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DAMIAN YOUNG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
Address1250 MOURSUND STREET
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionPathology


    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qin X, Wang Y, Ye Q, Hakenjos JM, Wang J, Teng M, Guo L, Tan Z, Young DW, Mackenzie KR, Li F. CYP3A Mediates an Unusual C(sp2)-C(sp3) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism. Angew Chem Int Ed Engl. 2024 Apr 04; e202405197. PMID: 38574245.
      Citations:    Fields:    
    2. Tang SA, Fults A, Boyd SR, Gattu N, Tran KA, Fan J, MacKenzie KR, Palzkill T, Young DW, Chamakuri S. Expanding Complex Morpholines Using Systematic Chemical Diversity. Org Lett. 2024 Mar 20. PMID: 38506470.
      Citations:    Fields:    
    3. Holmes S, Jain P, Rodriguez KG, Williams J, Yu Z, Cerda-Smith C, Samuel ELG, Campbell J, Hakenjos JM, Monsivais D, Li F, Chamakuri S, Matzuk MM, Santini C, MacKenzie KR, Young DW. Chemical Catalysis Guides Structural Identification for the Major In Vivo Metabolite of the BET Inhibitor JQ1. ACS Med Chem Lett. 2024 Jan 11; 15(1):107-115. PMID: 38229743; PMCID: PMC10788937.
      Citations:    
    4. Han X, Wang W, Ma LH, Ai-Ramahi I, Botas J, MacKenzie K, Allen GI, Young DW, Liu Z, Maletic-Savatic M. SPA-STOCSY: an automated tool for identifying annotated and non-annotated metabolites in high-throughput NMR spectra. Bioinformatics. 2023 10 03; 39(10). PMID: 37792497; PMCID: PMC10568371.
      Citations:    Fields:    Translation:HumansAnimals
    5. Viveki AB, Mansfield TM, Tran KA, Lenkeit E, MacKenzie KR, Young DW, Chamakuri S. Heterocyclic Merging of Stereochemically Diverse Chiral Piperazines and Morpholines with Indazoles. Chemistry. 2023 Oct 02; 29(55):e202301888. PMID: 37462979; PMCID: PMC10885319.
      Citations:    Fields:    
    6. Jimmidi R, Chamakuri S, Lu S, Ucisik MN, Chen PJ, Bohren KM, Moghadasi SA, Versteeg L, Nnabuife C, Li JY, Qin X, Chen YC, Faver JC, Nyshadham P, Sharma KL, Sankaran B, Judge A, Yu Z, Li F, Pollet J, Harris RS, Matzuk MM, Palzkill T, Young DW. DNA-encoded chemical libraries yield non-covalent and non-peptidic SARS-CoV-2 main protease inhibitors. Commun Chem. 2023 Aug 04; 6(1):164. PMID: 37542196; PMCID: PMC10403511.
      Citations: 1     
    7. Qin X, Wang Y, MacKenzie KR, Hakenjos JM, Chen S, Khalil SM, Jung SY, Young DW, Guo L, Li F. Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC-MS-Based Metabolomic Approaches. Chem Res Toxicol. 2023 08 21; 36(8):1427-1438. PMID: 37531179; PMCID: PMC10445284.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Han X, Wang W, Ma LH, Al-Ramahi I, Botas J, MacKenzie K, Allen GI, Young DW, Liu Z, Maletic-Savatic M. SPA-STOCSY: An Automated Tool for Identification of Annotated and Non-Annotated Metabolites in High-Throughput NMR Spectra. bioRxiv. 2023 Feb 22. PMID: 36865102; PMCID: PMC9980041.
      Citations:    
    9. Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 02 09; 66(3):2143-2160. PMID: 36719862; PMCID: PMC9924264.
