"Drug Design" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
Descriptor ID |
D015195
|
MeSH Number(s) |
E05.295.500 H01.158.703.007.675.500 H01.181.466.675.500
|
Concept/Terms |
Drug Design- Drug Design
- Design, Drug
- Designs, Drug
- Drug Designs
Drug Modeling- Drug Modeling
- Drug Modelings
- Modeling, Drug
- Modelings, Drug
|
Below are MeSH descriptors whose meaning is more general than "Drug Design".
Below are MeSH descriptors whose meaning is more specific than "Drug Design".
This graph shows the total number of publications written about "Drug Design" by people in this website by year, and whether "Drug Design" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 0 | 5 | 5 |
1999 | 1 | 5 | 6 |
2000 | 1 | 4 | 5 |
2001 | 1 | 9 | 10 |
2002 | 1 | 4 | 5 |
2003 | 2 | 6 | 8 |
2004 | 5 | 4 | 9 |
2005 | 6 | 11 | 17 |
2006 | 5 | 12 | 17 |
2007 | 10 | 13 | 23 |
2008 | 4 | 10 | 14 |
2009 | 4 | 7 | 11 |
2010 | 4 | 10 | 14 |
2011 | 6 | 8 | 14 |
2012 | 6 | 11 | 17 |
2013 | 1 | 13 | 14 |
2014 | 5 | 9 | 14 |
2015 | 6 | 7 | 13 |
2016 | 4 | 11 | 15 |
2017 | 6 | 14 | 20 |
2018 | 5 | 7 | 12 |
2019 | 0 | 1 | 1 |
2020 | 2 | 7 | 9 |
2021 | 2 | 3 | 5 |
2022 | 1 | 0 | 1 |
2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Drug Design" by people in Profiles.
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Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature. 2023 Oct; 622(7982):376-382.
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Design, synthesis, and biological evaluation of a small molecule oral agonist of the glucagon-like-peptide-1 receptor. J Biol Chem. 2022 05; 298(5):101889.
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1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded a-Synuclein Aggregates. ChemMedChem. 2022 01 19; 17(2):e202100611.
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Design and construction of a stereochemically diverse piperazine-based DNA-encoded chemical library. Bioorg Med Chem. 2021 10 15; 48:116387.
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Antiarrhythmic Hit to Lead Refinement in a Dish Using Patient-Derived iPSC Cardiomyocytes. J Med Chem. 2021 05 13; 64(9):5384-5403.
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Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo. J Med Chem. 2021 05 13; 64(9):5689-5709.
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Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem. 2021 Apr 05; 215:113252.
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Cell cycle inhibitors for the treatment of acute myeloid leukemia: a review of phase 2 & 3 clinical trials. Expert Opin Emerg Drugs. 2020 12; 25(4):491-499.
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Design, synthesis and comparative analysis of triphenyl-1,2,3-triazoles as anti-proliferative agents. Eur J Med Chem. 2020 Dec 01; 207:112813.
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Design and Applications of Bifunctional Small Molecules in Biology. Biochim Biophys Acta Proteins Proteom. 2021 01; 1869(1):140534.