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BRADLEY K. MCCONNELL

TitleAssociate Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 5024
Houston, TX 77204-5039
Houston TX 77204-5039
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    Collapse Research 
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    R15HL141963     (MCCONNELL, BRADLEY K)Apr 1, 2019 - Mar 31, 2022
    NIH
    Gravin Signalosome Protein Coordinates Cardiac Function via Adrenergic Receptor Signaling
    Role: Principal Investigator
    R15HL124458     (MCCONNELL, BRADLEY K)Apr 1, 2015 - Mar 31, 2019
    NIH
    Scaffolding Protein Interaction Network Regulates Cardiac Cell Signaling
    Role: Principal Investigator
    R15HL117034     (MCCONNELL, BRADLEY K)Jan 17, 2013 - Mar 31, 2017
    NIH
    Molecular Mechanism of Dilated Cardiomyopathy
    Role: Principal Investigator
    R01HL085487     (MCCONNELL, BRADLEY K)Sep 30, 2007 - Mar 31, 2014
    NIH
    Targeted Disruption of Beta-Adrenergic Signaling to Increase Cardiac Contractilit
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qasim H, Rajaei M, Xu Y, Reyes-Alcaraz A, Abdelnasser HY, Stewart MD, Lahiri SK, Wehrens XHT, McConnell BK, Qasim H, Rajaei M, Xu Y, Reyes-Alcaraz A, Abdelnasser HY, Stewart MD, McConnell BK. AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12; 134(8):1006-1022. PMID: 38506047.
      Citations:    Fields:    
    2. Reyes-Alcaraz A, Qasim H, Merlinsky E, Fox G, Islam T, Medina B, Schwartz RJ, Craft JW, McConnell BK. A Small Molecule That In Vitro Neutralizes Infection of SARS-CoV-2 and Its Most Infectious Variants, Delta, and Omicron. Biomedicines. 2023 Mar 15; 11(3). PMID: 36979895; PMCID: PMC10046252.
      Citations:    
    3. Prodan N, Ershad F, Reyes-Alcaraz A, Li L, Mistretta B, Gonzalez L, Rao Z, Yu C, Gunaratne PH, Li N, Schwartz RJ, McConnell BK. Direct reprogramming of cardiomyocytes into cardiac Purkinje-like cells. iScience. 2022 Nov 18; 25(11):105402. PMID: 36388958; PMCID: PMC9646947.
      Citations:    
    4. Lucero-Garcia Rojas EY, Reyes-Alcaraz A, Ruan K, McConnell BK, Bond RA. Fusion of the ?2-adrenergic receptor with either Gas or ?arrestin-2 produces constitutive signaling by each pathway and induces gain-of-function in BEAS-2B cells. FASEB Bioadv. 2022 Dec; 4(12):758-774. PMID: 36479208; PMCID: PMC9721090.
      Citations:    
    5. Arao Y, Gruzdev A, Scott GJ, Ray MK, Donoghue LJ, Neufeld TI, Lierz SL, Stefkovich ML, Mathura E, Jefferson T, Foley JF, Mahler BW, Asghari A, Le C, McConnell BK, Stephen R, Berridge BR, Hamilton KJ, Hewitt SC, Umetani M, Korach KS. A Novel Mouse Model to Analyze Non-Genomic ERa Physiological Actions. J Endocr Soc. 2022 Sep 01; 6(9):bvac109. PMID: 37283844; PMCID: PMC9338395.
      Citations:    
    6. Xiao S, Liang R, Lucero E, McConnell BK, Chen Z, Chang J, Navran S, Schwartz RJ, Iyer D. STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts. J Cardiovasc Aging. 2022 Jul; 2(3). PMID: 35891703; PMCID: PMC9311335.
