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SUE CRAWFORD

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
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    Collapse Research 
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    R01AI158683     (HYSER, JOSEPH M.)Sep 21, 2021 - Aug 31, 2026
    NIH
    Dissecting Rotavirus Viroporin and Enterotoxin Calcium Signaling Pathways
    Role: Co-Principal Investigator
    R21AI163439     (CRAWFORD, SUE ELLEN ;SLAGLE, BETTY L)Jul 15, 2021 - Jun 30, 2024
    NIH
    Small molecule inhibitors of HBx that decrease hepatitis B virus replication
    Role: Co-Principal Investigator
    R01AI080656     (ESTES, MARY KOLB)Aug 11, 2009 - Mar 31, 2025
    NIH
    Regulation of Rotavirus Replication
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kaundal S, Anish R, Ayyar BV, Shanker S, Kaur G, Crawford SE, Pollet J, Stossi F, Estes MK, Prasad BVV. RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories. Sci Adv. 2024 Dec 20; 10(51):eadp9333. PMID: 39705355; PMCID: PMC11661447.
      Citations:    Fields:    Translation:HumansCells
    2. Ettayebi K, Kaur G, Patil K, Dave J, Ayyar BV, Tenge VR, Neill FH, Zeng X-L, Speer AL, Di Rienzi SC, Britton RA, Blutt SE, Crawford SE, Ramani S, Atmar RL, Estes MK. Insights into human norovirus cultivation in human intestinal enteroids. mSphere. 2024 Nov 21; 9(11):e0044824. PMID: 39404443; PMCID: PMC11580437.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Ettayebi K, Kaur G, Patil K, Dave J, Ayyar BV, Tenge VR, Neill FH, Zeng XL, Speer AL, Di Rienzi SC, Britton RA, Blutt SE, Crawford SE, Ramani S, Atmar RL, Estes MK, Ettayebi K. Insights into Human Norovirus Cultivation in Human Intestinal Enteroids. bioRxiv. 2024 Sep 19. PMID: 38826387; PMCID: PMC11142254.
      Citations:    
    4. Kaundal S, Anish R, Ayyar BV, Shanker S, Kaur G, Crawford SE, Pollet J, Stossi F, Estes MK, Prasad BVV. RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories. bioRxiv. 2024 Sep 18. PMID: 39345611; PMCID: PMC11429606.
      Citations:    
    5. Adeniyi-Ipadeola GO, Hankins JD, Kambal A, Zeng X-L, Patil K, Poplaski V, Bomidi C, Nguyen-Phuc H, Grimm SL, Coarfa C, Stossi F, Crawford SE, Blutt SE, Speer AL, Estes MK, Ramani S. Infant and adult human intestinal enteroids are morphologically and functionally distinct. mBio. 2024 Aug 14; 15(8):e0131624. PMID: 38953637; PMCID: PMC11323560.
      Citations: 5     Fields:    Translation:HumansCells
    6. Tenge V, Ayyar BV, Ettayebi K, Crawford SE, Hayes NM, Shen Y-T, Neill FH, Atmar RL, Estes MK. Bile acid-sensitive human norovirus strains are susceptible to sphingosine-1-phosphate receptor 2 inhibition. J Virol. 2024 Jul 23; 98(7):e0202023. PMID: 38884472; PMCID: PMC11265423.
      Citations: 2     Fields:    Translation:HumansCells
    7. Kambal A, Zeng XL, Bomidi C, Nguyen-Phuc H, Grimm SL, Coarfa C, Crawford SE, Blutt SE, Speer AL, Estes MK, Ramani S, Adeniyi-Ipadeola GO, Hankins JD, Patil K, Poplaski V, Stossi F. Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct. bioRxiv. 2024 Feb 17. PMID: 37292968; PMCID: PMC10245709.
      Citations:    
    8. Tenge V, Vijayalakshmi Ayyar B, Ettayebi K, Crawford SE, Shen YT, Neill FH, Atmar RL, Estes MK. Bile acid-sensitive human norovirus strains are susceptible to sphingosine-1-phosphate receptor 2 inhibition. bioRxiv. 2024 Jan 03. PMID: 38260626; PMCID: PMC10802320.
      Citations:    
    9. Liu Z, Smith H, Criglar JM, Valentin AJ, Karandikar U, Zeng XL, Estes MK, Crawford SE. Rotavirus-mediated DGAT1 degradation: A pathophysiological mechanism of viral-induced malabsorptive diarrhea. Proc Natl Acad Sci U S A. 2023 Dec 19; 120(51):e2302161120. PMID: 38079544; PMCID: PMC10743370.
