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XANDER WEHRENS

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Integrative Physiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Space Medicine
    DivisionCenter for Space Medicine

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Cardiology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Cardiology


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    R01HL153350     (WEHRENS, XANDER H.T.)Apr 1, 2021 - Mar 31, 2025
    NIH
    Junctophilin-2 cleavage in ischemic heart disease
    Role: Principal Investigator
    R01HL147108     (LI, NA ;WEHRENS, XANDER H.T.)Apr 15, 2019 - Feb 29, 2024
    NIH
    Mechanisms underlying atrial fibrillation associated with chronic kidney disease
    Role: Principal Investigator
    R41HL129570     (WEHRENS, XANDER H.T.)Aug 1, 2015 - Jul 31, 2017
    NIH
    Development of novel compounds for the treatment of atrial fibrillation
    Role: Principal Investigator
    R01HL117641     (WEHRENS, XANDER H.T.)Apr 1, 2014 - Mar 31, 2020
    NIH
    Determining the Role of Junctophilin-2 in Cardiac Disease
    Role: Principal Investigator
    R01HL091947     (WEHRENS, XANDER H.T.)Apr 1, 2008 - Feb 28, 2021
    NIH
    Regulation of Sarcoplasmic Reticulum Calcium Release in Heart Failure
    Role: Principal Investigator
    R01HL089598     (WEHRENS, XANDER H.T.)Aug 1, 2007 - Jun 30, 2023
    NIH
    Ryanodine receptor regulation in post-operative atrial fibrillation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dardas Z, Fatih JM, Jolly A, Dawood M, Du H, Grochowski CM, Jones EG, Jhangiani SN, Wehrens XHT, Liu P, Bi W, Boerwinkle E, Posey JE, Muzny DM, Gibbs RA, Lupski JR, Coban-Akdemir Z, Morris SA. NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy. Genome Med. 2024 Apr 03; 16(1):53. PMID: 38570875; PMCID: PMC10988827.
      Citations:    Fields:    
    2. Qasim H, Rajaei M, Xu Y, Reyes-Alcaraz A, Abdelnasser HY, Stewart MD, Lahiri SK, Wehrens XHT, McConnell BK, Qasim H, Rajaei M, Xu Y, Reyes-Alcaraz A, Abdelnasser HY, Stewart MD, McConnell BK. AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction. Circ Res. 2024 Apr 12; 134(8):1006-1022. PMID: 38506047.
      Citations:    Fields:    
    3. Zhao S, Hulsurkar MM, Lahiri SK, Aguilar-Sanchez Y, Munivez E, M?ller FU, Jain A, Malovannaya A, Yiu K, Reilly S, Wehrens XHT, Yiu CHK. Atrial proteomic profiling reveals a switch towards profibrotic gene expression program in CREM-Ib?C-X mice with persistent atrial fibrillation. J Mol Cell Cardiol. 2024 Mar 19; 190:1-12. PMID: 38514002.
      Citations:    Fields:    
    4. Lahiri SK, Jin F, Zhou Y, Quick AP, Kramm CF, Wang MC, Wehrens XH. Altered myocardial lipid regulation in junctophilin-2-associated familial cardiomyopathies. Life Sci Alliance. 2024 May; 7(5). PMID: 38438248; PMCID: PMC10912815.
      Citations:    Fields:    Translation:HumansAnimals
    5. Asghari P, Scriven DRL, Shahrasebi S, Valdivia HH, Alsina KM, Valdivia CR, Navarro-Garcia JA, Wehrens XHT, Moore EDW. Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers. J Gen Physiol. 2024 Apr 01; 156(4). PMID: 38385988; PMCID: PMC10883851.
      Citations:    Fields:    Translation:AnimalsCells
    6. Navarro-Garcia JA, Bruns F, Moore OM, Tekook MA, Dobrev D, Miyake CY, Wehrens XHT. In Vivo Cardiac Electrophysiology in Mice: Determination of Atrial and Ventricular Arrhythmic Substrates. Curr Protoc. 2024 Feb; 4(2):e994. PMID: 38372479; PMCID: PMC10883620.
      Citations:    Fields:    Translation:Animals
    7. Zhao S, Hulsurkar MM, Lahiri SK, Aguilar-Sanchez Y, Munivez E, M?ller FU, Jain A, Malovannaya A, Yiu K, Reilly S, Wehrens XHT, Zhao S, Hulsurkar MM, Lahiri SK, Aguilar-Sanchez Y, Munivez E, M?ller FU, Jain A, Malovannaya A, Yiu K, Reilly S, Wehrens XHT. Atrial Proteomic Profiling Reveals a Switch Towards Profibrotic Gene Expression Program in CREM-Ib?C-X Mice with Persistent Atrial Fibrillation. bioRxiv. 2024 Jan 12. PMID: 38260363; PMCID: PMC10802622.
      Citations:    
    8. Keefe JA, Garber R, McCauley MD, Wehrens XHT. Tachycardia and Atrial Fibrillation-Related Cardiomyopathies: Potential Mechanisms and Current Therapies. JACC Heart Fail. 2024 Apr; 12(4):605-615. PMID: 38206235.
      Citations:    Fields:    
    9. Moore OM, Aguilar-Sanchez Y, Lahiri SK, Hulsurkar MM, Alberto Navarro-Garcia J, Word TA, Keefe JA, Barazi D, Munivez EM, Moore CT, Parthasarathy V, Davidson J, Lagor WR, Park SH, Bao G, Miyake CY, Wehrens XHT. Long-term efficacy and safety of cardiac genome editing for catecholaminergic polymorphic ventricular tachycardia. J Cardiovasc Aging. 2024 Jan; 4(1). PMID: 38464671; PMCID: PMC10919902.
      Citations:    
    10. Sun B, Rouzbehani OMT, Kramer RJ, Ghosh R, Perelli RM, Atkins S, Fatahian AN, Davis K, Szulik MW, Goodman MA, Hathaway MA, Chi E, Word TA, Tunuguntla H, Denfield SW, Wehrens XHT, Whitehead KJ, Abdelnasser HY, Warren JS, Wu M, Franklin S, Boudina S, Landstrom AP. Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-? Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice. Circ Heart Fail. 2023 12; 16(12):e010351. PMID: 38113297; PMCID: PMC10752244.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Wiedner HJ, Blue RE, Sadovsky M, Mills CA, Wehrens XHT, Herring LE, Giudice J. RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis. iScience. 2023 Nov 17; 26(11):108258. PMID: 38026174; PMCID: PMC10665822.
      Citations:    
    12. Moore OM, Keefe JA, Wehrens XHT. Endothelial cell dysfunction: the culprit for cardiac denervation in aging? J Cardiovasc Aging. 2023 Oct; 3(4). PMID: 38235058; PMCID: PMC10793999.
      Citations:    
    13. Song J, Navarro-Garcia JA, Wu J, Saljic A, Abu-Taha I, Li L, Lahiri SK, Keefe JA, Aguilar-Sanchez Y, Moore OM, Yuan Y, Wang X, Kamler M, Mitch WE, Ruiz-Hurtado G, Hu Z, Thomas SS, Dobrev D, Wehrens XH, Li N. Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation. J Clin Invest. 2023 10 02; 133(19). PMID: 37581942; PMCID: PMC10541185.
      Citations: 2     Fields:    Translation:HumansAnimals
    14. Yang Q, Tadros HJ, Sun B, Bidzimou MT, Ezekian JE, Li F, Ludwig A, Wehrens XHT, Landstrom AP. Junctional Ectopic Tachycardia Caused by Junctophilin-2 Expression Silencing Is Selectively Sensitive to Ryanodine Receptor Blockade. JACC Basic Transl Sci. 2023 Dec; 8(12):1577-1588. PMID: 38205351; PMCID: PMC10774596.
      Citations:    
    15. Abu-Taha I, Damen FW, Hanft LM, Aguilar-Sanchez Y, Levin B, Martin J, Akar JG, McDonald KS, Goergen CJ, Dobrev D, Wehrens XHT, Perike S, Gonzalez-Gonzalez FJ, Lizama KS, Aboonabi A, Capote AE, Han Z, Sridhar A, Grand J, Warren CM, Ong SG, Darbar D, Wolska BM, McCauley MD, Solaro RJ. PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation. Circ Res. 2023 10 13; 133(9):758-771. PMID: 37737016; PMCID: PMC10616980.
      Citations:    Fields:    Translation:HumansAnimalsCells
    16. Lee CS, Jung SY, Yee RSZ, Agha NH, Hong J, Chang T, Babcock LW, Fleischman JD, Clayton B, Hanna AD, Ward CS, Lanza D, Hurley AE, Zhang P, Wehrens XHT, Lagor WR, Rodney GG, Hamilton SL. Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads. Commun Biol. 2023 09 14; 6(1):942. PMID: 37709832; PMCID: PMC10502019.
      Citations:    Translation:Animals
    17. Navarro-Garcia JA, Lahiri SK, Aguilar-Sanchez Y, Reddy AK, Wehrens XHT. Characterization of atrial and ventricular remodeling in an improved minimally invasive mouse model of transverse aortic constriction. J Cardiovasc Aging. 2023 Jul; 3(3). PMID: 37538440; PMCID: PMC10399641.
      Citations:    
    18. Reyes Gaido OE, Pavlaki N, Granger JM, Mesubi OO, Liu B, Lin BL, Long A, Walker D, Mayourian J, Schole KL, Terrillion CE, Nkashama LJ, Hulsurkar MM, Dorn LE, Ferrero KM, Huganir RL, M?ller FU, Wehrens XHT, Liu JO, Luczak ED, Bezzerides VJ, Anderson ME. An improved reporter identifies ruxolitinib as a potent and cardioprotective CaMKII inhibitor. Sci Transl Med. 2023 06 21; 15(701):eabq7839. PMID: 37343080.
      Citations:    Fields:    Translation:HumansAnimalsCells
    19. Keefe JA, Wehrens XHT. Anti-Ro/SSA Antibodies in?Atrioventricular Block: Innocent Bystander or Mechanistic Driver? JACC Clin Electrophysiol. 2023 08; 9(8 Pt 3):1649-1651. PMID: 37354190.
      Citations:    Fields:    Translation:Humans
    20. Asghari P, Scriven DRL, Shahrasebi S, Valdivia HH, Wehrens XHT, Moore EDW. PHOSPHORYLATION OF RyR2 SIMULTANEOUSLY EXPANDS THE DYAD AND REARRANGES THE TETRAMERS. bioRxiv. 2023 May 23. PMID: 37292875; PMCID: PMC10245935.
      Citations:    
    21. Moore OM, Ho KS, Copeland JS, Parthasarathy V, Wehrens XHT. Genome Editing and Cardiac Arrhythmias. Cells. 2023 05 11; 12(10). PMID: 37408197; PMCID: PMC10216508.
