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ZHI TAN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
AddressOne Baylor Plaza
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Jimmidi R, Monsivais D, Ta HM, Sharma KL, Bohren KM, Chamakuri S, Liao Z, Li F, Hakenjos JM, Li JY, Mishina Y, Pan H, Qin X, Robers MB, Sankaran B, Tan Z, Tang S, Vasquez YM, Wilkinson J, Young DW, Palmer SS, MacKenzie KR, Kim C, Matzuk MM. Discovery of highly potent and ALK2/ALK1 selective kinase inhibitors using DNA-encoded chemistry technology. Proc Natl Acad Sci U S A. 2024 Nov 19; 121(47):e2413108121. PMID: 39541346; PMCID: PMC11588046.
      Citations:    Fields:    Translation:HumansCells
    2. Robichaux JP, Elamin YY, Tan Z, Carter BW, Zhang S, Liu S, Li S, Chen T, Poteete A, Estrada-Bernal A, Le AT, Truini A, Nilsson MB, Sun H, Roarty E, Goldberg SB, Brahmer JR, Altan M, Lu C, Papadimitrakopoulou V, Politi K, Doebele RC, Wong KK, Heymach JV. Author Correction: Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer. Nat Med. 2024 Sep; 30(9):2694-2695. PMID: 39164519.
      Citations:    Fields:    
    3. Mukherjee A, Kadam VD, Miao Q, Zhang W, MacKenzie KR, Tan Z, Teng M. On-demand modular assembly for expedited PROTAC development. Expert Opin Drug Discov. 2024 Jul; 19(7):769-772. PMID: 38842359.
      Citations:    Fields:    Translation:Humans
    4. Ku AF, Sharma KL, Ta HM, Sutton CM, Bohren KM, Wang Y, Chamakuri S, Chen R, Hakenjos JM, Jimmidi R, Kent K, Li F, Li JY, Ma L, Madasu C, Palaniappan M, Palmer SS, Qin X, Robers MB, Sankaran B, Tan Z, Vasquez YM, Wang J, Wilkinson J, Yu Z, Ye Q, Young DW, Teng M, Kim C, Matzuk MM. Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science. 2024 May 24; 384(6698):885-890. PMID: 38781365.
      Citations: 1     Fields:    Translation:HumansAnimals
    5. Madasu C, Liao Z, Parks SE, Sharma KL, Bohren KM, Ye Q, Li F, Palaniappan M, Tan Z, Yuan F, Creighton CJ, Tang S, Masand RP, Guan X, Young DW, Monsivais D, Matzuk MM. Identification of potent pan-ephrin receptor kinase inhibitors using DNA-encoded chemistry technology. Proc Natl Acad Sci U S A. 2024 May 07; 121(19):e2322934121. PMID: 38701119; PMCID: PMC11087803.
      Citations: 2     Fields:    Translation:Humans
    6. Qin X, Wang Y, Ye Q, Hakenjos JM, Wang J, Teng M, Guo L, Tan Z, Young DW, Mackenzie KR, Li F, Qin X, Wang Y, Ye Q, Hakenjos JM, Wang J, Teng M, Guo L, Tan Z, Young DW, MacKenzie KR, Li F. CYP3A Mediates an Unusual C(sp2)-C(sp3) Bond Cleavage via Ipso-Addition of Oxygen in Drug Metabolism. Angew Chem Int Ed Engl. 2024 06 03; 63(23):e202405197. PMID: 38574245; PMCID: PMC11126355.
      Citations: 1     Fields:    Translation:HumansCells
    7. Park S, Fan J, Chamakuri S, Palaniappan M, Sharma K, Qin X, Wang J, Tan Z, Judge A, Hu L, Sankaran B, Li F, Prasad BVV, Matzuk MM, Palzkill T. Exploiting the Carboxylate-Binding Pocket of ?-Lactamase Enzymes Using a Focused DNA-Encoded Chemical Library. J Med Chem. 2024 01 11; 67(1):620-642. PMID: 38117688; PMCID: PMC11489902.
      Citations:    Fields:    
    8. Miao Q, Kadam VD, Mukherjee A, Tan Z, Teng M. Unlocking DCAFs To Catalyze Degrader Development: An Arena for Innovative Approaches. J Med Chem. 2023 Oct 12; 66(19):13369-13383. PMID: 37738232.
