"Calcium Channels, L-Type" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
| Descriptor ID |
D020746
|
| MeSH Number(s) |
D12.776.157.530.400.150.400 D12.776.543.550.450.150.400 D12.776.543.585.400.150.400
|
| Concept/Terms |
Calcium Channels, L-Type- Calcium Channels, L-Type
- Calcium Channels, L Type
- L-Type VDCC
- L Type VDCC
- VDCC, L-Type
- L-Type Calcium Channel
- Calcium Channel, L-Type
- L Type Calcium Channel
- L-Type Voltage-Dependent Calcium Channels
- L Type Voltage Dependent Calcium Channels
- L-Type Calcium Channels
- L Type Calcium Channels
- Long-Lasting Calcium Channels
- Calcium Channels, Long-Lasting
- Long Lasting Calcium Channels
Receptors, Dihydropyridine- Receptors, Dihydropyridine
- L-Type VDCC alpha-1 Subunit
- L Type VDCC alpha 1 Subunit
- Dihydropyridine Receptor
- Receptor, Dihydropyridine
- Dihydropyridine Receptors
|
Below are MeSH descriptors whose meaning is more general than "Calcium Channels, L-Type".
Below are MeSH descriptors whose meaning is more specific than "Calcium Channels, L-Type".
This graph shows the total number of publications written about "Calcium Channels, L-Type" by people in this website by year, and whether "Calcium Channels, L-Type" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 2 | 0 | 2 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 1 | 3 |
| 2007 | 0 | 4 | 4 |
| 2008 | 1 | 1 | 2 |
| 2009 | 4 | 0 | 4 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 1 | 2 |
| 2012 | 1 | 1 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
| 2018 | 2 | 0 | 2 |
| 2021 | 2 | 1 | 3 |
| 2022 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Calcium Channels, L-Type" by people in Profiles.
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Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome. Nat Commun. 2024 Oct 17; 15(1):8980.
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Nerve injury augments Cacna2d1 transcription via CK2-mediated phosphorylation of the histone deacetylase HDAC2 in dorsal root ganglia. J Biol Chem. 2024 Nov; 300(11):107848.
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Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy. Brain. 2022 08 27; 145(8):2721-2729.
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a2d-1-Dependent NMDA Receptor Activity in the Hypothalamus Is an Effector of Genetic-Environment Interactions That Drive Persistent Hypertension. J Neurosci. 2021 07 28; 41(30):6551-6563.
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Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations. Genet Med. 2021 10; 23(10):1922-1932.
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Protein Kinase C-Mediated Phosphorylation and a2d-1 Interdependently Regulate NMDA Receptor Trafficking and Activity. J Neurosci. 2021 07 28; 41(30):6415-6429.
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a2d-1 Upregulation in Primary Sensory Neurons Promotes NMDA Receptor-Mediated Glutamatergic Input in Resiniferatoxin-Induced Neuropathy. J Neurosci. 2021 07 07; 41(27):5963-5978.
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Genetic neuroimaging of bipolar disorder: a systematic 2017-2020 update. Psychiatr Genet. 2021 04 01; 31(2):50-64.
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a2d-1-Bound N-Methyl-D-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents. Anesthesiology. 2019 05; 130(5):804-819.
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Identification of CACNA1D variants associated with sinoatrial node dysfunction and deafness in additional Pakistani families reveals a clinical significance. J Hum Genet. 2019 Feb; 64(2):153-160.