      Citations: 2     Fields:    Translation:HumansCells
    22. Wang X, Song J, Yuan Y, Li L, Abu-Taha I, Heijman J, Sun L, Dobrev S, Kamler M, Xie L, Wehrens XHT, Horrigan FT, Dobrev D, Li N. Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis. Circ Res. 2023 06 23; 133(1):e1-e16. PMID: 37154033; PMCID: PMC10330339.
      Citations: 1     Fields:    Translation:AnimalsCells
    23. Perike S, Gonzalez-Gonzalez FJ, Abu-Taha I, Damen FW, Lizama KS, Aboonabi A, Capote AE, Aguilar-Sanchez Y, Levin B, Han Z, Sridhar A, Grand J, Martin J, Akar JG, Warren CM, Solaro RJ, Ong SG, Darbar D, Goergen CJ, Wolska BM, Dobrev D, Wehrens XHT, McCauley MD. Myosin Light Chain Dephosphorylation by PPP1R12C Promotes Atrial Hypocontractility in Atrial Fibrillation. bioRxiv. 2023 Apr 20. PMID: 37131731; PMCID: PMC10153354.
      Citations:    
    24. Potter AS, Hulsurkar MM, Wu L, Narasimhan B, Karimzad K, Koutroumpakis E, Palaskas N, Deswal A, Kantharia BK, Wehrens XHT. Kinase Inhibitors and Atrial Fibrillation: Mechanisms of Action and Clinical Implications. JACC Clin Electrophysiol. 2023 04; 9(4):591-602. PMID: 37100538.
      Citations:    Fields:    Translation:Humans
    25. Moore OM, Dorn LE, Wehrens XHT. Variant-specific therapy for long QT syndrome type 3. Heart Rhythm. 2023 05; 20(5):718-719. PMID: 36806575; PMCID: PMC10913134.
      Citations:    Fields:    Translation:Humans
    26. Prisco SZ, Hartweck LM, Kazmirczak F, Mendelson JB, Deng SL, Lahiri SK, Wehrens XHT, Prins KW. Junctophilin-2 Regulates Mitochondrial Metabolism. bioRxiv. 2023 Feb 08. PMID: 36798293; PMCID: PMC9934637.
      Citations:    
    27. Perelli RM, Bidzimou MT, Zhang Z, Ludwig A, Landstrom AP, Yang Q, Sun B, Aguilar-Sanchez Y, Alsina KM, Cao S, Reynolds JO, Word TA, van der Sangen NMR, Wells Q, Kannankeril PJ, Kim JJ, Wehrens XHT. Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity. Circ Arrhythm Electrophysiol. 2023 02; 16(2):e010858. PMID: 36706317; PMCID: PMC9974897.
      Citations:    Fields:    Translation:AnimalsCells
    28. Sy MR, Keefe JA, Sutton JP, Wehrens XHT. Cardiac function, structural, and electrical remodeling by microgravity exposure. Am J Physiol Heart Circ Physiol. 2023 01 01; 324(1):H1-H13. PMID: 36399385; PMCID: PMC9762974.
      Citations: 2     Fields:    Translation:Humans
    29. Keefe JA, Avadhanula V, Nicholson EG, Devaraj S, Piedra PA, Bozkurt B, Wehrens XHT. Abnormalities in cardiac and inflammatory biomarkers in ambulatory subjects after COVID-19 infection. Int J Cardiol Heart Vasc. 2022 Dec; 43:101144. PMID: 36321063; PMCID: PMC9613792.
      Citations: 1     
    30. Smith HS, Sanchez CE, Maag R, Buentello A, Murdock DR, Metcalf GA, Hadley TD, Riconda DL, Boerwinkle E, Wehrens XHT, Ballantyne CM, Gibbs RA, McGuire AL, Pereira S. Patient and Clinician Perceptions of Precision Cardiology Care: Findings From the HeartCare Study. Circ Genom Precis Med. 2022 12; 15(6):e003605. PMID: 36282588; PMCID: PMC10163837.
      Citations:    Fields:    Translation:Humans
    31. Ni L, Lahiri SK, Nie J, Pan X, Abu-Taha I, Reynolds JO, Campbell HM, Wang H, Kamler M, Li N, Wei X, Wang DW, Dobrev D, Wehrens XHT, Schmitz W, M?ller FU. Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice. Cardiovasc Res. 2022 10 21; 118(13):2805-2818. PMID: 34648001; PMCID: PMC9586567.
      Citations: 2     Fields:    
    32. Keefe JA, Moore OM, Ho KS, Wehrens XHT. Role of Ca2+ in healthy and pathologic cardiac function: from normal excitation-contraction coupling to mutations that cause inherited arrhythmia. Arch Toxicol. 2023 01; 97(1):73-92. PMID: 36214829; PMCID: PMC10122835.
      Citations: 1     Fields:    Translation:HumansCells
    33. Himelman E, Nouet J, Lillo MA, Chong A, Zhou D, Wehrens XHT, Rodney GG, Xie LH, Shirokova N, Contreras JE, Fraidenraich D. A microtubule-connexin-43 regulatory link suppresses arrhythmias and cardiac fibrosis in Duchenne muscular dystrophy mice. Am J Physiol Heart Circ Physiol. 2022 11 01; 323(5):H983-H995. PMID: 36206047; PMCID: PMC9639757.
      Citations:    Fields:    Translation:AnimalsCells
    34. Keefe JA, Hulsurkar MM, Reilly S, Wehrens XHT. Mouse models of spontaneous atrial fibrillation. Mamm Genome. 2023 Jun; 34(2):298-311. PMID: 36173465; PMCID: PMC10898345.
      Citations: 1     Fields:    Translation:Animals
    35. Keefe JA, Wehrens XHT, Dobrev D. Common disease-promoting signalling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences. Cardiovasc Res. 2022 08 24; 118(11):2397-2399. PMID: 35788838.
      Citations:    Fields:    
    36. Shen X, van den Brink J, Bergan-Dahl A, Kolstad TR, Norden ES, Hou Y, Laasmaa M, Aguilar-Sanchez Y, Quick AP, Espe EKS, Sjaastad I, Wehrens XHT, Edwards AG, Soeller C, Louch WE. Prolonged ?-adrenergic stimulation disperses ryanodine receptor clusters in cardiomyocytes and has implications for heart failure. Elife. 2022 08 01; 11. PMID: 35913125; PMCID: PMC9410709.
      Citations:    
    37. Keefe JA, Navarro-Garcia JA, Ni L, Reilly S, Dobrev D, Wehrens XHT. In-depth characterization of a mouse model of postoperative atrial fibrillation. J Cardiovasc Aging. 2022; 2. PMID: 36337729; PMCID: PMC9632544.
      Citations: 2     
    38. Ho KS, Keefe JA, Wehrens XHT. Diagnosing atrial fibrillation: Can we do better than the ECG? Heart Rhythm. 2022 09; 19(9):1459-1460. PMID: 35697327; PMCID: PMC10077874.
      Citations:    Fields:    
    39. Groh WJ, Bhakta D, Tomaselli GF, Aleong RG, Teixeira RA, Amato A, Asirvatham SJ, Cha YM, Corrado D, Goldberger ZD, Horie M, Hornyak JE, Jefferies JL, Kalman JM, Kertesz NJ, Lakdawala NK, Lambiase PD, Lubitz SA, McMillan HJ, McNally EM, Milone M, Namboodiri N, Nazarian S, Patton KK, Russo V, Sacher F, Santangeli P, Shen WK, Sobral Filho DC, Stambler BS, Wehrens XHT, Weiner MM, Wheeler MT, Zeppenfeld K, Duboc D, K??b S, St?llberger C, Wahbi K. 2022 HRS expert consensus statement on evaluation and management of arrhythmic risk in neuromuscular disorders. Heart Rhythm. 2022 10; 19(10):e61-e120. PMID: 35500790.
      Citations:    Fields:    
    40. Hulsurkar MM, Lahiri SK, Karch J, Wang MC, Wehrens XHT. Targeting calcium-mediated inter-organellar crosstalk in cardiac diseases. Expert Opin Ther Targets. 2022 04; 26(4):303-317. PMID: 35426759; PMCID: PMC9081256.
      Citations:    Fields:    Translation:HumansCells
    41. Li N, Durgan DJ, Wehrens XHT. Gut microbiota: a key regulator of ageing-associated atrial fibrillation? Cardiovasc Res. 2022 02 21; 118(3):657-659. PMID: 34849621; PMCID: PMC8859633.
      Citations:    Fields:    Translation:Humans
    42. Wehrens XHT, Lehnart SE. The role of junctophilin proteins in cellular function. Physiol Rev. 2022 07 01; 102(3):1211-1261. PMID: 35001666; PMCID: PMC8934682.
      Citations: 3     Fields:    Translation:HumansCells
    43. Patel P, Mendoza A, Robichaux DJ, Wang MC, Wehrens XHT, Karch J. Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak. Front Cell Dev Biol. 2021; 9:765973. PMID: 34926454; PMCID: PMC8672142.
      Citations: 2     
    44. Wang Y, Liu H, Sun N, Li J, Peng X, Jia Y, Karch J, Yu B, Wehrens XHT, Tian J. Irisin: A Promising Target for Ischemia-Reperfusion Injury Therapy. Oxid Med Cell Longev. 2021; 2021:5391706. PMID: 34745418; PMCID: PMC8570861.
      Citations:    Fields:    Translation:HumansAnimals
    45. Lahiri SK, Hulsurkar MM, Wehrens XH. Cellular regeneration as a potential strategy to treat cardiac conduction disorders. J Clin Invest. 2021 10 01; 131(19). PMID: 34596049; PMCID: PMC8483745.
      Citations:    Fields:    Translation:Animals
    46. Hulsurkar MM, Lahiri SK, Moore O, Moreira LM, Abu-Taha I, Kamler M, Dobrev D, Nattel S, Reilly S, Wehrens XHT. Atrial-Specific LKB1 Knockdown Represents a Novel Mouse Model of Atrial Cardiomyopathy With Spontaneous Atrial Fibrillation. Circulation. 2021 09 14; 144(11):909-912. PMID: 34516304; PMCID: PMC8442761.
      Citations:    Fields:    Translation:HumansAnimals
    47. Campbell H, Aguilar-Sanchez Y, Quick AP, Dobrev D, Wehrens XHT. SPEG: a key regulator of cardiac calcium homeostasis. Cardiovasc Res. 2021 08 29; 117(10):2175-2185. PMID: 33067609; PMCID: PMC8404462.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    48. Murdock DR, Venner E, Muzny DM, Metcalf GA, Murugan M, Hadley TD, Chander V, de Vries PS, Jia X, Hussain A, Agha AM, Sabo A, Li S, Meng Q, Hu J, Tian X, Cohen M, Yi V, Kovar CL, Gingras MC, Korchina V, Howard C, Riconda DL, Pereira S, Smith HS, Huda ZA, Buentello A, Marino PR, Leiber L, Balasubramanyam A, Amos CI, Civitello AB, Chelu MG, Maag R, McGuire AL, Boerwinkle E, Wehrens XHT, Ballantyne CM, Gibbs RA. Genetic testing in ambulatory cardiology clinics reveals high rate of findings with clinical management implications. Genet Med. 2021 12; 23(12):2404-2414. PMID: 34363016; PMCID: PMC8931845.
