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HUI ZHENG

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience

    TitleDirector
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


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    R01AG088197     (ZHENG, HUI)Aug 15, 2024 - Jun 30, 2029
    NIH
    The Role of the Complement Pathway in Alzheimer's Disease
    Role: Principal Investigator
    P01AG066606     (ZHENG, HUI)Jun 1, 2021 - Feb 28, 2026
    NIH
    Lysosome Regulation and Signaling in Aging and Alzheimer's Disease
    Role: Principal Investigator
    U01AG068031     (WANG, JIN)Sep 15, 2020 - May 31, 2025
    NIH
    Developing Novel Soluble Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer's Disease
    Role: Co-Principal Investigator
    R01AG062257     (ZHENG, HUI)Sep 15, 2018 - May 31, 2023
    NIH/NIA
    Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapy
    Role: Principal Investigator
    RF1AG062257     (ZHENG, HUI)Sep 15, 2018 - Mar 31, 2023
    NIH
    Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapy
    Role: Principal Investigator
    RF1AG057587     (CAO, WEI)Jun 1, 2018 - Mar 31, 2023
    NIH
    Interrogating the Interferon Pathway in Aging and Alzheimer's Disease
    Role: Co-Principal Investigator
    R01AG057509     (ZHENG, HUI)Sep 30, 2017 - May 31, 2022
    NIH
    Convergence of tauopathy and Huntington's disease through selective autophagy
    Role: Principal Investigator
    RF1AG054111     (ZHENG, HUI)Aug 15, 2016 - Mar 31, 2021
    NIH
    Decoding the role of diverse astrocyte populations in aging and AD
    Role: Principal Investigator
    R01NS093652     (ZHENG, HUI)Jul 1, 2015 - May 31, 2026
    NIH
    ROLE OF TFEB IN TAUOPATHY
    Role: Principal Investigator
    RF1NS093652     (ZHENG, HUI)Jul 1, 2015 - May 31, 2024
    NIH
    ROLE OF TFEB IN TAUOPATHY
    Role: Principal Investigator
    R01NS076117     (LI, YUEMING)Jun 1, 2011 - May 31, 2017
    NIH
    Mechanism and therapy of AB-42-specific gamma-secretase
    Role: Co-Principal Investigator
    R01AG033467     (ZHENG, HUI)Feb 1, 2009 - Jan 31, 2015
    NIH
    Role of APP in Synaptic Regulation
    Role: Principal Investigator
    R01AG032051     (ZHENG, HUI)Mar 1, 2008 - Jun 30, 2018
    NIH
    Pathophysiology of APP in vivo
    Role: Principal Investigator
    R01AG021141     (ZHENG, HUI)Sep 1, 2002 - Aug 31, 2008
    NIH
    Defining presenilin-beta-catenin pathway in vivo
    Role: Principal Investigator
    R01AG020670     (ZHENG, HUI)Apr 1, 2002 - Mar 31, 2022
    NIH
    Knockin Mouse Models of Alzheimer's Disease
    Role: Principal Investigator
    R01NS040039     (ZHENG, HUI)Apr 20, 2000 - Jan 31, 2009
    NIH
    Presenilins in tumorigenesis and neurodegeneration
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu H, He Y, Liu H, Brouwers B, Yin N, Lawler K, Keogh JM, Henning E, Lee DK, Yu M, Tu L, Zhang N, Conde KM, Han J, Yan Z, Scarcelli NA, Liao L, Xu J, Tong Q, Zheng H, Sun Z, Yang Y, Wang C, He Y, Farooqi IS, Xu Y. Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans. Sci Adv. 2024 Jun 28; 10(26):eadl2675. PMID: 38941473; PMCID: PMC11212768.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Gedam M, Zheng H. Complement C3aR signaling: Immune and metabolic modulation and its impact on Alzheimer's disease. Eur J Immunol. 2024 Aug; 54(8):e2350815. PMID: 38778507; PMCID: PMC11305912.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Li X, Liu C, Li W, Dai Y, Gu C, Zhou W, Ciliberto VC, Liang J, Udhaya KS, Guan D, Hu Z, Zheng H, Chen H, Liu Z, Wan YW, Sun Z. Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model. bioRxiv. 2024 May 05. PMID: 38746443; PMCID: PMC11092636.
