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ZHAOYONG HU

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
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    Collapse Research 
    Collapse research activities and funding
    R56AR063686     (HU, ZHAOYONG)Sep 10, 2020 - Aug 31, 2021
    NIH
    Mechanisms of Protein-Energy-Wasting in chronic kidney disease
    Role: Principal Investigator
    R01AR063686     (HU, ZHAOYONG)Jul 1, 2013 - Apr 30, 2019
    NIH
    Mechanisms of Protein-Energy-Wasting in Chronic Kidney Disease
    Role: Principal Investigator
    R01DK037175     (HU, ZHAOYONG)Sep 1, 1985 - Jun 30, 2028
    NIH
    Protein Nutrition in Experimental Uremia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qin X, Chen S, Hakenjos JM, Wang J, Guo L, Dogra A, Hu Z, MacKenzie KR, Li F. Corrigendum to "Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver" [J. Pharm. Biomed. Anal. 265 (2025) 117034]. J Pharm Biomed Anal. 2026 Oct 15; 279:117523. PMID: 42140031.
      Citations:    Fields:    
    2. Wu J, Russo E, Verzola D, Li Q, Zhang H, Krishnan B, Sheikh-Hamad D, Hu Z, Mitch WE, Thomas SS. Myokine SIRPa exacerbates kidney disease in diabetes. JCI Insight. 2026 Feb 09; 11(3). PMID: 41657313; PMCID: PMC12893106.
      Citations:    Fields:    Translation:HumansAnimals
    3. Choubey A, Kumar S U, Yang T, Jager J, Hong S, Damle M, Yin H, Zhao R, Song C, Oturmaz ES, Tong H, Puglise J, Barton ER, Fang B, Hu Z, Liao L, Xu J, Lan Y, Sun Z. Intermittent AP-1 activation in muscles contributes to exercise-induced health benefits. bioRxiv. 2026 Jan 06. PMID: 41542537; PMCID: PMC12803081.
      Citations:    
    4. Sun J, Sun Y, Guo D, Ye H, Huang Q, Zhou H, Li C, Liao M, You Y, Shang H, Zhou P, Wu D, Witowski J, Hu Z, Peng H. Targeting STING to disrupt macrophage-mediated adhesion in encapsulating peritoneal sclerosis. Commun Biol. 2025 Aug 23; 8(1):1266. PMID: 40847090; PMCID: PMC12373792.
      Citations:    Translation:AnimalsCells
    5. Qin X, Chen S, Hakenjos JM, Wang J, Guo L, Dogra A, Hu Z, MacKenzie KR, Li F. Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver. J Pharm Biomed Anal. 2025 Nov 15; 265:117034. PMID: 40554835; PMCID: PMC12403197.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Si M, Chen J, Yu R, Lin H, Li F, Jung S, Thomas SS, Danesh FR, Wang Y, Peng H, Hu Z. Protein kinase ROCK1 activates mitochondrial fission linking to oxidative stress and muscle atrophy. Kidney Int. 2025 Oct; 108(4):626-641. PMID: 40505862.
      Citations:    Fields:    Translation:AnimalsCells
    7. Li X, Liu C, Li W, Qi G, Dai Y, Gu C, Sun Y, Zhou W, Ciliberto VC, Liang J, Kumar S U, Guan D, Hu Z, Zheng H, Liu Z, Chen H, Wan YW, Sun Z. Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model. Alzheimers Dement. 2025 03; 21(3):e70024. PMID: 40156268; PMCID: PMC11953571.
      Citations:    Fields:    Translation:AnimalsCells
    8. Khalil SM, Qin X, Hakenjos JM, Wang J, Hu Z, Liu X, Wang J, Maletic-Savatic M, MacKenzie KR, Matzuk MM, Li F. MALDI Imaging Mass Spectrometry Visualizes the Distribution of Antidepressant Duloxetine and Its Major Metabolites in Mouse Brain, Liver, Kidney, and Spleen Tissues. Drug Metab Dispos. 2024 06 17; 52(7):673-680. PMID: 38658163; PMCID: PMC11185819.
      Citations: 1     Fields:    Translation:Animals
    9. Li X, Liu C, Li W, Dai Y, Gu C, Zhou W, Ciliberto VC, Liang J, Udhaya KS, Guan D, Hu Z, Zheng H, Chen H, Liu Z, Wan YW, Sun Z. Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model. bioRxiv. 2024 May 05. PMID: 38746443; PMCID: PMC11092636.
      Citations:    
    10. Wang Y, Jiao B, Hu Z, Wang Y. Critical Role of histone deacetylase 3 in the regulation of kidney inflammation and fibrosis. Kidney Int. 2024 04; 105(4):775-790. PMID: 38286179; PMCID: PMC12256120.