      Citations: 1     
    7. Reyes-Alcaraz A, Lucero Garcia-Rojas EY, Merlinsky EA, Seong JY, Bond RA, McConnell BK. A NanoBiT assay to monitor membrane proteins trafficking for drug discovery and drug development. Commun Biol. 2022 03 08; 5(1):212. PMID: 35260793; PMCID: PMC8904512.
      Citations:    Translation:HumansCells
    8. Bagchi RA, Robinson EL, Hu T, Cao J, Hong JY, Tharp CA, Qasim H, Gavin KM, Pires da Silva J, Major JL, McConnell BK, Seto E, Lin H, McKinsey TA. Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling. Proc Natl Acad Sci U S A. 2022 02 15; 119(7). PMID: 35149557; PMCID: PMC8851525.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Liang R, Shen X, Wang F, Wang X, DesJarlais A, Syed A, Saba R, Tan Z, Yu F, Ji X, Shrestha S, Ren Y, Yang J, Park Y, Schwartz RJ, Soibam B, McConnell BK, Stewart MD, Kumar A, Liu Y. H19X-encoded miR-322(424)/miR-503 regulates muscle mass by targeting translation initiation factors. J Cachexia Sarcopenia Muscle. 2021 12; 12(6):2174-2186. PMID: 34704401; PMCID: PMC8718088.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Qasim H, McConnell BK. AKAP12 Signaling Complex: Impacts of Compartmentalizing cAMP-Dependent Signaling Pathways in the Heart and Various Signaling Systems. J Am Heart Assoc. 2020 07 07; 9(13):e016615. PMID: 32573313; PMCID: PMC7670535.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    11. Schwartz RJ, McConnell BK. Response to Zhao and Huang's Commentary Letter, "Conversion of Human Cardiac Progenitor Cells using Reprogramming Factors into Heterogeneous Cardiac Pacemaker-like Cells", regarding our Manuscript: "Conversion of Human Cardiac Progenitor Cells into Cardiac Pacemaker-like Cells". J Mol Cell Cardiol. 2020 04; 141:105-106. PMID: 32224038; PMCID: PMC8063682.
      Citations:    Fields:    Translation:HumansCells
    12. Roberston MJ, Raghunathan S, Potaman VN, Zhang F, Stewart MD, McConnell BK, Schwartz RJ. CRISPR-Cas9-induced IGF1 gene activation as a tool for enhancing muscle differentiation via multiple isoform expression. FASEB J. 2020 01; 34(1):555-570. PMID: 31914652; PMCID: PMC6956731.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    13. Raghunathan S, Mistretta B, Iyer D, Shi L, Gunaratne PH, Ko G, Schwartz RJ, McConnell BK, Islas JF. Conversion of human cardiac progenitor cells into cardiac pacemaker-like cells. J Mol Cell Cardiol. 2020 01; 138:12-22. PMID: 31678351; PMCID: PMC7035977.
      Citations: 7     Fields:    Translation:HumansCells
    14. Wang YT, Li X, Chen J, McConnell BK, Chen L, Li PL, Chen Y, Zhang Y. Activation of TFEB ameliorates dedifferentiation of arterial smooth muscle cells and neointima formation in mice with high-fat diet. Cell Death Dis. 2019 09 12; 10(9):676. PMID: 31515484; PMCID: PMC6742653.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Fan Q, Yin X, Rababa'h A, Diaz Diaz A, Wijaya CS, Singh S, Suryavanshi SV, Vo HH, Saeed M, Zhang Y, McConnell BK. Absence of gravin-mediated signaling inhibits development of high-fat diet-induced hyperlipidemia and atherosclerosis. Am J Physiol Heart Circ Physiol. 2019 10 01; 317(4):H793-H810. PMID: 31441691; PMCID: PMC6843010.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Zhang P, Guan Y, Chen J, Li X, McConnell BK, Zhou W, Boini KM, Zhang Y. Contribution of p62/SQSTM1 to PDGF-BB-induced myofibroblast-like phenotypic transition in vascular smooth muscle cells lacking Smpd1 gene. Cell Death Dis. 2018 11 19; 9(12):1145. PMID: 30451833; PMCID: PMC6242941.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    17. Raghunathan S, Reynolds CL, Schwartz RJ, Stewart MD, McConnell BK. C.B-17 SCID mice develop epicardial calcinosis with unaltered cardiac function. Fundam Clin Pharmacol. 2019 Feb; 33(1):25-30. PMID: 29959870; PMCID: PMC6311438.