      Citations: 3     Fields:    Translation:Humans
    49. Cheng N, Mo Q, Donelson J, Wang L, Breton G, Rodney GG, Wang J, Hirschi KD, Wehrens XHT, Nakata PA. Crucial Role of Mammalian Glutaredoxin 3 in Cardiac Energy Metabolism in Diet-induced Obese Mice Revealed by Transcriptome Analysis. Int J Biol Sci. 2021; 17(11):2871-2883. PMID: 34345213; PMCID: PMC8326124.
      Citations: 1     Fields:    Translation:AnimalsCells
    50. Word TA, Quick AP, Miyake CY, Shak MK, Pan X, Kim JJ, Allen HD, Sibrian-Vazquez M, Strongin RM, Landstrom AP, Wehrens XHT. Efficacy of RyR2 inhibitor EL20 in induced pluripotent stem cell-derived cardiomyocytes from a patient with catecholaminergic polymorphic ventricular tachycardia. J Cell Mol Med. 2021 Jun 10. PMID: 34110090; PMCID: PMC8366453.
      Citations: 3     Fields:    
    51. Chiang DY, Lahiri S, Wang G, Karch J, Wang MC, Jung SY, Heck AJR, Scholten A, Wehrens XHT. Phosphorylation-Dependent Interactome of Ryanodine Receptor Type 2 in the Heart. Proteomes. 2021 Jun 07; 9(2). PMID: 34200203; PMCID: PMC8293434.
      Citations: 2     
    52. Rao AN, Campbell HM, Guan X, Word TA, Wehrens XH, Xia Z, Cooper TA. Reversible cardiac disease features in an inducible CUG repeat RNA-expressing mouse model of myotonic dystrophy. JCI Insight. 2021 03 08; 6(5). PMID: 33497365; PMCID: PMC8021116.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    53. Lahiri SK, Aguilar-Sanchez Y, Wehrens XHT. Correction to: mechanisms underlying pathological Ca2+ handling in diseases of the heart. Pflugers Arch. 2021 Mar; 473(3):349. PMID: 33471192.
      Citations:    Fields:    
    54. Mesubi OO, Rokita AG, Abrol N, Wu Y, Chen B, Wang Q, Granger JM, Tucker-Bartley A, Luczak ED, Murphy KR, Umapathi P, Banerjee PS, Boronina TN, Cole RN, Maier LS, Wehrens XH, Pomerantz JL, Song LS, Ahima RS, Hart GW, Zachara NE, Anderson ME. Oxidized CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms. J Clin Invest. 2021 01 19; 131(2). PMID: 33151911; PMCID: PMC7810480.
      Citations: 11     Fields:    Translation:AnimalsCells
    55. Lahiri SK, Aguilar-Sanchez Y, Wehrens XHT. Mechanisms underlying pathological Ca2+ handling in diseases of the heart. Pflugers Arch. 2021 03; 473(3):331-347. PMID: 33399957; PMCID: PMC10070045.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    56. Markunas AM, Manivannan PKR, Ezekian JE, Agarwal A, Eisner W, Alsina K, Allen HD, Wray GA, Kim JJ, Wehrens XHT, Landstrom AP. TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death. Am J Med Genet A. 2021 03; 185(3):923-929. PMID: 33369127; PMCID: PMC7945047.
      Citations: 2     Fields:    Translation:HumansCells
    57. Moreira LM, Takawale A, Hulsurkar M, Menassa DA, Antanaviciute A, Lahiri SK, Mehta N, Evans N, Psarros C, Robinson P, Sparrow AJ, Gillis MA, Ashley N, Naud P, Barallobre-Barreiro J, Theofilatos K, Lee A, Norris M, Clarke MV, Russell PK, Casadei B, Bhattacharya S, Zajac JD, Davey RA, Sirois M, Mead A, Simmons A, Mayr M, Sayeed R, Krasopoulos G, Redwood C, Channon KM, Tardif JC, Wehrens XHT, Nattel S, Reilly S. Paracrine signalling by cardiac calcitonin controls atrial fibrogenesis and arrhythmia. Nature. 2020 11; 587(7834):460-465. PMID: 33149301.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    58. Wehrens XHT, Kranias EG, Cely-Ortiz A, Felice JI, D?az-Zegarra LA, Valverde CA, Federico M, Palomeque J, Aiello EA, Lascano EC, Negroni JA, Mattiazzi A. Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling. J Gen Physiol. 2020 11 02; 152(11). PMID: 32986800; PMCID: PMC7594441.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    59. Heijman J, Muna AP, Veleva T, Molina CE, Sutanto H, Tekook M, Wang Q, Abu-Taha IH, Gorka M, Kamler M, Ravens U, Li N, Wehrens XHT, Dobrev D, K?nzel S, El-Armouche A, Reichenspurner H, Nikolaev V, Nattel S. Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation. Circ Res. 2020 09 25; 127(8):1036-1055. PMID: 32762493; PMCID: PMC7604886.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    60. Campbell HM, Quick AP, Abu-Taha I, Chiang DY, Kramm CF, Word TA, Hulsurkar M, Alsina KM, Liu HB, Martin B, Uhlenkamp D, Moore OM, Lahiri SK, Corradini E, Kamler M, Heck AJR, Dobrev D, Wehrens XHT, Brandenburg S, Lehnart SE. Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation. Circulation. 2020 09 22; 142(12):1159-1172. PMID: 32683896; PMCID: PMC7508800.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    61. Marian AJ, Asatryan B, Wehrens XHT. Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies. Cardiovasc Res. 2020 07 15; 116(9):1600-1619. PMID: 32348453; PMCID: PMC7341170.
      Citations: 16     Fields:    Translation:HumansAnimals
    62. Lahiri SK, Quick AP, Samson-Couterie B, Hulsurkar M, Elzenaar I, van Oort RJ, Wehrens XHT. Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling. Basic Res Cardiol. 2020 06 26; 115(4):49. PMID: 32592107; PMCID: PMC10113426.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    63. Cheedipudi SM, Hu J, Fan S, Yuan P, Karmouch J, Czernuszewicz G, Robertson MJ, Coarfa C, Hong K, Yao Y, Campbell H, Wehrens X, Gurha P, Marian AJ. Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy. Cardiovasc Res. 2020 05 01; 116(6):1199-1213. PMID: 31350552; PMCID: PMC7177479.
      Citations: 22     Fields:    Translation:AnimalsCells
    64. Himelman E, Lillo MA, Nouet J, Gonzalez JP, Zhao Q, Xie LH, Li H, Liu T, Wehrens XH, Lampe PD, Fishman GI, Shirokova N, Contreras JE, Fraidenraich D. Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy. J Clin Invest. 2020 04 01; 130(4):1713-1727. PMID: 31910160; PMCID: PMC7108916.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    65. Coban-Akdemir ZH, Charng WL, Azamian M, Paine IS, Punetha J, Grochowski CM, Gambin T, Valdes SO, Cannon B, Zapata G, Hernandez PP, Jhangiani S, Doddapaneni H, Hu J, Boricha F, Muzny DM, Boerwinkle E, Yang Y, Gibbs RA, Posey JE, Wehrens XHT, Belmont JW, Kim JJ, Miyake CY, Lupski JR, Lalani SR. Wolff-Parkinson-White syndrome: De novo variants and evidence for mutational burden in genes associated with atrial fibrillation. Am J Med Genet A. 2020 06; 182(6):1387-1399. PMID: 32233023; PMCID: PMC7275694.
      Citations: 3     Fields:    Translation:Humans
    66. Levine AT, Born HA, Landstrom AP, Larson S, Lee WL, Dao AT, Wehrens XH, Lai YC, Anderson AE. Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. Sci Rep. 2020 03 04; 10(1):4043. PMID: 32132552; PMCID: PMC7055295.
      Citations: 1     Fields:    Translation:Animals
    67. Connell P, Word TA, Wehrens XHT. Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure. Expert Opin Ther Targets. 2020 01; 24(1):25-36. PMID: 31869254; PMCID: PMC6956596.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    68. Greer-Short A, Musa H, Alsina KM, Ni L, Word TA, Reynolds JO, Gratz D, Lane C, El-Refaey M, Unudurthi S, Skaf M, Li N, Fedorov VV, Wehrens XHT, Mohler PJ, Hund TJ. Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2020 03; 17(3):503-511. PMID: 31622781; PMCID: PMC7056561.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    69. Siebert V, Allencherril J, Ye Y, Wehrens XHT, Birnbaum Y. The Role of Non-coding RNAs in Ischemic Myocardial Reperfusion Injury. Cardiovasc Drugs Ther. 2019 08; 33(4):489-498. PMID: 31332654.
      Citations: 9     Fields:    Translation:HumansAnimals
    70. Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L. Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 07 30; 140(5):440-442. PMID: 31356139; PMCID: PMC6699770.
      Citations: 7     Fields:    Translation:AnimalsCells
    71. Jones EG, Mazaheri N, Maroofian R, Zamani M, Seifi T, Sedaghat A, Shariati G, Jamshidi Y, Allen HD, Wehrens XHT, Galehdari H, Landstrom AP. Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy. Sci Rep. 2019 06 21; 9(1):9038. PMID: 31227780; PMCID: PMC6588559.
      Citations: 10     Fields:    Translation:Humans
    72. Wehrens XH, Kohl P, Rog-Zielinska EA, Brandenburg S, Pawlowitz J, Eikenbusch B, Peper J, Kohl T, Mitronova GY, Sossalla S, Hasenfuss G, Lehnart SE. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight. 2019 06 20; 4(12). PMID: 31217359; PMCID: PMC6629097.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    73. Alsina KM, Hulsurkar M, Kownatzki-Danger D, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Wehrens XHT, Brandenburg S, Lenz C, Urlaub H, Lehnart SE. Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. Circulation. 2019 08 20; 140(8):681-693. PMID: 31185731; PMCID: PMC6699925.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    74. Donelson J, Wang Q, Monroe TO, Jiang X, Zhou J, Yu H, Mo Q, Sun Q, Marini JC, Wang X, Nakata PA, Hirschi KD, Wang J, Rodney GG, Wehrens XHT, Cheng N. Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 04; 7(8):e14071. PMID: 31033205; PMCID: PMC6487472.
