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YONGCHENG SONG

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza
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    Collapse Research 
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    R01CA266057     (SONG, YONGCHENG)Dec 10, 2021 - Nov 30, 2025
    NIH
    Novel Small-Molecule Probes Targeting Oncogenic Fusion MLL in Pediatric Leukemia
    Role: Principal Investigator
    R21AI159323     (SONG, YONGCHENG)Dec 1, 2020 - Nov 30, 2022
    NIH
    Novel small-molecule inhibitors of SARS-CoV-2 protease
    Role: Principal Investigator
    R01NS080963     (SONG, YONGCHENG)Sep 30, 2012 - Aug 31, 2018
    NIH
    Chemical Probes Targeting Gliomas with IDH Mutation
    Role: Principal Investigator
    R21AI088123     (SONG, YONGCHENG)Jun 18, 2010 - Nov 30, 2012
    NIH
    Novel inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR)
    Role: Principal Investigator
    R21AI090190     (SONG, YONGCHENG)Jun 1, 2010 - Nov 30, 2012
    NIH
    Novel Metallo-beta-lactamase Inhibitors
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pham S, Zhao B, Neetu N, Sankaran B, Patil K, Ramani S, Song Y, Estes MK, Palzkill T, Prasad BVV. CONFORMATIONAL FLEXIBILITY IS A CRITICAL FACTOR IN DESIGNING BROAD-SPECTRUM HUMAN NOROVIRUS PROTEASE INHIBITORS. bioRxiv. 2024 Sep 19. PMID: 39345439; PMCID: PMC11430002.
      Citations:    
    2. Ashraf-Uz-Zaman M, Chua TK, Li X, Yao Y, Moku BK, Mishra CB, Avadhanula V, Piedra PA, Song Y. Design, Synthesis, X-ray Crystallography, and Biological Activities of Covalent, Non-Peptidic Inhibitors of SARS-CoV-2 Main Protease. ACS Infect Dis. 2024 02 09; 10(2):715-731. PMID: 38192109; PMCID: PMC10922772.
      Citations: 1     Fields:    Translation:HumansCells
    3. Li X, Song Y. Targeting SARS-CoV-2 nonstructural protein 3: Function, structure, inhibition, and perspective in drug discovery. Drug Discov Today. 2024 Jan; 29(1):103832. PMID: 37977285; PMCID: PMC10872262.
      Citations:    Fields:    Translation:HumansCells
    4. Li X, Wu X, Nie S, Zhao J, Yao Y, Wu F, Mishra CB, Ashraf-Uz-Zaman M, Moku BK, Song Y. Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L. Cancers (Basel). 2023 Nov 03; 15(21). PMID: 37958457; PMCID: PMC10650850.
      Citations:    
    5. Lin FT, Liu K, Garan LAW, Folly-Kossi H, Song Y, Lin SJ, Lin WC. A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and synergy with PARP inhibitors. Proc Natl Acad Sci U S A. 2023 Oct 31; 120(44):e2307793120. PMID: 37878724; PMCID: PMC10622895.
      Citations:    Fields:    Translation:HumansAnimals
    6. Li X, Song Y. Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review. Eur J Med Chem. 2023 Nov 15; 260:115772. PMID: 37659195; PMCID: PMC10529944.
      Citations: 13     Fields:    Translation:HumansCells
    7. Nie S, Wu F, Wu J, Li X, Zhou C, Yao Y, Song Y. Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur J Med Chem. 2022 Jul 05; 237:114407. PMID: 35512565; PMCID: PMC9165588.
      Citations:    Fields:    Translation:HumansCells
    8. Li X, Yao Y, Wu F, Song Y. A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth. J Hematol Oncol. 2022 04 08; 15(1):41. PMID: 35395864; PMCID: PMC8994274.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Kogiso M, Qi L, Du Y, Braun FK, Zhang H, Huang LF, Guo L, Huang Y, Teo WY, Lindsay H, Zhao S, Injac SG, Liu Z, Mehta V, Tran D, Li F, Baxter PA, Su JM, Perlaky L, Parsons DW, Chintagumpala M, Adesina A, Song Y, Li XN. Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma. Transl Oncol. 2022 Apr; 18:101368. PMID: 35182954; PMCID: PMC8857594.
