"Calsequestrin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Acidic protein found in SARCOPLASMIC RETICULUM that binds calcium to the extent of 700-900 nmoles/mg. It plays the role of sequestering calcium transported to the interior of the intracellular vesicle.
| Descriptor ID |
D002155
|
| MeSH Number(s) |
D12.776.157.125.155 D12.776.210.500.220
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Calsequestrin".
Below are MeSH descriptors whose meaning is more specific than "Calsequestrin".
This graph shows the total number of publications written about "Calsequestrin" by people in this website by year, and whether "Calsequestrin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2017 | 0 | 2 | 2 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Calsequestrin" by people in Profiles.
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Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation. FASEB J. 2021 05; 35(5):e21349.
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A Calsequestrin Cis-Regulatory Motif Coupled to a Cardiac Troponin T Promoter Improves Cardiac Adeno-Associated Virus Serotype 9 Transduction Specificity. Hum Gene Ther. 2018 08; 29(8):927-937.
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Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia. J Am Heart Assoc. 2018 05 02; 7(10).
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Interpreting Incidentally Identified Variants in Genes Associated With Catecholaminergic Polymorphic Ventricular Tachycardia in a Large Cohort of Clinical Whole-Exome Genetic Test Referrals. Circ Arrhythm Electrophysiol. 2017 Apr; 10(4).
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A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017 03 24; 8:14659.
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Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia. J Physiol. 2013 Sep 15; 591(18):4439-57.
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Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol. 2010 Nov; 2(11):a003996.
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Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle. Cell Calcium. 2009 May; 45(5):474-84.
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The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model. J Clin Invest. 2002 Apr; 109(8):1013-20.