      Citations: 6     Fields:    Translation:AnimalsCells
    75. Kranias EG, Wehrens XHT, Valverde CA, Mazzocchi G, Di Carlo MN, Ciocci Pardo A, Salas N, Ragone MI, Felice JI, Cely-Ortiz A, Consolini AE, Portiansky E, Mosca S, Mattiazzi A. Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovasc Res. 2019 03 01; 115(3):556-569. PMID: 30169578; PMCID: PMC6383052.
      Citations: 12     Fields:    Translation:AnimalsCells
    76. El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ. Protein Phosphatase 2A Regulates Cardiac Na+ Channels. Circ Res. 2019 03; 124(5):737-746. PMID: 30602331; PMCID: PMC6395500.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    77. Monroe TO, Hill MC, Morikawa Y, Leach JP, Heallen T, Cao S, Krijger PHL, de Laat W, Wehrens XHT, Rodney GG, Martin JF. YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In?Vivo. Dev Cell. 2019 03 25; 48(6):765-779.e7. PMID: 30773489; PMCID: PMC6435425.
      Citations: 62     Fields:    Translation:AnimalsCells
    78. Ni L, Scott L, Campbell HM, Pan X, Alsina KM, Reynolds J, Philippen LE, Hulsurkar M, Lagor WR, Li N, Wehrens XHT. Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262. PMID: 30582449; PMCID: PMC6336523.
      Citations: 18     Fields:    Translation:AnimalsCells
    79. Nie J, Duan Q, He M, Li X, Wang B, Zhou C, Wu L, Wen Z, Chen C, Wang DW, Alsina KM, Wehrens XHT, Wang DW, Ni L. Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling. J Cell Physiol. 2019 07; 234(7):11587-11601. PMID: 30488495; PMCID: PMC6515545.
      Citations: 13     Fields:    Translation:AnimalsCells
    80. Yao C, Veleva T, Scott L, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N, Schmitz W, M?ller FU. Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation. 2018 11 13; 138(20):2227-2242. PMID: 29802206; PMCID: PMC6252285.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    81. Hulsurkar M, Quick AP, Wehrens XH. STAT3: a link between CaMKII-?IV-spectrin and maladaptive remodeling? J Clin Invest. 2018 12 03; 128(12):5219-5221. PMID: 30418170; PMCID: PMC6264720.
      Citations: 2     Fields:    Translation:Cells
    82. Ni L, Wehrens XHT. Cardiac troponin I-more than a biomarker for myocardial ischemia? Ann Transl Med. 2018 Nov; 6(Suppl 1):S17. PMID: 30613592; PMCID: PMC6291546.
      Citations: 5     
    83. Chiang DY, Alsina KM, Corradini E, Fitzpatrick M, Ni L, Lahiri SK, Reynolds JO, Pan X, Scott L, Heck AJR, Wehrens XHT. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Circulation. 2018 10 09; 138(15):1569-1581. PMID: 29669786; PMCID: PMC6193872.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    84. Molina CE, Abu-Taha IH, Wang Q, Kamler M, Nattel S, Ravens U, Wehrens XHT, Hove-Madsen L, Heijman J, Dobrev D, Rosell?-D?ez E. Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Front Physiol. 2018; 9:1383. PMID: 30356673; PMCID: PMC6189336.
      Citations: 35     
    85. Pang PD, Alsina KM, Cao S, Koushik AB, Wehrens XHT, Cooper TA. CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias. J Am Heart Assoc. 2018 10 02; 7(19):e010393. PMID: 30371314; PMCID: PMC6404881.
      Citations: 9     Fields:    Translation:AnimalsCells
    86. Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHT. In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 2018 Sep 28; 123(8):953-963. PMID: 30355031; PMCID: PMC6206886.
      Citations: 20     Fields:    Translation:AnimalsCells
    87. Dobrev D, Fender AC, Wehrens XHT. Pro-arrhythmic RyR2 channels in heart failure: do their localisation and mechanism of activation really matter? Cardiovasc Res. 2018 09 01; 114(11):1428-1429. PMID: 29982290; PMCID: PMC6106099.
      Citations:    Fields:    Translation:HumansCells
    88. Wehrens XHT. Unraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure Development. JACC Basic Transl Sci. 2018 Aug; 3(4):518-520. PMID: 30175275; PMCID: PMC6115702.
      Citations: 1     
    89. Dobrev D, Wehrens XHT. Mouse Models of Cardiac Arrhythmias. Circ Res. 2018 07 20; 123(3):332-334. PMID: 30026380; PMCID: PMC6055525.
      Citations: 16     Fields:    Translation:Animals
    90. Campbell HM, Wehrens XHT. Genetics of atrial fibrillation: an update. Curr Opin Cardiol. 2018 05; 33(3):304-310. PMID: 29461262; PMCID: PMC10108376.
      Citations: 4     Fields:    Translation:Humans
    91. Wang Q, Quick AP, Cao S, Reynolds J, Chiang DY, Beavers D, Li N, Wang G, Rodney GG, Anderson ME, Wehrens XHT. Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy. Circ Arrhythm Electrophysiol. 2018 04; 11(4):e005682. PMID: 29654126; PMCID: PMC5903581.
      Citations: 18     Fields:    Translation:AnimalsCells
    92. Lai YC, Li N, Lawrence W, Wang S, Levine A, Burchhardt DM, Pautler RG, Wehrens XH, Anderson AE, Valderr?bano M. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. Epilepsia Open. 2018 Jun; 3(2):213-223. PMID: 29881800; PMCID: PMC5983128.
      Citations: 3     Fields:    
    93. Klipp RC, Li N, Wang Q, Word TA, Sibrian-Vazquez M, Strongin RM, Wehrens XHT, Abramson JJ. EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. Heart Rhythm. 2018 04; 15(4):578-586. PMID: 29248564; PMCID: PMC5879004.
      Citations: 11     Fields:    Translation:AnimalsCells
    94. Kitagawa MG, Reynolds JO, Wehrens XHT, Bryan RM, Pandit LM. Hemodynamic and Pathologic Characterization of the TASK-1-/- Mouse Does Not Demonstrate Pulmonary Hypertension. Front Med (Lausanne). 2017; 4:177. PMID: 29109948; PMCID: PMC5660113.
      Citations: 11     
    95. Wehrens XHT, Lezcano N, Mari?ngelo JIE, Vittone L, Said M, Mundi?a-Weilenmann C. Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes. J Mol Cell Cardiol. 2018 01; 114:1-9. PMID: 29037982; PMCID: PMC5801154.
      Citations: 2     Fields:    Translation:AnimalsCells
    96. Karmouch J, Zhou QQ, Miyake CY, Lombardi R, Kretzschmar K, Bannier-H?laou?t M, Clevers H, Wehrens XHT, Willerson JT, Marian AJ. Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes. Circ Res. 2017 Dec 08; 121(12):1346-1359. PMID: 29018034; PMCID: PMC5722680.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    97. Liu R, Lee J, Kim BS, Wang Q, Buxton SK, Balasubramanyam N, Kim JJ, Dong J, Zhang A, Li S, Gupte AA, Hamilton DJ, Martin JF, Rodney GG, Coarfa C, Wehrens XH, Yechoor VK, Moulik M. Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017 09 07; 2(17). PMID: 28878117; PMCID: PMC5621883.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    98. Miyake CY, Asaki SY, Webster G, Czosek RJ, Atallah J, Avasarala K, Rao SO, Thomas PE, Kim JJ, Valdes SO, de la Uz C, Wang Y, Wehrens XHT, Abrams D. Circadian Variation of Ventricular Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia. JACC Clin Electrophysiol. 2017 11; 3(11):1308-1317. PMID: 29759629; PMCID: PMC7269550.
      Citations: 4     Fields:    Translation:Humans
    99. Landstrom AP, Dobrev D, Wehrens XHT. Calcium Signaling and Cardiac Arrhythmias. Circ Res. 2017 Jun 09; 120(12):1969-1993. PMID: 28596175; PMCID: PMC5607780.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    100. Dobrev D, Wehrens XHT. Calcium-mediated cellular triggered activity in atrial fibrillation. J Physiol. 2017 06 15; 595(12):4001-4008. PMID: 28181690; PMCID: PMC5471363.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    101. Alvarado FJ, Dedman J, Kaetzel M, Wehrens XHT, Federico M, Portiansky EL, Sommese L, Blanco PG, Zanuzzi CN, Mattiazzi A, Palomeque J. Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance. J Physiol. 2017 06 15; 595(12):4089-4108. PMID: 28105734; PMCID: PMC5471423.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    102. Quick AP, Landstrom AP, Wang Q, Beavers DL, Reynolds JO, Barreto-Torres G, Tran V, Showell J, Philippen LE, Morris SA, Skapura D, Bos JM, Pedersen SE, Pautler RG, Ackerman MJ, Wehrens XH. Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction. JACC Basic Transl Sci. 2017 Feb; 2(1):56-67. PMID: 28393127; PMCID: PMC5384575.
      Citations: 16     
    103. Heijman J, Ghezelbash S, Wehrens XH, Dobrev D. Serine/Threonine Phosphatases in Atrial Fibrillation. J Mol Cell Cardiol. 2017 02; 103:110-120. PMID: 28077320; PMCID: PMC5346472.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    104. Hinton AO, Yang Y, Quick AP, Xu P, Reddy CL, Yan X, Reynolds CL, Tong Q, Zhu L, Xu J, Wehrens XH, Xu Y, Reddy AK. SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. PLoS One. 2016; 11(12):e0168644. PMID: 28006821; PMCID: PMC5179266.
      Citations: 3     Fields:    Translation:Animals
    105. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149. PMID: 27894063; PMCID: PMC5374299.
      Citations: 4     Fields:    Translation:AnimalsCells
    106. Ward CS, Wehrens XH, Neul JL, Herrera JA. Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis. Hum Mol Genet. 2016 11 15; 25(22):4983-4995. PMID: 28159985; PMCID: PMC6078594.
      Citations: 5     Fields:    Translation:AnimalsCells
    107. Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. J Physiol. 2016 11 01; 594(21):6433-6435. PMID: 27800622; PMCID: PMC5088243.
      Citations: 1     Fields:    
    108. Li N, Wang Q, Sibrian-Vazquez M, Klipp RC, Reynolds JO, Word TA, Scott L, Salama G, Strongin RM, Abramson JJ, Wehrens XHT. Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs. Int J Cardiol. 2017 Jan 15; 227:668-673. PMID: 27838126; PMCID: PMC5164850.
      Citations: 18     Fields:    Translation:Animals
    109. Munro ML, Wang Q, Quick A, Wang W, Baddeley D, Wehrens XH, Soeller C, Jayasinghe I. Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. J Cell Sci. 2016 12 01; 129(23):4388-4398. PMID: 27802169; PMCID: PMC5201013.