      Citations: 2     Fields:    Translation:HumansCells
    10. Qin X, Xie C, Hakenjos JM, MacKenzie KR, Boyd SR, Barzi M, Bissig KD, Young DW, Li F. The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice. Eur J Pharm Sci. 2023 Feb 01; 181:106358. PMID: 36513193; PMCID: PMC10395004.
      Citations:    Fields:    Translation:HumansAnimals
    11. Ye Q, Belabed H, Wang Y, Yu Z, Palaniappan M, Li JY, Kalovidouris SA, MacKenzie KR, Teng M, Young DW, Fujihara Y, Matzuk MM. Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-encoded chemical library selections. Andrology. 2023 07; 11(5):808-815. PMID: 36209044.
      Citations:    Fields:    Translation:HumansAnimals
    12. Teng M, Young DW, Tan Z. The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush. J Med Chem. 2022 11 10; 65(21):14289-14304. PMID: 36265019.
      Citations:    Fields:    Translation:HumansCells
    13. Bokhari RS, Beheshti A, Blutt SE, Bowles DE, Brenner D, Britton R, Bronk L, Cao X, Chatterjee A, Clay DE, Courtney C, Fox DT, Gaber MW, Gerecht S, Grabham P, Grosshans D, Guan F, Jezuit EA, Kirsch DG, Liu Z, Maletic-Savatic M, Miller KM, Montague RA, Nagpal P, Osenberg S, Parkitny L, Pierce NA, Porada C, Rosenberg SM, Sargunas P, Sharma S, Spangler J, Tavakol DN, Thomas D, Vunjak-Novakovic G, Wang C, Whitcomb L, Young DW, Donoviel D. Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel. Life Sci Space Res (Amst). 2022 Nov; 35:105-112. PMID: 36336356.
      Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
    14. McNerlin C, Guan F, Bronk L, Lei K, Grosshans D, Young DW, Gaber MW, Maletic-Savatic M. Targeting hippocampal neurogenesis to protect astronauts' cognition and mood from decline due to space radiation effects. Life Sci Space Res (Amst). 2022 Nov; 35:170-179. PMID: 36336363.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    15. Young DW, Chamakuri S. Trisubstituted triumph. Nat Chem. 2022 Jun; 14(6):595-597. PMID: 35668207.
      Citations:    Fields:    
    16. Modukuri RK, Yu Z, Tan Z, Ta HM, Ucisik MN, Jin Z, Anglin JL, Sharma KL, Nyshadham P, Li F, Riehle K, Faver JC, Duong K, Nagarajan S, Simmons N, Palmer SS, Teng M, Young DW, Yi JS, Kim C, Matzuk MM. Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2122506119. PMID: 35622893; PMCID: PMC9295786.
      Citations:    Fields:    Translation:HumansCells
    17. Chamakuri S, Tang SA, Tran KA, Guduru SKR, Bolin PK, MacKenzie KR, Young DW. A Concise Synthetic Method for Constructing 3-Substituted Piperazine-2-Acetic Acid Esters from 1,2-Diamines. Molecules. 2022 May 25; 27(11). PMID: 35684357; PMCID: PMC9182393.
      Citations:    Fields:    
    18. Moghadasi SA, Esler MA, Otsuka Y, Becker JT, Moraes SN, Anderson CB, Chamakuri S, Belica C, Wick C, Harki DA, Young DW, Scampavia L, Spicer TP, Shi K, Aihara H, Brown WL, Harris RS. Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 Mpro/3CLpro in Living Cells. mBio. 2022 06 28; 13(3):e0078422. PMID: 35471084; PMCID: PMC9239272.
      Citations:    Fields:    Translation:Cells
    19. Kandel P, Semerci F, Mishra R, Choi W, Bajic A, Baluya D, Ma L, Chen K, Cao AC, Phongmekhin T, Matinyan N, Chamakuri S, Raji IO, Chang L, Fuentes-Prior P, MacKenzie KR, Benn CL, Venken K, Moore DD, Young DW, Maletic-Savatic M, Jim?nez-Panizo A, Est?banez-Perpi?? E. Oleic acid is an endogenous ligand of TLX/NR2E1 that triggers hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2023784119. PMID: 35333654; PMCID: PMC9060471.
