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TIMOTHY PALZKILL

TitleChair
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry and Molecular Pharmacology
    DivisionBiochemistry & Mol Pharmacology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


    Collapse Research 
    Collapse research activities and funding
    R21AI168780     (PALZKILL, TIMOTHY)Apr 25, 2022 - Mar 31, 2025
    NIH
    Using DNA-encoded Chemical Libraries to Develop Inhibitors of the MCR-1 Colistin Resistance Enzyme
    Role: Principal Investigator
    R01AI143832     (PALZKILL, TIMOTHY)Jan 18, 2019 - Dec 31, 2024
    NIH
    Discovery of Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries
    Role: Principal Investigator
    R01AI106863     (PALZKILL, TIMOTHY)May 15, 2013 - Apr 30, 2019
    NIH
    Analysis of metallo-beta-lactamase sequence constraints at high resolution
    Role: Principal Investigator
    R21AI092063     (PALZKILL, TIMOTHY)Mar 7, 2011 - Aug 28, 2013
    NIH
    Development of Protein-Based Beta-lactam Antibiotic Resistance Diagnostics
    Role: Principal Investigator
    R90DA023418     (PALZKILL, TIMOTHY)Sep 30, 2006 - Jul 31, 2011
    NIH
    Training in Biomedical Discovery from Large Scale Data Sets
    Role: Principal Investigator
    T90DA022885     (PALZKILL, TIMOTHY)Sep 30, 2006 - Jul 31, 2011
    NIH
    Training in Biomedical Discovery from Large Scale Data Sets
    Role: Principal Investigator
    R01AI045842     (PALZKILL, TIMOTHY)Jul 15, 1999 - Feb 28, 2008
    NIH
    FUNCTIONAL GENOMICS STUDY OF TREPONEMA PALLIDUM
    Role: Principal Investigator
    R01AI032956     (PALZKILL, TIMOTHY)Jul 1, 1992 - Dec 31, 2026
    NIH
    BETA LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCE
    Role: Principal Investigator
    R56AI032956     (PALZKILL, TIMOTHY)Jul 1, 1992 - Jan 19, 2017
    NIH
    Beta Lactamase Mutations in Antibiotic Resistance
    Role: Principal Investigator
    R37AI032956     (PALZKILL, TIMOTHY)Jul 1, 1992 - Apr 30, 2011
    NIH
    Beta Lactamase Mutations in Antibiotic Resistance
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pham S, Zhao B, Neetu N, Sankaran B, Patil K, Ramani S, Song Y, Estes MK, Palzkill T, Prasad BVV. CONFORMATIONAL FLEXIBILITY IS A CRITICAL FACTOR IN DESIGNING BROAD-SPECTRUM HUMAN NOROVIRUS PROTEASE INHIBITORS. bioRxiv. 2024 Sep 19. PMID: 39345439; PMCID: PMC11430002.
      Citations:    
    2. Tang SA, Fults A, Boyd SR, Gattu N, Tran KA, Fan J, MacKenzie KR, Palzkill T, Young DW, Chamakuri S. Expanding Complex Morpholines Using Systematic Chemical Diversity. Org Lett. 2024 May 03; 26(17):3493-3497. PMID: 38506470.
      Citations: 1     Fields:    Translation:Cells
    3. Judge A, Sankaran B, Hu L, Palaniappan M, Birgy A, Prasad BVV, Palzkill T. Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning. Proc Natl Acad Sci U S A. 2024 Mar 19; 121(12):e2313513121. PMID: 38483989; PMCID: PMC10962969.
      Citations: 2     Fields:    Translation:Cells
    4. Birgy A, Nnabuife C, Palzkill T. The mechanism of ceftazidime and cefiderocol hydrolysis by D179Y variants of KPC carbapenemases is similar and involves the formation of a long-lived covalent intermediate. Antimicrob Agents Chemother. 2024 Mar 06; 68(3):e0110823. PMID: 38259088; PMCID: PMC10916376.
      Citations: 1     Fields:    Translation:Cells
    5. Park S, Fan J, Chamakuri S, Palaniappan M, Sharma K, Qin X, Wang J, Tan Z, Judge A, Hu L, Sankaran B, Li F, Prasad BVV, Matzuk MM, Palzkill T. Exploiting the Carboxylate-Binding Pocket of ?-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J Med Chem. 2024 01 11; 67(1):620-642. PMID: 38117688; PMCID: PMC11489902.
      Citations:    Fields:    
    6. Sun Z, Lin H, Hu L, Neetu N, Sankaran B, Wang J, Prasad BVV, Palzkill T. Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J Biol Chem. 2024 Jan; 300(1):105493. PMID: 38000656; PMCID: PMC10716778.
      Citations:    Fields:    Translation:HumansCells
    7. Jimmidi R, Chamakuri S, Lu S, Ucisik MN, Chen PJ, Bohren KM, Moghadasi SA, Versteeg L, Nnabuife C, Li JY, Qin X, Chen YC, Faver JC, Nyshadham P, Sharma KL, Sankaran B, Judge A, Yu Z, Li F, Pollet J, Harris RS, Matzuk MM, Palzkill T, Young DW. DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors. Commun Chem. 2023 Aug 04; 6(1):164. PMID: 37542196; PMCID: PMC10403511.
      Citations: 1     
    8. Materon IC, Palzkill T. Structural biology of MCR-1-mediated resistance to polymyxin antibiotics. Curr Opin Struct Biol. 2023 10; 82:102647. PMID: 37399693; PMCID: PMC10527939.
      Citations:    Fields:    
    9. Su L, Huang W, Neill FH, Estes MK, Atmar RL, Palzkill T. Mapping human norovirus antigens during infection reveals the breadth of the humoral immune response. NPJ Vaccines. 2023 Jun 06; 8(1):87. PMID: 37280322; PMCID: PMC10242225.
      Citations:    
    10. Moghadasi SA, Heilmann E, Khalil AM, Nnabuife C, Kearns FL, Ye C, Moraes SN, Costacurta F, Esler MA, Aihara H, von Laer D, Martinez-Sobrido L, Palzkill T, Amaro RE, Harris RS. Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. Sci Adv. 2023 03 29; 9(13):eade8778. PMID: 36989354; PMCID: PMC10058310.
      Citations: 21     Fields:    Translation:HumansCells
    11. Sankaran B, Lu S, Montoya M, Hu L, Neetu N, Prasad BVV, Palzkill T. Mutagenesis and structural analysis reveal the CTX-M ?-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J Biol Chem. 2023 05; 299(5):104630. PMID: 36963495; PMCID: PMC10139949.
      Citations:    Fields:    Translation:Cells
    12. Judge A, Hu L, Sankaran B, Van Riper J, Venkataram Prasad BV, Palzkill T. Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M ?-lactamase. Commun Biol. 2023 01 12; 6(1):35. PMID: 36635385; PMCID: PMC9837174.
      Citations:    Translation:Cells
    13. Yin C, Song Z, Tian H, Palzkill T, Tao P. Unveiling the structural features that regulate carbapenem deacylation in KPC-2 through QM/MM and interpretable machine learning. Phys Chem Chem Phys. 2023 Jan 04; 25(2):1349-1362. PMID: 36537692; PMCID: PMC11162551.
      Citations: 1     Fields:    
    14. Moghadasi SA, Heilmann E, Khalil AM, Nnabuife C, Kearns FL, Ye C, Moraes SN, Costacurta F, Esler MA, Aihara H, von Laer D, Martinez-Sobrido L, Palzkill T, Amaro RE, Harris RS. Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors. bioRxiv. 2022 Dec 26. PMID: 35982678; PMCID: PMC9387136.
      Citations:    
    15. Lu S, Hu L, Lin H, Judge A, Rivera P, Palaniappan M, Sankaran B, Wang J, Prasad BVV, Palzkill T. An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M ?-lactamase drug-resistance enzymes. Nat Commun. 2022 11 07; 13(1):6726. PMID: 36344533; PMCID: PMC9640584.