      Citations: 33     Fields:    Translation:AnimalsCells
    110. Quick AP, Wang Q, Philippen LE, Barreto-Torres G, Chiang DY, Beavers D, Wang G, Khalid M, Reynolds JO, Campbell HM, Showell J, McCauley MD, Scholten A, Wehrens XH. SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circ Res. 2017 Jan 06; 120(1):110-119. PMID: 27729468; PMCID: PMC5218854.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    111. Reynolds JO, Quick AP, Wang Q, Beavers DL, Philippen LE, Showell J, Barreto-Torres G, Thuerauf DJ, Doroudgar S, Glembotski CC, Wehrens XH. Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release. Int J Cardiol. 2016 Dec 15; 225:371-380. PMID: 27760414; PMCID: PMC5101129.
      Citations: 39     Fields:    Translation:AnimalsCells
    112. Wang Q, Wehrens XH. Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy. Ann Transl Med. 2016 Oct; 4(Suppl 1):S23. PMID: 27867991; PMCID: PMC5104620.
      Citations: 1     
    113. Chiang DY, Heck AJ, Dobrev D, Wehrens XH. Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome. J Mol Cell Cardiol. 2016 Dec; 101:165-172. PMID: 27663175; PMCID: PMC5154861.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    114. Aiba I, Wehrens XH, Noebels JL. Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903. PMID: 27482086; PMCID: PMC4995941.
      Citations: 26     Fields:    Translation:AnimalsCells
    115. Becerra R, Di Carlo MN, Mariangelo JI, Salas M, Vittone L, Wehrens XH, Said M, Rom?n B, Sanchez G, Donoso P, Schinella GR, Mundi?a-Weilenmann C. Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart. Am J Physiol Heart Circ Physiol. 2016 09 01; 311(3):H713-24. PMID: 27422983; PMCID: PMC5142185.
      Citations: 12     Fields:    Translation:AnimalsCells
    116. Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72. PMID: 27318036; PMCID: PMC5026590.
      Citations: 34     Fields:    Translation:AnimalsCells
    117. Bal NC, Maurya SK, Singh S, Wehrens XH, Periasamy M. Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function. J Biol Chem. 2016 08 12; 291(33):17247-57. PMID: 27298322; PMCID: PMC5016124.
      Citations: 30     Fields:    Translation:AnimalsCells
    118. Nutter CA, Jaworski EA, Verma SK, Deshmukh V, Wang Q, Botvinnik OB, Lozano MJ, Abass IJ, Ijaz T, Brasier AR, Garg NJ, Wehrens XHT, Yeo GW, Kuyumcu-Martinez MN. Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. Cell Rep. 2016 06 07; 15(10):2200-2213. PMID: 27239029; PMCID: PMC4899142.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    119. Skapura D, McCauley MD, Kranias EG, Wehrens XH, Mazzocchi G, Sommese L, Palomeque J, Felice JI, Di Carlo MN, Fainstein D, Gonzalez P, Contreras P, Lascano EC, Negroni JA, Valverde CA, Mattiazzi A. Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814. J Physiol. 2016 06 01; 594(11):3005-30. PMID: 26695843; PMCID: PMC4887664.
      Citations: 14     Fields:    Translation:AnimalsCells
    120. Wu Y, Wehrens XH, Anderson ME, Valdivia HH. A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003180. PMID: 26857906; PMCID: PMC4755317.
      Citations: 7     Fields:    Translation:AnimalsCells
    121. Li N, Wehrens XH, Schulte JS, Fehrmann E, Tekook MA, Kranick D, Fels B, Heinick A, Seidl MD, Schmitz W, M?ller FU. Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. Basic Res Cardiol. 2016 Mar; 111(2):15. PMID: 26818679; PMCID: PMC4729809.
      Citations: 7     Fields:    Translation:AnimalsCells
    122. Li N, Dobrev D, Wehrens XH. PITX2: a master regulator of cardiac channelopathy in atrial fibrillation? Cardiovasc Res. 2016 Mar 01; 109(3):345-7. PMID: 26782118; PMCID: PMC4752046.
      Citations: 5     Fields:    Translation:Humans
    123. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93. PMID: 26515697; PMCID: PMC4784170.
      Citations: 20     Fields:    Translation:Animals
    124. Heijman J, Voigt N, Wehrens XH, Dobrev D, Algalarrondo V, Melka J, Nattel S. The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovasc Res. 2016 Apr 01; 109(4):467-79. PMID: 26705366; PMCID: PMC4777910.
      Citations: 71     Fields:    Translation:HumansAnimals
    125. Quick AP, Landstrom AP, Wehrens XH. Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling. Heart Rhythm. 2016 Mar; 13(3):753-4. PMID: 26598319; PMCID: PMC5168722.
      Citations: 5     Fields:    Translation:Humans
    126. Wang Q, Wang W, Wang G, Rodney GG, Wehrens XH. Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):177-84. PMID: 26555638; PMCID: PMC4689641.
      Citations: 20     Fields:    Translation:AnimalsCells
    127. Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Wehrens XH, Hund TJ, Mohler PJ, Gy?rke S. Protein phosphatase 2A regulatory subunit B56a limits phosphatase activity in the heart. Sci Signal. 2015 Jul 21; 8(386):ra72. PMID: 26198358; PMCID: PMC4680974.
      Citations: 28     Fields:    Translation:AnimalsCells
    128. Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH. Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505. PMID: 26162324; PMCID: PMC5109931.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    129. Landstrom AP, Sun JJ, Ray RS, Wehrens XH. It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov; 12(11):2294-5. PMID: 26164374; PMCID: PMC5103306.
      Citations: 2     Fields:    Translation:Animals
    130. Doroudgar S, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Wehrens XH, Sussman MA, Glembotski CC, V?lkers M, M?ller OJ. Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes. Circ Res. 2015 Aug 28; 117(6):536-46. PMID: 26137860; PMCID: PMC4670262.
      Citations: 51     Fields:    Translation:AnimalsCells
    131. Chiang DY, Kim JJ, Valdes SO, de la Uz C, Fan Y, Orcutt J, Domino M, Smith M, Wehrens XH, Miyake CY. Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture. Circ Arrhythm Electrophysiol. 2015 Oct; 8(5):1105-12. PMID: 26111534; PMCID: PMC5119522.
      Citations: 5     Fields:    Translation:Humans
    132. Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C. PHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71. PMID: 26075818; PMCID: PMC4563684.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    133. Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH. CaMKIId mediates ?-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ?-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91. PMID: 26080362; PMCID: PMC4530053.
      Citations: 34     Fields:    Translation:AnimalsCells
    134. Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME. Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jun 03; 6:7241. PMID: 26037243; PMCID: PMC5132347.
      Citations:    Fields:    
    135. Xi Y, James Chao ZY, Yan W, Abbasi S, Yin X, Mathuria N, Patel M, Fan C, Sun J, Wu G, Wang S, Elayda M, Gao L, Wehrens XH, Lin SF, Cheng J. Neuronally released vasoactive intestinal polypeptide alters atrial electrophysiological properties and may promote atrial fibrillation. Heart Rhythm. 2015 Jun; 12(6):1352-61. PMID: 25748673; PMCID: PMC4684179.
      Citations: 3     Fields:    Translation:Animals
    136. Ward CS, Pitcher MR, Percy AK, Skinner S, Kaufmann WE, Glaze DG, Wehrens XH, Neul JL, Herrera JA. Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. Dis Model Mech. 2015 Apr; 8(4):363-71. PMID: 25713300; PMCID: PMC4381335.
      Citations: 8     Fields:    Translation:Animals
    137. Chiang DY, Zhang M, Voigt N, Alsina KM, Jakob H, Martin JF, Dobrev D, Wehrens XHT, Li N. Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. Int J Cardiol. 2015 Apr 01; 184:190-197. PMID: 25706326; PMCID: PMC4417399.
      Citations: 22     Fields:    Translation:Humans
    138. Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME. The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jan 20; 6:6081. PMID: 25603276; PMCID: PMC4398998.
      Citations: 84     Fields:    Translation:AnimalsCells
    139. Chiang DY, Lebesgue N, Beavers DL, Alsina KM, Damen JM, Voigt N, Dobrev D, Wehrens XH, Scholten A. Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients. J Am Coll Cardiol. 2015 Jan 20; 65(2):163-73. PMID: 25593058; PMCID: PMC4690213.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    140. Aschar-Sobbi R, Izaddoustdar F, Korogyi AS, Wang Q, Farman GP, Yang F, Yang W, Dorian D, Simpson JA, Tuomi JM, Jones DL, Nanthakumar K, Cox B, Wehrens XH, Dorian P, Backx PH. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFa. Nat Commun. 2015 Jan 19; 6:6018. PMID: 25598495; PMCID: PMC4661059.
      Citations: 47     Fields:    Translation:Animals
    141. Shirokova N, Kang C, Fernandez-Tenorio M, Wang W, Wang Q, Wehrens XHT, Niggli E. Oxidative stress and ca(2+) release events in mouse cardiomyocytes. Biophys J. 2014 Dec 16; 107(12):2815-2827. PMID: 25517148; PMCID: PMC4269787.
      Citations: 5     Fields:    Translation:AnimalsCells
    142. Van Wagoner DR, Piccini JP, Albert CM, Anderson ME, Benjamin EJ, Brundel B, Califf RM, Calkins H, Chen PS, Chiamvimonvat N, Darbar D, Eckhardt LL, Ellinor PT, Exner DV, Fogel RI, Gillis AM, Healey J, Hohnloser SH, Kamel H, Lathrop DA, Lip GY, Mehra R, Narayan SM, Olgin J, Packer D, Peters NS, Roden DM, Ross HM, Sheldon R, Wehrens XH. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013. Heart Rhythm. 2015 Jan; 12(1):e5-e29. PMID: 25460864; PMCID: PMC4425127.
      Citations: 39     Fields:    Translation:Humans
    143. Chiang DY, Kongchan N, Beavers DL, Alsina KM, Voigt N, Neilson JR, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1214-22. PMID: 25389315; PMCID: PMC4270890.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    144. Yang X, Wang T, Lin X, Yue X, Wang Q, Wang G, Fu Q, Ai X, Chiang DY, Miyake CY, Wehrens XHT, Chang J. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res. 2015 Jan 02; 116(1):e1-e10. PMID: 25348166; PMCID: PMC4282622.
      Citations: 18     Fields:    Translation:AnimalsCells
    145. Nabben M, van Bree BWJ, Lenaers E, Hoeks J, Hesselink MKC, Schaart G, Gijbels MJJ, Glatz JFC, da Silva GJJ, de Windt LJ, Tian R, Mike E, Skapura DG, Wehrens XHT, Schrauwen P. Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death. Basic Res Cardiol. 2014; 109(6):447. PMID: 25344084; PMCID: PMC4329241.