      Citations: 6     Fields:    Translation:HumansCells
    10. Engevik KA, Scribano FJ, Gebert JT, Perry JL, Crawford SE, Hyser JM. Distribution of P2Y and P2X purinergic receptor expression within the intestine. Am J Physiol Gastrointest Liver Physiol. 2024 02 01; 326(2):G107-G119. PMID: 37987757; PMCID: PMC11208031.
      Citations:    Fields:    Translation:HumansCells
    11. Marin-Muller C, Li D, L? JM, Liang Z, Vega-Mart?nez O, Crawford SE, Estes MK, Fisher WE, Chen C, Yao Q. Nanoparticle-Mediated Therapy with miR-198 Sensitizes Pancreatic Cancer to Gemcitabine Treatment through Downregulation of VCP-Mediated Autophagy. Pharmaceutics. 2023 Jul 28; 15(8). PMID: 37631252; PMCID: PMC10457905.
      Citations:    
    12. Ayyar BV, Ettayebi K, Salmen W, Karandikar UC, Neill FH, Tenge VR, Crawford SE, Bieberich E, Prasad BVV, Atmar RL, Estes MK. CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection. Nat Commun. 2023 02 28; 14(1):1148. PMID: 36854760; PMCID: PMC9974061.
      Citations: 2     Fields:    Translation:HumansCells
    13. Hu L, Salmen W, Sankaran B, Lasanajak Y, Smith DF, Crawford SE, Estes MK, Prasad BVV. Novel fold of rotavirus glycan-binding domain predicted by AlphaFold2 and determined by X-ray crystallography. Commun Biol. 2022 05 05; 5(1):419. PMID: 35513489; PMCID: PMC9072675.
      Citations:    Translation:HumansCells
    14. Criglar JM, Estes MK, Crawford SE. Rotavirus-Induced Lipid Droplet Biogenesis Is Critical for Virus Replication. Front Physiol. 2022; 13:836870. PMID: 35492603; PMCID: PMC9040889.
      Citations:    
    15. Maeda K, Zachos NC, Orzalli MH, Schmieder SS, Chang D, Bugda Gwilt K, Doucet M, Baetz NW, Lee S, Crawford SE, Estes MK, Kagan JC, Turner JR, Lencer WI. Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces. Cell Host Microbe. 2022 02 09; 30(2):216-231.e5. PMID: 35143768; PMCID: PMC8852832.
      Citations:    Fields:    Translation:Cells
    16. Criss ZK, Bhasin N, Di Rienzi SC, Rajan A, Deans-Fielder K, Swaminathan G, Kamyabi N, Zeng XL, Doddapaneni H, Menon VK, Chakravarti D, Estrella C, Yu X, Patil K, Petrosino JF, Fleet JC, Verzi MP, Christakos S, Helmrath MA, Arimura S, DePinho RA, Britton RA, Maresso AW, Grande-Allen KJ, Blutt SE, Crawford SE, Estes MK, Ramani S, Shroyer NF. Drivers of transcriptional variance in human intestinal epithelial organoids. Physiol Genomics. 2021 11 01; 53(11):486-508. PMID: 34612061; PMCID: PMC8616596.
      Citations: 3     Fields:    Translation:HumansCells
    17. Blutt SE, Crawford SE, Bomidi C, Zeng XL, Broughman JR, Robertson M, Coarfa C, Tessier MEM, Savidge T, Hollinger FB, Curley SA, Donowitz M, Estes MK. Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation. Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(3):G270-G279. PMID: 34288725; PMCID: PMC8461792.
      Citations:    Fields:    Translation:HumansCells
    18. Tenge VR, Murakami K, Salmen W, Lin SC, Crawford SE, Neill FH, Prasad BVV, Atmar RL, Estes MK. Bile Goes Viral. Viruses. 2021 05 27; 13(6). PMID: 34071855; PMCID: PMC8227374.
      Citations: 4     Fields:    Translation:HumansCells
    19. Crawford SE, Ramani S, Blutt SE, Estes MK. Organoids to Dissect Gastrointestinal Virus-Host Interactions: What Have We Learned? Viruses. 2021 05 27; 13(6). PMID: 34071878; PMCID: PMC8230193.
      Citations: 4     Fields:    Translation:HumansCells
    20. Ettayebi K, Tenge VR, Cortes-Penfield NW, Crawford SE, Neill FH, Zeng XL, Yu X, Ayyar BV, Burrin D, Ramani S, Atmar RL, Estes MK. New Insights and Enhanced Human Norovirus Cultivation in Human Intestinal Enteroids. mSphere. 2021 01 27; 6(1). PMID: 33504663; PMCID: PMC7885322.