      Citations:    
    4. Wang B, Martini-Stoica H, Qi C, Lu TC, Wang S, Xiong W, Qi Y, Xu Y, Sardiello M, Li H, Zheng H. TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. Nat Neurosci. 2024 Jan; 27(1):48-62. PMID: 37985800.
      Citations:    Fields:    Translation:AnimalsCells
    5. Wu Y, Du S, Bimler LH, Mauk KE, Lortal L, Kichik N, Griffiths JS, Osicka R, Song L, Polsky K, Kasper L, Sebo P, Weatherhead J, Knight JM, Kheradmand F, Zheng H, Richardson JP, Hube B, Naglik JR, Corry DB. Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis. Cell Rep. 2023 10 31; 42(10):113240. PMID: 37819761; PMCID: PMC10753853.
      Citations:    Fields:    Translation:AnimalsCells
    6. Comerota MM, Gedam M, Xiong W, Jin F, Deng L, Wang MC, Wang J, Zheng H. Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates A? pathology in a mouse model of Alzheimer's disease. Mol Neurodegener. 2023 08 15; 18(1):56. PMID: 37580742; PMCID: PMC10426131.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Wang B, Martini-Stoica H, Qi C, Lu TC, Wang S, Xiong W, Qi Y, Xu Y, Sardiello M, Li H, Zheng H. TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. bioRxiv. 2023 Feb 06. PMID: 36798205; PMCID: PMC9934527.
      Citations:    
    8. Comerota M, Gedam M, Xiong W, Jin F, Deng L, Wang M, Wang J, Zheng H. Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates Ab pathology in a mouse model of Alzheimer's disease. Res Sq. 2023 Jan 20. PMID: 36711875; PMCID: PMC9882642.
      Citations:    
    9. Niu M, Cao W, Wang Y, Zhu Q, Luo J, Wang B, Zheng H, Weitz DA, Zong C. Droplet-based transcriptome profiling of individual synapses. Nat Biotechnol. 2023 09; 41(9):1332-1344. PMID: 36646931.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Roy ER, Chiu G, Li S, Propson NE, Kanchi R, Wang B, Coarfa C, Zheng H, Cao W. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid ? plaques. Immunity. 2022 05 10; 55(5):879-894.e6. PMID: 35443157; PMCID: PMC9109419.
      Citations:    Fields:    Translation:AnimalsCells
    11. Du S, Zheng H. Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases. Cell Biosci. 2021 Nov 02; 11(1):188. PMID: 34727995; PMCID: PMC8561869.
      Citations:    
    12. Du S, Jin F, Maneix L, Gedam M, Xu Y, Catic A, Wang MC, Zheng H. FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology. Aging Cell. 2021 08; 20(8):e13432. PMID: 34247441; PMCID: PMC8373366.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Xu Y, Propson NE, Du S, Xiong W, Zheng H. Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading. Proc Natl Acad Sci U S A. 2021 07 06; 118(27). PMID: 34187889; PMCID: PMC8271658.
      Citations: 9     Fields:    Translation:AnimalsCells
    14. Chen F, Swartzlander DB, Ghosh A, Fryer JD, Wang B, Zheng H. Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology. Mol Neurodegener. 2021 01 31; 16(1):5. PMID: 33517893; PMCID: PMC7849119.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    15. Ghosh A, Comerota MM, Wan D, Chen F, Propson NE, Hwang SH, Hammock BD, Zheng H. An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease. Sci Transl Med. 2020 12 09; 12(573). PMID: 33298560; PMCID: PMC7784555.
      Citations: 17     Fields:    Translation:HumansAnimals
    16. Propson NE, Gedam M, Zheng H. Complement in Neurologic Disease. Annu Rev Pathol. 2021 01 24; 16:277-298. PMID: 33234021.
      Citations: 4     Fields:    Translation:HumansAnimals
    17. Lyu Q, Wang H, Kang Y, Wu X, Zheng HS, Laprocina K, Junghans K, Ding X, Huang CC. RNA-Seq Reveals Sub-Zones in Mouse Adrenal Zona Fasciculata and the Sexually Dimorphic Responses to Thyroid Hormone. Endocrinology. 2020 09 01; 161(9). PMID: 32697836; PMCID: PMC7446775.