      Citations:    Fields:    Translation:Animals
    18. Suryavanshi SV, Jadhav SM, Anderson KL, Katsonis P, Lichtarge O, McConnell BK. Human muscle-specific A-kinase anchoring protein polymorphisms modulate the susceptibility to cardiovascular diseases by altering cAMP/PKA signaling. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H109-H121. PMID: 29600899; PMCID: PMC6087776.
      Citations: 6     Fields:    Translation:HumansCells
    19. Suryavanshi SV, Jadhav SM, McConnell BK. Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System. J Cardiovasc Dev Dis. 2018 Jan 25; 5(1). PMID: 29370121; PMCID: PMC5872355.
      Citations: 6     
    20. Li Z, Singh S, Suryavanshi SV, Ding W, Shen X, Wijaya CS, Gao WD, McConnell BK. Force development and intracellular Ca2+ in intact cardiac muscles from gravin mutant mice. Eur J Pharmacol. 2017 Jul 15; 807:117-126. PMID: 28428008; PMCID: PMC5490489.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Liu Y, Chen L, Diaz AD, Benham A, Xu X, Wijaya CS, Fa'ak F, Luo W, Soibam B, Azares A, Yu W, Lyu Q, Stewart MD, Gunaratne P, Cooney A, McConnell BK, Schwartz RJ. Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts. Sci Rep. 2016 08 19; 6:31457. PMID: 27538477; PMCID: PMC4990963.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Valenzuela N, Fan Q, Fa'ak F, Soibam B, Nagandla H, Liu Y, Schwartz RJ, McConnell BK, Stewart MD. Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis. Dis Model Mech. 2016 Mar; 9(3):335-45. PMID: 26935106; PMCID: PMC4833330.
      Citations: 9     Fields:    Translation:AnimalsCells
    23. Rababa'h AM, Deo SV, Altarabsheh SE, De Caro J, Tarboush NA, Alzoubi KH, Ababneh M, McConnell BK, Markowitz AH, Park SJ. N-Acetyl Cysteine Therapy Does Not Prevent Renal Failure in High-Risk Patients Undergoing Open-Heart Surgery. Heart Surg Forum. 2016 Feb 22; 19(1):E16-22. PMID: 26913679.
      Citations:    Fields:    Translation:Humans
    24. McConnell BK, Singh S, Fan Q, Hernandez A, Portillo JP, Reiser PJ, Tikunova SB. Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy. Front Physiol. 2015; 6:242. PMID: 26379556; PMCID: PMC4550777.
      Citations: 7     
    25. Jiang J, Burgon PG, Wakimoto H, Onoue K, Gorham JM, O'Meara CC, Fomovsky G, McConnell BK, Lee RT, Seidman JG, Seidman CE. Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9046-51. PMID: 26153423; PMCID: PMC4517252.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    26. Rababa'h A, Singh S, Suryavanshi SV, Altarabsheh SE, Deo SV, McConnell BK. Compartmentalization role of A-kinase anchoring proteins (AKAPs) in mediating protein kinase A (PKA) signaling and cardiomyocyte hypertrophy. Int J Mol Sci. 2014 Dec 24; 16(1):218-29. PMID: 25547489; PMCID: PMC4307244.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    27. Motawea HK, Blazek AD, Zirwas MJ, Pleister AP, Ahmed AA, McConnell BK, Chotani MA. Delocalization of Endogenous A-kinase Antagonizes Rap1-Rho-a2C-Adrenoceptor Signaling in Human Microvascular Smooth Muscle Cells. J Cytol Mol Biol. 2014 Jan 10; 1(1). PMID: 24701590; PMCID: PMC3970818.
