon JC, Martinez-Yamout MA, Dyson HJ, Wright PE. Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1853-62. PMID: 26976603; PMCID: PMC4822595.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    26. Ferreon AC, Ferreon JC, Wright PE, Deniz AA. Modulation of allostery by protein intrinsic disorder. Nature. 2013 Jun 20; 498(7454):390-4. PMID: 23783631; PMCID: PMC3718496.
      Citations: 144     Fields:    Translation:HumansAnimalsCells
    27. Arai M, Ferreon JC, Wright PE. Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP. J Am Chem Soc. 2012 Feb 29; 134(8):3792-803. PMID: 22280219; PMCID: PMC3290704.
      Citations: 69     Fields:    Translation:Cells
    28. Lee CW, Ferreon JC, Ferreon AC, Arai M, Wright PE. Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19290-5. PMID: 20962272; PMCID: PMC2984141.
      Citations: 99     Fields:    Translation:Cells
    29. Ferreon AC, Moran CR, Ferreon JC, Deniz AA. Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease. Angew Chem Int Ed Engl. 2010 May 03; 49(20):3469-72. PMID: 20544898; PMCID: PMC2972640.
      Citations: 34     Fields:    Translation:Cells
    30. Ferreon JC, Martinez-Yamout MA, Dyson HJ, Wright PE. Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13260-5. PMID: 19651603; PMCID: PMC2726373.
      Citations: 65     Fields:    Translation:AnimalsCells
    31. Manson A, Whitten ST, Ferreon JC, Fox RO, Hilser VJ. Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity. J Am Chem Soc. 2009 May 20; 131(19):6785-93. PMID: 19397330; PMCID: PMC2711448.
      Citations: 8     Fields:    Translation:AnimalsCells
    32. Ferreon JC, Lee CW, Arai M, Martinez-Yamout MA, Dyson HJ, Wright PE. Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6591-6. PMID: 19357310; PMCID: PMC2672497.
      Citations: 99     Fields:    Translation:AnimalsCells
    33. Ferreon AC, Ferreon JC, Bolen DW, R?sgen J. Protein phase diagrams II: nonideal behavior of biochemical reactions in the presence of osmolytes. Biophys J. 2007 Jan 01; 92(1):245-56. PMID: 17028144; PMCID: PMC1697851.
      Citations: 8     Fields:    Translation:Cells
    34. Ferreon JC, Ferreon AC, Li K, Lemon SM. Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease. J Biol Chem. 2005 May 27; 280(21):20483-92. PMID: 15767257.
      Citations: 38     Fields:    Translation:Cells
    35. Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, Gale M, Lemon SM. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2992-7. PMID: 15710891; PMCID: PMC548795.
      Citations: 423     Fields:    Translation:HumansCells
    36. Ferreon JC, Hamburger JB, Hilser VJ. An experimental strategy to evaluate the thermodynamic stability of highly dynamic binding sites in proteins using hydrogen exchange. J Am Chem Soc. 2004 Oct 13; 126(40):12774-5. PMID: 15469262.
      Citations: 4     Fields:    Translation:Cells
    37. Hamburger JB, Ferreon JC, Whitten ST, Hilser VJ. Thermodynamic mechanism and consequences of the polyproline II (PII) structural bias in the denatured states of proteins. Biochemistry. 2004 Aug 03; 43(30):9790-9. PMID: 15274633.
      Citations: 15     Fields:    Translation:AnimalsCells
    38. Ferreon JC, Hilser VJ. Thermodynamics of binding to SH3 domains: the energetic impact of polyproline II (PII) helix formation. Biochemistry. 2004 Jun 22; 43(24):7787-97. PMID: 15196021.
      Citations: 19     Fields:    Translation:Cells
    39. Ferguson MR, Fan X, Mukherjee M, Luo J, Khan R, Ferreon JC, Hilser VJ, Shope RE, Fox RO. Directed discovery of bivalent peptide ligands to an SH3 domain. Protein Sci. 2004 Mar; 13(3):626-32. PMID: 14978303; PMCID: PMC2286729.
      Citations: 3     Fields:    Translation:AnimalsCells
    40. Ferreon JC, Volk DE, Luxon BA, Gorenstein DG, Hilser VJ. Solution structure, dynamics, and thermodynamics of the native state ensemble of the Sem-5 C-terminal SH3 domain. Biochemistry. 2003 May 20; 42(19):5582-91. PMID: 12741814.
      Citations: 11     Fields:    Translation:AnimalsCells
    41. Ferreon JC, Hilser VJ. Ligand-induced changes in dynamics in the RT loop of the C-terminal SH3 domain of Sem-5 indicate cooperative conformational coupling. Protein Sci. 2003 May; 12(5):982-96. PMID: 12717021; PMCID: PMC2323869.
      Citations: 12     Fields:    Translation:Cells
    42. Ferreon JC, Hilser VJ. The effect of the polyproline II (PPII) conformation on the denatured state entropy. Protein Sci. 2003 Mar; 12(3):447-57. PMID: 12592015; PMCID: PMC2312442.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    43. Soman KV, Midoro-Horiuti T, Ferreon JC, Goldblum RM, Brooks EG, Kurosky A, Braun W, Schein CH. Homology modeling and characterization of IgE binding epitopes of mountain cedar allergen Jun a 3. Biophys J. 2000 Sep; 79(3):1601-9. PMID: 10969020; PMCID: PMC1301052.
      Citations: 24     Fields:    Translation:AnimalsCells
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