      Citations: 16     Fields:    Translation:HumansCells
    21. Engevik MA, Danhof HA, Auchtung J, Endres BT, Ruan W, Engevik AC, Wu Q, Nicholson M, Luna RA, Garey KW, Crawford SE, Estes MK, Lux R, Yacyshyn MB, Yacyshyn B, Savidge T, Britton RA, Versalovic J, Bass?res E. Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus. Gastroenterology. 2021 03; 160(4):1301-1314.e8. PMID: 33227279; PMCID: PMC7956072.
      Citations: 11     Fields:    Translation:HumansCells
    22. Criglar JM, Crawford SE, Estes MK. Plasmid-based reverse genetics for probing phosphorylation-dependent viroplasm formation in rotaviruses. Virus Res. 2021 01 02; 291:198193. PMID: 33053412; PMCID: PMC8820476.
      Citations: 3     Fields:    Translation:HumansCells
    23. Lin SC, Qu L, Ettayebi K, Crawford SE, Blutt SE, Robertson MJ, Zeng XL, Tenge VR, Ayyar BV, Karandikar UC, Yu X, Coarfa C, Atmar RL, Ramani S, Estes MK. Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23782-23793. PMID: 32907944; PMCID: PMC7519316.
      Citations: 21     Fields:    Translation:HumansCells
    24. Criglar JM, Crawford SE, Zhao B, Smith HG, Stossi F, Estes MK. A Genetically Engineered Rotavirus NSP2 Phosphorylation Mutant Impaired in Viroplasm Formation and Replication Shows an Early Interaction between vNSP2 and Cellular Lipid Droplets. J Virol. 2020 07 16; 94(15). PMID: 32461314; PMCID: PMC7375380.
      Citations: 9     Fields:    Translation:AnimalsCells
    25. Kumar D, Yu X, Crawford SE, Moreno R, Jakana J, Sankaran B, Anish R, Kaundal S, Hu L, Estes MK, Wang Z, Prasad BVV. 2.7 ? cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity. Sci Adv. 2020 04; 6(16):eaay6410. PMID: 32494598; PMCID: PMC7159914.
      Citations: 1     Fields:    Translation:Cells
    26. Murakami K, Tenge VR, Karandikar UC, Lin SC, Ramani S, Ettayebi K, Crawford SE, Zeng XL, Neill FH, Ayyar BV, Katayama K, Graham DY, Bieberich E, Atmar RL, Estes MK. Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 01 21; 117(3):1700-1710. PMID: 31896578; PMCID: PMC6983410.
      Citations: 35     Fields:    Translation:HumansCells
    27. Crawford SE, Criglar JM, Liu Z, Broughman JR, Estes MK. COPII Vesicle Transport Is Required for Rotavirus NSP4 Interaction with the Autophagy Protein LC3 II and Trafficking to Viroplasms. J Virol. 2019 12 12; 94(1). PMID: 31597778; PMCID: PMC6912103.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    28. Engevik MA, Morra CN, Engevik K, Spinler JK, Devaraj S, Crawford SE, Estes MK, Kalkum M, Versalovic J, R?th D. Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors. Front Microbiol. 2019; 10:2305. PMID: 31649646; PMCID: PMC6795088.
      Citations: 31     
    29. Estes MK, Ettayebi K, Tenge VR, Murakami K, Karandikar U, Lin SC, Ayyar BV, Cortes-Penfield NW, Haga K, Neill FH, Opekun AR, Broughman JR, Zeng XL, Blutt SE, Crawford SE, Ramani S, Graham DY, Atmar RL. Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges. Viruses. 2019 07 11; 11(7). PMID: 31336765; PMCID: PMC6669637.
      Citations: 24     Fields:    Translation:HumansCells
    30. Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MK. Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections. Methods Mol Biol. 2019; 1576:229-247. PMID: 28361480; PMCID: PMC5752619.
      Citations: 65     Fields:    Translation:HumansCells
    31. Criglar JM, Anish R, Hu L, Crawford SE, Sankaran B, Prasad BVV, Estes MK. Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E12015-E12023. PMID: 30509975; PMCID: PMC6304940.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    32. Ramani S, Crawford SE, Blutt SE, Estes MK. Human organoid cultures: transformative new tools for human virus studies. Curr Opin Virol. 2018 04; 29:79-86. PMID: 29656244; PMCID: PMC5944856.
      Citations: 42     Fields:    Translation:Humans
    33. Blutt SE, Crawford SE, Ramani S, Zou WY, Estes MK. Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. Cell Mol Gastroenterol Hepatol. 2018 Mar; 5(3):241-251. PMID: 29675450; PMCID: PMC5904028.
      Citations: 38     Fields:    
    34. Crawford SE, Ramani S, Tate JE, Parashar UD, Greenberg HB, O'Ryan M, Kang G, Desselberger U, Estes MK, Svensson L, Hagbom M, Franco MA. Rotavirus infection. Nat Rev Dis Primers. 2017 Nov 09; 3:17083. PMID: 29119972; PMCID: PMC5858916.
