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DORIT DONOVIEL

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
Address2450 HOLCOMBE
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Space Medicine
    DivisionCenter for Space Medicine


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jones CW, Overbey EG, Lacombe J, Ecker AJ, Meydan C, Ryon K, Tierney B, Damle N, MacKay M, Afshin EE, Foox J, Park J, Nelson T, Suhail M, Byhaqui SG, Aslam B, Tali UA, Nisa L, Menon P, Patel CO, Khan SA, Ebert DJ, Everson A, Schubert MC, Ali NN, Sarma MS, Kim J, Houerbi N, Grigorev K, Garcia Medina S, Summers AJ, Gu J, Altin JA, Fattahi A, Hirzallah MI, Wu JH, Stahn AC, Beheshti A, Klotz R, Ortiz V, Yu M, Patras L, Matei I, Lyden D, Melnick A, Banerjee N, Mullane S, Kleinman A, Loesche M, Menon AS, Donoviel DB, Urquieta E, Mateus J, Sargsyan AE, Shelhamer M, Zenhausern F, Bershad EM, Basner M, Mason CE, Jones CW, Overbey EG, Lacombe J, Ecker AJ, Meydan C, Ryon K, Tierney B, Damle N, MacKay M, Afshin EE, Foox J, Park J, Nelson TM, Suhail Mohamad M, Byhaqui SGA, Aslam B, Tali UA, Nisa L, Menon PV, Patel CO, Khan SA, Ebert DJ, Everson A, Schubert MC, Ali NN, Sarma MS, Kim J, Houerbi N, Grigorev K, Garcia Medina JS, Summers AJ, Gu J, Altin JA, Fattahi A, Hirzallah MI, Wu JH, Stahn AC, Beheshti A, Klotz R, Ortiz V, Yu M, Patras L, Matei I, Lyden D, Melnick A, Banerjee N, Mullane S, Kleinman AS, Loesche M, Menon AS, Donoviel DB, Urquieta E, Mateus J, Sargsyan AE, Shelhamer M, Zenhausern F, Bershad EM, Basner M, Mason CE. Molecular and physiological changes in the SpaceX Inspiration4 civilian crew. Nature. 2024 Aug; 632(8027):1155-1164. PMID: 38862026; PMCID: PMC11357997.
      Citations: 8     Fields:    Translation:Humans
    2. Rahimzadeh V, Caulfield T, Au??n-Chancellor S, Borry P, Candia J, Cohen IG, Covington M, Lynch HF, Greely HT, Hanlon M, Hatt J, Low L, Menikoff J, Meslin EM, Platts S, Ravitsky V, Ruttley T, Seidler RD, Sugarman J, Williams MA, Wolpe PR, McGuire AL, Fogarty J, Urquieta E, Donoviel D. Ethically cleared to launch? Science. 2023 09 29; 381(6665):1408-1411. PMID: 37769066.
      Citations:    Fields:    Translation:Humans
    3. Pathare NN, Fayet-Moore F, Fogarty JA, Jacka FN, Strandwitz P, Strangman GE, Donoviel DB. Nourishing the brain on deep space missions: nutritional psychiatry in promoting resilience. Front Neural Circuits. 2023; 17:1170395. PMID: 37663891; PMCID: PMC10469890.
      Citations:    Fields:    
    4. Weiman S, Cable J, Greenleaf W, Rundel F, Whitfield KE, Wingate L, Gallagher R, Pesanelli J, Orr D, Jarvis TC, Cadar R, Uva M, Ruediger D, Vaez R, Frisby A, Ahmed S, Donoviel D, Klinman J, Johnson D. Reimagining scientific conferences-a Keystone Symposia report. Ann N Y Acad Sci. 2023 09; 1527(1):49-59. PMID: 37534923.
      Citations:    Fields:    Translation:HumansPHPublic Health
    5. Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton R, Bronk L, Cao X, Chatterjee A, Clay DE, Courtney C, Fox DT, Gaber MW, Gerecht S, Grabham P, Grosshans D, Guan F, Jezuit EA, Kirsch DG, Liu Z, Maletic-Savatic M, Miller KM, Montague RA, Nagpal P, Osenberg S, Parkitny L, Pierce NA, Porada C, Rosenberg SM, Sargunas P, Sharma S, Spangler J, Tavakol DN, Thomas D, Vunjak-Novakovic G, Wang C, Whitcomb L, Young DW, Donoviel D. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci Space Res (Amst). 2022 Nov; 35:105-112. PMID: 36336356.
      Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
    6. Urquieta E, Wu J, Hury J, Donoviel D. Establishment of an open biomedical database for commercial spaceflight. Nat Med. 2022 04; 28(4):611-612. PMID: 35318465.
      Citations:    Fields:    
    7. LaPelusa M, Donoviel D, Branzini SE, Carlson PE, Culler S, Cheema AK, Kaddurah-Daouk R, Kelly D, de Cremoux I, Knight R, Krajmalnik-Brown R, Mayo SL, Mazmanian SK, Mayer EA, Petrosino JF, Garrison K. Microbiome for Mars: surveying microbiome connections to healthcare with implications for long-duration human spaceflight, virtual workshop, July 13, 2020. Microbiome. 2021 01 04; 9(1):2. PMID: 33397500; PMCID: PMC7781430.
      Citations: 3     Fields:    Translation:HumansAnimals
    8. Dempsey R, Domingo C, Donoviel D, Worman ZF. NASA launch for jobless postdocs. Nature. 2020 11; 587(7833):197. PMID: 33173223.
      Citations:    Fields:    Translation:Humans
    9. Soeken TA, Alonso A, Grant A, Calvillo E, Gutierrez-Flores B, Clark J, Donoviel D, Bershad EM. Quantitative Pupillometry for Detection of Intracranial Pressure Changes During Head-Down Tilt. Aerosp Med Hum Perform. 2018 Aug 01; 89(8):717-723. PMID: 30020056.
      Citations: 5     Fields:    Translation:Humans
    10. Marshall-Goebel K, Stevens B, Rao CV, Suarez JI, Calvillo E, Arbeille P, Sangi-Haghpeykar H, Donoviel DB, Mulder E, Bershad EM. Internal Jugular Vein Volume During Head-Down Tilt and Carbon Dioxide Exposure in the SPACECOT Study. Aerosp Med Hum Perform. 2018 Apr 01; 89(4):351-356. PMID: 29562964.
      Citations: 4     Fields:    Translation:Humans
    11. Basner M, Nasrini J, Hermosillo E, McGuire S, Dinges DF, Moore TM, Gur RC, Mulder E, Wittkowski M, Donoviel D, Stevens B, Bershad EM, SPACECOT Investigator Group, Rittweger J. Effects of -12? head-down tilt with and without elevated levels of CO2 on cognitive performance: the SPACECOT study. J Appl Physiol (1985). 2018 03 01; 124(3):750-760. PMID: 29357516.
      Citations: 10     Fields:    Translation:Humans
    12. Chang HC, Sorensen M, Harper JD, Bailey MR, Donoviel D. Re: Leapman et?al.: Up and Away: Five Decades of Urologic Investigation in Microgravity (Urology 106:18-25). Urology. 2017 12; 110:265-266. PMID: 28890152; PMCID: PMC5876934.
      Citations:    Fields:    
    13. McLaughlin MF, Donoviel DB, Jones JA. Novel Indications for Commonly Used Medications as Radiation Protectants in Spaceflight. Aerosp Med Hum Perform. 2017 Jul 01; 88(7):665-676. PMID: 28641684; PMCID: PMC5937128.
      Citations: 9     Fields:    Translation:HumansPHPublic Health
    14. Marshall-Goebel K, Mulder E, Donoviel D, Strangman G, Suarez JI, Venkatasubba Rao C, Frings-Meuthen P, Limper U, Bershad EM, Rittweger J. An international collaboration studying the physiological and anatomical cerebral effects of carbon dioxide during head-down tilt bed rest: the SPACECOT study. J Appl Physiol (1985). 2017 Jun 01; 122(6):1398-1405. PMID: 28235859.