      Citations:    
    10. Zhao B, Hu L, Song Y, Patil K, Ramani S, Atmar RL, Estes MK, Prasad BVV. Norovirus Protease Structure and Antivirals Development. Viruses. 2021 10 14; 13(10). PMID: 34696498; PMCID: PMC8537771.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Wu F, Nie S, Yao Y, Huo T, Li X, Wu X, Zhao J, Lin YL, Zhang Y, Mo Q, Song Y. Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth. Theranostics. 2021; 11(17):8172-8184. PMID: 34373735; PMCID: PMC8344022.
      Citations: 3     Fields:    Translation:AnimalsCells
    12. Li X, Song Y. Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins. J Hematol Oncol. 2021 04 06; 14(1):56. PMID: 33823889; PMCID: PMC8022399.
      Citations: 7     Fields:    Translation:Humans
    13. Nie S, Yao Y, Wu F, Wu X, Zhao J, Hua Y, Wu J, Huo T, Lin YL, Kneubehl AR, Vogt MB, Ferreon J, Rico-Hesse R, Song Y. Synthesis, Structure-Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B-NS3 Protease. J Med Chem. 2021 03 11; 64(5):2777-2800. PMID: 33596380; PMCID: PMC8052950.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    14. Mullany LK, Rohira AD, Leach JP, Kim JH, Monroe TO, Ortiz AR, Stork B, Gaber MW, Sarkar P, Sikora AG, Rosengart TK, York B, Song Y, Dacso CC, Lonard DM, Martin JF, O'Malley BW. A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31353-31364. PMID: 33229578; PMCID: PMC7733826.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Li X, Song Y. Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy. J Hematol Oncol. 2020 05 13; 13(1):50. PMID: 32404196; PMCID: PMC7218526.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    16. Gao Y, Chen L, Han Y, Wu F, Yang WS, Zhang Z, Huo T, Zhu Y, Yu C, Kim H, Lee M, Tang Z, Phillips K, He B, Jung SY, Song Y, Zhu B, Xu RM, Feng Q. Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha. Commun Biol. 2020 04 07; 3(1):165. PMID: 32265480; PMCID: PMC7138820.
      Citations: 11     Translation:HumansCells
    17. Wu F, Song T, Yao Y, Song Y. Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1. PLoS One. 2019; 14(5):e0216203. PMID: 31048839; PMCID: PMC6497270.
      Citations:    Fields:    Translation:HumansCells
    18. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2019 02 22; 10(16):1603. PMID: 30899429; PMCID: PMC6422187.
      Citations: 1     Fields:    
    19. Conley ZC, Carlson-Banning KM, Carter AG, de la Cova A, Song Y, Zechiedrich L. Sugar and iron: Toward understanding the antibacterial effect of ciclopirox in Escherichia coli. PLoS One. 2019; 14(1):e0210547. PMID: 30633761; PMCID: PMC6329577.
      Citations: 4     Fields:    Translation:Cells
    20. Lu L, Wen Y, Yao Y, Chen F, Wang G, Wu F, Wu J, Narayanan P, Redell M, Mo Q, Song Y. Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). Theranostics. 2018; 8(8):2189-2201. PMID: 29721072; PMCID: PMC5928880.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    21. Wu F, Cheng G, Yao Y, Kogiso M, Jiang H, Li XN, Song Y. Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer. Med Chem. 2018; 14(7):715-724. PMID: 29792149; PMCID: PMC6205205.
      Citations: 2     Fields:    Translation:HumansCells
    22. Zhou C, Wu F, Lu L, Wei L, Pai E, Yao Y, Song Y. Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1. PLoS One. 2017; 12(2):e0170301. PMID: 28158205; PMCID: PMC5291514.