      Citations: 121     Fields:    Translation:Humans
    35. Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK. A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E570-E579. PMID: 28069942; PMCID: PMC5278484.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    36. Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MK. Replication of human noroviruses in stem cell-derived human enteroids. Science. 2016 09 23; 353(6306):1387-1393. PMID: 27562956; PMCID: PMC5305121.
      Citations: 532     Fields:    Translation:HumansCells
    37. Karandikar UC, Crawford SE, Ajami NJ, Murakami K, Kou B, Ettayebi K, Papanicolaou GA, Jongwutiwes U, Perales MA, Shia J, Mercer D, Finegold MJ, Atmar RL, Estes MK, Vinj? J. Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients. J Gen Virol. 2016 09; 97(9):2291-2300. PMID: 27412790; PMCID: PMC5756488.
      Citations: 48     Fields:    Translation:HumansCells
    38. Crawford SE, Desselberger U. Lipid droplets form complexes with viroplasms and are crucial for rotavirus replication. Curr Opin Virol. 2016 08; 19:11-5. PMID: 27341619; PMCID: PMC5125616.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    39. Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK. Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol. 2016 01 01; 90(1):43-56. PMID: 26446608; PMCID: PMC4702582.
      Citations: 177     Fields:    Translation:HumansCells
    40. Crawford SE, Ajami N, Parker TD, Kitamoto N, Natori K, Takeda N, Tanaka T, Kou B, Atmar RL, Estes MK. Mapping broadly reactive norovirus genogroup I and II monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):168-77. PMID: 25428246; PMCID: PMC4308866.
      Citations: 9     Fields:    Translation:AnimalsCells
    41. Kou B, Crawford SE, Ajami NJ, Neill FH, Tanaka TN, Kitamoto N, Palzkill TG, Estes MK, Atmar RL, Czak? R. Characterization of cross-reactive norovirus-specific monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):160-7. PMID: 25428247; PMCID: PMC4308874.
      Citations: 14     Fields:    Translation:HumansCells
    42. Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT. Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science. 2014 Nov 14; 346(6211):861-5. PMID: 25395539; PMCID: PMC4788408.
      Citations: 111     Fields:    Translation:Animals
    43. Katayama K, Murakami K, Sharp TM, Guix S, Oka T, Takai-Todaka R, Nakanishi A, Crawford SE, Atmar RL, Estes MK. Plasmid-based human norovirus reverse genetics system produces reporter-tagged progeny virus containing infectious genomic RNA. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):E4043-52. PMID: 25192933; PMCID: PMC4183323.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    44. Venkataram Prasad BV, Shanker S, Hu L, Choi JM, Crawford SE, Ramani S, Czako R, Atmar RL, Estes MK. Structural basis of glycan interaction in gastroenteric viral pathogens. Curr Opin Virol. 2014 Aug; 7:119-27. PMID: 25073118; PMCID: PMC4251800.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    45. Huang W, Samanta M, Crawford SE, Estes MK, Neill FH, Atmar RL, Palzkill T. Identification of human single-chain antibodies with broad reactivity for noroviruses. Protein Eng Des Sel. 2014 Oct; 27(10):339-49. PMID: 24946948; PMCID: PMC4191442.
      Citations: 17     Fields:    Translation:HumansCells
    46. Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M. Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood). 2014 Sep; 239(9):1124-34. PMID: 24719375; PMCID: PMC4380516.
      Citations: 102     Fields:    Translation:HumansCells
    47. Ajami NJ, Kavanagh OV, Ramani S, Crawford SE, Atmar RL, Jiang ZD, Okhuysen PC, Estes MK, DuPont HL. Seroepidemiology of norovirus-associated travelers' diarrhea. J Travel Med. 2014 Jan-Feb; 21(1):6-11. PMID: 24383649; PMCID: PMC3904865.
      Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
    48. Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Ramani S, Hill H, Ferreira J, Graham DY. Determination of the 50% human infectious dose for Norwalk virus. J Infect Dis. 2014 Apr 01; 209(7):1016-22. PMID: 24253285; PMCID: PMC3952671.
      Citations: 110     Fields:    Translation:HumansCells
    49. Criglar JM, Hu L, Crawford SE, Hyser JM, Broughman JR, Prasad BV, Estes MK. A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly. J Virol. 2014 Jan; 88(2):786-98. PMID: 24198401; PMCID: PMC3911676.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    50. Hyser JM, Utama B, Crawford SE, Broughman JR, Estes MK. Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity. J Virol. 2013 Dec; 87(24):13579-88. PMID: 24109210; PMCID: PMC3838237.
      Citations: 29     Fields:    Translation:HumansCells
    51. Hertel PM, Crawford SE, Bessard BC, Estes MK. Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles. Vaccine. 2013 Nov 19; 31(48):5778-84. PMID: 23887039; PMCID: PMC3883562.
