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HIRAM GILBERT

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
Address5611 Purdue Ave
Dallas, TX 75209
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    Collapse Research 
    Collapse research activities and funding
    K12GM084897     (SMITH, CAROLYN LOUISE)Aug 1, 2008 - Jul 31, 2018
    NIH
    Research Education and Career Horizons Program
    Role: Co-Principal Investigator
    R01GM040379     (GILBERT, HIRAM F)Jul 1, 1988 - Nov 30, 2009
    NIH
    Catalysis of Thiol-Disulfide Exchange
    Role: Principal Investigator
    K04HL001020     (GILBERT, HIRAM F)Jul 1, 1982 - Jun 30, 1987
    NIH
    REDOX CONTROL OF HMG-COA REDUCTASE ACTIVITY
    Role: Principal Investigator
    R01HL028521     (GILBERT, HIRAM F)Apr 1, 1982 - Dec 31, 1995
    NIH
    REDOX REGULATION OF HMG COA REDUCTASE
    Role: Principal Investigator
    R01GM025347     (GILBERT, HIRAM F)Dec 1, 1978 - Nov 30, 1987
    NIH
    ENZYME CATALYSIS OF PROTON TRANSFER FROM CARBON
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stojanoski V, Chow DC, Hu L, Sankaran B, Gilbert HF, Prasad BV, Palzkill T. A triple mutant in the O-loop of TEM-1 ?-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis. J Biol Chem. 2015 Apr 17; 290(16):10382-94. PMID: 25713062; PMCID: PMC4400348.
      Citations: 20     Fields:    Translation:Cells
    2. Cardenas AM, Brown NG, Horton LB, Sankaran B, Prasad BV, Gilbert HF, Palzkill T, Adamski CJ. Molecular basis for the catalytic specificity of the CTX-M extended-spectrum ?-lactamases. Biochemistry. 2015 Jan 20; 54(2):447-57. PMID: 25489790; PMCID: PMC4303298.
      Citations: 29     Fields:    Translation:HumansCells
    3. Yuan J, Cardenas AM, Gilbert HF, Palzkill T. Determination of the amino acid sequence requirements for catalysis by the highly proficient orotidine monophosphate decarboxylase. Protein Sci. 2011 Nov; 20(11):1891-906. PMID: 21898650; PMCID: PMC3267953.
      Citations: 4     Fields:    Translation:Cells
    4. Arredondo SA, Chen TF, Riggs AF, Gilbert HF, Georgiou G. Role of dimerization in the catalytic properties of the Escherichia coli disulfide isomerase DsbC. J Biol Chem. 2009 Sep 04; 284(36):23972-9. PMID: 19581640; PMCID: PMC2781991.
      Citations: 5     Fields:    Translation:Cells
    5. Kim JH, Zhao Y, Pan X, He X, Gilbert HF. The unfolded protein response is necessary but not sufficient to compensate for defects in disulfide isomerization. J Biol Chem. 2009 Apr 17; 284(16):10400-8. PMID: 19233841; PMCID: PMC2667727.
      Citations: 6     Fields:    Translation:AnimalsCells
    6. Arredondo S, Segatori L, Gilbert HF, Georgiou G. De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC. J Biol Chem. 2008 Nov 14; 283(46):31469-76. PMID: 18782764; PMCID: PMC2581571.
      Citations: 8     Fields:    Translation:Cells
    7. Segatori L, Murphy L, Arredondo S, Kadokura H, Gilbert H, Beckwith J, Georgiou G. Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB. J Biol Chem. 2006 Feb 24; 281(8):4911-9. PMID: 16280324.
      Citations: 18     Fields:    Translation:Cells
    8. Samudio I, Konopleva M, Hail N, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. J Biol Chem. 2005 Oct 28; 280(43):36273-82. PMID: 16118208.
      Citations: 51     Fields:    Translation:HumansCells
    9. Xiao R, Holmgren A, Gilbert HF, Lundstr?m-Ljung J. Catalysis of thiol/disulfide exchange. Glutaredoxin 1 and protein-disulfide isomerase use different mechanisms to enhance oxidase and reductase activities. J Biol Chem. 2005 Jun 03; 280(22):21099-106. PMID: 15814611.
      Citations: 19     Fields:    Translation:AnimalsCells
    10. Wilkinson B, Xiao R, Gilbert HF. A structural disulfide of yeast protein-disulfide isomerase destabilizes the active site disulfide of the N-terminal thioredoxin domain. J Biol Chem. 2005 Mar 25; 280(12):11483-7. PMID: 15649885.