      Citations: 1     Fields:    Translation:Animals
    20. Sarrion-Perdigones A, Gonzalez Y, Chang L, Gallego-Flores T, Young DW, Venken KJT. Multiplex Hextuple Luciferase Assaying. Methods Mol Biol. 2022; 2524:433-456. PMID: 35821491; PMCID: PMC10157609.
      Citations:    Fields:    Translation:Cells
    21. Samuel ELG, Holmes SL, Young DW. Processing binding data using an open-source workflow. J Cheminform. 2021 Dec 11; 13(1):99. PMID: 34895330; PMCID: PMC8666039.
      Citations:    
    22. Chamakuri S, Chung MK, Samuel ELG, Tran KA, Chen YC, Nyshadham P, Santini C, Matzuk MM, Young DW. Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library. Bioorg Med Chem. 2021 10 15; 48:116387. PMID: 34571488.
      Citations: 2     Fields:    Translation:Cells
    23. Chamakuri S, Lu S, Ucisik MN, Bohren KM, Chen YC, Du HC, Faver JC, Jimmidi R, Li F, Li JY, Nyshadham P, Palmer SS, Pollet J, Qin X, Ronca SE, Sankaran B, Sharma KL, Tan Z, Versteeg L, Yu Z, Matzuk MM, Palzkill T, Young DW. DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Proc Natl Acad Sci U S A. 2021 09 07; 118(36). PMID: 34426525; PMCID: PMC8433497.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    24. Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT. Proc Natl Acad Sci U S A. 2021 03 02; 118(9). PMID: 33637650; PMCID: PMC7936271.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    25. Bowling EA, Wang JH, Gong F, Wu W, Neill NJ, Kim IS, Tyagi S, Orellana M, Kurley SJ, Chung HC, Hsu TY, Dubrulle J, Saltzman AB, Li H, Meena JK, Canlas GM, Chamakuri S, Singh S, Simon LM, Olson CM, Dobrolecki LE, Lewis MT, Zhang B, Golding I, Rosen JM, Young DW, Malovannaya A, Stossi F, Miles G, Ellis MJ, Yu L, Buonamici S, Lin CY, Karlin KL, Zhang XH, Westbrook TF, Dominguez-Vida?a R. Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer. Cell. 2021 01 21; 184(2):384-403.e21. PMID: 33450205; PMCID: PMC8635244.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    26. Chang L, Campbell J, Raji IO, Guduru SKR, Kandel P, Nguyen M, Liu S, Tran K, Venugopal NK, Taylor BC, Holt MV, Young NL, Samuel ELG, Jain P, Santini C, Sankaran B, MacKenzie KR, Young DW. Discovery of small molecules targeting the tandem tudor domain of the epigenetic factor UHRF1 using fragment-based ligand discovery. Sci Rep. 2021 01 13; 11(1):1121. PMID: 33441849; PMCID: PMC7806715.
      Citations: 4     Fields:    Translation:Cells
    27. Chamakuri S, Shah MM, Yang DCH, Santini C, Young DW. Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines. Org Biomol Chem. 2020 11 12; 18(43):8844-8849. PMID: 33118584.
      Citations: 1     Fields:    
    28. Monty OBC, Simmons N, Chamakuri S, Matzuk MM, Young DW. Solution-Phase Fmoc-Based Peptide Synthesis for DNA-Encoded Chemical Libraries: Reaction Conditions, Protecting Group Strategies, and Pitfalls. ACS Comb Sci. 2020 12 14; 22(12):833-843. PMID: 33074645.
