Amyloid beta-Protein Precursor
"Amyloid beta-Protein Precursor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-pass type I membrane protein. It is cleaved by AMYLOID PRECURSOR PROTEIN SECRETASES to produce peptides of varying amino acid lengths. A 39-42 amino acid peptide, AMYLOID BETA-PEPTIDES is a principal component of the extracellular amyloid in SENILE PLAQUES.
| Descriptor ID |
D016564
|
| MeSH Number(s) |
D12.776.049.407.249 D12.776.543.039 D12.776.645.468.500 D12.776.811.050
|
| Concept/Terms |
Amyloid beta-Protein Precursor- Amyloid beta-Protein Precursor
- Amyloid beta Protein Precursor
- beta-Protein Precursor, Amyloid
- Amyloid beta Precursor Protein
- Protease Nexin II
- Nexin II, Protease
- beta-Amyloid Protein Precursor
- beta Amyloid Protein Precursor
- Protease Nexin 2
- Nexin 2, Protease
- Amyloid A4 Protein Precursor
- Amyloid Protein Precursor
|
Below are MeSH descriptors whose meaning is more general than "Amyloid beta-Protein Precursor".
Below are MeSH descriptors whose meaning is more specific than "Amyloid beta-Protein Precursor".
This graph shows the total number of publications written about "Amyloid beta-Protein Precursor" by people in this website by year, and whether "Amyloid beta-Protein Precursor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 5 | 5 |
| 2002 | 2 | 0 | 2 |
| 2003 | 1 | 1 | 2 |
| 2004 | 2 | 1 | 3 |
| 2005 | 3 | 2 | 5 |
| 2006 | 3 | 1 | 4 |
| 2007 | 3 | 1 | 4 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 2 | 2 | 4 |
| 2011 | 5 | 2 | 7 |
| 2012 | 5 | 1 | 6 |
| 2013 | 1 | 0 | 1 |
| 2014 | 3 | 3 | 6 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 4 | 4 |
| 2017 | 2 | 2 | 4 |
| 2019 | 1 | 2 | 3 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 4 | 5 |
| 2022 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
| 2025 | 1 | 2 | 3 |
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Below are the most recent publications written about "Amyloid beta-Protein Precursor" by people in Profiles.
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Mitochondrial dynamics and bioenergetics in Alzheimer's induced pluripotent stem cell-derived neurons. Brain. 2025 Apr 03; 148(4):1405-1420.
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Frequency of variants in Mendelian Alzheimer's disease genes within the Alzheimer's Disease Sequencing Project. J Alzheimers Dis. 2025 Apr; 104(3):841-851.
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Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model. Alzheimers Dement. 2025 Mar; 21(3):e70024.
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Persistent ?FosB expression limits recurrent seizure activity and provides neuroprotection in the dentate gyrus of APP mice. Prog Neurobiol. 2024 Jun; 237:102612.
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Early Mitochondrial Defects in the 5xFAD Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2023; 91(4):1323-1338.
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Neuronal Rubicon Represses Extracellular APP/Amyloid ? Deposition in Alzheimer's Disease. Cells. 2022 06 07; 11(12).
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Temporal and spatially controlled APP transgene expression using Cre-dependent alleles. Dis Model Mech. 2022 05 01; 15(5).
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Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid ? plaques. Immunity. 2022 05 10; 55(5):879-894.e6.
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APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer's pathology in trisomy 21 neurons. Mol Psychiatry. 2022 04; 27(4):1970-1989.
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Restoring activity in the thalamic reticular nucleus improves sleep architecture and reduces A? accumulation in mice. Sci Transl Med. 2021 11 03; 13(618):eabh4284.