      Citations: 24     Fields:    Translation:AnimalsCells
    11. Xiao R, Wilkinson B, Solovyov A, Winther JR, Holmgren A, Gilbert HF, Lundstr?m-Ljung J. The contributions of protein disulfide isomerase and its homologues to oxidative protein folding in the yeast endoplasmic reticulum. J Biol Chem. 2004 Nov 26; 279(48):49780-6. PMID: 15377672.
      Citations: 19     Fields:    Translation:AnimalsCells
    12. Segatori L, Paukstelis PJ, Gilbert HF, Georgiou G. Engineered DsbC chimeras catalyze both protein oxidation and disulfide-bond isomerization in Escherichia coli: Reconciling two competing pathways. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10018-23. PMID: 15220477; PMCID: PMC454158.
      Citations: 21     Fields:    Translation:HumansCells
    13. Solovyov A, Xiao R, Gilbert HF. Sulfhydryl oxidation, not disulfide isomerization, is the principal function of protein disulfide isomerase in yeast Saccharomyces cerevisiae. J Biol Chem. 2004 Aug 13; 279(33):34095-100. PMID: 15175335.
      Citations: 12     Fields:    Translation:AnimalsCells
    14. Wilkinson B, Gilbert HF. Protein disulfide isomerase. Biochim Biophys Acta. 2004 Jun 01; 1699(1-2):35-44. PMID: 15158710.
      Citations: 285     Fields:    Translation:HumansAnimalsCells
    15. Solovyov A, Gilbert HF. Zinc-dependent dimerization of the folding catalyst, protein disulfide isomerase. Protein Sci. 2004 Jul; 13(7):1902-7. PMID: 15169950; PMCID: PMC2279941.
      Citations: 16     Fields:    Translation:AnimalsCells
    16. Schwaller M, Wilkinson B, Gilbert HF. Reduction-reoxidation cycles contribute to catalysis of disulfide isomerization by protein-disulfide isomerase. J Biol Chem. 2003 Feb 28; 278(9):7154-9. PMID: 12486139.
      Citations: 49     Fields:    Translation:Cells
    17. Liu CW, Millen L, Roman TB, Xiong H, Gilbert HF, Noiva R, DeMartino GN, Thomas PJ. Conformational remodeling of proteasomal substrates by PA700, the 19 S regulatory complex of the 26 S proteasome. J Biol Chem. 2002 Jul 26; 277(30):26815-20. PMID: 12011044.
      Citations: 24     Fields:    Translation:AnimalsCells
    18. Zheng J, Gilbert HF. Discrimination between native and non-native disulfides by protein-disulfide isomerase. J Biol Chem. 2001 May 11; 276(19):15747-52. PMID: 11278905.
      Citations: 7     Fields:    Translation:AnimalsCells
    19. Primm TP, Gilbert HF. Hormone binding by protein disulfide isomerase, a high capacity hormone reservoir of the endoplasmic reticulum. J Biol Chem. 2001 Jan 05; 276(1):281-6. PMID: 11035025.
      Citations: 27     Fields:    Translation:AnimalsCells
    20. Sideraki V, Huang W, Palzkill T, Gilbert HF. A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation. Proc Natl Acad Sci U S A. 2001 Jan 02; 98(1):283-8. PMID: 11114163; PMCID: PMC14582.
      Citations: 62     Fields:    Translation:Cells
    21. Sideraki V, Gilbert HF. Mechanism of the antichaperone activity of protein disulfide isomerase: facilitated assembly of large, insoluble aggregates of denatured lysozyme and PDI. Biochemistry. 2000 Feb 08; 39(5):1180-8. PMID: 10653666.
      Citations: 6     Fields:    Translation:AnimalsCells
    22. Gilbert HF. Protein disulfide isomerase. Methods Enzymol. 1998; 290:26-50. PMID: 9534149.
      Citations: 31     Fields:    Translation:Cells
    23. Puig A, Primm TP, Surendran R, Lee JC, Ballard KD, Orkiszewski RS, Makarov V, Gilbert HF. A 21-kDa C-terminal fragment of protein-disulfide isomerase has isomerase, chaperone, and anti-chaperone activities. J Biol Chem. 1997 Dec 26; 272(52):32988-94. PMID: 9407079.