      Citations: 3     Fields:    Translation:Cells
    29. Boyd SR, Chang L, Rezende W, Raji IO, Kandel P, Holmes SL, Young DW. Design and Applications of Bifunctional Small Molecules in Biology. Biochim Biophys Acta Proteins Proteom. 2021 01; 1869(1):140534. PMID: 32871274.
      Citations: 1     Fields:    Translation:Humans
    30. Li F, MacKenzie KR, Jain P, Santini C, Young DW, Matzuk MM. Metabolism of JQ1, an inhibitor of bromodomain and extra terminal bromodomain proteins, in human and mouse liver microsomes?. Biol Reprod. 2020 08 04; 103(2):427-436. PMID: 32285106; PMCID: PMC7401416.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    31. Sarrion-Perdigones A, Chang L, Gonzalez Y, Gallego-Flores T, Young DW, Venken KJT. Simultaneous Examination of Cellular Pathways using Multiplex Hextuple Luciferase Assaying. Curr Protoc Mol Biol. 2020 06; 131(1):e122. PMID: 32539239; PMCID: PMC7806208.
      Citations: 2     Fields:    Translation:HumansCells
    32. Monty OBC, Nyshadham P, Bohren KM, Palaniappan M, Matzuk MM, Young DW, Simmons N. Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries. ACS Comb Sci. 2020 02 10; 22(2):80-88. PMID: 31913011; PMCID: PMC7014401.
      Citations: 7     Fields:    Translation:Cells
    33. Sarrion-Perdigones A, Chang L, Gonzalez Y, Gallego-Flores T, Young DW, Venken KJT. Examining multiple cellular pathways at once using multiplex hextuple luciferase assaying. Nat Commun. 2019 12 13; 10(1):5710. PMID: 31836712; PMCID: PMC6911020.
      Citations: 16     Fields:    Translation:HumansCells
    34. Boyd SR, Young DW. Max-imizing the Attenuation of Myc Using Small Molecules. Trends Pharmacol Sci. 2019 09; 40(9):608-612. PMID: 31280901.
      Citations: 1     Fields:    Translation:Humans
    35. Jain P, Raji IO, Chamakuri S, MacKenzie KR, Ebright BT, Santini C, Young DW. Synthesis of Enantiomerically Pure 5-Substituted Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2019 05 17; 84(10):6040-6064. PMID: 30848904.
      Citations: 3     Fields:    
    36. Chamakuri S, Jain P, Guduru SRK, Arney JW, MacKenzie KR, Santini C, Young DW. Correction to Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2019 Apr 05; 84(7):4575. PMID: 30855144.
      Citations:    Fields:    
    37. Reddy Guduru SK, Chamakuri S, Raji IO, MacKenzie KR, Santini C, Young DW. Synthesis of Enantiomerically Pure 3-Substituted Piperazine-2-acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018 10 05; 83(19):11777-11793. PMID: 30180575.
      Citations: 5     Fields:    
    38. Chamakuri S, Jain P, Reddy Guduru SK, Arney JW, MacKenzie KR, Santini C, Young DW. Synthesis of Enantiomerically Pure 6-Substituted-Piperazine-2-Acetic Acid Esters as Intermediates for Library Production. J Org Chem. 2018 06 15; 83(12):6541-6555. PMID: 29751727.
      Citations: 5     Fields:    
    39. Wang Y, Wach JY, Sheehan P, Zhong C, Zhan C, Harris R, Almo SC, Bishop J, Haggarty SJ, Ramek A, Berry KN, O'Herin C, Koehler AN, Hung AW, Young DW. Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3?. ACS Med Chem Lett. 2016 Sep 08; 7(9):852-6. PMID: 27660690; PMCID: PMC5018862.