      Citations: 1     Fields:    Translation:Cells
    16. Rossi MA, Palzkill T, Almeida FCL, Vila AJ. Slow Protein Dynamics Elicits New Enzymatic Functions by Means of Epistatic Interactions. Mol Biol Evol. 2022 10 07; 39(10). PMID: 36136729; PMCID: PMC9547502.
      Citations:    
    17. Sun Z, Su L, Cotroneo N, Critchley I, Pucci M, Jain A, Palzkill T. Evaluation of Tebipenem Hydrolysis by ?-Lactamases Prevalent in Complicated Urinary Tract Infections. Antimicrob Agents Chemother. 2022 05 17; 66(5):e0239621. PMID: 35491852; PMCID: PMC9112902.
      Citations:    Fields:    Translation:HumansCells
    18. Bradford PA, Bonomo RA, Bush K, Carattoli A, Feldgarden M, Haft DH, Ishii Y, Jacoby GA, Klimke W, Palzkill T, Poirel L, Rossolini GM, Tamma PD, Arias CA. Consensus on ?-Lactamase Nomenclature. Antimicrob Agents Chemother. 2022 04 19; 66(4):e0033322. PMID: 35380458; PMCID: PMC9017354.
      Citations: 1     Fields:    
    19. Boragine DM, Huang W, Su LH, Palzkill T. Deep Sequencing of a Systematic Peptide Library Reveals Conformationally-Constrained Protein Interface Peptides that Disrupt a Protein-Protein Interaction. Chembiochem. 2022 02 04; 23(3):e202100504. PMID: 34821011; PMCID: PMC8939392.
      Citations:    Fields:    Translation:Cells
    20. Taylor DM, Anglin J, Hu L, Wang L, Sankaran B, Wang J, Matzuk MM, Prasad BVV, Palzkill T. Unique Diacidic Fragments Inhibit the OXA-48 Carbapenemase and Enhance the Killing of Escherichia coli Producing OXA-48. ACS Infect Dis. 2021 12 10; 7(12):3345-3354. PMID: 34817169; PMCID: PMC9677231.
      Citations: 1     Fields:    Translation:Cells
    21. Sun Z, Palzkill T. Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1. mBio. 2021 12 21; 12(6):e0277621. PMID: 34781730; PMCID: PMC8593676.
      Citations:    Fields:    Translation:Cells
    22. Song Z, Trozzi F, Palzkill T, Tao P. QM/MM modeling of class A ?-lactamases reveals distinct acylation pathways for ampicillin and cefalexin. Org Biomol Chem. 2021 Nov 03; 19(42):9182-9189. PMID: 34647114; PMCID: PMC8613693.
      Citations:    Fields:    
    23. Chamakuri S, Lu S, Ucisik MN, Bohren KM, Chen YC, Du HC, Faver JC, Jimmidi R, Li F, Li JY, Nyshadham P, Palmer SS, Pollet J, Qin X, Ronca SE, Sankaran B, Sharma KL, Tan Z, Versteeg L, Yu Z, Matzuk MM, Palzkill T, Young DW. DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Proc Natl Acad Sci U S A. 2021 09 07; 118(36). PMID: 34426525; PMCID: PMC8433497.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    24. Furey IM, Mehta SC, Sankaran B, Hu L, Prasad BVV, Palzkill T. Local interactions with the Glu166 base and the conformation of an active site loop play key roles in carbapenem hydrolysis by the KPC-2 ?-lactamase. J Biol Chem. 2021 Jan-Jun; 296:100799. PMID: 34022225; PMCID: PMC8189571.
      Citations: 4     Fields:    Translation:HumansCells
    25. Rincon S, Carvajal LP, Gomez-Villegas SI, Echeverri AM, Rios R, Dinh A, Pedroza C, Sun Z, Fowler VG, Murray BE, Miller WR, Palzkill T, Diaz L, Arias CA, Reyes J, Ordo?ez KM, Nannini E. A Test for the Rapid Detection of the Cefazolin Inoculum Effect in Methicillin-Susceptible Staphylococcus aureus. J Clin Microbiol. 2021 03 19; 59(4). PMID: 33536292; PMCID: PMC8092731.
      Citations: 2     Fields:    Translation:HumansCells
    26. Stojanoski V, Hu L, Sankaran B, Wang F, Tao P, Prasad BVV, Palzkill T. Mechanistic Basis of OXA-48-like ?-Lactamases' Hydrolysis of Carbapenems. ACS Infect Dis. 2021 02 12; 7(2):445-460. PMID: 33492952; PMCID: PMC8571991.
      Citations: 8     Fields:    Translation:Cells
    27. Mehta SC, Furey IM, Pemberton OA, Boragine DM, Chen Y, Palzkill T. KPC-2 ?-lactamase enables carbapenem antibiotic resistance through fast deacylation of the covalent intermediate. J Biol Chem. 2021 Jan-Jun; 296:100155. PMID: 33273017; PMCID: PMC7895804.
      Citations: 5     Fields:    Translation:Cells
    28. Huang W, Soeung V, Boragine DM, Hu L, Prasad BVV, Estes MK, Atmar RL, Palzkill T. High-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing. J Virol. 2020 12 09; 95(1). PMID: 33055250; PMCID: PMC7737742.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    29. Soeung V, Lu S, Hu L, Judge A, Sankaran B, Prasad BVV, Palzkill T. A drug-resistant ?-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J Biol Chem. 2020 12 25; 295(52):18239-18255. PMID: 33109613.
      Citations: 3     Fields:    Translation:Cells
    30. Lam FW, Brown CA, Valladolid C, Emebo DC, Palzkill TG, Cruz MA. The vimentin rod domain blocks P-selectin-P-selectin glycoprotein ligand 1 interactions to attenuate leukocyte adhesion to inflamed endothelium. PLoS One. 2020; 15(10):e0240164. PMID: 33048962; PMCID: PMC7553327.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    31. Huang W, Soeung V, Boragine DM, Palzkill T. Mapping Protein-Protein Interaction Interface Peptides with Jun-Fos Assisted Phage Display and Deep Sequencing. ACS Synth Biol. 2020 07 17; 9(7):1882-1896. PMID: 32502338; PMCID: PMC7671604.
      Citations: 2     Fields:    Translation:Cells
    32. Zhu L, Olsen RJ, Beres SB, Saavedra MO, Kubiak SL, Cantu CC, Jenkins L, Waller AS, Sun Z, Palzkill T, Porter AR, DeLeo FR, Musser JM. Streptococcus pyogenes genes that promote pharyngitis in primates. JCI Insight. 2020 06 04; 5(11). PMID: 32493846; PMCID: PMC7308061.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    33. Brown CA, Hu L, Sun Z, Patel MP, Singh S, Porter JR, Sankaran B, Prasad BVV, Bowman GR, Palzkill T. Antagonism between substitutions in ?-lactamase explains a path not taken in the evolution of bacterial drug resistance. J Biol Chem. 2020 05 22; 295(21):7376-7390. PMID: 32299911; PMCID: PMC7247304.
      Citations: 7     Fields:    Translation:Cells
    34. Valladolid C, Martinez-Vargas M, Sekhar N, Lam F, Brown C, Palzkill T, Tischer A, Auton M, Vijayan KV, Rumbaut RE, Nguyen TC, Cruz MA. Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation. Blood Adv. 2020 04 14; 4(7):1340-1349. PMID: 32259201; PMCID: PMC7160269.
      Citations: 5     Fields:    Translation:Animals
    35. Musser JM, Beres SB, Zhu L, Olsen RJ, Vuopio J, Kristinsson KG, Darenberg J, Henriques-Normark B, Hoffmann S, Caugant DA, Smith AJ, Lindsay DSJ, Boragine DM, Palzkill T, Hyyryl?inen HL, Gr?ndahl-Yli-Hannuksela K. Reduced In Vitro Susceptibility of Streptococcus pyogenes to ?-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread. J Clin Microbiol. 2020 03 25; 58(4). PMID: 31996443; PMCID: PMC7098749.