      Citations: 5     Fields:    Translation:Animals
    18. Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, Martini-Stoica H, Zheng H, Mei H, Zhong X, Kim JW, Dawson VL, Dawson TM, Pao PC, Tsai LH, Haure-Mirande JV, Ehrlich ME, Chakrabarty P, Levites Y, Wang X, Dammer EB, Srivastava G, Mukherjee S, Sieberts SK, Omberg L, Dang KD, Eddy JA, Snyder P, Chae Y, Amberkar S, Wei W, Hide W, Preuss C, Ergun A, Ebert PJ, Airey DC, Mostafavi S, Yu L, Klein HU, Carter GW, Collier DA, Golde TE, Levey AI, Bennett DA, Estrada K, Townsend TM, Zhang B, Schadt E, De Jager PL, Price ND, Liu Z, Shulman JM, Mangravite LM, Logsdon BA, Accelerating Medicines Partnership-Alzheimer?s Disease Consortium, Ertekin-Taner N. Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models. Cell Rep. 2020 07 14; 32(2):107908. PMID: 32668255; PMCID: PMC7428328.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    19. Xu Y, Du S, Marsh JA, Horie K, Sato C, Ballabio A, Karch CM, Holtzman DM, Zheng H. TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading. Mol Psychiatry. 2021 10; 26(10):5925-5939. PMID: 32366951; PMCID: PMC7609570.
      Citations: 17     Fields:    Translation:AnimalsCells
    20. Lyu Q, Zheng HS, Laprocina K, Huang CC. Microwaving and Fluorophore-Tyramide for Multiplex Immunostaining on Mouse Adrenals - Using Unconjugated Primary Antibodies from the Same Host Species. J Vis Exp. 2020 02 21; (156). PMID: 32150172; PMCID: PMC7216306.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Wu Y, Du S, Johnson JL, Tung HY, Landers CT, Liu Y, Seman BG, Wheeler RT, Costa-Mattioli M, Kheradmand F, Zheng H, Corry DB. Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. Nat Commun. 2019 01 04; 10(1):58. PMID: 30610193; PMCID: PMC6320369.
      Citations: 28     Fields:    Translation:AnimalsCells
    22. Litvinchuk A, Wan YW, Swartzlander DB, Chen F, Cole A, Propson NE, Wang Q, Zhang B, Liu Z, Zheng H. Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease. Neuron. 2018 12 19; 100(6):1337-1353.e5. PMID: 30415998; PMCID: PMC6309202.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    23. Cao W, Zheng H. Correction to: Peripheral immune system in aging and Alzheimer's disease. Mol Neurodegener. 2018 10 24; 13(1):58. PMID: 30355319; PMCID: PMC6201538.
      Citations: 5     Fields:    
    24. Xu Y, Zhang S, Zheng H. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. 2019 04; 15(4):583-598. PMID: 30290707; PMCID: PMC6526869.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    25. Cao W, Zheng H. Peripheral immune system in aging and Alzheimer's disease. Mol Neurodegener. 2018 10 03; 13(1):51. PMID: 30285785; PMCID: PMC6169078.
      Citations: 67     Fields:    Translation:HumansAnimals
    26. Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, Bader DA, Lee VMY, Trojanowski JQ, Liu Z, Sardiello M, Zheng H. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. J Exp Med. 2018 09 03; 215(9):2355-2377. PMID: 30108137; PMCID: PMC6122971.
      Citations: 70     Fields:    Translation:AnimalsCells
    27. Jankowsky JL, Zheng H. Practical considerations for choosing a mouse model of Alzheimer's disease. Mol Neurodegener. 2017 12 22; 12(1):89. PMID: 29273078; PMCID: PMC5741956.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    28. Li Y, Chen Z, Gao Y, Pan G, Zheng H, Zhang Y, Xu H, Bu G, Zheng H. Synaptic Adhesion Molecule Pcdh-?C5 Mediates Synaptic Dysfunction in Alzheimer's Disease. J Neurosci. 2017 09 20; 37(38):9259-9268. PMID: 28842416; PMCID: PMC5607468.