      Citations: 19     Fields:    Translation:Animals
    11. Lin H, Peng H, Sun Y, Si M, Wu J, Wang Y, Thomas SS, Sun Z, Hu Z. Reprogramming of cis-regulatory networks during skeletal muscle atrophy in male mice. Nat Commun. 2023 10 18; 14(1):6581. PMID: 37853001; PMCID: PMC10584982.
      Citations: 8     Fields:    Translation:AnimalsCells
    12. Song J, Navarro-Garcia JA, Wu J, Saljic A, Abu-Taha I, Li L, Lahiri SK, Keefe JA, Aguilar-Sanchez Y, Moore OM, Yuan Y, Wang X, Kamler M, Mitch WE, Ruiz-Hurtado G, Hu Z, Thomas SS, Dobrev D, Wehrens XH, Li N. Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation. J Clin Invest. 2023 10 02; 133(19). PMID: 37581942; PMCID: PMC10541185.
      Citations: 29     Fields:    Translation:HumansAnimals
    13. Thomas SS, Wu J, Davogustto G, Holliday MW, Eckel-Mahan K, Hu Z, Mitch WE, Taegtmeyer H, Verzola D, Garibotto G. SIRPa Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease. Circ Res. 2022 07 22; 131(3):207-221. PMID: 35722884; PMCID: PMC10010047.
      Citations:    Fields:    Translation:AnimalsCells
    14. Lin H, Ma X, Sun Y, Peng H, Wang Y, Thomas SS, Hu Z. Decoding the transcriptome of denervated muscle at single-nucleus resolution. J Cachexia Sarcopenia Muscle. 2022 08; 13(4):2102-2117. PMID: 35726356; PMCID: PMC9398230.
      Citations:    Fields:    
    15. Wu Y, An C, Jin X, Hu Z, Wang Y. Disruption of CXCR6 Ameliorates Kidney Inflammation and Fibrosis in Deoxycorticosterone Acetate/Salt Hypertension. Sci Rep. 2020 01 10; 10(1):133. PMID: 31924817; PMCID: PMC6954216.
      Citations: 5     Fields:    Translation:AnimalsCells
    16. Zhou J, An C, Jin X, Hu Z, Safirstein RL, Wang Y. TAK1 deficiency attenuates cisplatin-induced acute kidney injury. Am J Physiol Renal Physiol. 2020 01 01; 318(1):F209-F215. PMID: 31813254; PMCID: PMC6985823.
      Citations: 10     Fields:    Translation:AnimalsCells
    17. Wu J, Dong J, Hruska K, Hu Z, Mitch WE, Thomas SS, Verzola D, Garibotto G. Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk. J Cachexia Sarcopenia Muscle. 2019 12; 10(6):1210-1227. PMID: 31507080; PMCID: PMC6903446.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    18. Si M, Wang Q, Li Y, Lin H, Luo D, Zhao W, Dou X, Liu J, Zhang H, Huang Y, Lou T, Hu Z, Peng H. Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis. Sci Transl Med. 2019 06 05; 11(495). PMID: 31167927.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    19. Peng H, Wang Q, Lou T, Qin J, Jung S, Shetty V, Li F, Wang Y, Feng XH, Mitch WE, Graham BH, Hu Z. Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys. Nat Commun. 2017 11 14; 8(1):1493. PMID: 29138395; PMCID: PMC5686208.
      Citations: 44     Fields:    Translation:Animals
    20. Cao J, Yu Y, Zhang Z, Chen X, Hu Z, Tong Q, Chang J, Feng XH, Lin X. SCP4 Promotes Gluconeogenesis Through FoxO1/3a Dephosphorylation. Diabetes. 2018 01; 67(1):46-57. PMID: 28851713; PMCID: PMC5741142.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    21. Zhou J, Jia L, Hu Z, Wang Y. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Sci Rep. 2017 08 25; 7(1):9503. PMID: 28842716; PMCID: PMC5572703.
      Citations: 12     Fields:    Translation:AnimalsCells
    22. Liang H, Zhang Z, Yan J, Wang Y, Hu Z, Mitch WE, Wang Y. The IL-4 receptor a has a critical role in bone marrow-derived fibroblast activation and renal fibrosis. Kidney Int. 2017 12; 92(6):1433-1443. PMID: 28739140; PMCID: PMC5696054.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    23. Wang Y, Jia L, Hu Z, Entman ML, Mitch WE, Wang Y. AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis. Kidney Int. 2018 01; 93(1):81-94. PMID: 28739141; PMCID: PMC5750062.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    24. Liu X, Yu R, Sun L, Garibotto G, Lin X, Wang Y, Thomas SS, Li R, Hu Z. The nuclear phosphatase SCP4 regulates FoxO?transcription factors during muscle wasting?in chronic kidney disease. Kidney Int. 2017 08; 92(2):336-348. PMID: 28506762; PMCID: PMC5511577.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    25. Liang H, Ma Z, Peng H, He L, Hu Z, Wang Y. CXCL16 Deficiency Attenuates Renal Injury and Fibrosis in Salt-Sensitive Hypertension. Sci Rep. 2016 06 29; 6:28715. PMID: 27353044; PMCID: PMC4926114.