      Citations:    Fields:    
    9. Zhang Y, Zhao Z, Huang LA, Liu Y, Yao J, Sun C, Li Y, Zhang Z, Ye Y, Yuan F, Nguyen TK, Garlapati NR, Wu A, Egranov SD, Caudle AS, Sahin AA, Lim B, Beretta L, Calin GA, Yu D, Hung MC, Curran MA, Rezvani K, Gan B, Tan Z, Han L, Lin C, Yang L. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab. 2023 08 08; 35(8):1457-1473.e13. PMID: 37329887; PMCID: PMC10712687.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Kriseman ML, Tang S, Liao Z, Jiang P, Parks SE, Cope DI, Yuan F, Chen F, Masand RP, Castro PD, Ittmann MM, Creighton CJ, Tan Z, Monsivais D. SMAD2/3 signaling in the uterine epithelium controls endometrial cell homeostasis and regeneration. Commun Biol. 2023 03 11; 6(1):261. PMID: 36906706; PMCID: PMC10008566.
      Citations:    Translation:Animals
    11. Tan Z, Garcia TX. SLO3 in the fast lane: The latest male contraceptive target with a promising small-molecule inhibitor. Proc Natl Acad Sci U S A. 2023 02 21; 120(8):e2221758120. PMID: 36791103; PMCID: PMC9974486.
      Citations:    Fields:    Translation:HumansCells
    12. Sun C, Ye Y, Tan Z, Liu Y, Li Y, Hu W, Liang K, Egranov SD, Huang LA, Zhang Z, Zhang Y, Yao J, Nguyen TK, Zhao Z, Wu A, Marks JR, Caudle AS, Sahin AA, Gao J, Gammon ST, Piwnica-Worms D, Hu J, Chiao PJ, Yu D, Hung MC, Curran MA, Calin GA, Ying H, Han L, Lin C, Yang L. Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Sci Adv. 2023 02 03; 9(5):eadd6995. PMID: 36724291; PMCID: PMC9891701.
      Citations: 5     Fields:    Translation:HumansCells
    13. Modukuri RK, Monsivais D, Li F, Palaniappan M, Bohren KM, Tan Z, Ku AF, Wang Y, Madasu C, Li JY, Tang S, Miklossy G, Palmer SS, Young DW, Matzuk MM. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 02 09; 66(3):2143-2160. PMID: 36719862; PMCID: PMC9924264.
      Citations: 2     Fields:    Translation:HumansCells
    14. Tantawy SI, Sarkar A, Hubner S, Tan Z, Wierda WG, Eldeib A, Zhang S, Kornblau S, Gandhi V. Mechanisms of MCL-1 Protein Stability Induced by MCL-1 Antagonists in B-Cell Malignancies. Clin Cancer Res. 2023 01 17; 29(2):446-457. PMID: 36346691; PMCID: PMC9852224.
      Citations: 3     Fields:    Translation:HumansCells
    15. Teng M, Young DW, Tan Z. The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush. J Med Chem. 2022 11 10; 65(21):14289-14304. PMID: 36265019.
      Citations:    Fields:    Translation:HumansCells
    16. Modukuri RK, Yu Z, Tan Z, Ta HM, Ucisik MN, Jin Z, Anglin JL, Sharma KL, Nyshadham P, Li F, Riehle K, Faver JC, Duong K, Nagarajan S, Simmons N, Palmer SS, Teng M, Young DW, Yi JS, Kim C, Matzuk MM. Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections. Proc Natl Acad Sci U S A. 2022 05 31; 119(22):e2122506119. PMID: 35622893; PMCID: PMC9295786.
      Citations:    Fields:    Translation:HumansCells
    17. Liang R, Shen X, Wang F, Wang X, DesJarlais A, Syed A, Saba R, Tan Z, Yu F, Ji X, Shrestha S, Ren Y, Yang J, Park Y, Schwartz RJ, Soibam B, McConnell BK, Stewart MD, Kumar A, Liu Y. H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors. J Cachexia Sarcopenia Muscle. 2021 12; 12(6):2174-2186. PMID: 34704401; PMCID: PMC8718088.