      Citations: 12     Fields:    Translation:AnimalsCells
    29. Wang B, Li H, Mutlu SA, Bowser DA, Moore MJ, Wang MC, Zheng H. The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance. eNeuro. 2017 May-Jun; 4(3). PMID: 28785723; PMCID: PMC5534435.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    30. Lee JH, Lin L, Xu P, Saito K, Wei Q, Meadows AG, Bongmba OY, Pradhan G, Zheng H, Xu Y, Sun Y. Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity. Diabetes. 2016 08; 65(8):2169-78. PMID: 27207529; PMCID: PMC4955988.
      Citations: 35     Fields:    Translation:AnimalsCells
    31. Xu Y, Martini-Stoica H, Zheng H. A seeding based cellular assay of tauopathy. Mol Neurodegener. 2016 Apr 26; 11:32. PMID: 27112488; PMCID: PMC4845507.
      Citations: 13     Fields:    Translation:AnimalsCells
    32. Martini-Stoica H, Xu Y, Ballabio A, Zheng H. The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective. Trends Neurosci. 2016 Apr; 39(4):221-234. PMID: 26968346; PMCID: PMC4928589.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    33. Lian H, Zheng H. Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease. J Neurochem. 2016 Feb; 136(3):475-91. PMID: 26546579; PMCID: PMC4720533.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    34. Justice NJ, Huang L, Tian JB, Cole A, Pruski M, Hunt AJ, Flores R, Zhu MX, Arenkiel BR, Zheng H. Posttraumatic stress disorder-like induction elevates ?-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses. J Neurosci. 2015 Feb 11; 35(6):2612-23. PMID: 25673853; PMCID: PMC4323535.
      Citations: 30     Fields:    Translation:AnimalsCells
    35. Lian H, Yang L, Cole A, Sun L, Chiang AC, Fowler SW, Shim DJ, Rodriguez-Rivera J, Taglialatela G, Jankowsky JL, Lu HC, Zheng H. NF?B-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease. Neuron. 2015 Jan 07; 85(1):101-115. PMID: 25533482; PMCID: PMC4289109.
      Citations: 188     Fields:    Translation:HumansAnimalsCells
    36. Wang B, Wang Z, Sun L, Yang L, Li H, Cole AL, Rodriguez-Rivera J, Lu HC, Zheng H. The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons. J Neurosci. 2014 Oct 01; 34(40):13314-25. PMID: 25274811; PMCID: PMC4180470.
      Citations: 55     Fields:    Translation:AnimalsCells
    37. Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander DB, Palmieri M, di Ronza A, Lee VM, Sardiello M, Ballabio A, Zheng H. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014 Sep; 6(9):1142-60. PMID: 25069841; PMCID: PMC4197862.
      Citations: 152     Fields:    Translation:AnimalsCells
    38. Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. J Neurosci. 2014 Mar 12; 34(11):3826-40. PMID: 24623762; PMCID: PMC3951689.
      Citations: 78     Fields:    Translation:HumansAnimals
    39. Guo Q, Li H, Cole AL, Hur JY, Li Y, Zheng H. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of A? and tau. PLoS One. 2013; 8(11):e80706. PMID: 24278307; PMCID: PMC3835479.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    40. Lian H, Shim DJ, Gaddam SS, Rodriguez-Rivera J, Bitner BR, Pautler RG, Robertson CS, Zheng H. I?Ba deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery. Mol Neurodegener. 2012 Sep 19; 7:47. PMID: 22992283; PMCID: PMC3473257.
      Citations: 17     Fields:    Translation:AnimalsCells
    41. Wiese M, Antebi A, Zheng H. Regulation of neuronal APL-1 expression by cholesterol starvation. PLoS One. 2012; 7(2):e32038. PMID: 22363792; PMCID: PMC3283687.
      Citations: 4     Fields:    Translation:AnimalsCells
    42. Guo Q, Zheng H, Justice NJ. Central CRF system perturbation in an Alzheimer's disease knockin mouse model. Neurobiol Aging. 2012 Nov; 33(11):2678-91. PMID: 22336193; PMCID: PMC3361634.
      Citations: 15     Fields:    Translation:HumansAnimals
    43. Wang Z, Yang L, Zheng H. Role of APP and A? in synaptic physiology. Curr Alzheimer Res. 2012 Feb; 9(2):217-26. PMID: 21605029.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    44. Guo Q, Li H, Gaddam SS, Justice NJ, Robertson CS, Zheng H. Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem. 2012 Jan 20; 287(4):2437-45. PMID: 22144675; PMCID: PMC3268404.