      Citations: 4     Fields:    Translation:Humans
    15. Kramer LA, Hasan KM, Sargsyan AE, Marshall-Goebel K, Donoviel D, Higashi S, Mwangi B, Gerlach DA, Bershad EM, SPACECOT Investigators Group, Rittweger J. Quantitative MRI volumetry, diffusivity, cerebrovascular flow, and cranial hydrodynamics during head-down tilt and hypercapnia: the SPACECOT study. J Appl Physiol (1985). 2017 May 01; 122(5):1155-1166. PMID: 28209740.
      Citations: 7     Fields:    Translation:Humans
    16. Bershad EM, Anand A, DeSantis SM, Yang M, Tang RA, Calvillo E, Malkin-Gosdin L, Foroozan R, Damani R, Maldonado N, Gupta P, Tan B, Venkatasubba Rao CP, Suarez JI, Clark JB, Sutton JP, Donoviel DB. Clinical Validation of a Transcranial Doppler-Based Noninvasive Intracranial Pressure Meter: A Prospective Cross-Sectional Study. World Neurosurg. 2016 May; 89:647-653.e1. PMID: 26724629.
      Citations: 11     Fields:    Translation:Humans
    17. Donoviel DB, Bershad EM, Hiles LA. Noninvasive Brain Physiology Monitoring for Extreme Environments: A Critical Review. J Neurosurg Anesthesiol. 2015 Oct; 27(4):318-28. PMID: 25811362.
      Citations: 1     Fields:    Translation:Humans
    18. Mark S, Scott GB, Donoviel DB, Leveton LB, Mahoney E, Charles JB, Siegel B. The impact of sex and gender on adaptation to space: executive summary. J Womens Health (Larchmt). 2014 Nov; 23(11):941-7. PMID: 25401937; PMCID: PMC4236030.
      Citations: 18     Fields:    Translation:Humans
    19. Brommage R, Desai U, Revelli JP, Donoviel DB, Fontenot GK, Dacosta CM, Smith DD, Kirkpatrick LL, Coker KJ, Donoviel MS, Eberhart DE, Holt KH, Kelly MR, Paradee WJ, Philips AV, Platt KA, Suwanichkul A, Hansen GM, Sands AT, Zambrowicz BP, Powell DR. High-throughput screening of mouse knockout lines identifies true lean and obese phenotypes. Obesity (Silver Spring). 2008 Oct; 16(10):2362-7. PMID: 18719666.
      Citations: 30     Fields:    Translation:Animals
    20. To MD, Gokgoz N, Doyle TG, Donoviel DB, Knight JA, Hyslop PS, Bernstein A, Andrulis IL. Functional characterization of novel presenilin-2 variants identified in human breast cancers. Oncogene. 2006 Jun 15; 25(25):3557-64. PMID: 16474849.
      Citations: 17     Fields:    Translation:HumansAnimals
    21. Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D. A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage. J Neurochem. 2006 Jan; 96(1):118-25. PMID: 16300640.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, Donoviel DB, Bernstein A, Tomita T, Iwatsubo T, Hori M, Otsu K. Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling. FASEB J. 2005 Dec; 19(14):2069-71. PMID: 16204356.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    23. Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem. 2003 Jun 20; 278(25):22475-81. PMID: 12684521.
      Citations: 72     Fields:    Translation:AnimalsCells
    24. Donoho G, Brenneman MA, Cui TX, Donoviel D, Vogel H, Goodwin EH, Chen DJ, Hasty P. Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer. 2003 Apr; 36(4):317-31. PMID: 12619154.
      Citations: 43     Fields:    Translation:AnimalsCells
    25. Finch RA, Donoviel DB, Potter D, Shi M, Fan A, Freed DD, Wang CY, Zambrowicz BP, Ramirez-Solis R, Sands AT, Zhang N. mdmx is a negative regulator of p53 activity in vivo. Cancer Res. 2002 Jun 01; 62(11):3221-5. PMID: 12036937.
      Citations: 102     Fields:    Translation:AnimalsCells
    26. Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D. Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev. 2002 Apr 01; 16(7):846-58. PMID: 11937492; PMCID: PMC186324.
