"Proinsulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pancreatic polypeptide of about 110 amino acids, depending on the species, that is the precursor of insulin. Proinsulin, produced by the PANCREATIC BETA CELLS, is comprised sequentially of the N-terminal B-chain, the proteolytically removable connecting C-peptide, and the C-terminal A-chain. It also contains three disulfide bonds, two between A-chain and B-chain. After cleavage at two locations, insulin and C-peptide are the secreted products. Intact proinsulin with low bioactivity also is secreted in small amounts.
| Descriptor ID |
D011384
|
| MeSH Number(s) |
D06.472.699.587.200.500 D12.644.548.586.200.500 D12.776.811.706
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Proinsulin".
Below are MeSH descriptors whose meaning is more specific than "Proinsulin".
This graph shows the total number of publications written about "Proinsulin" by people in this website by year, and whether "Proinsulin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Proinsulin" by people in Profiles.
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Osteocalcin protects islet identity in low-density lipoprotein receptor knockout mice on high-fat diet. J Endocrinol. 2024 Apr 01; 261(1).
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Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB J. 2015 Aug; 29(8):3537-48.
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Elevated plasma SPARC levels are associated with insulin resistance, dyslipidemia, and inflammation in gestational diabetes mellitus. PLoS One. 2013; 8(12):e81615.
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Pathogenesis of diabetic neuropathy: bad to the bone. Ann N Y Acad Sci. 2011 Dec; 1240:70-6.
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PDX-1 expression is associated with islet proliferation in vitro and in vivo. J Surg Res. 2008 Jan; 144(1):8-16.
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Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab. 2007 Mar; 9(2):166-74.
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Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4030-5.
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Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus: is history repeating itself? Endocr J. 2006 Dec; 53(6):715-22.
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Waist circumference is an independent predictor of insulin resistance in black and white youths. J Pediatr. 2006 Feb; 148(2):188-94.
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Chronic diabetic complications: the body's adaptive response to hyperglycemia gone awry? Trans Am Clin Climatol Assoc. 2006; 117:341-51; discussion 351-2.