      Citations: 8     
    40. Yuan Y, Hartland K, Boskovic Z, Wang Y, Walpita D, Lysy PA, Zhong C, Young DW, Kim YK, Tolliday NJ, Sokal EM, Schreiber SL, Wagner BK. A small-molecule inducer of PDX1 expression identified by high-throughput screening. Chem Biol. 2013 Dec 19; 20(12):1513-22. PMID: 24290880; PMCID: PMC3927138.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    41. Wang Y, Jimenez M, Sheehan P, Zhong C, Hung AW, Tam CP, Young DW. Selective access to trisubstituted macrocyclic E- and Z-alkenes from the ring-closing metathesis of vinylsiloxanes. Org Lett. 2013 Mar 15; 15(6):1218-21. PMID: 23448432.
      Citations:    Fields:    Translation:Cells
    42. Zhong C, Wang Y, Hung AW, Schreiber SL, Young DW. Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts. Org Lett. 2011 Oct 21; 13(20):5556-9. PMID: 21916463.
      Citations: 6     Fields:    Translation:Cells
    43. Pandya BA, Dandapani S, Duvall JR, Rowley A, Mulrooney CA, Ryba T, Dombrowski M, Harton M, Young DW, Marcaurelle LA. Practical asymmetric synthesis of ?-hydroxy ?-amino acids via complimentary aldol reactions. Tetrahedron. 2011 Aug 26; 67(34):6131-6137. PMID: 21822337; PMCID: PMC3150486.
      Citations: 2     Fields:    
    44. Wang Y, Jimenez M, Hansen AS, Raiber EA, Schreiber SL, Young DW. Control of olefin geometry in macrocyclic ring-closing metathesis using a removable silyl group. J Am Chem Soc. 2011 Jun 22; 133(24):9196-9. PMID: 21557625; PMCID: PMC5436309.
      Citations: 11     Fields:    
    45. Hung AW, Ramek A, Wang Y, Kaya T, Wilson JA, Clemons PA, Young DW. Route to three-dimensional fragments using diversity-oriented synthesis. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):6799-804. PMID: 21482811; PMCID: PMC3084099.
      Citations: 53     Fields:    
    46. Marcaurelle LA, Comer E, Dandapani S, Duvall JR, Gerard B, Kesavan S, Lee MD, Liu H, Lowe JT, Marie JC, Mulrooney CA, Pandya BA, Rowley A, Ryba TD, Suh BC, Wei J, Young DW, Akella LB, Ross NT, Zhang YL, Fass DM, Reis SA, Zhao WN, Haggarty SJ, Palmer M, Foley MA. An aldol-based build/couple/pair strategy for the synthesis of medium- and large-sized rings: discovery of macrocyclic histone deacetylase inhibitors. J Am Chem Soc. 2010 Dec 01; 132(47):16962-76. PMID: 21067169; PMCID: PMC3004530.
      Citations: 78     Fields:    Translation:AnimalsCells
    47. Seiler KP, Young DW, Schreiber SL, Clemons PA, Danc?k V. Distinct biological network properties between the targets of natural products and disease genes. J Am Chem Soc. 2010 Jul 14; 132(27):9259-61. PMID: 20565092; PMCID: PMC2898216.
      Citations: 22     Fields:    Translation:HumansCells
    48. Young DW. Synthetic chemistry: An upfront investment. Nat Chem Biol. 2010 Mar; 6(3):174-175. PMID: 20154664.
      Citations: 1     Fields:    
    49. Kelly AR, Wei J, Kesavan S, Windmon N, Young DW, Marcaurelle LA, Mari? JC. Accessing skeletal diversity using catalyst control: formation of n and n + 1 macrocyclic triazole rings. Org Lett. 2009 Jun 04; 11(11):2257-60. PMID: 19473044; PMCID: PMC2702139.
      Citations: 12     Fields:    Translation:Cells
    50. Young DW, Comins DL. Tandem directed lithiations of N-Boc-1,2-dihydropyridines toward highly functionalized 2,3-dihydro-4-pyridones. Org Lett. 2005 Dec 08; 7(25):5661-4. PMID: 16321016.
      Citations: 4     Fields:    Translation:Cells
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