      Citations: 24     Fields:    Translation:HumansCells
    36. Taylor DM, Anglin J, Park S, Ucisik MN, Faver JC, Simmons N, Jin Z, Palaniappan M, Nyshadham P, Li F, Campbell J, Hu L, Sankaran B, Prasad BVV, Huang H, Matzuk MM, Palzkill T. Identifying Oxacillinase-48 Carbapenemase Inhibitors Using DNA-Encoded Chemical Libraries. ACS Infect Dis. 2020 05 08; 6(5):1214-1227. PMID: 32182432; PMCID: PMC7673237.
      Citations: 10     Fields:    Translation:Cells
    37. Mack AR, Barnes MD, Taracila MA, Hujer AM, Hujer KM, Feldgarden M, Haft DH, Klimke W, van den Akker F, Vila AJ, Haider S, Papp-Wallace KM, Bradford PA, Rossolini GM, Docquier JD, Hanson ND, Poirel L, Nordmann P, Palzkill TG, Jacoby GA, Bush K, Bonomo RA, Cabot G, Smania A, Fr?re JM, Galleni M, Oliver A, Pl?siat P. A Standard Numbering Scheme for Class C ?-Lactamases. Antimicrob Agents Chemother. 2020 02 21; 64(3). PMID: 31712217; PMCID: PMC7038296.
      Citations: 11     Fields:    Translation:Cells
    38. Lu S, Soeung V, Nguyen HAT, Long SW, Musser JM, Palzkill T. Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC ?-Lactamases from Klebsiella pneumoniae Clinical Isolates. mSphere. 2020 01 08; 5(1). PMID: 31915233; PMCID: PMC6952207.
      Citations:    Fields:    Translation:Cells
    39. Sutton MN, Lu Z, Li YC, Zhou Y, Huang T, Reger AS, Hurwitz AM, Palzkill T, Logsdon C, Liang X, Gray JW, Nan X, Hancock J, Wahl GM, Bast RC. DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters. Cell Rep. 2019 12 10; 29(11):3448-3459.e6. PMID: 31825828; PMCID: PMC6948147.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    40. Beggs GA, Zalucki YM, Brown NG, Rastegari S, Phillips RK, Palzkill T, Shafer WM, Kumaraswami M, Brennan RG. Structural, Biochemical, and In Vivo Characterization of MtrR-Mediated Resistance to Innate Antimicrobials by the Human Pathogen Neisseria gonorrhoeae. J Bacteriol. 2019 10 15; 201(20). PMID: 31331979; PMCID: PMC6755732.
      Citations: 4     Fields:    Translation:HumansCells
    41. Khan A, Tran TT, Hanson B, Shropshire WC, Sun Z, Diaz L, Dinh AQ, Wanger A, Ostrosky-Zeichner L, Palzkill T, Arias CA, Miller WR, Rios R. Extensively Drug-Resistant Pseudomonas aeruginosa ST309 Harboring Tandem Guiana Extended Spectrum ?-Lactamase Enzymes: A Newly Emerging Threat in the United States. Open Forum Infect Dis. 2019 Jul; 6(7):ofz273. PMID: 31281867; PMCID: PMC6602888.
      Citations: 12     
    42. Sutton MN, Huang GY, Liang X, Sharma R, Reger AS, Mao W, Pang L, Rask PJ, Lee K, Gray JP, Hurwitz AM, Palzkill T, Millward SW, Kim C, Lu Z, Bast RC. DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1. Cancers (Basel). 2019 Apr 18; 11(4). PMID: 31003488; PMCID: PMC6521623.
      Citations: 7     
    43. Viskovska MA, Zhao B, Shanker S, Choi JM, Deng L, Song Y, Palzkill T, Hu L, Estes MK, Venkataram Prasad BV. GII.4 Norovirus Protease Shows pH-Sensitive Proteolysis with a Unique Arg-His Pairing in the Catalytic Site. J Virol. 2019 03 15; 93(6). PMID: 30626675; PMCID: PMC6401421.
      Citations: 6     Fields:    Translation:HumansCells
    44. Wang L, Pang K, Han K, Adamski CJ, Wang W, He L, Lai JK, Bondar VV, Duman JG, Richman R, Tolias KF, Barth P, Palzkill T, Liu Z, Holder JL, Zoghbi HY. An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function. Mol Psychiatry. 2020 10; 25(10):2534-2555. PMID: 30610205; PMCID: PMC6609509.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    45. Jiang X, Zhang C, Chen J, Choi S, Zhou Y, Zhao M, Song X, Chen X, Maletic-Savatic M, Palzkill T, Moore D, Wang MC, Wang J. Quantitative Real-Time Imaging of Glutathione with Subcellular Resolution. Antioxid Redox Signal. 2019 06 01; 30(16):1900-1910. PMID: 30358421; PMCID: PMC6486671.
      Citations: 8     Fields:    Translation:HumansCells
    46. Sun Z, Hu L, Sankaran B, Prasad BVV, Palzkill T. Differential active site requirements for NDM-1 ?-lactamase hydrolysis of carbapenem versus penicillin and cephalosporin antibiotics. Nat Commun. 2018 10 30; 9(1):4524. PMID: 30375382; PMCID: PMC6207675.
      Citations: 20     Fields:    Translation:Cells
    47. Patel MP, Hu L, Brown CA, Sun Z, Adamski CJ, Stojanoski V, Sankaran B, Prasad BVV, Palzkill T. Synergistic effects of functionally distinct substitutions in ?-lactamase variants shed light on the evolution of bacterial drug resistance. J Biol Chem. 2018 11 16; 293(46):17971-17984. PMID: 30275013; PMCID: PMC6240883.
      Citations: 8     Fields:    Translation:Cells
    48. Palzkill T. Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC ?-lactamases. Front Mol Biosci. 2018; 5:16. PMID: 29527530; PMCID: PMC5829062.
      Citations: 50     
    49. Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J. Reversible Reaction-Based Fluorescent Probe for Real-Time Imaging of Glutathione Dynamics in Mitochondria. ACS Sens. 2017 Sep 22; 2(9):1257-1261. PMID: 28809477; PMCID: PMC5771714.
      Citations: 28     Fields:    
    50. Patel MP, Hu L, Stojanoski V, Sankaran B, Prasad BVV, Palzkill T. The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M ?-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry. 2017 07 11; 56(27):3443-3453. PMID: 28613873; PMCID: PMC5645026.
      Citations: 15     Fields:    Translation:Cells
    51. Adamski CJ, Palzkill T. Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A ?-lactamases. BMC Biochem. 2017 03 06; 18(1):2. PMID: 28264645; PMCID: PMC5340008.
      Citations: 4     Fields:    Translation:Cells
    52. Adamski CJ, Palzkill T. BLIP-II Employs Differential Hotspot Residues To Bind Structurally Similar Staphylococcus aureus PBP2a and Class A ?-Lactamases. Biochemistry. 2017 02 28; 56(8):1075-1084. PMID: 28182405; PMCID: PMC5641629.
      Citations: 2     Fields:    Translation:Cells
    53. Hurwitz AM, Huang W, Kou B, Estes MK, Atmar RL, Palzkill T. Identification and Characterization of Single-Chain Antibodies that Specifically Bind GI Noroviruses. PLoS One. 2017; 12(1):e0170162. PMID: 28095447; PMCID: PMC5240998.
      Citations: 3     Fields:    Translation:HumansCells
    54. Hurwitz AM, Huang W, Estes MK, Atmar RL, Palzkill T. Deep sequencing of phage-displayed peptide libraries reveals sequence motif that detects norovirus. Protein Eng Des Sel. 2017 Feb; 30(2):129-139. PMID: 28035012; PMCID: PMC5241761.
      Citations: 4     Fields:    Translation:Cells
    55. Chow DC, Rice K, Huang W, Atmar RL, Palzkill T. Engineering Specificity from Broad to Narrow: Design of a ?-Lactamase Inhibitory Protein (BLIP) Variant That Exclusively Binds and Detects KPC ?-Lactamase. ACS Infect Dis. 2016 12 09; 2(12):969-979. PMID: 27756125; PMCID: PMC5656002.