      Citations: 5     Fields:    Translation:HumansCells
    23. Rau RE, Rodriguez BA, Luo M, Jeong M, Rosen A, Rogers JH, Campbell CT, Daigle SR, Deng L, Song Y, Sweet S, Chevassut T, Andreeff M, Kornblau SM, Li W, Goodell MA. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 08 18; 128(7):971-81. PMID: 27335278; PMCID: PMC4990856.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    24. Song Y, Wu F, Wu J. Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives. J Hematol Oncol. 2016 06 17; 9(1):49. PMID: 27316347; PMCID: PMC4912745.
      Citations: 55     Fields:    Translation:Cells
    25. Prasad BV, Shanker S, Muhaxhiri Z, Deng L, Choi JM, Estes MK, Song Y, Palzkill T, Atmar RL. Antiviral targets of human noroviruses. Curr Opin Virol. 2016 06; 18:117-25. PMID: 27318434; PMCID: PMC4983487.
      Citations: 17     Fields:    Translation:HumansCells
    26. Bharadwaj U, Eckols TK, Xu X, Kasembeli MM, Chen Y, Adachi M, Song Y, Mo Q, Lai SY, Tweardy DJ. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 03; 7(18):26307-30. PMID: 27027445; PMCID: PMC5041982.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    27. Feng Z, Yao Y, Zhou C, Chen F, Wu F, Wei L, Liu W, Dong S, Redell M, Mo Q, Song Y. Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. J Hematol Oncol. 2016 Mar 12; 9:24. PMID: 26970896; PMCID: PMC4789278.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    28. Wu F, Zhou C, Yao Y, Wei L, Feng Z, Deng L, Song Y. 3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1. J Med Chem. 2016 Jan 14; 59(1):253-263. PMID: 26652247; PMCID: PMC4878443.
      Citations: 19     Fields:    Translation:HumansCells
    29. Wu F, Jiang H, Zheng B, Kogiso M, Yao Y, Zhou C, Li XN, Song Y. Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds. J Med Chem. 2015 Sep 10; 58(17):6899-6908. PMID: 26280302; PMCID: PMC4567406.
      Citations: 15     Fields:    Translation:HumansCells
    30. Chowdhury P, Lin GE, Liu K, Song Y, Lin FT, Lin WC. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nat Commun. 2014 Nov 17; 5:5476. PMID: 25400145; PMCID: PMC4254804.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    31. Zhang L, Deng L, Chen F, Yao Y, Wu B, Wei L, Mo Q, Song Y. Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer. Oncotarget. 2014 Nov 15; 5(21):10665-77. PMID: 25359765; PMCID: PMC4279401.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    32. Yao Y, Kogiso M, Zheng B, Deng L, Qiu JJ, Dong S, Lv H, Gallo JM, Li XN, Song Y, Liu Z. Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity. J Med Chem. 2014 Oct 23; 57(20):8307-18. PMID: 25271760; PMCID: PMC4207540.
      Citations: 17     Fields:    Translation:HumansAnimals
    33. Feng Q, Zhang Z, Shea MJ, Creighton CJ, Coarfa C, Hilsenbeck SG, Lanz R, He B, Wang L, Fu X, Nardone A, Song Y, Bradner J, Mitsiades N, Mitsiades CS, Osborne CK, Schiff R, O'Malley BW. An epigenomic approach to therapy for tamoxifen-resistant breast cancer. Cell Res. 2014 Jul; 24(7):809-19. PMID: 24874954; PMCID: PMC4085766.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    34. Liu W, Deng L, Song Y, Redell M. DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy. PLoS One. 2014; 9(5):e98270. PMID: 24858818; PMCID: PMC4032273.
      Citations: 41     Fields:    Translation:HumansCells
    35. Deng L, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song Y. Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors. Medchemcomm. 2013 Oct; 4(10). PMID: 24244836; PMCID: PMC3826262.
      Citations: 14     
    36. Anglin JL, Song Y. A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L. J Med Chem. 2013 Nov 27; 56(22):8972-83. PMID: 23879463; PMCID: PMC4109313.