      Citations: 5     
    28. Guillory AN, Yin X, Wijaya CS, Diaz Diaz AC, Rababa'h A, Singh S, Atrooz F, Sadayappan S, McConnell BK. Enhanced cardiac function in Gravin mutant mice involves alterations in the ?-adrenergic receptor signaling cascade. PLoS One. 2013; 8(9):e74784. PMID: 24058627; PMCID: PMC3776749.
      Citations: 17     Fields:    Translation:AnimalsCells
    29. Rababa'h A, Craft JW, Wijaya CS, Atrooz F, Fan Q, Singh S, Guillory AN, Katsonis P, Lichtarge O, McConnell BK. Protein kinase A and phosphodiesterase-4D3 binding to coding polymorphisms of cardiac muscle anchoring protein (mAKAP). J Mol Biol. 2013 Sep 23; 425(18):3277-88. PMID: 23806656; PMCID: PMC3808176.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    30. Nguyen VT, Wu Y, Guillory AN, McConnell BK, Fujise K, Huang MH. Delta-opioid augments cardiac contraction through ?-adrenergic and CGRP-receptor co-signaling. Peptides. 2012 Jan; 33(1):77-82. PMID: 22108711; PMCID: PMC3396132.
      Citations: 5     Fields:    Translation:AnimalsCells
    31. Huang MH, Wu Y, Nguyen V, Rastogi S, McConnell BK, Wijaya C, Uretsky BF, Poh KK, Tan HC, Fujise K. Heart protection by combination therapy with esmolol and milrinone at late-ischemia and early reperfusion. Cardiovasc Drugs Ther. 2011 Jun; 25(3):223-32. PMID: 21562974; PMCID: PMC3110274.
      Citations: 5     Fields:    Translation:AnimalsCells
    32. Wu Y, Yin X, Wijaya C, Huang MH, McConnell BK. Acute myocardial infarction in rats. J Vis Exp. 2011 Feb 16; (48). PMID: 21372786; PMCID: PMC3197402.
      Citations: 36     Fields:    Translation:Animals
    33. McConnell BK, Popovic Z, Mal N, Lee K, Bautista J, Forudi F, Schwartzman R, Jin JP, Penn M, Bond M. Disruption of protein kinase A interaction with A-kinase-anchoring proteins in the heart in vivo: effects on cardiac contractility, protein kinase A phosphorylation, and troponin I proteolysis. J Biol Chem. 2009 Jan 16; 284(3):1583-92. PMID: 18945669; PMCID: PMC2615525.
      Citations: 43     Fields:    Translation:AnimalsCells
    34. Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DW. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem. 2004 Aug; 263(1-2):73-80. PMID: 15524168.
      Citations: 23     Fields:    Translation:AnimalsCells
    35. Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DW. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Mol Cell Biochem. 2004 Aug; 263(1):73-80. PMID: 27520666.
      Citations: 4     Fields:    
    36. Song Q, Schmidt AG, Hahn HS, Carr AN, Frank B, Pater L, Gerst M, Young K, Hoit BD, McConnell BK, Haghighi K, Seidman CE, Seidman JG, Dorn GW, Kranias EG. Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy. J Clin Invest. 2003 Mar; 111(6):859-67. PMID: 12639992; PMCID: PMC153769.
      Citations: 39     Fields:    Translation:AnimalsCells
    37. Berul CI, McConnell BK, Wakimoto H, Moskowitz IP, Maguire CT, Semsarian C, Vargas MM, Gehrmann J, Seidman CE, Seidman JG. Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene. Circulation. 2001 Nov 27; 104(22):2734-9. PMID: 11723028.