      Citations: 5     Fields:    Translation:Cells
    56. Stojanoski V, Sankaran B, Prasad BV, Poirel L, Nordmann P, Palzkill T. Structure of the catalytic domain of the colistin resistance enzyme MCR-1. BMC Biol. 2016 Sep 21; 14(1):81. PMID: 27655155; PMCID: PMC5031297.
      Citations: 47     Fields:    
    57. Sun Z, Mehta SC, Adamski CJ, Gibbs RA, Palzkill T. Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-?-Lactamase is Fragile to Mutations. Sci Rep. 2016 09 12; 6:33195. PMID: 27616327; PMCID: PMC5018959.
      Citations: 6     Fields:    Translation:Cells
    58. Prasad BV, Shanker S, Muhaxhiri Z, Deng L, Choi JM, Estes MK, Song Y, Palzkill T, Atmar RL. Antiviral targets of human noroviruses. Curr Opin Virol. 2016 06; 18:117-25. PMID: 27318434; PMCID: PMC4983487.
      Citations: 17     Fields:    Translation:HumansCells
    59. Jacoby GA, Bonomo RA, Bradford PA, Bush K, Doi Y, Feldgarden M, Haft D, Klimke W, Nordmann P, Palzkill T, Poirel L, Prasad A, Rossolini GM, Walsh T. Comment on: Resistance gene naming and numbering: is it a new gene or not? J Antimicrob Chemother. 2016 09; 71(9):2677-8. PMID: 27261266; PMCID: PMC6281366.
      Citations: 3     Fields:    Translation:HumansCells
    60. Stojanoski V, Adamski CJ, Hu L, Mehta SC, Sankaran B, Zwart P, Prasad BV, Palzkill T. Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine ?-Lactamases by Relieving Steric Strain. Biochemistry. 2016 05 03; 55(17):2479-90. PMID: 27073009; PMCID: PMC5124363.
      Citations: 8     Fields:    Translation:Cells
    61. Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):4970-5. PMID: 27084884; PMCID: PMC4983835.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    62. Kou B, Huang W, Neill FH, Palzkill T, Estes MK, Atmar RL. Norovirus Antigen Detection with a Combination of Monoclonal and Single-Chain Antibodies. J Clin Microbiol. 2015 Dec; 53(12):3916-8. PMID: 26447115; PMCID: PMC4652105.
      Citations: 5     Fields:    Translation:HumansCells
    63. Patel MP, Fryszczyn BG, Palzkill T. Characterization of the global stabilizing substitution A77V and its role in the evolution of CTX-M ?-lactamases. Antimicrob Agents Chemother. 2015 Nov; 59(11):6741-8. PMID: 26282414; PMCID: PMC4604362.
      Citations: 11     Fields:    Translation:Cells
    64. Wang L, Yu Y, Chow DC, Yan F, Hsu CC, Stossi F, Mancini MA, Palzkill T, Liao L, Zhou S, Xu J, Lonard DM, O'Malley BW. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10; 28(2):240-52. PMID: 26267537; PMCID: PMC4536575.
      Citations: 46     Fields:    Translation:HumansCells
    65. Mehta SC, Rice K, Palzkill T. Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability. PLoS Pathog. 2015 Jun; 11(6):e1004949. PMID: 26030609; PMCID: PMC4452179.
      Citations: 47     Fields:    Translation:Cells
    66. Stojanoski V, Chow DC, Fryszczyn B, Hu L, Sankaran B, Prasad BV, Palzkill T, Nordmann P, Poirel L. Structural Basis for Different Substrate Profiles of Two Closely Related Class D ?-Lactamases and Their Inhibition by Halogens. Biochemistry. 2015 Jun 02; 54(21):3370-80. PMID: 25938261; PMCID: PMC5123777.
      Citations: 19     Fields:    Translation:HumansCells
    67. Palzkill T, Abriata LA, Dal Peraro M. How structural and physicochemical determinants shape sequence constraints in a functional enzyme. PLoS One. 2015; 10(2):e0118684. PMID: 25706742; PMCID: PMC4338278.
      Citations: 20     Fields:    Translation:Cells
    68. Stojanoski V, Chow DC, Hu L, Sankaran B, Gilbert HF, Prasad BV, Palzkill T. A triple mutant in the O-loop of TEM-1 ?-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis. J Biol Chem. 2015 Apr 17; 290(16):10382-94. PMID: 25713062; PMCID: PMC4400348.
      Citations: 20     Fields:    Translation:Cells
    69. Humphreys AF, Tan J, Peng R, Benton SM, Qin X, Worley KC, Mikulski RL, Chow DC, Palzkill TG, Ling PD. Generation and characterization of antibodies against Asian elephant (Elephas maximus) IgG, IgM, and IgA. PLoS One. 2015; 10(2):e0116318. PMID: 25658336; PMCID: PMC4320114.
      Citations: 9     Fields:    Translation:AnimalsCells
    70. Cardenas AM, Brown NG, Horton LB, Sankaran B, Prasad BV, Gilbert HF, Palzkill T, Adamski CJ. Molecular basis for the catalytic specificity of the CTX-M extended-spectrum ?-lactamases. Biochemistry. 2015 Jan 20; 54(2):447-57. PMID: 25489790; PMCID: PMC4303298.
      Citations: 29     Fields:    Translation:HumansCells
    71. He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N. GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18261-6. PMID: 25489091; PMCID: PMC4280633.
      Citations: 55     Fields:    Translation:HumansCells
    72. Kou B, Crawford SE, Ajami NJ, Neill FH, Tanaka TN, Kitamoto N, Palzkill TG, Estes MK, Atmar RL, Czak? R. Characterization of cross-reactive norovirus-specific monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):160-7. PMID: 25428247; PMCID: PMC4308874.
      Citations: 14     Fields:    Translation:HumansCells
    73. Viskovska M, Anish R, Hu L, Chow DC, Hurwitz AM, Brown NG, Palzkill T, Estes MK, Prasad BV. Probing the sites of interactions of rotaviral proteins involved in replication. J Virol. 2014 Nov; 88(21):12866-81. PMID: 25165107; PMCID: PMC4248930.
      Citations: 12     Fields:    Translation:Cells
    74. Long SW, Olsen RJ, Mehta SC, Palzkill T, Cernoch PL, Perez KK, Musick WL, Rosato AE, Musser JM. PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates. Antimicrob Agents Chemother. 2014 Nov; 58(11):6668-74. PMID: 25155594; PMCID: PMC4249384.
      Citations: 56     Fields:    Translation:HumansCells
    75. Fryszczyn BG, Adamski CJ, Brown NG, Rice K, Huang W, Palzkill T. Role of ?-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II. Protein Sci. 2014 Sep; 23(9):1235-46. PMID: 24947275; PMCID: PMC4243995.
      Citations: 5     Fields:    Translation:Cells
    76. Huang W, Samanta M, Crawford SE, Estes MK, Neill FH, Atmar RL, Palzkill T. Identification of human single-chain antibodies with broad reactivity for noroviruses. Protein Eng Des Sel. 2014 Oct; 27(10):339-49. PMID: 24946948; PMCID: PMC4191442.
      Citations: 17     Fields:    Translation:HumansCells
    77. Yan F, Yu Y, Chow DC, Palzkill T, Madoux F, Hodder P, Chase P, Griffin PR, O'Malley BW, Lonard DM. Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. PLoS One. 2014; 9(4):e95243. PMID: 24743578; PMCID: PMC3990629.
      Citations: 21     Fields:    Translation:HumansCells
    78. Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BW. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 01; 74(5):1506-1517. PMID: 24390736; PMCID: PMC3947477.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    79. Dave K, Palzkill T, Pratt RF. Neutral ?-Lactams Inactivate High Molecular Mass Penicillin-Binding Proteins of Class B1, Including PBP2a of MRSA. ACS Med Chem Lett. 2014 Feb 13; 5(2):154-7. PMID: 24900789; PMCID: PMC4027764.
      Citations: 3     
    80. Deng L, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song Y. Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors. Medchemcomm. 2013 Oct; 4(10). PMID: 24244836; PMCID: PMC3826262.