      Citations: 2     Fields:    Translation:Animals
    52. Ramani S, Cortes-Penfield NW, Hu L, Crawford SE, Czako R, Smith DF, Kang G, Ramig RF, Le Pendu J, Prasad BV, Estes MK. The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans. J Virol. 2013 Jul; 87(13):7255-64. PMID: 23616650; PMCID: PMC3700318.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    53. Crawford SE, Estes MK. Viroporin-mediated calcium-activated autophagy. Autophagy. 2013 May; 9(5):797-8. PMID: 23442576; PMCID: PMC3669193.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    54. Crawford SE, Hyser JM, Utama B, Estes MK. Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-? signaling is required for rotavirus replication. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):E3405-13. PMID: 23184977; PMCID: PMC3528557.
      Citations: 82     Fields:    Translation:AnimalsCells
    55. Kavanagh O, Zeng XL, Ramani S, Mukhopadhya I, Crawford SE, Kang G, Estes MK. A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein. J Virol Methods. 2013 Apr; 189(1):228-31. PMID: 23183143; PMCID: PMC3617367.
      Citations: 4     Fields:    Translation:HumansCells
    56. Sharp TM, Crawford SE, Ajami NJ, Neill FH, Atmar RL, Katayama K, Utama B, Estes MK. Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses. Virol J. 2012 Sep 03; 9:181. PMID: 22943503; PMCID: PMC3493335.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    57. Hu L, Crawford SE, Hyser JM, Estes MK, Prasad BV. Rotavirus non-structural proteins: structure and function. Curr Opin Virol. 2012 Aug; 2(4):380-8. PMID: 22789743; PMCID: PMC3422752.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    58. Hu L, Crawford SE, Czako R, Cortes-Penfield NW, Smith DF, Le Pendu J, Estes MK, Prasad BV. Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen. Nature. 2012 Apr 15; 485(7397):256-9. PMID: 22504179; PMCID: PMC3350622.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    59. Hyser JM, Utama B, Crawford SE, Estes MK. Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies. J Virol. 2012 May; 86(9):4921-34. PMID: 22357281; PMCID: PMC3347366.
      Citations: 12     Fields:    Translation:AnimalsCells
    60. Patel NC, Hertel PM, Hanson IC, Krance RA, Crawford SE, Estes M, Paul ME. Chronic rotavirus infection in an infant with severe combined immunodeficiency: successful treatment by hematopoietic stem cell transplantation. Clin Immunol. 2012 Mar; 142(3):399-401. PMID: 22244360; PMCID: PMC3932121.
      Citations: 6     Fields:    Translation:HumansCells
    61. Baclayon M, Shoemaker GK, Uetrecht C, Crawford SE, Estes MK, Prasad BV, Heck AJ, Wuite GJ, Roos WH. Prestress strengthens the shell of Norwalk virus nanoparticles. Nano Lett. 2011 Nov 09; 11(11):4865-9. PMID: 21967663; PMCID: PMC4059365.
      Citations: 18     Fields:    Translation:Cells
    62. Gladstone BP, Ramani S, Mukhopadhya I, Muliyil J, Sarkar R, Rehman AM, Jaffar S, Gomara MI, Gray JJ, Brown DW, Desselberger U, Crawford SE, John J, Babji S, Estes MK, Kang G. Protective effect of natural rotavirus infection in an Indian birth cohort. N Engl J Med. 2011 Jul 28; 365(4):337-46. PMID: 21793745; PMCID: PMC3596855.
      Citations: 80     Fields:    Translation:HumansCells
    63. Hertel PM, Crawford SE, Finegold MJ, Estes MK. Osteopontin upregulation in rotavirus-induced murine biliary atresia requires replicating virus but is not necessary for development of biliary atresia. Virology. 2011 Sep 01; 417(2):281-92. PMID: 21742364; PMCID: PMC3170515.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    64. Maalouf H, Schaeffer J, Parnaudeau S, Le Pendu J, Atmar RL, Crawford SE, Le Guyader FS. Strain-dependent norovirus bioaccumulation in oysters. Appl Environ Microbiol. 2011 May; 77(10):3189-96. PMID: 21441327; PMCID: PMC3126434.
      Citations: 46     Fields:    Translation:AnimalsCells
    65. Sharp TM, Guix S, Katayama K, Crawford SE, Estes MK. Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. PLoS One. 2010 Oct 18; 5(10):e13130. PMID: 20976190; PMCID: PMC2956632.