      Citations: 7     Fields:    Translation:AnimalsCells
    146. Pandit LM, Lloyd EE, Reynolds JO, Lawrence WS, Reynolds C, Wehrens XH, Bryan RM. TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process. Hypertension. 2014 Dec; 64(6):1260-5. PMID: 25245387; PMCID: PMC4231005.
      Citations: 16     Fields:    Translation:Animals
    147. Respress JL, Gershovich PM, Wang T, Reynolds JO, Skapura DG, Sutton JP, Miyake CY, Wehrens XH. Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice. Int J Cardiol. 2014 Oct 20; 176(3):994-1000. PMID: 25227892; PMCID: PMC4195800.
      Citations: 9     Fields:    Translation:AnimalsCells
    148. Wang W, Landstrom AP, Wang Q, Munro ML, Beavers D, Ackerman MJ, Soeller C, Wehrens XH. Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. Am J Physiol Heart Circ Physiol. 2014 Nov 01; 307(9):H1317-26. PMID: 25193470; PMCID: PMC4217007.
      Citations: 16     Fields:    Translation:AnimalsCells
    149. Ling H, Skapura DG, Respress JL, Brown JH, Wehrens XH, Di Carlo MN, Said M, Valverde CA, De Giusti VC, Sommese L, Palomeque J, Aiello EA, Rinaldi G, Salas MA, Mattiazzi A. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83. PMID: 24949568; PMCID: PMC4131282.
      Citations: 34     Fields:    Translation:AnimalsCells
    150. Beavers DL, Landstrom AP, Chiang DY, Wehrens XH. Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases. Cardiovasc Res. 2014 Jul 15; 103(2):198-205. PMID: 24935431; PMCID: PMC4809974.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    151. Wang J, Bai Y, Li N, Ye W, Zhang M, Greene SB, Tao Y, Chen Y, Wehrens XH, Martin JF. Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9181-6. PMID: 24927531; PMCID: PMC4078868.
      Citations: 53     Fields:    Translation:HumansAnimals
    152. Chiang DY, Li N, Wang Q, Alsina KM, Quick AP, Reynolds JO, Wang G, Skapura D, Voigt N, Dobrev D, Wehrens XH. Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation. Cardiovasc Res. 2014 Jul 01; 103(1):178-87. PMID: 24812280; PMCID: PMC4133595.
      Citations: 33     Fields:    Translation:AnimalsCells
    153. Giudice J, Xia Z, Wang ET, Scavuzzo MA, Ward AJ, Kalsotra A, Wang W, Wehrens XH, Burge CB, Li W, Cooper TA. Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nat Commun. 2014 Apr 22; 5:3603. PMID: 24752171; PMCID: PMC4018662.
      Citations: 76     Fields:    Translation:AnimalsCells
    154. Dobrev D, Wehrens XH. Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res. 2014 Apr 11; 114(8):1311-9; discussion 1319. PMID: 24723656; PMCID: PMC4008932.
      Citations: 78     Fields:    Translation:HumansAnimals
    155. Landstrom AP, Beavers DL, Wehrens XH. The junctophilin family of proteins: from bench to bedside. Trends Mol Med. 2014 Jun; 20(6):353-62. PMID: 24636942; PMCID: PMC4041816.
      Citations: 30     Fields:    Translation:HumansCells
    156. Heijman J, Voigt N, Wehrens XH, Dobrev D. Calcium dysregulation in atrial fibrillation: the role of CaMKII. Front Pharmacol. 2014; 5:30. PMID: 24624086; PMCID: PMC3940963.
      Citations: 26     
    157. Zhang C, Chen B, Guo A, Zhu Y, Miller JD, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS. Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation. 2014 Apr 29; 129(17):1742-50. PMID: 24519927; PMCID: PMC4006305.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    158. Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Valderrabano M, Dobrev D, Wehrens XHT, Schmitz W, M?ller FU, Nattel S. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285. PMID: 24398018; PMCID: PMC4026172.
      Citations: 83     Fields:    Translation:AnimalsCells
    159. Voigt N, Heijman J, Wang Q, Chiang DY, Li N, Karck M, Wehrens XHT, Dobrev D, Nattel S. Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation. 2014 Jan 14; 129(2):145-156. PMID: 24249718; PMCID: PMC4342412.
      Citations: 174     Fields:    Translation:HumansCells
    160. Ho HT, Liu B, Snyder JS, Lou Q, Brundage EA, Velez-Cortes F, Wang H, Ziolo MT, Anderson ME, Sen CK, Wehrens XH, Fedorov VV, Biesiadecki BJ, Hund TJ, Gy?rke S. Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res. 2014 Jan 01; 101(1):165-74. PMID: 24104877; PMCID: PMC3868350.
      Citations: 26     Fields:    Translation:AnimalsCells
    161. Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One. 2013; 8(9):e75882. PMID: 24086656; PMCID: PMC3785418.
      Citations: 31     Fields:    Translation:AnimalsCells
    162. Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME. Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013 Oct 15; 128(16):1748-57. PMID: 24030498; PMCID: PMC3876034.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    163. Beavers DL, Wang W, Ather S, Voigt N, Garbino A, Dixit SS, Landstrom AP, Li N, Wang Q, Olivotto I, Dobrev D, Ackerman MJ, Wehrens XHT. Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization. J Am Coll Cardiol. 2013 Nov 19; 62(21):2010-9. PMID: 23973696; PMCID: PMC3830688.
      Citations: 86     Fields:    Translation:AnimalsCells
    164. Chen B, Guo A, Zhang C, Chen R, Zhu Y, Hong J, Kutschke W, Zimmerman K, Weiss RM, Zingman L, Anderson ME, Wehrens XH, Song LS. Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovasc Res. 2013 Oct 01; 100(1):54-62. PMID: 23860812; PMCID: PMC3778961.
      Citations: 54     Fields:    Translation:AnimalsCells
    165. Ather S, Respress JL, Li N, Wehrens XH. Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta. 2013 Dec; 1832(12):2425-31. PMID: 23770282; PMCID: PMC3800473.
      Citations: 25     Fields:    Translation:HumansAnimals
    166. Wu SP, Cheng CM, Lanz RB, Wang T, Respress JL, Ather S, Chen W, Tsai SJ, Wehrens XH, Tsai MJ, Tsai SY. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013 May 28; 25(4):417-26. PMID: 23725765; PMCID: PMC3687546.
      Citations: 57     Fields:    Translation:AnimalsCells
    167. Reynolds JO, Chiang DY, Wang W, Beavers DL, Dixit SS, Skapura DG, Landstrom AP, Song LS, Ackerman MJ, Wehrens XH. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013 Oct 01; 100(1):44-53. PMID: 23715556; PMCID: PMC3778955.
      Citations: 62     Fields:    Translation:AnimalsCells
    168. Wehrens XH, Chiang DY, Li N. Chronic exercise: a contributing factor to atrial fibrillation? J Am Coll Cardiol. 2013 Jul 02; 62(1):78-80. PMID: 23583764; PMCID: PMC3702168.
      Citations: 1     Fields:    Translation:Animals
    169. Dixit SS, Wang T, Manzano EJ, Yoo S, Lee J, Chiang DY, Ryan N, Respress JL, Yechoor VK, Wehrens XH. Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS One. 2013; 8(3):e58655. PMID: 23516528; PMCID: PMC3596297.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    170. Heijman J, Wehrens XH, Dobrev D. Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia--is there a mechanistic link between sarcoplasmic reticulum Ca(2+) leak and re-entry? Acta Physiol (Oxf). 2013 Feb; 207(2):208-11. PMID: 23157571; PMCID: PMC4327838.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    171. Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM, Pereira L. Epac2 mediates cardiac ?1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22. PMID: 23363625; PMCID: PMC3690126.
      Citations: 76     Fields:    Translation:AnimalsCells
    172. Ather S, Wang W, Wang Q, Li N, Anderson ME, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm. 2013 Apr; 10(4):592-9. PMID: 23246599; PMCID: PMC3605194.
      Citations: 30     Fields:    Translation:AnimalsCells
    173. Li N, Wehrens XH. Extinguishing intracellular calcium leak: a promising antiarrhythmic approach. Heart Rhythm. 2013 Jan; 10(1):108-9. PMID: 23085093; PMCID: PMC4327983.
      Citations: 1     Fields:    Translation:Animals
    174. DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJ. CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm. 2012 Dec; 9(12):2034-41. PMID: 23059182; PMCID: PMC3630478.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    175. Wu Y, Luczak ED, Lee EJ, Hidalgo C, Yang J, Gao Z, Li J, Wehrens XH, Granzier H, Anderson ME. CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol. 2012 Sep; 53(3):429-36. PMID: 22796260; PMCID: PMC3936404.
      Citations: 10     Fields:    Translation:AnimalsCells
    176. Liu D, Huang L, Wang Y, Wang W, Wehrens XH, Belousova T, Abdelrahim M, DiMattia G, Sheikh-Hamad D. Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway. PLoS One. 2012; 7(5):e36994. PMID: 22693564; PMCID: PMC3365029.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    177. Ather S, Bavishi C, McCauley MD, Dhaliwal A, Deswal A, Johnson S, Chan W, Aguilar D, Pritchett AM, Ramasubbu K, Wehrens XH, Bozkurt B. Worsening renal function is not associated with response to treatment in acute heart failure. Int J Cardiol. 2013 Sep 01; 167(5):1912-7. PMID: 22633437; PMCID: PMC4682884.
      Citations: 8     Fields:    Translation:Humans
    178. Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 05; 125(22):2751-61. PMID: 22570371; PMCID: PMC3503489.
      Citations: 80     Fields:    Translation:AnimalsCells
    179. Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A, Voigt N, Lawrence WS, Skapura DG, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XH, Sk?rdal K, Wisl?ff U. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83. PMID: 22511749; PMCID: PMC3371642.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    180. Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 01; 125(17):2059-70. PMID: 22456474; PMCID: PMC4663993.
      Citations: 243     Fields:    Translation:HumansAnimalsCells
    181. Ather S, Chan W, Bozkurt B, Aguilar D, Ramasubbu K, Zachariah AA, Wehrens XH, Deswal A. Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction. J Am Coll Cardiol. 2012 Mar 13; 59(11):998-1005. PMID: 22402071; PMCID: PMC4687406.
      Citations: 224     Fields:    Translation:Humans
    182. Baddeley D, Kong CH, Wehrens XH, Cannell MB, Soeller C, Jayasinghe I. Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes. Biophys J. 2012 03 07; 102(5):L19-21. PMID: 22404946; PMCID: PMC3296050.
      Citations: 26     Fields:    Translation:AnimalsCells
    183. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK, Ripperger JA. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Feb 22; 483(7387):96-9. PMID: 22367544; PMCID: PMC3297978.
