"Drug Discovery" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process of finding chemicals for potential therapeutic use.
| Descriptor ID |
D055808
|
| MeSH Number(s) |
E05.295 H01.158.703.007.675 H01.181.466.675
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Drug Discovery".
Below are MeSH descriptors whose meaning is more specific than "Drug Discovery".
This graph shows the total number of publications written about "Drug Discovery" by people in this website by year, and whether "Drug Discovery" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 2 | 2 |
| 2010 | 3 | 5 | 8 |
| 2011 | 2 | 3 | 5 |
| 2012 | 2 | 0 | 2 |
| 2013 | 4 | 4 | 8 |
| 2014 | 1 | 3 | 4 |
| 2015 | 3 | 5 | 8 |
| 2016 | 2 | 7 | 9 |
| 2017 | 3 | 3 | 6 |
| 2018 | 2 | 8 | 10 |
| 2019 | 3 | 6 | 9 |
| 2020 | 3 | 4 | 7 |
| 2021 | 3 | 5 | 8 |
| 2022 | 4 | 6 | 10 |
| 2023 | 3 | 2 | 5 |
| 2024 | 1 | 2 | 3 |
| 2025 | 1 | 2 | 3 |
| 2026 | 0 | 2 | 2 |
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Below are the most recent publications written about "Drug Discovery" by people in Profiles.
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Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity. Cell. 2026 Mar 05; 189(5):1356-1370.e26.
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Discovery and Characterization of a First-In-Class HCK/BTK PROTAC DFCI-002-06 for the Treatment of MYD88 Mutated B Cell Malignancies. J Med Chem. 2026 Jan 22; 69(2):1119-1134.
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Discovery of Bis-Acyl Hydrazides as Potent and Bioavailable MTA-Cooperative PRMT5 Inhibitors: A Case Study of Leveraging the Deuterium Kinetic Isotope Effect. J Med Chem. 2026 Jan 08; 69(1):289-304.
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A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases. Nat Biomed Eng. 2025 Dec; 9(12):2155-2180.
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Differential ex vivo susceptibility of Plasmodium malariae and Plasmodium falciparum clinical isolates from Ghana and Mali to current and lead discovery candidate antimalarial drugs. Microbiol Spectr. 2025 Apr; 13(4):e0217624.
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Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology. Proc Natl Acad Sci U S A. 2024 Nov 19; 121(47):e2413108121.
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On-demand modular assembly for expedited PROTAC development. Expert Opin Drug Discov. 2024 Jul; 19(7):769-772.
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A Gram-negative-selective antibiotic that spares the gut microbiome. Nature. 2024 06; 630(8016):429-436.
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Targeting SARS-CoV-2 nonstructural protein 3: Function, structure, inhibition, and perspective in drug discovery. Drug Discov Today. 2024 01; 29(1):103832.
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Report of the Assay Guidance Workshop on 3-Dimensional Tissue Models for Antiviral Drug Development. J Infect Dis. 2023 10 03; 228(Suppl 5):S337-S354.