      Citations: 18     Fields:    Translation:Animals
    38. Sprung J, Ogletree-Hughes ML, McConnell BK, Zakhary DR, Smolsky SM, Moravec CS. The effects of propofol on the contractility of failing and nonfailing human heart muscles. Anesth Analg. 2001 Sep; 93(3):550-9. PMID: 11524317.
      Citations: 16     Fields:    Translation:HumansCells
    39. McConnell BK, Fatkin D, Semsarian C, Jones KA, Georgakopoulos D, Maguire CT, Healey MJ, Mudd JO, Moskowitz IP, Conner DA, Giewat M, Wakimoto H, Berul CI, Schoen FJ, Kass DA, Seidman CE, Seidman JG. Comparison of two murine models of familial hypertrophic cardiomyopathy. Circ Res. 2001 Mar 02; 88(4):383-9. PMID: 11230104.
      Citations: 49     Fields:    Translation:AnimalsCells
    40. Fatkin D, McConnell BK, Mudd JO, Semsarian C, Moskowitz IG, Schoen FJ, Giewat M, Seidman CE, Seidman JG. An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy. J Clin Invest. 2000 Dec; 106(11):1351-9. PMID: 11104788; PMCID: PMC381468.
      Citations: 93     Fields:    Translation:AnimalsCells
    41. McConnell BK, Jones KA, Fatkin D, Arroyo LH, Lee RT, Aristizabal O, Turnbull DH, Georgakopoulos D, Kass D, Bond M, Niimura H, Schoen FJ, Conner D, Fischman DA, Seidman CE, Seidman JG. Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice J Clin Invest. 1999 Dec; 104(12):1771. PMID: 10606631; PMCID: PMC480917.
      Citations: 18     Fields:    
    42. Kim SJ, Iizuka K, Kelly RA, Geng YJ, Bishop SP, Yang G, Kudej A, McConnell BK, Seidman CE, Seidman JG, Vatner SF. An alpha-cardiac myosin heavy chain gene mutation impairs contraction and relaxation function of cardiac myocytes. Am J Physiol. 1999 05; 276(5):H1780-7. PMID: 10330263.
      Citations: 28     Fields:    Translation:AnimalsCells
    43. Fatkin D, Christe ME, Aristizabal O, McConnell BK, Srinivasan S, Schoen FJ, Seidman CE, Turnbull DH, Seidman JG. Neonatal cardiomyopathy in mice homozygous for the Arg403Gln mutation in the alpha cardiac myosin heavy chain gene. J Clin Invest. 1999 Jan; 103(1):147-53. PMID: 9884344; PMCID: PMC407864.
      Citations: 28     Fields:    Translation:HumansAnimals
    44. McConnell BK, Moravec CS, Bond M. Troponin I phosphorylation and myofilament calcium sensitivity during decompensated cardiac hypertrophy. Am J Physiol. 1998 02; 274(2):H385-96. PMID: 9486239.
      Citations: 16     Fields:    Translation:AnimalsCells
    45. McConnell BK, Moravec CS, Morano I, Bond M. Troponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation. Am J Physiol. 1997 Sep; 273(3 Pt 2):H1440-51. PMID: 9321836.
      Citations: 6     Fields:    Translation:AnimalsCells
    46. Zhang BX, Ma X, McConnell BK, Damron DS, Bond M. Activation of purinergic receptors triggers oscillatory contractions in adult rat ventricular myocytes. Circ Res. 1996 Jul; 79(1):94-102. PMID: 8925574.
      Citations: 1     Fields:    Translation:AnimalsCells
    47. Xing M, Wilkins PL, McConnell BK, Mattera R. Regulation of phospholipase A2 activity in undifferentiated and neutrophil-like HL60 cells. Linkage between impaired responses to agonists and absence of protein kinase C-dependent phosphorylation of cytosolic phospholipase A2. J Biol Chem. 1994 Jan 28; 269(4):3117-24. PMID: 8300648.
      Citations: 10     Fields:    Translation:HumansCells
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