"Dystrophin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
| Descriptor ID |
D016189
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| MeSH Number(s) |
D12.776.210.500.250 D12.776.220.250 D12.776.543.250
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dystrophin".
Below are MeSH descriptors whose meaning is more specific than "Dystrophin".
This graph shows the total number of publications written about "Dystrophin" by people in this website by year, and whether "Dystrophin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 3 | 3 |
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 1 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 4 | 5 |
| 2022 | 0 | 2 | 2 |
| 2024 | 0 | 1 | 1 |
| 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dystrophin" by people in Profiles.
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Systemic investigation of bone and muscle abnormalities in dystrophin/utrophin double knockout mice during postnatal development and the mechanisms. Hum Mol Genet. 2019 05 15; 28(10):1738-1751.
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Loss of peroxiredoxin-2 exacerbates eccentric contraction-induced force loss in dystrophin-deficient muscle. Nat Commun. 2018 11 30; 9(1):5104.
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Establishment of stably expandable induced myogenic stem cells by four transcription factors. Cell Death Dis. 2018 10 25; 9(11):1092.
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DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011 Feb 01; 25(3):263-74.
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Short-term mechanical unloading and reverse remodeling of failing hearts in children. J Heart Lung Transplant. 2010 Jan; 29(1):98-104.
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The sarcolemmal calcium pump, alpha-1 syntrophin, and neuronal nitric-oxide synthase are parts of a macromolecular protein complex. J Biol Chem. 2006 Aug 18; 281(33):23341-8.
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[Dystrophin and utrophin expression in muscle tissues of DMD mouse model after transplantation treatment by bone marrow mesenchymal stem cells]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Jun; 26(3):294-7.
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[Ultrastructural changes in muscular tissues of dystrophin/utrophin double-knockout mice after bone marrow-derived mesenchymal stem cell transplantation]. Di Yi Jun Yi Da Xue Xue Bao. 2004 May; 24(5):501-4.
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Mutations in the muscle LIM protein and alpha-actinin-2 genes in dilated cardiomyopathy and endocardial fibroelastosis. Mol Genet Metab. 2003 Sep-Oct; 80(1-2):207-15.
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[Cloning and sequencing of junction fragment with exon 51 deletion of Dystrophin gene]. Yi Chuan Xue Bao. 2002 Feb; 29(2):105-10.