      Citations: 14     
    81. Brown NG, Chow DC, Ruprecht KE, Palzkill T. Identification of the ?-lactamase inhibitor protein-II (BLIP-II) interface residues essential for binding affinity and specificity for class A ?-lactamases. J Biol Chem. 2013 Jun 14; 288(24):17156-66. PMID: 23625930; PMCID: PMC3682521.
      Citations: 9     Fields:    Translation:Cells
    82. Brown NG, Chow DC, Palzkill T. BLIP-II is a highly potent inhibitor of Klebsiella pneumoniae carbapenemase (KPC-2). Antimicrob Agents Chemother. 2013 Jul; 57(7):3398-401. PMID: 23587951; PMCID: PMC3697393.
      Citations: 5     Fields:    Translation:Cells
    83. Rogers JD, Ajami NJ, Fryszczyn BG, Estes MK, Atmar RL, Palzkill T. Identification and characterization of a peptide affinity reagent for detection of noroviruses in clinical samples. J Clin Microbiol. 2013 Jun; 51(6):1803-8. PMID: 23554202; PMCID: PMC3716098.
      Citations: 8     Fields:    Translation:HumansCells
    84. Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y, Prasad BV. Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol. 2013 Apr; 87(8):4281-92. PMID: 23365454; PMCID: PMC3624372.
      Citations: 32     Fields:    Translation:Cells
    85. Palzkill T. Metallo-?-lactamase structure and function. Ann N Y Acad Sci. 2013 Jan; 1277:91-104. PMID: 23163348; PMCID: PMC3970115.
      Citations: 174     Fields:    Translation:Cells
    86. Deng Z, Huang W, Bakkalbasi E, Brown NG, Adamski CJ, Rice K, Muzny D, Gibbs RA, Palzkill T. Deep sequencing of systematic combinatorial libraries reveals ?-lactamase sequence constraints at high resolution. J Mol Biol. 2012 Dec 07; 424(3-4):150-67. PMID: 23017428; PMCID: PMC3524589.
      Citations: 40     Fields:    Translation:Cells
    87. McWilliams BD, Palzkill T, Weinstock GM, Petrosino JF. Identification of novel and cross-species seroreactive proteins from Bacillus anthracis using a ligation-independent cloning-based, SOS-inducible expression system. Microb Pathog. 2012 Nov-Dec; 53(5-6):250-8. PMID: 22975444; PMCID: PMC3779308.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    88. Horton LB, Shanker S, Mikulski R, Brown NG, Phillips KJ, Lykissa E, Venkataram Prasad BV, Palzkill T. Mutagenesis of zinc ligand residue Cys221 reveals plasticity in the IMP-1 metallo-?-lactamase active site. Antimicrob Agents Chemother. 2012 Nov; 56(11):5667-77. PMID: 22908171; PMCID: PMC3486559.
      Citations: 11     Fields:    Translation:Cells
    89. Chen P, Horton LB, Mikulski RL, Deng L, Sundriyal S, Palzkill T, Song Y. 2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-?-lactamases. Bioorg Med Chem Lett. 2012 Oct 01; 22(19):6229-32. PMID: 22921080; PMCID: PMC3463135.
      Citations: 12     Fields:    Translation:Cells
    90. Hu L, Chow DC, Patton JT, Palzkill T, Estes MK, Prasad BV. Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity. J Virol. 2012 Oct; 86(19):10547-57. PMID: 22811529; PMCID: PMC3457270.
      Citations: 15     Fields:    Translation:Cells
    91. Cai G, Deng L, Fryszczyn BG, Brown NG, Liu Z, Jiang H, Palzkill T, Song Y. Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase. ACS Med Chem Lett. 2012 Jun 14; 3(6):496-500. PMID: 23050057; PMCID: PMC3462030.
      Citations: 5     
    92. Shelburne SA, Olsen RJ, Makthal N, Brown NG, Sahasrabhojane P, Watkins EM, Palzkill T, Musser JM, Kumaraswami M. An amino-terminal signal peptide of Vfr protein negatively influences RopB-dependent SpeB expression and attenuates virulence in Streptococcus pyogenes. Mol Microbiol. 2011 Dec; 82(6):1481-95. PMID: 22040048; PMCID: PMC4571278.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    93. Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, O'Malley BW. Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. Mol Endocrinol. 2011 Dec; 25(12):2041-53. PMID: 22053001; PMCID: PMC3231837.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    94. Yuan J, Cardenas AM, Gilbert HF, Palzkill T. Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase. Protein Sci. 2011 Nov; 20(11):1891-906. PMID: 21898650; PMCID: PMC3267953.
      Citations: 4     Fields:    Translation:Cells
    95. Brown NG, Horton LB, Huang W, Vongpunsawad S, Palzkill T. Analysis of the functional contributions of Asn233 in metallo-?-lactamase IMP-1. Antimicrob Agents Chemother. 2011 Dec; 55(12):5696-702. PMID: 21896903; PMCID: PMC3232802.
      Citations: 19     Fields:    Translation:Cells
    96. Fryszczyn BG, Brown NG, Huang W, Balderas MA, Palzkill T. Use of periplasmic target protein capture for phage display engineering of tight-binding protein-protein interactions. Protein Eng Des Sel. 2011 Nov; 24(11):819-28. PMID: 21900304; PMCID: PMC3196869.
      Citations: 2     Fields:    Translation:HumansCells
    97. Brown NG, Chow DC, Sankaran B, Zwart P, Prasad BV, Palzkill T. Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases. J Biol Chem. 2011 Sep 16; 286(37):32723-35. PMID: 21775426; PMCID: PMC3173220.
      Citations: 11     Fields:    Translation:Cells
    98. Kim JJ, Casteel DE, Huang G, Kwon TH, Ren RK, Zwart P, Headd JJ, Brown NG, Chow DC, Palzkill T, Kim C. Co-crystal structures of PKG I? (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One. 2011 Apr 19; 6(4):e18413. PMID: 21526164; PMCID: PMC3080414.
      Citations: 31     Fields:    Translation:HumansCells
    99. Yuan J, Chow DC, Huang W, Palzkill T. Identification of a ?-lactamase inhibitory protein variant that is a potent inhibitor of Staphylococcus PC1 ?-lactamase. J Mol Biol. 2011 Mar 11; 406(5):730-44. PMID: 21238457; PMCID: PMC3081586.
      Citations: 9     Fields:    Translation:Cells
    100. Gao H, Wang X, Yang ZK, Chen J, Liang Y, Chen H, Palzkill T, Zhou J. Physiological roles of ArcA, Crp, and EtrA and their interactive control on aerobic and anaerobic respiration in Shewanella oneidensis. PLoS One. 2010 Dec 28; 5(12):e15295. PMID: 21203399; PMCID: PMC3011009.
      Citations: 44     Fields:    Translation:Cells
    101. Brown NG, Pennington JM, Huang W, Ayvaz T, Palzkill T. Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM ?-lactamases. J Mol Biol. 2010 Dec 17; 404(5):832-46. PMID: 20955714; PMCID: PMC3032993.
      Citations: 37     Fields:    Translation:Cells
    102. Brown NG, Palzkill T. Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display. Protein Eng Des Sel. 2010 Jun; 23(6):469-78. PMID: 20308189; PMCID: PMC2865362.
      Citations: 9     Fields:    Translation:Cells
    103. Brown NG, Shanker S, Prasad BV, Palzkill T. Structural and biochemical evidence that a TEM-1 beta-lactamase N170G active site mutant acts via substrate-assisted catalysis. J Biol Chem. 2009 Nov 27; 284(48):33703-12. PMID: 19812041; PMCID: PMC2785212.
      Citations: 21     Fields:    Translation:Cells
    104. Marciano DC, Brown NG, Palzkill T. Analysis of the plasticity of location of the Arg244 positive charge within the active site of the TEM-1 beta-lactamase. Protein Sci. 2009 Oct; 18(10):2080-9. PMID: 19672877; PMCID: PMC2786972.