      Citations: 38     Fields:    Translation:Cells
    66. Frias AH, Vijay-Kumar M, Gentsch JR, Crawford SE, Carvalho FA, Estes MK, Gewirtz AT. Intestinal epithelia activate anti-viral signaling via intracellular sensing of rotavirus structural components. Mucosal Immunol. 2010 Nov; 3(6):622-32. PMID: 20664578; PMCID: PMC2957552.
      Citations:    
    67. Deal EM, Jaimes MC, Crawford SE, Estes MK, Greenberg HB. Rotavirus structural proteins and dsRNA are required for the human primary plasmacytoid dendritic cell IFNalpha response. PLoS Pathog. 2010 Jun 03; 6(6):e1000931. PMID: 20532161; PMCID: PMC2880586.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    68. Shoemaker GK, van Duijn E, Crawford SE, Uetrecht C, Baclayon M, Roos WH, Wuite GJ, Estes MK, Prasad BV, Heck AJ. Norwalk virus assembly and stability monitored by mass spectrometry. Mol Cell Proteomics. 2010 Aug; 9(8):1742-51. PMID: 20418222; PMCID: PMC2938053.
      Citations: 56     Fields:    Translation:Cells
    69. Kavanagh OV, Ajami NJ, Cheng E, Ciarlet M, Guerrero RA, Zeng CQ, Crawford SE, Estes MK. Rotavirus enterotoxin NSP4 has mucosal adjuvant properties. Vaccine. 2010 Apr 19; 28(18):3106-11. PMID: 20197138; PMCID: PMC3663485.
      Citations: 7     Fields:    Translation:Animals
    70. Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Graham DY. Norwalk virus shedding after experimental human infection. Emerg Infect Dis. 2008 Oct; 14(10):1553-7. PMID: 18826818; PMCID: PMC2609865.
      Citations: 252     Fields:    Translation:HumansCells
    71. Seo NS, Zeng CQ, Hyser JM, Utama B, Crawford SE, Kim KJ, Estes MK, H??k M. Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8811-8. PMID: 18587047; PMCID: PMC3021436.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    72. Guix S, Asanaka M, Katayama K, Crawford SE, Neill FH, Atmar RL, Estes MK. Norwalk virus RNA is infectious in mammalian cells. J Virol. 2007 Nov; 81(22):12238-48. PMID: 17855551; PMCID: PMC2168986.
      Citations: 78     Fields:    Translation:HumansCells
    73. Blutt SE, Matson DO, Crawford SE, Staat MA, Azimi P, Bennett BL, Piedra PA, Conner ME. Rotavirus antigenemia in children is associated with viremia. PLoS Med. 2007 Apr; 4(4):e121. PMID: 17439294; PMCID: PMC1852122.
      Citations: 46     Fields:    Translation:HumansCells
    74. Berkova Z, Crawford SE, Blutt SE, Morris AP, Estes MK. Expression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilin. J Virol. 2007 Apr; 81(7):3545-53. PMID: 17229686; PMCID: PMC1866088.
      Citations: 19     Fields:    Translation:HumansCells
    75. Warfield KL, Blutt SE, Crawford SE, Kang G, Conner ME. Rotavirus infection enhances lipopolysaccharide-induced intussusception in a mouse model. J Virol. 2006 Dec; 80(24):12377-86. PMID: 17005639; PMCID: PMC1676276.
      Citations: 7     Fields:    Translation:AnimalsCells
    76. Berkova Z, Crawford SE, Trugnan G, Yoshimori T, Morris AP, Estes MK. Rotavirus NSP4 induces a novel vesicular compartment regulated by calcium and associated with viroplasms. J Virol. 2006 Jun; 80(12):6061-71. PMID: 16731945; PMCID: PMC1472611.
      Citations: 64     Fields:    Translation:HumansCells
    77. Crawford SE, Patel DG, Cheng E, Berkova Z, Hyser JM, Ciarlet M, Finegold MJ, Conner ME, Estes MK. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol. 2006 May; 80(10):4820-32. PMID: 16641274; PMCID: PMC1472071.
      Citations: 56     Fields:    Translation:AnimalsCells
    78. Pesavento JB, Crawford SE, Estes MK, Prasad BV. Rotavirus proteins: structure and assembly. Curr Top Microbiol Immunol. 2006; 309:189-219. PMID: 16913048.
      Citations: 52     Fields:    Translation:Cells
    79. Asanaka M, Atmar RL, Ruvolo V, Crawford SE, Neill FH, Estes MK. Replication and packaging of Norwalk virus RNA in cultured mammalian cells. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10327-32. PMID: 16002473; PMCID: PMC1177355.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    80. Pesavento JB, Crawford SE, Roberts E, Estes MK, Prasad BV. pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization. J Virol. 2005 Jul; 79(13):8572-80. PMID: 15956598; PMCID: PMC1143764.