      Citations: 39     Fields:    Translation:AnimalsCells
    45. Wang B, Harrison W, Overbeek PA, Zheng H. Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development. 2011 Oct; 138(20):4487-97. PMID: 21937600; PMCID: PMC3177318.
      Citations: 21     Fields:    Translation:AnimalsCells
    46. Guo Q, Wang Z, Li H, Wiese M, Zheng H. APP physiological and pathophysiological functions: insights from animal models. Cell Res. 2012 Jan; 22(1):78-89. PMID: 21769132; PMCID: PMC3351924.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    47. Shim DJ, Yang L, Reed JG, Noebels JL, Chiao PJ, Zheng H. Disruption of the NF-?B/I?Ba Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons. Mol Neurodegener. 2011 Jun 10; 6:42. PMID: 21663635; PMCID: PMC3141554.
      Citations: 14     Fields:    
    48. Barbagallo AP, Wang Z, Zheng H, D'Adamio L. The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function. PLoS One. 2011 Mar 22; 6(3):e18006. PMID: 21445342; PMCID: PMC3062548.
      Citations: 14     Fields:    Translation:Animals
    49. Barbagallo AP, Wang Z, Zheng H, D'Adamio L. A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function. J Biol Chem. 2011 Mar 18; 286(11):8717-21. PMID: 21266574; PMCID: PMC3059018.
      Citations: 31     Fields:    Translation:AnimalsCells
    50. Peethumnongsin E, Yang L, Hu L, Takashima A, Pautler RG, Zheng H, Kallhoff-Mu?oz V. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci. 2010 Oct 06; 30(40):13409-18. PMID: 20926667; PMCID: PMC2962595.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    51. Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Zheng H, S?dhof TC. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17362-7. PMID: 20855613; PMCID: PMC2951422.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    52. Wiese M, Antebi A, Zheng H. Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans. PLoS One. 2010 Sep 20; 5(9). PMID: 20862215; PMCID: PMC2942829.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    53. Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15193-8. PMID: 20696914; PMCID: PMC2930541.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    54. Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Wang R, Zheng H, S?dhof TC. Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem. 2010 Oct 01; 285(40):30598-605. PMID: 20693289; PMCID: PMC2945554.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    55. Umeda T, Mori H, Zheng H, Tomiyama T. Regulation of cholesterol efflux by amyloid beta secretion. J Neurosci Res. 2010 Jul; 88(9):1985-94. PMID: 20155813.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    56. Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT. Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J Neurosci. 2010 Feb 17; 30(7):2442-53. PMID: 20164328; PMCID: PMC2947456.
      Citations: 67     Fields:    Translation:AnimalsCells
    57. Smith KD, Peethumnongsin E, Lin H, Zheng H, Pautler RG. Increased Human Wildtype Tau Attenuates Axonal Transport Deficits Caused by Loss of APP in Mouse Models. Magn Reson Insights. 2010; 4:11-18. PMID: 20798780; PMCID: PMC2927830.
      Citations: 13     
    58. Yang L, Wang Z, Wang B, Justice NJ, Zheng H. Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity. J Neurosci. 2009 Dec 16; 29(50):15660-8. PMID: 20016080; PMCID: PMC2833283.
      Citations: 60     Fields:    Translation:AnimalsCells
    59. Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20228-33. PMID: 19906985; PMCID: PMC2787169.
      Citations: 42     Fields:    Translation:HumansCells
    60. Wang Z, Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, Zheng H. Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci. 2009 Sep 02; 29(35):10788-801. PMID: 19726636; PMCID: PMC2757256.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    61. Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem. 2009 Jan 30; 284(5):2967-2977. PMID: 19036728; PMCID: PMC2631949.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    62. Kallhoff-Munoz V, Hu L, Chen X, Pautler RG, Zheng H. Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death. J Neurosci. 2008 Oct 29; 28(44):11421-31. PMID: 18971484; PMCID: PMC2615184.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    63. Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B. Dimorphic effects of Notch signaling in bone homeostasis. Nat Med. 2008 Mar; 14(3):299-305. PMID: 18297084; PMCID: PMC2671578.