      Citations: 18     Fields:    Translation:Animals
    26. Peng H, Cao J, Yu R, Danesh F, Wang Y, Mitch WE, Xu J, Hu Z. CKD Stimulates Muscle Protein Loss Via Rho-associated Protein Kinase 1 Activation. J Am Soc Nephrol. 2016 Feb; 27(2):509-19. PMID: 26054539; PMCID: PMC4731120.
      Citations: 12     Fields:    Translation:Animals
    27. Lin J, Shi Y, Peng H, Shen X, Thomas S, Wang Y, Truong LD, Dryer SE, Hu Z, Xu J. Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy. J Pathol. 2015 May; 236(1):30-40. PMID: 25641678; PMCID: PMC4398628.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    28. Yang J, Lin SC, Chen G, He L, Hu Z, Chan L, Trial J, Entman ML, Wang Y. Adiponectin promotes monocyte-to-fibroblast transition in renal fibrosis. J Am Soc Nephrol. 2013 Oct; 24(10):1644-59. PMID: 23833260; PMCID: PMC3785282.
      Citations: 55     Fields:    Translation:AnimalsCells
    29. Jin X, Chen J, Hu Z, Chan L, Wang Y. Genetic deficiency of adiponectin protects against acute kidney injury. Kidney Int. 2013 Apr; 83(4):604-14. PMID: 23302722; PMCID: PMC3612389.
      Citations: 42     Fields:    Translation:AnimalsCells
    30. Xu J, Li R, Workeneh B, Dong Y, Wang X, Hu Z. Transcription factor FoxO1, the dominant mediator of muscle wasting in chronic kidney disease, is inhibited by microRNA-486. Kidney Int. 2012 Aug; 82(4):401-11. PMID: 22475820; PMCID: PMC3393843.
      Citations: 100     Fields:    Translation:AnimalsCells
    31. Wang W, He B, Shi W, Liang X, Ma J, Shan Z, Hu Z, Danesh FR. Deletion of scavenger receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia. Kidney Int. 2012 May; 81(10):1002-1014. PMID: 22377830; PMCID: PMC3343314.
      Citations: 9     Fields:    Translation:AnimalsCells
    32. Zhang L, Rajan V, Lin E, Hu Z, Han HQ, Zhou X, Song Y, Min H, Wang X, Du J, Mitch WE. Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease. FASEB J. 2011 May; 25(5):1653-63. PMID: 21282204; PMCID: PMC3079306.
      Citations: 132     Fields:    Translation:AnimalsCells
    33. Hu Z, Wang H, Lee IH, Modi S, Wang X, Du J, Mitch WE. PTEN inhibition improves muscle regeneration in mice fed a high-fat diet. Diabetes. 2010 Jun; 59(6):1312-20. PMID: 20200318; PMCID: PMC2874691.
      Citations: 58     Fields:    Translation:AnimalsCells
    34. Hu Z, Wang H, Lee IH, Du J, Mitch WE. Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice. J Clin Invest. 2009 Oct; 119(10):3059-69. PMID: 19759515; PMCID: PMC2752071.
      Citations: 84     Fields:    Translation:AnimalsCells
    35. Zhang L, Du J, Hu Z, Han G, Delafontaine P, Garcia G, Mitch WE. IL-6 and serum amyloid A synergy mediates angiotensin II-induced muscle wasting. J Am Soc Nephrol. 2009 Mar; 20(3):604-12. PMID: 19158350; PMCID: PMC2653674.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    36. Hu Z, Lee IH, Wang X, Sheng H, Zhang L, Du J, Mitch WE. PTEN expression contributes to the regulation of muscle protein degradation in diabetes. Diabetes. 2007 Oct; 56(10):2449-56. PMID: 17623817.
      Citations: 33     Fields:    Translation:AnimalsCells
    37. Workeneh BT, Rondon-Berrios H, Zhang L, Hu Z, Ayehu G, Ferrando A, Kopple JD, Wang H, Storer T, Fournier M, Lee SW, Du J, Mitch WE. Development of a diagnostic method for detecting increased muscle protein degradation in patients with catabolic conditions. J Am Soc Nephrol. 2006 Nov; 17(11):3233-9. PMID: 17005936.
      Citations: 44     Fields:    Translation:Humans
    38. Du J, Hu Z, Mitch WE. Cellular signals activating muscle proteolysis in chronic kidney disease: a two-stage process. Int J Biochem Cell Biol. 2005 Oct; 37(10):2147-55. PMID: 15982920.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
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