      Citations: 15     Fields:    Translation:Cells
    81. Blutt SE, Crawford SE, Warfield KL, Lewis DE, Estes MK, Conner ME. The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. J Virol. 2004 Jul; 78(13):6974-81. PMID: 15194774; PMCID: PMC421650.
      Citations: 17     Fields:    Translation:AnimalsCells
    82. Kudo T, Nurgalieva ZZ, Conner ME, Crawford S, Odenbreit S, Haas R, Graham DY, Yamaoka Y. Correlation between Helicobacter pylori OipA protein expression and oipA gene switch status. J Clin Microbiol. 2004 May; 42(5):2279-81. PMID: 15131212; PMCID: PMC404672.
      Citations: 30     Fields:    Translation:HumansCells
    83. Jayakumar A, Cataltepe S, Kang Y, Frederick MJ, Mitsudo K, Henderson Y, Crawford SE, Silverman GA, Clayman GL. Production of serpins using baculovirus expression systems. Methods. 2004 Feb; 32(2):177-84. PMID: 14698630.
      Citations: 3     Fields:    Translation:AnimalsCells
    84. Bertolotti-Ciarlet A, Crawford SE, Hutson AM, Estes MK. The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein. J Virol. 2003 Nov; 77(21):11603-15. PMID: 14557646; PMCID: PMC229252.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    85. Bertolotti-Ciarlet A, Ciarlet M, Crawford SE, Conner ME, Estes MK. Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice. Vaccine. 2003 Sep 08; 21(25-26):3885-900. PMID: 12922123.
      Citations: 36     Fields:    Translation:AnimalsCells
    86. Casola A, Garofalo RP, Crawford SE, Estes MK, Mercurio F, Crowe SE, Brasier AR. Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation. Virology. 2002 Jun 20; 298(1):8-19. PMID: 12093168.
      Citations: 22     Fields:    Translation:HumansCells
    87. Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MK. VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002 Feb; 76(3):1109-23. PMID: 11773387; PMCID: PMC135817.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    88. Ciarlet M, Crawford SE, Estes MK. Differential infection of polarized epithelial cell lines by sialic acid-dependent and sialic acid-independent rotavirus strains. J Virol. 2001 Dec; 75(23):11834-50. PMID: 11689665; PMCID: PMC114770.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    89. Crawford SE, Mukherjee SK, Estes MK, Lawton JA, Shaw AL, Ramig RF, Prasad BV. Trypsin cleavage stabilizes the rotavirus VP4 spike. J Virol. 2001 Jul; 75(13):6052-61. PMID: 11390607; PMCID: PMC114321.
      Citations: 62     Fields:    Translation:AnimalsCells
    90. Estes MK, Kang G, Zeng CQ, Crawford SE, Ciarlet M. Pathogenesis of rotavirus gastroenteritis. Novartis Found Symp. 2001; 238:82-96; discussion 96-100. PMID: 11444037.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    91. Yuan L, Geyer A, Hodgins DC, Fan Z, Qian Y, Chang KO, Crawford SE, Parreño V, Ward LA, Estes MK, Conner ME, Saif LJ, Parre?o V. Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs. J Virol. 2000 Oct; 74(19):8843-53. PMID: 10982326; PMCID: PMC102078.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    92. Rowley AH, Shulman ST, Mask CA, Finn LS, Terai M, Baker SC, Galliani CA, Takahashi K, Naoe S, Kalelkar MB, Crawford SE. IgA plasma cell infiltration of proximal respiratory tract, pancreas, kidney, and coronary artery in acute Kawasaki disease. J Infect Dis. 2000 Oct; 182(4):1183-91. PMID: 10979916.
      Citations: 80     Fields:    Translation:HumansCells
    93. Crawford SE, Estes MK, Ciarlet M, Barone C, O'Neal CM, Cohen J, Conner ME. Heterotypic protection and induction of a broad heterotypic neutralization response by rotavirus-like particles. J Virol. 1999 Jun; 73(6):4813-22. PMID: 10233942; PMCID: PMC112524.
      Citations: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    94. Lane RH, Crawford SE, Flozak AS, Simmons RA. Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats. Am J Physiol. 1999 01; 276(1):E135-42. PMID: 9886959.
      Citations: 12     Fields:    Translation:Animals
    95. Hale AD, Crawford SE, Ciarlet M, Green J, Gallimore C, Brown DW, Jiang X, Estes MK. Expression and self-assembly of Grimsby virus: antigenic distinction from Norwalk and Mexico viruses. Clin Diagn Lab Immunol. 1999 Jan; 6(1):142-5. PMID: 9874680; PMCID: PMC95676.
      Citations: 31     Fields:    Translation:HumansCells
    96. Ciarlet M, Crawford SE, Barone C, Bertolotti-Ciarlet A, Ramig RF, Estes MK, Conner ME. Subunit rotavirus vaccine administered parenterally to rabbits induces active protective immunity. J Virol. 1998 Nov; 72(11):9233-46. PMID: 9765471; PMCID: PMC110343.