      Citations: 21     Fields:    Translation:Cells
    105. Yuan J, Huang W, Chow DC, Palzkill T. Fine mapping of the sequence requirements for binding of beta-lactamase inhibitory protein (BLIP) to TEM-1 beta-lactamase using a genetic screen for BLIP function. J Mol Biol. 2009 Jun 05; 389(2):401-12. PMID: 19389404; PMCID: PMC2728291.
      Citations: 12     Fields:    Translation:Cells
    106. Wang J, Palzkill T, Chow DC. Structural insight into the kinetics and DeltaCp of interactions between TEM-1 beta-lactamase and beta-lactamase inhibitory protein (BLIP). J Biol Chem. 2009 Jan 02; 284(1):595-609. PMID: 18840610; PMCID: PMC2610523.
      Citations: 15     Fields:    Translation:Cells
    107. Marciano DC, Pennington JM, Wang X, Wang J, Chen Y, Thomas VL, Shoichet BK, Palzkill T. Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase. J Mol Biol. 2008 Dec 05; 384(1):151-64. PMID: 18822298; PMCID: PMC2644635.
      Citations: 31     Fields:    Translation:Cells
    108. Gao H, Pattison D, Yan T, Klingeman DM, Wang X, Petrosino J, Hemphill L, Wan X, Leaphart AB, Weinstock GM, Palzkill T, Zhou J. Generation and validation of a Shewanella oneidensis MR-1 clone set for protein expression and phage display. PLoS One. 2008 Aug 20; 3(8):e2983. PMID: 18714347; PMCID: PMC2500165.
      Citations: 8     Fields:    Translation:Cells
    109. Wang X, Gao H, Shen Y, Weinstock GM, Zhou J, Palzkill T. A high-throughput percentage-of-binding strategy to measure binding energies in DNA-protein interactions: application to genome-scale site discovery. Nucleic Acids Res. 2008 Sep; 36(15):4863-71. PMID: 18653527; PMCID: PMC2528174.
      Citations: 16     Fields:    Translation:Cells
    110. Rajagopala SV, Goll J, McKevitt MT, Palzkill T, Uetz P, Titz B, H?user R. The binary protein interactome of Treponema pallidum--the syphilis spirochete. PLoS One. 2008 May 28; 3(5):e2292. PMID: 18509523; PMCID: PMC2386257.
      Citations: 48     Fields:    Translation:Cells
    111. Strouhal M, Smajs D, Norris SJ, Palzkill T, Petrosino JF, Sodergren E, Norton JE, Singh J, Richmond TA, Molla MN, Albert TJ, Weinstock GM, Matejkov? P. Complete genome sequence of Treponema pallidum ssp. pallidum strain SS14 determined with oligonucleotide arrays. BMC Microbiol. 2008 May 15; 8:76. PMID: 18482458; PMCID: PMC2408589.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    112. Brinkman MB, McGill MA, Pettersson J, Rogers A, Smajs D, Weinstock GM, Norris SJ, Palzkill T, Matejkov? P. A novel Treponema pallidum antigen, TP0136, is an outer membrane protein that binds human fibronectin. Infect Immun. 2008 May; 76(5):1848-57. PMID: 18332212; PMCID: PMC2346692.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    113. Gao H, Wang X, Yang ZK, Palzkill T, Zhou J. Probing regulon of ArcA in Shewanella oneidensis MR-1 by integrated genomic analyses. BMC Genomics. 2008 Jan 25; 9:42. PMID: 18221523; PMCID: PMC2262068.
      Citations: 57     Fields:    Translation:Cells
    114. Hyser JM, Zeng CQ, Beharry Z, Palzkill T, Estes MK. Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4. Virology. 2008 Mar 30; 373(1):211-28. PMID: 18164740; PMCID: PMC2377065.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    115. Rajagopala SV, Goll J, Parrish JR, Wohlbold K, McKevitt MT, Palzkill T, Mori H, Finley RL, Uetz P, Titz B. The protein network of bacterial motility. Mol Syst Biol. 2007; 3:128. PMID: 17667950; PMCID: PMC1943423.
      Citations: 54     Fields:    Translation:Cells
    116. Marciano DC, Karkouti OY, Palzkill T. A fitness cost associated with the antibiotic resistance enzyme SME-1 beta-lactamase. Genetics. 2007 Aug; 176(4):2381-92. PMID: 17565956; PMCID: PMC1950639.
      Citations: 26     Fields:    Translation:Cells
    117. Wang J, Zhang Z, Palzkill T, Chow DC. Thermodynamic investigation of the role of contact residues of beta-lactamase-inhibitory protein for binding to TEM-1 beta-lactamase. J Biol Chem. 2007 Jun 15; 282(24):17676-84. PMID: 17430899.
      Citations: 12     Fields:    Translation:Cells
    118. Holloway AK, Palzkill T, Bull JJ. Experimental evolution of gene duplicates in a bacterial plasmid model. J Mol Evol. 2007 Feb; 64(2):215-22. PMID: 17211548.
      Citations: 5     Fields:    Translation:Cells
    119. Cushman I, Palzkill T, Moore MS. Using peptide arrays to define nuclear carrier binding sites on nucleoporins. Methods. 2006 Aug; 39(4):329-41. PMID: 16908185.
      Citations: 12     Fields:    Translation:Cells
    120. Brinkman MB, McKevitt M, McLoughlin M, Perez C, Howell J, Weinstock GM, Norris SJ, Palzkill T. Reactivity of antibodies from syphilis patients to a protein array representing the Treponema pallidum proteome. J Clin Microbiol. 2006 Mar; 44(3):888-91. PMID: 16517872; PMCID: PMC1393150.
      Citations: 28     Fields:    Translation:HumansCells
    121. Majiduddin FK, Palzkill T. Amino acid residues that contribute to substrate specificity of class A beta-lactamase SME-1. Antimicrob Agents Chemother. 2005 Aug; 49(8):3421-7. PMID: 16048956; PMCID: PMC1196253.
      Citations: 27     Fields:    Translation:Cells
    122. McKevitt M, Brinkman MB, McLoughlin M, Perez C, Howell JK, Weinstock GM, Norris SJ, Palzkill T. Genome scale identification of Treponema pallidum antigens. Infect Immun. 2005 Jul; 73(7):4445-50. PMID: 15972547; PMCID: PMC1168556.
      Citations: 27     Fields:    Translation:AnimalsCells
    123. Adediran SA, Zhang Z, Nukaga M, Palzkill T, Pratt RF. The D-methyl group in beta-lactamase evolution: evidence from the Y221G and GC1 mutants of the class C beta-lactamase of Enterobacter cloacae P99. Biochemistry. 2005 May 24; 44(20):7543-52. PMID: 15895997.
      Citations: 4     Fields:    Translation:Cells
    124. Beharry Z, Palzkill T. Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosa. J Biol Chem. 2005 May 06; 280(18):17786-91. PMID: 15741169.
      Citations: 18     Fields:    Translation:Cells
    125. Smajs D, McKevitt M, Howell JK, Norris SJ, Cai WW, Palzkill T, Weinstock GM. Transcriptome of Treponema pallidum: gene expression profile during experimental rabbit infection. J Bacteriol. 2005 Mar; 187(5):1866-74. PMID: 15716460; PMCID: PMC1063989.
      Citations: 41     Fields:    Translation:AnimalsCells
    126. Materon IC, Beharry Z, Huang W, Perez C, Palzkill T. Analysis of the context dependent sequence requirements of active site residues in the metallo-beta-lactamase IMP-1. J Mol Biol. 2004 Nov 26; 344(3):653-63. PMID: 15533435.
      Citations: 32     Fields:    Translation:Cells
    127. Zhang Z, Palzkill T. Dissecting the protein-protein interface between beta-lactamase inhibitory protein and class A beta-lactamases. J Biol Chem. 2004 Oct 08; 279(41):42860-6. PMID: 15284234.
      Citations: 28     Fields:    Translation:Cells
    128. Mustafi D, Hofer JE, Huang W, Palzkill T, Makinen MW. Chromophoric spin-labeled beta-lactam antibiotics for ENDOR structural characterization of reaction intermediates of class A and class C beta-lactamases. Spectrochim Acta A Mol Biomol Spectrosc. 2004 May; 60(6):1279-89. PMID: 15134725.
