"TRPC6 Cation Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
| Descriptor ID |
D000074287
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| MeSH Number(s) |
D12.776.157.530.400.150.850 D12.776.157.530.400.901.500.500 D12.776.543.550.450.150.900 D12.776.543.585.400.150.850 D12.776.543.585.400.901.500.500
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| Concept/Terms |
TRPC6 Cation Channel- TRPC6 Cation Channel
- Cation Channel, TRPC6
- Channel, TRPC6 Cation
- Transient Receptor Potential Cation Channel Subfamily C, Member 6
- TRPC6
|
Below are MeSH descriptors whose meaning is more general than "TRPC6 Cation Channel".
Below are MeSH descriptors whose meaning is more specific than "TRPC6 Cation Channel".
This graph shows the total number of publications written about "TRPC6 Cation Channel" by people in this website by year, and whether "TRPC6 Cation Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
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Below are the most recent publications written about "TRPC6 Cation Channel" by people in Profiles.
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TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1041-1066.
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Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases. Biochim Biophys Acta Mol Basis Dis. 2018 10; 1864(10):3527-3536.
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Trpc6 inactivation confers protection in a model of severe nephrosis in rats. J Mol Med (Berl). 2018 07; 96(7):631-644.
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Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors. Biochim Biophys Acta Mol Basis Dis. 2017 09; 1863(9):2342-2354.
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Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria. J Am Soc Nephrol. 2016 Nov; 27(11):3308-3319.
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Second Messenger-Operated Calcium Entry Through TRPC6. Adv Exp Med Biol. 2016; 898:201-49.
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Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt A):2610-20.
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Pleiotropic signaling evoked by tumor necrosis factor in podocytes. Am J Physiol Renal Physiol. 2015 Jul 15; 309(2):F98-108.
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Angiotensin II and canonical transient receptor potential-6 activation stimulate release of a signal transducer and activator of transcription 3-activating factor from mouse podocytes. Mol Pharmacol. 2014 Aug; 86(2):150-8.
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A mutation in TRPC6 channels abolishes their activation by hypoosmotic stretch but does not affect activation by diacylglycerol or G protein signaling cascades. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1018-25.