      Citations: 26     Fields:    Translation:HumansAnimals
    37. Carlson-Banning KM, Chou A, Liu Z, Hamill RJ, Song Y, Zechiedrich L. Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae. PLoS One. 2013; 8(7):e69646. PMID: 23936064; PMCID: PMC3720592.
      Citations: 28     Fields:    Translation:HumansCells
    38. Zheng B, Yao Y, Liu Z, Deng L, Anglin JL, Jiang H, Prasad BV, Song Y. Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett. 2013 Jun 13; 4(6):542-546. PMID: 23795241; PMCID: PMC3686309.
      Citations: 27     
    39. Deng L, Zhang L, Yao Y, Wang C, Redell MS, Dong S, Song Y. Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L. Medchemcomm. 2013 May 01; 4(5):822-826. PMID: 23795283; PMCID: PMC3686528.
      Citations: 18     
    40. Xue J, Diao J, Cai G, Deng L, Zheng B, Yao Y, Song Y. Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase. ACS Med Chem Lett. 2013 Feb 14; 4(2):278-282. PMID: 23795240; PMCID: PMC3685428.
      Citations: 11     
    41. Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y, Prasad BV. Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol. 2013 Apr; 87(8):4281-92. PMID: 23365454; PMCID: PMC3624372.
      Citations: 32     Fields:    Translation:Cells
    42. Cai G, Deng L, Xue J, Moreno SN, Striepen B, Song Y. Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2158-61. PMID: 23428849; PMCID: PMC3602143.
      Citations: 3     Fields:    Translation:AnimalsCells
    43. Anglin JL, Deng L, Yao Y, Cai G, Liu Z, Jiang H, Cheng G, Chen P, Dong S, Song Y. Synthesis and structure-activity relationship investigation of adenosine-containing inhibitors of histone methyltransferase DOT1L. J Med Chem. 2012 Sep 27; 55(18):8066-74. PMID: 22924785; PMCID: PMC3475323.
      Citations: 39     Fields:    Translation:HumansCells
    44. Chen P, Horton LB, Mikulski RL, Deng L, Sundriyal S, Palzkill T, Song Y. 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-?-lactamases. Bioorg Med Chem Lett. 2012 Oct 01; 22(19):6229-32. PMID: 22921080; PMCID: PMC3463135.
      Citations: 12     Fields:    Translation:Cells
    45. Cai G, Deng L, Fryszczyn BG, Brown NG, Liu Z, Jiang H, Palzkill T, Song Y. Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. ACS Med Chem Lett. 2012 Jun 14; 3(6):496-500. PMID: 23050057; PMCID: PMC3462030.
      Citations: 5     
    46. Yao Y, Chen P, Diao J, Cheng G, Deng L, Anglin JL, Prasad BV, Song Y. Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies. J Am Chem Soc. 2011 Oct 26; 133(42):16746-9. PMID: 21936531; PMCID: PMC3492951.
      Citations: 74     Fields:    Translation:HumansCells
    47. Deng L, Diao J, Chen P, Pujari V, Yao Y, Cheng G, Crick DC, Prasad BV, Song Y. Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies. J Med Chem. 2011 Jul 14; 54(13):4721-34. PMID: 21561155; PMCID: PMC3601441.
      Citations: 17     Fields:    Translation:Cells
    48. Deng L, Endo K, Kato M, Cheng G, Yajima S, Song Y. Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes. ACS Med Chem Lett. 2011 Feb 10; 2(2):165-170. PMID: 21379374; PMCID: PMC3046873.
      Citations: 15     
    49. Deng L, Sundriyal S, Rubio V, Shi ZZ, Song Y. Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase. J Med Chem. 2009 Nov 12; 52(21):6539-42. PMID: 19888756.
      Citations: 22     Fields:    Translation:HumansCells
    50. Feng Q, He B, Jung SY, Song Y, Qin J, Tsai SY, Tsai MJ, O'Malley BW. Biochemical control of CARM1 enzymatic activity by phosphorylation. J Biol Chem. 2009 Dec 25; 284(52):36167-36174. PMID: 19843527; PMCID: PMC2794732.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
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