      Citations: 3     Fields:    Translation:AnimalsCells
    24. Gilbert HF. Protein disulfide isomerase and assisted protein folding. J Biol Chem. 1997 Nov 21; 272(47):29399-402. PMID: 9367991.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    25. Walker KW, Gilbert HF. Scanning and escape during protein-disulfide isomerase-assisted protein folding. J Biol Chem. 1997 Apr 04; 272(14):8845-8. PMID: 9082998.
      Citations: 44     Fields:    Translation:AnimalsCells
    26. Primm TP, Walker KW, Gilbert HF. Facilitated protein aggregation. Effects of calcium on the chaperone and anti-chaperone activity of protein disulfide-isomerase. J Biol Chem. 1996 Dec 27; 271(52):33664-9. PMID: 8969236.
      Citations: 21     Fields:    Translation:AnimalsCells
    27. Chang Z, Primm TP, Jakana J, Lee IH, Serysheva I, Chiu W, Gilbert HF, Quiocho FA. Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation. J Biol Chem. 1996 Mar 22; 271(12):7218-23. PMID: 8636160.
      Citations: 64     Fields:    Translation:Cells
    28. Walker KW, Lyles MM, Gilbert HF. Catalysis of oxidative protein folding by mutants of protein disulfide isomerase with a single active-site cysteine. Biochemistry. 1996 Feb 13; 35(6):1972-80. PMID: 8639681.
      Citations: 50     Fields:    Translation:AnimalsCells
    29. Walker KW, Gilbert HF. Oxidation of kinetically trapped thiols by protein disulfide isomerase. Biochemistry. 1995 Oct 17; 34(41):13642-50. PMID: 7577954.
      Citations: 17     Fields:    Translation:AnimalsCells
    30. Gilbert HF. Thiol/disulfide exchange equilibria and disulfide bond stability. Methods Enzymol. 1995; 251:8-28. PMID: 7651233.
      Citations: 133     Fields:    Translation:AnimalsCells
    31. Lyles MM, Gilbert HF. Mutations in the thioredoxin sites of protein disulfide isomerase reveal functional nonequivalence of the N- and C-terminal domains. J Biol Chem. 1994 Dec 09; 269(49):30946-52. PMID: 7983029.
      Citations: 27     Fields:    Translation:Cells
    32. Walker KW, Gilbert HF. Effect of redox environment on the in vitro and in vivo folding of RTEM-1 beta-lactamase and Escherichia coli alkaline phosphatase. J Biol Chem. 1994 Nov 11; 269(45):28487-93. PMID: 7961790.
      Citations: 16     Fields:    Translation:Cells
    33. Puig A, Gilbert HF. Anti-chaperone behavior of BiP during the protein disulfide isomerase-catalyzed refolding of reduced denatured lysozyme. J Biol Chem. 1994 Oct 14; 269(41):25889-96. PMID: 7929293.
      Citations: 6     Fields:    Translation:AnimalsCells
    34. Gilbert HF. Protein chaperones and protein folding. Curr Opin Biotechnol. 1994 Oct; 5(5):534-9. PMID: 7765469.
      Citations: 8     Fields:    Translation:AnimalsCells
    35. Puig A, Lyles MM, Noiva R, Gilbert HF. The role of the thiol/disulfide centers and peptide binding site in the chaperone and anti-chaperone activities of protein disulfide isomerase. J Biol Chem. 1994 Jul 22; 269(29):19128-35. PMID: 7913469.
      Citations: 22     Fields:    Translation:AnimalsCells
    36. Morjana NA, Gilbert HF. Catalysis of protein folding by agarose-immobilized protein disulfide isomerase. Protein Expr Purif. 1994 Apr; 5(2):144-8. PMID: 8054846.
      Citations: 2     Fields:    Translation:AnimalsCells
    37. Puig A, Gilbert HF. Protein disulfide isomerase exhibits chaperone and anti-chaperone activity in the oxidative refolding of lysozyme. J Biol Chem. 1994 Mar 11; 269(10):7764-71. PMID: 7907332.
      Citations: 48     Fields:    Translation:AnimalsCells
    38. Morjana NA, McKeone BJ, Gilbert HF. Guanidine hydrochloride stabilization of a partially unfolded intermediate during the reversible denaturation of protein disulfide isomerase. Proc Natl Acad Sci U S A. 1993 Mar 15; 90(6):2107-11. PMID: 8460117; PMCID: PMC46034.