      Citations: 188     Fields:    Translation:HumansAnimalsCells
    64. Yang L, Wang B, Long C, Wu G, Zheng H. Increased asynchronous release and aberrant calcium channel activation in amyloid precursor protein deficient neuromuscular synapses. Neuroscience. 2007 Nov 23; 149(4):768-78. PMID: 17919826; PMCID: PMC2199265.
      Citations: 21     Fields:    Translation:AnimalsCells
    65. Repetto E, Yoon IS, Zheng H, Kang DE. Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J Biol Chem. 2007 Oct 26; 282(43):31504-16. PMID: 17716970.
      Citations: 45     Fields:    Translation:AnimalsCells
    66. Wang B, Yang L, Wang Z, Zheng H. Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14140-5. PMID: 17709753; PMCID: PMC1955810.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    67. Kallhoff V, Peethumnongsin E, Zheng H. Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2007 Mar 16; 2:6. PMID: 17367539; PMCID: PMC1832188.
      Citations: 18     Fields:    
    68. Smith KD, Kallhoff V, Zheng H, Pautler RG. In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease. Neuroimage. 2007 May 01; 35(4):1401-8. PMID: 17369054; PMCID: PMC2063432.
      Citations: 67     Fields:    Translation:Animals
    69. Zheng H, Koo EH. The amyloid precursor protein: beyond amyloid. Mol Neurodegener. 2006 Jul 03; 1:5. PMID: 16930452; PMCID: PMC1538601.
      Citations: 139     Fields:    
    70. Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci. 2006 Apr 05; 26(14):3845-54. PMID: 16597739; PMCID: PMC6674120.
      Citations: 27     Fields:    Translation:AnimalsCells
    71. Wang R, Wang B, He W, Zheng H. Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology. J Biol Chem. 2006 Jun 02; 281(22):15330-6. PMID: 16574645.
      Citations: 35     Fields:    Translation:HumansAnimals
    72. Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1936-40. PMID: 16449385; PMCID: PMC1413666.
      Citations: 56     Fields:    Translation:AnimalsCells
    73. Wang R, Tang P, Wang P, Boissy RE, Zheng H. Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):353-8. PMID: 16384915; PMCID: PMC1326180.
      Citations: 43     Fields:    Translation:AnimalsCells
    74. Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J Neurosci. 2005 Dec 14; 25(50):11542-52. PMID: 16354912; PMCID: PMC6726015.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    75. Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, Zhao NM, Dominguez B, Lee KF, Gan WB, Zheng H. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci. 2005 Feb 02; 25(5):1219-25. PMID: 15689559; PMCID: PMC6725967.
      Citations: 125     Fields:    Translation:AnimalsCells
    76. Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol. 2004 Sep 27; 166(7):1041-54. PMID: 15452145; PMCID: PMC2172014.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    77. Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry. 2004 May 11; 43(18):5352-9. PMID: 15122901.
      Citations: 25     Fields:    Translation:AnimalsCells
    78. Sun Y, Wang P, Zheng H, Smith RG. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4679-84. PMID: 15070777; PMCID: PMC384806.
      Citations: 241     Fields:    Translation:AnimalsCells
    79. Wang R, Dineley KT, Sweatt JD, Zheng H. Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience. 2004; 126(2):305-12. PMID: 15207348.
      Citations: 73     Fields:    Translation:Animals
    80. Wang P, Pereira FA, Beasley D, Zheng H. Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development. 2003 Oct; 130(20):5019-29. PMID: 12930775.
      Citations: 41     Fields:    Translation:AnimalsCells
    81. Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem. 2003 Jan 31; 278(5):3446-54. PMID: 12435726.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    82. Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H. The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8760-5. PMID: 12070348; PMCID: PMC124372.
      Citations: 12     Fields:    Translation:AnimalsCells
    83. Dineley KT, Xia X, Bui D, Sweatt JD, Zheng H. Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J Biol Chem. 2002 Jun 21; 277(25):22768-80. PMID: 11912199.
      Citations: 84     Fields:    Translation:AnimalsCells
    84. Morton RA, Kuenzi FM, Fitzjohn SM, Rosahl TW, Smith D, Zheng H, Shearman M, Collingridge GL, Seabrook GR. Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1. Neurosci Lett. 2002 Feb 08; 319(1):37-40. PMID: 11814648.
      Citations: 9     Fields:    Translation:AnimalsCells
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