      Citations: 1     Fields:    Translation:Cells
    129. Buynak JD, Chen H, Vogeti L, Gadhachanda VR, Buchanan CA, Palzkill T, Shaw RW, Spencer J, Walsh TR. Penicillin-derived inhibitors that simultaneously target both metallo- and serine-beta-lactamases. Bioorg Med Chem Lett. 2004 Mar 08; 14(5):1299-304. PMID: 14980686.
      Citations: 28     Fields:    Translation:Humans
    130. Beharry Z, Chen H, Gadhachanda VR, Buynak JD, Palzkill T. Evaluation of penicillin-based inhibitors of the class A and B beta-lactamases from Bacillus anthracis. Biochem Biophys Res Commun. 2004 Jan 16; 313(3):541-5. PMID: 14697223.
      Citations: 11     Fields:    Translation:Cells
    131. Huang W, Beharry Z, Zhang Z, Palzkill T. A broad-spectrum peptide inhibitor of beta-lactamase identified using phage display and peptide arrays. Protein Eng. 2003 Nov; 16(11):853-60. PMID: 14631075.
      Citations: 8     Fields:    Translation:Cells
    132. Zhang Z, Palzkill T. Determinants of binding affinity and specificity for the interaction of TEM-1 and SME-1 beta-lactamase with beta-lactamase inhibitory protein. J Biol Chem. 2003 Nov 14; 278(46):45706-12. PMID: 12933802.
      Citations: 25     Fields:    Translation:Cells
    133. McKevitt M, Patel K, Smajs D, Marsh M, McLoughlin M, Norris SJ, Weinstock GM, Palzkill T. Systematic cloning of Treponema pallidum open reading frames for protein expression and antigen discovery. Genome Res. 2003 Jul; 13(7):1665-74. PMID: 12805273; PMCID: PMC403740.
      Citations: 25     Fields:    Translation:Cells
    134. Materon IC, Queenan AM, Koehler TM, Bush K, Palzkill T. Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis. Antimicrob Agents Chemother. 2003 Jun; 47(6):2040-2. PMID: 12760895; PMCID: PMC155864.
      Citations: 31     Fields:    Translation:Cells
    135. Majiduddin FK, Palzkill T. Amino acid sequence requirements at residues 69 and 238 for the SME-1 beta-lactamase to confer resistance to beta-lactam antibiotics. Antimicrob Agents Chemother. 2003 Mar; 47(3):1062-7. PMID: 12604542; PMCID: PMC149323.
      Citations: 27     Fields:    Translation:Cells
    136. Majiduddin FK, Palzkill T. An analysis of why highly similar enzymes evolve differently. Genetics. 2003 Feb; 163(2):457-66. PMID: 12618385; PMCID: PMC1462441.
      Citations: 9     Fields:    
    137. Rudgers GW, Palzkill T. Minimization of proteins by random fragmentation and selection. Methods Mol Biol. 2003; 230:71-81. PMID: 12824570.
      Citations: 1     Fields:    Translation:Cells
    138. Reid SD, Green NM, Sylva GL, Voyich JM, Stenseth ET, DeLeo FR, Palzkill T, Low DE, Hill HR, Musser JM. Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response. J Bacteriol. 2002 Nov; 184(22):6316-24. PMID: 12399501; PMCID: PMC151937.
      Citations: 27     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    139. Majiduddin FK, Materon IC, Palzkill TG. Molecular analysis of beta-lactamase structure and function. Int J Med Microbiol. 2002 Jul; 292(2):127-37. PMID: 12195735.
      Citations: 60     Fields:    Translation:HumansCells
    140. Palzkill T. Finding new antibiotics: the power of computational methods. Drug Discov Today. 2002 Mar 15; 7(6):347-8. PMID: 11893541.
      Citations:    Fields:    Translation:Cells
    141. Smajs D, McKevitt M, Wang L, Howell JK, Norris SJ, Palzkill T, Weinstock GM. BAC library of T. pallidum DNA in E. coli. Genome Res. 2002 Mar; 12(3):515-22. PMID: 11875041; PMCID: PMC155280.
      Citations: 16     Fields:    Translation:AnimalsCells
    142. Materon IC, Palzkill T. Identification of residues critical for metallo-beta-lactamase function by codon randomization and selection. Protein Sci. 2001 Dec; 10(12):2556-65. PMID: 11714924; PMCID: PMC2374027.
      Citations: 26     Fields:    Translation:Cells
    143. Rudgers GW, Huang W, Palzkill T. Binding properties of a peptide derived from beta-lactamase inhibitory protein. Antimicrob Agents Chemother. 2001 Dec; 45(12):3279-86. PMID: 11709298; PMCID: PMC90827.
      Citations: 9     Fields:    Translation:Cells
    144. Zhang Z, Yu Y, Musser JM, Palzkill T. Amino acid sequence determinants of extended spectrum cephalosporin hydrolysis by the class C P99 beta-lactamase. J Biol Chem. 2001 Dec 07; 276(49):46568-74. PMID: 11591698.
      Citations: 13     Fields:    Translation:Cells
    145. Rudgers GW, Palzkill T. Protein minimization by random fragmentation and selection. Protein Eng. 2001 Jul; 14(7):487-92. PMID: 11522922.
      Citations: 3     Fields:    Translation:Cells
    146. Sideraki V, Huang W, Palzkill T, Gilbert HF. A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation. Proc Natl Acad Sci U S A. 2001 Jan 02; 98(1):283-8. PMID: 11114163; PMCID: PMC14582.
      Citations: 62     Fields:    Translation:Cells
    147. Palzkill T. Impending doom: antibiotic exposure and bacterial gene expression. Genome Res. 2001 Jan; 11(1):1-2. PMID: 11156610.
      Citations: 1     Fields:    
    148. Hoe NP, Kordari P, Cole R, Liu M, Palzkill T, Huang W, McLellan D, Adams GJ, Hu M, Vuopio-Varkila J, Cate TR, Pichichero ME, Edwards KM, Eskola J, Low DE, Musser JM. Human immune response to streptococcal inhibitor of complement, a serotype M1 group A Streptococcus extracellular protein involved in epidemics. J Infect Dis. 2000 Nov; 182(5):1425-36. PMID: 11015234.
      Citations: 21     Fields:    Translation:HumansCells
    149. Huang W, McKevitt M, Palzkill T. Use of the arabinose p(bad) promoter for tightly regulated display of proteins on bacteriophage. Gene. 2000 Jun 27; 251(2):187-97. PMID: 10876095.
      Citations: 6     Fields:    Translation:Cells
    150. Huang W, Zhang Z, Palzkill T. Design of potent beta-lactamase inhibitors by phage display of beta-lactamase inhibitory protein. J Biol Chem. 2000 May 19; 275(20):14964-8. PMID: 10748011.
      Citations: 8     Fields:    Translation:Cells
    151. Savoie A, Sanschagrin F, Palzkill T, Voyer N, Levesque RC, Savoie A. Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases. Protein Eng. 2000 Apr; 13(4):267-74. PMID: 10810158.
      Citations: 3     Fields:    Translation:Cells
    152. Petrosino JF, Baker M, Palzkill T. Susceptibility of beta-lactamase to core amino acid substitutions. Protein Eng. 1999 Sep; 12(9):761-9. PMID: 10506286.
      Citations: 2     Fields:    Translation:Cells
    153. Rudgers GW, Palzkill T. Identification of residues in beta-lactamase critical for binding beta-lactamase inhibitory protein. J Biol Chem. 1999 Mar 12; 274(11):6963-71. PMID: 10066750.
      Citations: 12     Fields:    Translation:Cells
    154. Petrosino J, Rudgers G, Gilbert H, Palzkill T. Contributions of aspartate 49 and phenylalanine 142 residues of a tight binding inhibitory protein of beta-lactamases. J Biol Chem. 1999 Jan 22; 274(4):2394-400. PMID: 9891008.