      Citations: 18     Fields:    Translation:AnimalsCells
    39. Cappel RE, Gilbert HF. Oxidative inactivation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and subunit cross-linking involve different dithiol/disulfide centers. J Biol Chem. 1993 Jan 05; 268(1):342-8. PMID: 8416941.
      Citations: 1     Fields:    Translation:AnimalsCells
    40. Lu X, Gilbert HF, Harper JW. Conserved residues flanking the thiol/disulfide centers of protein disulfide isomerase are not essential for catalysis of thiol/disulfide exchange. Biochemistry. 1992 May 05; 31(17):4205-10. PMID: 1567868.
      Citations: 3     Fields:    Translation:AnimalsCells
    41. Chung PM, Cappel RE, Gilbert HF. Inhibition of glutathione disulfide reductase by glutathione. Arch Biochem Biophys. 1991 Jul; 288(1):48-53. PMID: 1898023.
      Citations: 10     Fields:    Translation:Animals
    42. Morjana NA, Gilbert HF. Effect of protein and peptide inhibitors on the activity of protein disulfide isomerase. Biochemistry. 1991 May 21; 30(20):4985-90. PMID: 2036365.
      Citations: 14     Fields:    Translation:AnimalsCells
    43. Gilbert HF, Kruzel ML, Lyles MM, Harper JW. Expression and purification of recombinant rat protein disulfide isomerase from Escherichia coli. Protein Expr Purif. 1991 Apr-Jun; 2(2-3):194-8. PMID: 1821789.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    44. Lyles MM, Gilbert HF. Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer. Biochemistry. 1991 Jan 22; 30(3):613-9. PMID: 1988050.
      Citations: 112     Fields:    Translation:Cells
    45. Lyles MM, Gilbert HF. Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: pre-steady-state kinetics and the utilization of the oxidizing equivalents of the isomerase. Biochemistry. 1991 Jan 22; 30(3):619-25. PMID: 1988051.
      Citations: 40     Fields:    Translation:Cells
    46. Cappel RE, Gilbert HF. The effects of NADPH and 3-hydroxy-3-methylglutaryl-CoA on the thiol/disulfide redox behavior of rat liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase. J Biol Chem. 1990 Sep 15; 265(26):15464-70. PMID: 2394734.
      Citations:    Fields:    Translation:AnimalsCells
    47. Gilbert HF. Molecular and cellular aspects of thiol-disulfide exchange. Adv Enzymol Relat Areas Mol Biol. 1990; 63:69-172. PMID: 2407068.
      Citations: 221     Fields:    Translation:Cells
    48. Gilbert HF. Catalysis of thiol/disulfide exchange: single-turnover reduction of protein disulfide-isomerase by glutathione and catalysis of peptide disulfide reduction. Biochemistry. 1989 Sep 05; 28(18):7298-305. PMID: 2819070.
      Citations: 9     Fields:    Translation:Cells
    49. Izbicka E, Gilbert HF. Examination of the role of thiolimidate formation in the cleavage of acetoacetyl-CoA catalyzed by thiolase I from porcine heart. Arch Biochem Biophys. 1989 Aug 01; 272(2):476-80. PMID: 2568819.
      Citations:    Fields:    Translation:AnimalsCells
    50. Cappel RE, Gilbert HF. The effects of mevinolin on the thiol/disulfide exchange between 3-hydroxy-3-methyglutaryl-coenzyme A reductase and glutathione. J Biol Chem. 1989 Jun 05; 264(16):9180-7. PMID: 2722823.
      Citations: 1     Fields:    Translation:AnimalsCells
    51. Cappel RE, Gilbert HF. Thiol/disulfide exchange between 3-hydroxy-3-methylglutaryl-CoA reductase and glutathione. A thermodynamically facile dithiol oxidation. J Biol Chem. 1988 Sep 05; 263(25):12204-12. PMID: 3410841.
      Citations: 13     Fields:    Translation:AnimalsCells
    52. Clancey CJ, Gilbert HF. Thiol/disulfide exchange in the thioredoxin-catalyzed reductive activation of spinach chloroplast fructose-1,6-bisphosphatase. Kinetics and thermodynamics. J Biol Chem. 1987 Oct 05; 262(28):13545-9. PMID: 2820974.
      Citations: 11     Fields:    Translation:AnimalsCells
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