      Citations: 159     Fields:    Translation:AnimalsCells
    184. McCauley MD, Wang T, Mike E, Herrera J, Beavers DL, Huang TW, Ward CS, Skinner S, Percy AK, Glaze DG, Wehrens XH, Neul JL. Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci Transl Med. 2011 Dec 14; 3(113):113ra125. PMID: 22174313; PMCID: PMC3633081.
      Citations: 40     Fields:    Translation:HumansAnimals
    185. Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 03; 110(3):465-70. PMID: 22158709; PMCID: PMC3272138.
      Citations: 65     Fields:    Translation:AnimalsCells
    186. Wang T, Wehrens XH. Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform. Heart Rhythm. 2012 Apr; 9(4):598-9. PMID: 22138134; PMCID: PMC4324321.
      Citations: 3     Fields:    Translation:Humans
    187. Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Kirchhof P, Hatem S, M?ller FU. Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol. 2013 Jun 20; 166(2):366-74. PMID: 22093963; PMCID: PMC7647839.
      Citations: 27     Fields:    Translation:Animals
    188. Cunha SR, Hund TJ, Hashemi S, Voigt N, Li N, Wright P, Koval O, Li J, Gudmundsson H, Gumina RJ, Karck M, Schott JJ, Probst V, Le Marec H, Anderson ME, Dobrev D, Wehrens XH, Mohler PJ. Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 2011 Sep 13; 124(11):1212-22. PMID: 21859974; PMCID: PMC3211046.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    189. Becerra R, Valverde CA, Kaetzel MA, Dedman JR, Wehrens XH, Vittone L, Mattiazzi A, Said M, Mundi?a-Weilenmann C. Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias. J Mol Cell Cardiol. 2011 Dec; 51(6):936-44. PMID: 21888910; PMCID: PMC3208750.
      Citations: 43     Fields:    Translation:AnimalsCells
    190. McCauley MD, Wehrens XH. Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin. 2011 Jun; 32(6):749-57. PMID: 21642946; PMCID: PMC4009959.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    191. Ather S, Chan W, Chillar A, Aguilar D, Pritchett AM, Ramasubbu K, Wehrens XH, Deswal A, Bozkurt B. Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship. Am Heart J. 2011 Mar; 161(3):567-73. PMID: 21392613; PMCID: PMC3073655.
      Citations: 19     Fields:    Translation:Humans
    192. van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 2011 Mar 08; 123(9):979-88. PMID: 21339484; PMCID: PMC3056402.
      Citations: 144     Fields:    Translation:AnimalsCells
    193. McCauley MD, Wehrens XH. Ryanodine receptor phosphorylation, calcium/calmodulin-dependent protein kinase II, and life-threatening ventricular arrhythmias. Trends Cardiovasc Med. 2011 Feb; 21(2):48-51. PMID: 22578240; PMCID: PMC3356691.
      Citations: 12     Fields:    Translation:HumansCells
    194. Landstrom AP, Kellen CA, Dixit SS, van Oort RJ, Garbino A, Weisleder N, Ma J, Wehrens XH, Ackerman MJ. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011 Mar; 4(2):214-23. PMID: 21216834; PMCID: PMC3059380.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    195. van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21; 122(25):2669-79. PMID: 21098440; PMCID: PMC3075419.
      Citations: 144     Fields:    Translation:AnimalsCells
    196. Dobrev D, Voigt N, Wehrens XH. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2011 Mar 01; 89(4):734-43. PMID: 20943673; PMCID: PMC3039246.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    197. Wehrens XH. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm. 2011 Feb; 8(2):323-5. PMID: 20887810; PMCID: PMC3020993.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    198. Garbino A, Wehrens XH. Emerging role of junctophilin-2 as a regulator of calcium handling in the heart. Acta Pharmacol Sin. 2010 Sep; 31(9):1019-21. PMID: 20694023; PMCID: PMC3659429.
      Citations: 17     Fields:    Translation:HumansAnimals
    199. Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XH. Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13165-70. PMID: 20615971; PMCID: PMC2919918.
      Citations: 35     Fields:    Translation:AnimalsCells
    200. Respress JL, Wehrens XH. Transthoracic echocardiography in mice. J Vis Exp. 2010 May 28; (39). PMID: 20517201; PMCID: PMC3144600.
      Citations: 34     Fields:    Translation:Animals
    201. McCauley MD, Wehrens XH. Ambulatory ECG recording in mice. J Vis Exp. 2010 May 27; (39). PMID: 20517202; PMCID: PMC3152865.
      Citations: 10     Fields:    Translation:Animals
    202. Li N, Wehrens XH. Programmed electrical stimulation in mice. J Vis Exp. 2010 May 26; (39). PMID: 20512106; PMCID: PMC3152855.
      Citations: 23     Fields:    Translation:Animals
    203. Ather S, Peterson LE, Divakaran VG, Deswal A, Ramasubbu K, Giorgberidze I, Blaustein A, Wehrens XH, Mann DL, Bozkurt B. Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data. Int J Cardiol. 2011 Aug 04; 150(3):264-9. PMID: 20471706; PMCID: PMC2923690.
      Citations: 6     Fields:    Translation:Humans
    204. Wang J, Klysik E, Sood S, Johnson RL, Wehrens XH, Martin JF. Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9753-8. PMID: 20457925; PMCID: PMC2906838.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    205. deAlmeida AC, van Oort RJ, Wehrens XH. Transverse aortic constriction in mice. J Vis Exp. 2010 Apr 21; (38). PMID: 20410870; PMCID: PMC3164086.
      Citations: 106     Fields:    Translation:HumansAnimals
    206. van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG, De Windt LJ, Wehrens XH. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010 Apr; 55(4):932-8. PMID: 20157052; PMCID: PMC2843393.
      Citations: 31     Fields:    Translation:AnimalsCells
    207. Wang W, Wehrens XH. Stress synchronizes calcium release and promotes SR calcium leak. J Physiol. 2010 Feb 01; 588(Pt 3):391-2. PMID: 20123791; PMCID: PMC2825603.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    208. Koshelev M, Sarma S, Price RE, Wehrens XH, Cooper TA. Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet. 2010 Mar 15; 19(6):1066-75. PMID: 20051426; PMCID: PMC2830830.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    209. Dobrev D, Wehrens XH. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan; 20(1):30-4. PMID: 20685575; PMCID: PMC2917388.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    210. Mathur N, Sood S, Wang S, van Oort RJ, Sarma S, Li N, Skapura DG, Bayle JH, Wehrens XH, Valderr?bano M. Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):677-85. PMID: 20009080; PMCID: PMC2796595.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    211. Wang GS, Kuyumcu-Martinez MN, Sarma S, Mathur N, Wehrens XH, Cooper TA. PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. J Clin Invest. 2009 Dec; 119(12):3797-806. PMID: 19907076; PMCID: PMC2786786.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    212. McCauley MD, Wehrens XH. Animal models of arrhythmogenic cardiomyopathy. Dis Model Mech. 2009 Nov-Dec; 2(11-12):563-70. PMID: 19892887; PMCID: PMC2776113.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    213. Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Schmitz W, Schotten U, Anderson ME, Dobrev D, Wehrens XH, M?ller FU, Valderr?bano M. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51. PMID: 19603549; PMCID: PMC2701862.
      Citations: 213     Fields:    Translation:HumansAnimalsCells
    214. Garbino A, van Oort RJ, Dixit SS, Landstrom AP, Ackerman MJ, Wehrens XH. Molecular evolution of the junctophilin gene family. Physiol Genomics. 2009 May 13; 37(3):175-86. PMID: 19318539; PMCID: PMC2685503.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    215. Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5972-7. PMID: 19276108; PMCID: PMC2667018.
      Citations: 85     Fields:    Translation:AnimalsCells
    216. Shao CH, Wehrens XH, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, Bidasee KR. Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (1985). 2009 Apr; 106(4):1280-92. PMID: 19131475; PMCID: PMC2698642.
      Citations: 41     Fields:    Translation:AnimalsCells
    217. Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansmann I, Ai T, Sood S, Wehrens XH, Martin JF, Belmont JW, Potocki L. 20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. J Med Genet. 2009 Mar; 46(3):168-75. PMID: 18812404; PMCID: PMC2680125.
      Citations: 18     Fields:    Translation:HumansAnimals
    218. van Oort RJ, Altamirano J, Lederer WJ, Wehrens XH. Alternative splicing: a key mechanism for ankyrin-B functional diversity? J Mol Cell Cardiol. 2008 Dec; 45(6):709-11. PMID: 18838078; PMCID: PMC2606664.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    219. Bourajjaj M, Armand AS, da Costa Martins PA, Weijts B, van der Nagel R, Heeneman S, Wehrens XH, De Windt LJ. NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem. 2008 Aug 08; 283(32):22295-303. PMID: 18477567.
      Citations: 59     Fields:    Translation:Animals
    220. Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008 Jul; 5(7):1047-54. PMID: 18598963; PMCID: PMC2525570.
      Citations: 69     Fields:    Translation:AnimalsCells
    221. Chelu MG, Wehrens XH. Sarcoplasmic reticulum calcium leak and cardiac arrhythmias. Biochem Soc Trans. 2007 Nov; 35(Pt 5):952-6. PMID: 17956253.
      Citations: 25     Fields:    Translation:HumansCells
    222. Mohler PJ, Wehrens XH. Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda). 2007 Oct; 22:342-50. PMID: 17928548.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    223. Wehrens XH. Istaroxime, a novel luso-inotropic agent for the treatment of acute heart failure. Curr Opin Investig Drugs. 2007 Sep; 8(9):769-77. PMID: 17729189.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    224. Clancy CE, Wehrens XH. Mutation-specific effects of lidocaine in Brugada syndrome. Int J Cardiol. 2007 Oct 18; 121(3):249-52. PMID: 17761312.
      Citations:    Fields:    Translation:Humans
    225. Chen-Izu Y, Ward CW, Stark W, Banyasz T, Sumandea MP, Balke CW, Izu LT, Wehrens XH. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2409-17. PMID: 17630346.
      Citations: 29     Fields:    Translation:AnimalsCells
    226. Santonastasi M, Wehrens XH. Ryanodine receptors as pharmacological targets for heart disease. Acta Pharmacol Sin. 2007 Jul; 28(7):937-44. PMID: 17588328.
      Citations: 11     Fields:    Translation:HumansCells
    227. Wehrens XH. Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias. Eur Heart J. 2007 May; 28(9):1054-6. PMID: 17459904.
      Citations: 1     Fields:    Translation:Humans
    228. van Oort RJ, Wehrens XH. Subcellular targeting of phosphatases: a novel function of ankyrins. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H15-6. PMID: 17449551.
      Citations: 1     Fields:    Translation:Cells
    229. Landstrom AP, Weisleder N, Batalden KB, Bos JM, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ. Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol. 2007 Jun; 42(6):1026-35. PMID: 17509612; PMCID: PMC4318564.