      Citations: 2     Fields:    Translation:AnimalsCells
    18. Chamakuri S, Lu S, Ucisik MN, Bohren KM, Chen YC, Du HC, Faver JC, Jimmidi R, Li F, Li JY, Nyshadham P, Palmer SS, Pollet J, Qin X, Ronca SE, Sankaran B, Sharma KL, Tan Z, Versteeg L, Yu Z, Matzuk MM, Palzkill T, Young DW. DNA-encoded chemistry technology yields expedient access to SARS-CoV-2 Mpro inhibitors. Proc Natl Acad Sci U S A. 2021 09 07; 118(36). PMID: 34426525; PMCID: PMC8433497.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    19. Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C, Liao L, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD, Putluri N, Coarfa C, Hawke DH, Gunaratne PH, Tsai KL, Han L, Hung MC, Calin GA, Namour F, Muntau AC, Blau N, Sutton VR, Zhang S, Lin C, Yang L, Gu?ant JL, Schiff M, Feillet F. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science. 2021 08 06; 373(6555):662-673. PMID: 34353949; PMCID: PMC9714245.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    20. Wang L, Jia Z, Xie D, Zhao T, Tan Z, Zhang S, Kong F, Wei D, Xie K. Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics. Cancer Res. 2020 10 15; 80(20):4500-4513. PMID: 32699135.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    21. Chaudhari R, Fong LW, Tan Z, Huang B, Zhang S. An up-to-date overview of computational polypharmacology in modern drug discovery. Expert Opin Drug Discov. 2020 09; 15(9):1025-1044. PMID: 32452701; PMCID: PMC7415563.
      Citations: 8     Fields:    Translation:Humans
    22. Chen P, Hsu WH, Chang A, Tan Z, Lan Z, Zhou A, Spring DJ, Lang FF, Wang YA, DePinho RA. Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment. Cancer Discov. 2020 03; 10(3):371-381. PMID: 31919052; PMCID: PMC7058515.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    23. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. 2019 04; 568(7752):410-414. PMID: 30918400; PMCID: PMC6661074.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    24. Robichaux JP, Elamin YY, Tan Z, Carter BW, Zhang S, Liu S, Li S, Chen T, Poteete A, Estrada-Bernal A, Le AT, Truini A, Nilsson MB, Sun H, Roarty E, Goldberg SB, Brahmer JR, Altan M, Lu C, Papadimitrakopoulou V, Politi K, Doebele RC, Wong KK, Heymach JV. Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer. Nat Med. 2018 05; 24(5):638-646. PMID: 29686424; PMCID: PMC5964608.
      Citations: 125     Fields:    Translation:HumansAnimalsCells
    25. Tsao AS, Wistuba I, Xia D, Byers L, Diao L, Wang J, Papadimitrakopoulou V, Tang X, Lu W, Kadara H, Grigoryev DN, Selvan ME, G?m?s ZH, Tan Z, Zhang S, Nilsson M, Heymach JV. Germline and Somatic Smoothened Mutations in Non-Small-Cell Lung Cancer Are Potentially Responsive to Hedgehog Inhibitor Vismodegib. JCO Precis Oncol. 2017 Nov; 1:1-10. PMID: 35172522.
      Citations: 1     Fields:    
    26. Chaudhari R, Tan Z, Huang B, Zhang S. Computational polypharmacology: a new paradigm for drug discovery. Expert Opin Drug Discov. 2017 Mar; 12(3):279-291. PMID: 28067061; PMCID: PMC7241838.
      Citations: 27     Fields:    Translation:Humans
    27. Hu B, Wang Q, Wang YA, Hua S, Ong D, Lan ZD, Chang Q, Ho YW, Monasterio MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, Wang G, Liao WT, Corley LJ, Yan H, Zhang J, You Y, Liu N, Cai L, Finocchiaro G, Phillips JJ, Berger MS, Spring DJ, Hu J, Sulman EP, Fuller GN, Chin L, Verhaak RGW, DePinho RA, Sauv? CG. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell. 2016 11 17; 167(5):1281-1295.e18. PMID: 27863244; PMCID: PMC5320931.
      Citations: 110     Fields:    Translation:HumansCells
    28. Tan Z, Chen L, Zhang S. Comprehensive Modeling and Discovery of Mebendazole as a Novel TRAF2- and NCK-interacting Kinase Inhibitor. Sci Rep. 2016 09 21; 6:33534. PMID: 27650168; PMCID: PMC5030704.
      Citations: 11     Fields:    Translation:Humans
    29. Tan Z, Chaudhai R, Zhang S. Polypharmacology in Drug Development: A Minireview of Current Technologies. ChemMedChem. 2016 Jun 20; 11(12):1211-8. PMID: 27154144.
      Citations: 10     Fields:    Translation:HumansCells
    30. Zhang S, Tan Z. Editorial: The Elephant in the Room: Targeting Ras for Therapeutic Development. Mini Rev Med Chem. 2016; 16(5):343-4. PMID: 26873479.
      Citations:    Fields:    Translation:Humans
    31. Reddy AS, Tan Z, Zhang S. Curation and analysis of multitargeting agents for polypharmacological modeling. J Chem Inf Model. 2014 Sep 22; 54(9):2536-43. PMID: 25133604; PMCID: PMC4170814.
      Citations: 8     Fields:    
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