      Citations: 249     Fields:    Translation:AnimalsCells
    27. Taniguchi Y, Lundkvist J, Mizutani T, Otaka A, Vestling M, Bernstein A, Donoviel D, Lendahl U, Honjo T, Karlstr?m H. Notch receptor cleavage depends on but is not directly executed by presenilins. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):4014-9. PMID: 11891288; PMCID: PMC122640.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    28. Berechid BE, Kitzmann M, Foltz DR, Roach AH, Seiffert D, Thompson LA, Olson RE, Bernstein A, Donoviel DB, Nye JS. Identification and characterization of presenilin-independent Notch signaling. J Biol Chem. 2002 Mar 08; 277(10):8154-65. PMID: 11756438.
      Citations: 16     Fields:    Translation:AnimalsCells
    29. Shiels A, Bassnett S, Varadaraj K, Mathias R, Al-Ghoul K, Kuszak J, Donoviel D, Lilleberg S, Friedrich G, Zambrowicz B. Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice. Physiol Genomics. 2001 Dec 21; 7(2):179-86. PMID: 11773604.
      Citations: 87     Fields:    Translation:AnimalsCells
    30. Donoviel DB, Freed DD, Vogel H, Potter DG, Hawkins E, Barrish JP, Mathur BN, Turner CA, Geske R, Montgomery CA, Starbuck M, Brandt M, Gupta A, Ramirez-Solis R, Zambrowicz BP, Powell DR. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol Cell Biol. 2001 Jul; 21(14):4829-36. PMID: 11416156; PMCID: PMC87176.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    31. Sato N, Urano F, Yoon Leem J, Kim SH, Li M, Donoviel D, Bernstein A, Lee AS, Ron D, Veselits ML, Sisodia SS, Thinakaran G. Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression. Nat Cell Biol. 2000 Dec; 2(12):863-70. PMID: 11146649.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    32. Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol. 2000 Jul; 2(7):463-5. PMID: 10878814.
      Citations: 110     Fields:    Translation:AnimalsCells
    33. Donoviel DB, Hadjantonakis AK, Ikeda M, Zheng H, Hyslop PS, Bernstein A. Mice lacking both presenilin genes exhibit early embryonic patterning defects. Genes Dev. 1999 Nov 01; 13(21):2801-10. PMID: 10557208; PMCID: PMC317124.
      Citations: 157     Fields:    Translation:AnimalsCells
    34. Donoviel DB, Bernstein A. SEL-1L maps to human chromosome 14, near the insulin-dependent diabetes mellitus locus 11. Genomics. 1999 Mar 01; 56(2):232-3. PMID: 10051412.
      Citations: 4     Fields:    Translation:HumansCells
    35. Donoviel DB, Donoviel MS, Fan E, Hadjantonakis A, Bernstein A. Cloning and characterization of Sel-1l, a murine homolog of the C. elegans sel-1 gene. Mech Dev. 1998 Nov; 78(1-2):203-7. PMID: 9858735.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    36. Donoviel DB, Brunkow ME, Motro B, Bernstein A, Kl?ppel M. Embryonic and adult expression patterns of the Tec tyrosine kinase gene suggest a role in megakaryocytopoiesis, blood vessel development, and melanogenesis. Cell Growth Differ. 1997 Dec; 8(12):1249-56. PMID: 9419413.
      Citations: 1     Fields:    Translation:AnimalsCells
    37. Donoviel DB, Shield MA, Buskin JN, Haugen HS, Clegg CH, Hauschka SD. Analysis of muscle creatine kinase gene regulatory elements in skeletal and cardiac muscles of transgenic mice. Mol Cell Biol. 1996 Apr; 16(4):1649-58. PMID: 8657140; PMCID: PMC231151.
      Citations: 36     Fields:    Translation:AnimalsCells
    38. Donoviel DB, Amacher SL, Judge KW, Bornstein P. Thrombospondin gene expression is associated with mitogenesis in 3T3 cells: induction by basic fibroblast growth factor. J Cell Physiol. 1990 Oct; 145(1):16-23. PMID: 2211838.
      Citations: 13     Fields:    Translation:AnimalsCells
    39. Donoviel DB, Framson P, Eldridge CF, Cooke M, Kobayashi S, Bornstein P. Structural analysis and expression of the human thrombospondin gene promoter. J Biol Chem. 1988 Dec 15; 263(35):18590-3. PMID: 2848801.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
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