      Citations: 99     Fields:    Translation:HumansCells
    230. Durham WJ, Wehrens XH, Sood S, Hamilton SL. Diseases associated with altered ryanodine receptor activity. Subcell Biochem. 2007; 45:273-321. PMID: 18193641.
      Citations: 17     Fields:    Translation:Humans
    231. Wehrens XH. The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms? Heart Rhythm. 2007 Jun; 4(6):794-7. PMID: 17556207; PMCID: PMC3046465.
      Citations: 10     Fields:    Translation:Humans
    232. Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12179-84. PMID: 16873551; PMCID: PMC1567715.
      Citations: 77     Fields:    Translation:Animals
    233. Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS, Tillman EJ, Mancarella S, Coromilas J, Lederer WJ, Kass RS, Marks AR. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7906-10. PMID: 16672364; PMCID: PMC1472543.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    234. Huang F, Shan J, Reiken S, Wehrens XH, Marks AR. Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3456-61. PMID: 16481613; PMCID: PMC1413925.
      Citations: 31     Fields:    Translation:AnimalsCells
    235. Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):511-8. PMID: 16407108; PMCID: PMC1334677.
      Citations: 155     Fields:    Translation:AnimalsCells
    236. Wehrens XH. Structural determinants of potassium channel blockade and drug-induced arrhythmias. Handb Exp Pharmacol. 2006; (171):123-57. PMID: 16610343.
      Citations: 2     Fields:    Translation:HumansAnimals
    237. Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005 Oct 07; 123(1):25-35. PMID: 16213210; PMCID: PMC2901878.
      Citations: 197     Fields:    Translation:AnimalsCells
    238. Lehnart SE, Wehrens XH, Marks AR. Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation. 2005 Jun 28; 111(25):3342-6. PMID: 15983258.
      Citations: 13     Fields:    Translation:HumansCells
    239. Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9607-12. PMID: 15972811; PMCID: PMC1172237.
      Citations: 73     Fields:    Translation:Animals
    240. Wehrens XH, Lehnart SE, Marks AR. Ryanodine receptor-targeted anti-arrhythmic therapy. Ann N Y Acad Sci. 2005 Jun; 1047:366-75. PMID: 16093511.
      Citations: 22     Fields:    Translation:Humans
    241. Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32. PMID: 15851612.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    242. Wehrens XH, Lehnart SE, Marks AR. Intracellular calcium release and cardiac disease. Annu Rev Physiol. 2005; 67:69-98. PMID: 15709953.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    243. Wehrens XH, Marks AR. Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations. Mayo Clin Proc. 2004 Nov; 79(11):1367-71. PMID: 15544013.
      Citations: 7     Fields:    Translation:Humans
    244. Lehnart SE, Wehrens XH, Marks AR. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1267-79. PMID: 15336974.
      Citations: 27     Fields:    Translation:HumansAnimals
    245. Wehrens XH, Marks AR. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov. 2004 Jul; 3(7):565-73. PMID: 15232578.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    246. Lehnart SE, Wehrens XH, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR, Laitinen PJ. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation. 2004 Jun 29; 109(25):3208-14. PMID: 15197150.
      Citations: 119     Fields:    Translation:HumansCells
    247. Wehrens XH, Doevendans PA. Cardiac rupture complicating myocardial infarction. Int J Cardiol. 2004 Jun; 95(2-3):285-92. PMID: 15193834.
      Citations: 17     Fields:    Translation:Humans
    248. Lehnart SE, Wehrens XH, Kushnir A, Marks AR. Cardiac ryanodine receptor function and regulation in heart disease. Ann N Y Acad Sci. 2004 May; 1015:144-59. PMID: 15201156.
      Citations: 34     Fields:    Translation:HumansCells
    249. Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science. 2004 Apr 09; 304(5668):292-6. PMID: 15073377.
      Citations: 169     Fields:    Translation:HumansAnimalsCells
    250. Wehrens XH, Doevendans PA. Congenital and drug-induced long-QT syndrome: an update. Neth Heart J. 2004 Apr; 12(4):165-172. PMID: 25696318; PMCID: PMC2497094.
      Citations:    
    251. Wehrens XH, Lehnart SE, Reiken SR, Marks AR. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004 Apr 02; 94(6):e61-70. PMID: 15016728.
      Citations: 295     Fields:    Translation:HumansAnimalsCells
    252. Wehrens XH, Offermans JP, Snijders M, Peeters LL. Fetal cardiovascular response to large placental chorioangiomas. J Perinat Med. 2004; 32(2):107-12. PMID: 15085884.
      Citations: 6     Fields:    Translation:Humans
    253. Wehrens XH, Marks AR. Molecular determinants of altered contractility in heart failure. Ann Med. 2004; 36 Suppl 1:70-80. PMID: 15176427.
      Citations: 8     Fields:    Translation:HumansCells
    254. Wehrens XH, Marks AR. Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends Biochem Sci. 2003 Dec; 28(12):671-8. PMID: 14659699.
      Citations: 41     Fields:    Translation:HumansCells
    255. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell. 2003 Jun 27; 113(7):829-40. PMID: 12837242.
      Citations: 280     Fields:    Translation:AnimalsCells
    256. Wehrens XH, Doevendans PA. Cardiac rupture. N Engl J Med. 2003 May 29; 348(22):2264. PMID: 12773664.
      Citations:    Fields:    Translation:Humans
    257. Reiken S, Wehrens XH, Vest JA, Barbone A, Klotz S, Mancini D, Burkhoff D, Marks AR. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation. 2003 May 20; 107(19):2459-66. PMID: 12743001.
      Citations: 92     Fields:    Translation:HumansCellsCTClinical Trials
    258. Wehrens XH, Rossenbacker T, Jongbloed RJ, Gewillig M, Doevendans PA, Vos MA, Wellens HJ, Kass RS, Heidb?chel H. A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating. Hum Mutat. 2003 May; 21(5):552. PMID: 12673799.
      Citations: 24     Fields:    Translation:HumansCells
    259. Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 2003 May 06; 107(17):2233-7. PMID: 12695286.
      Citations: 64     Fields:    Translation:HumansCells
    260. Wehrens XH, Vos MA, Doevendans PA, Wellens HJ. Novel insights in the congenital long QT syndrome. Ann Intern Med. 2002 Dec 17; 137(12):981-92. PMID: 12484714.
      Citations: 20     Fields:    Translation:Humans
    261. Buehler A, Martire A, Strohm C, Wolfram S, Fernandez B, Palmen M, Wehrens XH, Doevendans PA, Franz WM, Schaper W, Zimmermann R. Angiogenesis-independent cardioprotection in FGF-1 transgenic mice. Cardiovasc Res. 2002 Sep; 55(4):768-77. PMID: 12176126.
      Citations: 19     Fields:    Translation:AnimalsCells
    262. Wehrens XH, Rouwet EV, oude Egbrink MG, Slaaf DW, Ramsay G. Effects of experimental lower-limb ischaemia-reperfusion injury on the mesenteric microcirculation. Br J Surg. 2002 Feb; 89(2):185-91. PMID: 11856131.
      Citations: 4     Fields:    Translation:AnimalsCells
    263. Clancy CE, Kurokawa J, Tateyama M, Wehrens XH, Kass RS. K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annu Rev Pharmacol Toxicol. 2003; 43:441-61. PMID: 12540747.
      Citations: 26     Fields:    Translation:Humans
    264. Wehrens XH, Marks AR. Myocardial disease in failing hearts: defective excitation-contraction coupling. Cold Spring Harb Symp Quant Biol. 2002; 67:533-41. PMID: 12858580.
      Citations:    Fields:    Translation:HumansAnimalsCells
    265. Wehrens XH, Doevendans PA, Widdershoven JW, Dassen WR, Prenger K, Wellens HJ, Gorgels AP. Usefulness of sinus tachycardia and ST-segment elevation in V(5) to identify impending left ventricular free wall rupture in inferior wall myocardial infarction. Am J Cardiol. 2001 Aug 15; 88(4):414-7. PMID: 11545766.
      Citations: 1     Fields:    Translation:Humans
    266. Dammers R, Wehrens XH, oude Egbrink MG, Slaaf DW, Kurvers HA, Ramsay G. Microcirculatory effects of experimental acute limb ischaemia-reperfusion. Br J Surg. 2001 Jun; 88(6):816-24. PMID: 11412251.
      Citations: 3     Fields:    Translation:AnimalsCells
    267. Abriel H, Cabo C, Wehrens XH, Rivolta I, Motoike HK, Memmi M, Napolitano C, Priori SG, Kass RS. Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel. Circ Res. 2001 Apr 13; 88(7):740-5. PMID: 11304498.
      Citations: 44     Fields:    Translation:HumansCells
    268. Wehrens XH, van Breda E, van Velzen JS, oude Egbrink MG, Slaaf DW. Use of an intact mouse skeletal muscle preparation for endocrine vascular studies: evaluation of the model. Horm Metab Res. 2000 Sep; 32(9):378-80. PMID: 11014388.
      Citations:    Fields:    Translation:Animals
    269. Abriel H, Wehrens XH, Benhorin J, Kerem B, Kass RS. Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome. Circulation. 2000 Aug 22; 102(8):921-5. PMID: 10952963.
      Citations: 28     Fields:    Translation:HumansCells
    270. Wehrens XH, Abriel H, Cabo C, Benhorin J, Kass RS. Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis. Circulation. 2000 Aug 01; 102(5):584-90. PMID: 10920073.
      Citations: 29     Fields:    Translation:HumansCells
    271. Wehrens XH, Doevendans PA, Ophuis TJ, Wellens HJ. A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty. Am Heart J. 2000 Mar; 139(3):430-6. PMID: 10689257.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    272. Wehrens XH, Kirchhoff S, Doevendans PA. Mouse electrocardiography: an interval of thirty years. Cardiovasc Res. 2000 Jan 01; 45(1):231-7. PMID: 10728340.
      Citations: 33     Fields:    Translation:HumansAnimals
    273. Wehrens XH, Mies B, Gimona M, Ramaekers FC, Van Eys GJ, Small JV. Localization of smoothelin in avian smooth muscle and identification of a vascular-specific isoform. FEBS Lett. 1997 Apr 01; 405(3):315-20. PMID: 9108311.
      Citations: 5     Fields:    Translation:AnimalsCells
    274. van Eys GJ, Timmer ED, Wehrens XH, Small JV, Schalken JA, Ramaekers FC, van der Loop FT, V?ller MC. Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant. Cell Struct Funct. 1997 Feb; 22(1):65-72. PMID: 9113392.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    275. Wehrens XH, Doevendans PA, van Dantzig JM, Snoep G, Wellens HJ. Infected sternal fracture hematoma after cardiopulmonary resuscitation initially seen as pericarditis. Am Heart J. 1996 Sep; 132(3):685-6. PMID: 8800042.
      Citations:    Fields:    Translation:Humans
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