      Citations: 34     Fields:    Translation:Cells
    155. Huang W, Petrosino J, Palzkill T. Display of functional beta-lactamase inhibitory protein on the surface of M13 bacteriophage. Antimicrob Agents Chemother. 1998 Nov; 42(11):2893-7. PMID: 9797222; PMCID: PMC105962.
      Citations: 3     Fields:    Translation:Cells
    156. Palzkill T, Huang W, Weinstock GM. Mapping protein-ligand interactions using whole genome phage display libraries. Gene. 1998 Oct 09; 221(1):79-83. PMID: 9852952.
      Citations: 7     Fields:    Translation:Cells
    157. Cantu C, Palzkill T. The role of residue 238 of TEM-1 beta-lactamase in the hydrolysis of extended-spectrum antibiotics. J Biol Chem. 1998 Oct 09; 273(41):26603-9. PMID: 9756899.
      Citations: 24     Fields:    Translation:Cells
    158. Therrien C, Sanschagrin F, Palzkill T, Levesque RC, Therrien C. Roles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidime. Antimicrob Agents Chemother. 1998 Oct; 42(10):2576-83. PMID: 9756758; PMCID: PMC105900.
      Citations: 3     Fields:    Translation:Cells
    159. Sabbagh Y, Thériault E, Sanschagrin F, Voyer N, Palzkill T, Levesque RC, Sabbagh Y, Th?riault E. Characterization of a PSE-4 mutant with different properties in relation to penicillanic acid sulfones: importance of residues 216 to 218 in class A beta-lactamases. Antimicrob Agents Chemother. 1998 Sep; 42(9):2319-25. PMID: 9736556; PMCID: PMC105826.
      Citations: 2     Fields:    Translation:Cells
    160. Petrosino J, Cantu C, Palzkill T. beta-Lactamases: protein evolution in real time. Trends Microbiol. 1998 Aug; 6(8):323-7. PMID: 9746943.
      Citations: 39     Fields:    Translation:Cells
    161. Cantu C, Huang W, Palzkill T. Cephalosporin substrate specificity determinants of TEM-1 beta-lactamase. J Biol Chem. 1997 Nov 14; 272(46):29144-50. PMID: 9360991.
      Citations: 27     Fields:    Translation:Cells
    162. Huang W, Palzkill T. A natural polymorphism in beta-lactamase is a global suppressor. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8801-6. PMID: 9238058; PMCID: PMC23137.
      Citations: 65     Fields:    Translation:Cells
    163. Cantu C, Huang W, Palzkill T. Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime. J Biol Chem. 1996 Sep 13; 271(37):22538-45. PMID: 8798421.
      Citations: 27     Fields:    Translation:Cells
    164. Huang W, Petrosino J, Hirsch M, Shenkin PS, Palzkill T. Amino acid sequence determinants of beta-lactamase structure and activity. J Mol Biol. 1996 May 17; 258(4):688-703. PMID: 8637002.
      Citations: 68     Fields:    Translation:Cells
    165. Vanhove M, Raquet X, Palzkill T, Pain RH, Frère JM, Vanhove M, Fr?re JM. The rate-limiting step in the folding of the cis-Pro167Thr mutant of TEM-1 beta-lactamase is the trans to cis isomerization of a non-proline peptide bond. Proteins. 1996 May; 25(1):104-11. PMID: 8727322.
      Citations: 17     Fields:    Translation:Cells
    166. Petrosino JF, Palzkill T. Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase. J Bacteriol. 1996 Apr; 178(7):1821-8. PMID: 8606154; PMCID: PMC177875.
      Citations: 46     Fields:    Translation:Cells
    167. Palzkill T, Thomson KS, Sanders CC, Moland ES, Huang W, Milligan TW. New variant of TEM-10 beta-lactamase gene produced by a clinical isolate of proteus mirabilis. Antimicrob Agents Chemother. 1995 May; 39(5):1199-200. PMID: 7625817; PMCID: PMC162712.
      Citations: 16     Fields:    Translation:HumansCells
    168. Huang W, Le QQ, LaRocco M, Palzkill T. Effect of threonine-to-methionine substitution at position 265 on structure and function of TEM-1 beta-lactamase. Antimicrob Agents Chemother. 1994 Oct; 38(10):2266-9. PMID: 7840555; PMCID: PMC284728.
      Citations: 10     Fields:    Translation:Cells
    169. Venkatachalam KV, Huang W, LaRocco M, Palzkill T. Characterization of TEM-1 beta-lactamase mutants from positions 238 to 241 with increased catalytic efficiency for ceftazidime. J Biol Chem. 1994 Sep 23; 269(38):23444-50. PMID: 8089110.
      Citations: 29     Fields:    Translation:Cells
    170. Palzkill T, Le QQ, Venkatachalam KV, LaRocco M, Ocera H. Evolution of antibiotic resistance: several different amino acid substitutions in an active site loop alter the substrate profile of beta-lactamase. Mol Microbiol. 1994 Apr; 12(2):217-29. PMID: 8057847.
      Citations: 46     Fields:    Translation:Cells
    171. Klann AG, Hull RA, Palzkill T, Hull SI. Alanine-scanning mutagenesis reveals residues involved in binding of pap-3-encoded pili. J Bacteriol. 1994 Apr; 176(8):2312-7. PMID: 7908904; PMCID: PMC205354.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    172. Clark CD, Palzkill T, Botstein D. Systematic mutagenesis of the yeast mating pheromone receptor third intracellular loop. J Biol Chem. 1994 Mar 25; 269(12):8831-41. PMID: 8132618.
      Citations: 23     Fields:    Translation:AnimalsCells
    173. Palzkill T, Le QQ, Wong A, Botstein D. Selection of functional signal peptide cleavage sites from a library of random sequences. J Bacteriol. 1994 Feb; 176(3):563-8. PMID: 8300511; PMCID: PMC205091.
      Citations: 8     Fields:    Translation:Cells
    174. Naumovski L, Quinn JP, Miyashiro D, Patel M, Bush K, Singer SB, Graves D, Palzkill T, Arvin AM. Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients. Antimicrob Agents Chemother. 1992 Sep; 36(9):1991-6. PMID: 1416892; PMCID: PMC192997.
      Citations: 59     Fields:    Translation:Cells
    175. Palzkill T, Botstein D. Probing beta-lactamase structure and function using random replacement mutagenesis. Proteins. 1992 Sep; 14(1):29-44. PMID: 1329081.
      Citations: 23     Fields:    Translation:Cells
    176. Palzkill T, Botstein D. Identification of amino acid substitutions that alter the substrate specificity of TEM-1 beta-lactamase. J Bacteriol. 1992 Aug; 174(16):5237-43. PMID: 1644749; PMCID: PMC206357.
      Citations: 31     Fields:    Translation:Cells
    177. Newlon CS, Lipchitz LR, Collins I, Deshpande A, Devenish RJ, Green RP, Klein HL, Palzkill TG, Ren RB, Synn S, et al. Analysis of a circular derivative of Saccharomyces cerevisiae chromosome III: a physical map and identification and location of ARS elements. Genetics. 1991 Oct; 129(2):343-57. PMID: 1683846; PMCID: PMC1204628.
      Citations: 69     Fields:    Translation:AnimalsCells
    178. Palzkill TG, Newlon CS. A yeast replication origin consists of multiple copies of a small conserved sequence. Cell. 1988 May 06; 53(3):441-50. PMID: 3284655.
      Citations: 76     Fields:    Translation:AnimalsCells
    179. Palzkill TG, Oliver SG, Newlon CS. DNA sequence analysis of ARS elements from chromosome III of Saccharomyces cerevisiae: identification of a new conserved sequence. Nucleic Acids Res. 1986 Aug 11; 14(15):6247-64. PMID: 3529036; PMCID: PMC311634.
      Citations: 35     Fields:    Translation:AnimalsCells
    180. Nickla H, Anderson J, Palzkill T. Enzymes involved in oxygen detoxification during development of Drosophila melanogaster. Experientia. 1983 Jun 15; 39(6):610-2. PMID: 6406261.
      Citations: 7     Fields:    Translation:Animals
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