      Citations: 34     Fields:    Translation:AnimalsCellsPHPublic Health
    97. Qu XW, Rozenfeld RA, Huang W, Crawford SE, Gonzalez-Crussi F, Hsueh W. Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats. J Physiol. 1998 Oct 01; 512 ( Pt 1):227-34. PMID: 9729632; PMCID: PMC2231185.
      Citations: 5     Fields:    Translation:Animals
    98. Casola A, Estes MK, Crawford SE, Ogra PL, Ernst PB, Garofalo RP, Crowe SE. Rotavirus infection of cultured intestinal epithelial cells induces secretion of CXC and CC chemokines. Gastroenterology. 1998 May; 114(5):947-55. PMID: 9558283.
      Citations: 31     Fields:    Translation:Humans
    99. Fernandez FM, Conner ME, Hodgins DC, Parwani AV, Nielsen PR, Crawford SE, Estes MK, Saif LJ. Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant SA11 rotavirus core-like particle (CLP) or virus-like particle (VLP) vaccines. Vaccine. 1998 Mar; 16(5):507-16. PMID: 9491505; PMCID: PMC7131086.
      Citations: 26     Fields:    Translation:AnimalsPHPublic Health
    100. O'Neal CM, Crawford SE, Estes MK, Conner ME. Rotavirus virus-like particles administered mucosally induce protective immunity. J Virol. 1997 Nov; 71(11):8707-17. PMID: 9343229; PMCID: PMC192335.
      Citations: 75     Fields:    Translation:AnimalsCells
    101. Estes MK, Ball JM, Crawford SE, O'Neal C, Opekun AA, Graham DY, Conner ME. Virus-like particle vaccines for mucosal immunization. Adv Exp Med Biol. 1997; 412:387-95. PMID: 9192045.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    102. Fernandez FM, Conner ME, Parwani AV, Todhunter D, Smith KL, Crawford SE, Estes MK, Saif LJ. Isotype-specific antibody responses to rotavirus and virus proteins in cows inoculated with subunit vaccines composed of recombinant SA11 rotavirus core-like particles (CLP) or virus-like particles (VLP). Vaccine. 1996 Oct; 14(14):1303-12. PMID: 9004438; PMCID: PMC7131174.
      Citations: 9     Fields:    Translation:AnimalsCells
    103. Conner ME, Crawford SE, Barone C, O'Neal C, Zhou YJ, Fernandez F, Parwani A, Saif LJ, Cohen J, Estes MK. Rotavirus subunit vaccines. Arch Virol Suppl. 1996; 12:199-206. PMID: 9015116.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    104. Crawford SE, Labbé M, Cohen J, Burroughs MH, Zhou YJ, Estes MK, Labb? M. Characterization of virus-like particles produced by the expression of rotavirus capsid proteins in insect cells. J Virol. 1994 Sep; 68(9):5945-52. PMID: 8057471; PMCID: PMC237000.
      Citations: 102     Fields:    Translation:AnimalsCells
    105. Conner ME, Crawford SE, Barone C, Estes MK. Rotavirus vaccine administered parenterally induces protective immunity. J Virol. 1993 Nov; 67(11):6633-41. PMID: 8411366; PMCID: PMC238101.
      Citations: 32     Fields:    Translation:AnimalsCells
    106. Labbé M, Charpilienne A, Crawford SE, Estes MK, Cohen J, Labb? M. Expression of rotavirus VP2 produces empty corelike particles. J Virol. 1991 Jun; 65(6):2946-52. PMID: 1851866; PMCID: PMC240932.
      Citations: 71     Fields:    Translation:AnimalsCells
    107. Welch SK, Crawford SE, Estes MK. Rotavirus SA11 genome segment 11 protein is a nonstructural phosphoprotein. J Virol. 1989 Sep; 63(9):3974-82. PMID: 2548010; PMCID: PMC250994.
      Citations: 33     Fields:    Translation:AnimalsCells
    108. Estes MK, Crawford SE, Penaranda ME, Petrie BL, Burns JW, Chan WK, Ericson B, Smith GE, Summers MD. Synthesis and immunogenicity of the rotavirus major capsid antigen using a baculovirus expression system. J Virol. 1987 May; 61(5):1488-94. PMID: 3033276; PMCID: PMC254127.
      Citations: 53     Fields:    Translation:Cells
    109. Chan WK, Penaranda ME, Crawford SE, Estes MK. Two glycoproteins are produced from the rotavirus neutralization gene. Virology. 1986 Jun; 151(2):243-52. PMID: 3010552.
      Citations: 26     Fields:    Translation:Cells
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