"TRPC Cation Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subgroup of TRP cation channels that contain 3-4 ANKYRIN REPEAT DOMAINS and a conserved C-terminal domain. Members are highly expressed in the CENTRAL NERVOUS SYSTEM. Selectivity for calcium over sodium ranges from 0.5 to 10.
| Descriptor ID |
D050052
|
| MeSH Number(s) |
D12.776.157.530.400.901.500 D12.776.543.585.400.901.500
|
| Concept/Terms |
TRPC Cation Channels- TRPC Cation Channels
- Cation Channels, TRPC
- Channels, TRPC Cation
- Transient Receptor Potential Channels, Type C
- Transient Receptor Potential Cation Channel Subfamily C
|
Below are MeSH descriptors whose meaning is more general than "TRPC Cation Channels".
Below are MeSH descriptors whose meaning is more specific than "TRPC Cation Channels".
This graph shows the total number of publications written about "TRPC Cation Channels" by people in this website by year, and whether "TRPC Cation Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 3 | 1 | 4 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "TRPC Cation Channels" by people in Profiles.
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Loss of transient receptor potential channel 5 causes obesity and postpartum depression. Cell. 2024 Aug 08; 187(16):4176-4192.e17.
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Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility. Proc Natl Acad Sci U S A. 2021 03 16; 118(11).
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Calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells. PLoS Genet. 2021 02; 17(2):e1009066.
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Cerebral ischemia induces TRPC6 via HIF1a/ZEB2 axis in the glomerular podocytes and contributes to proteinuria. Sci Rep. 2019 11 29; 9(1):17897.
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Mechanisms underlying modulation of podocyte TRPC6 channels by suPAR: Role of NADPH oxidases and Src family tyrosine kinases. Biochim Biophys Acta Mol Basis Dis. 2018 10; 1864(10):3527-3536.
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Oxidative stress impairs cGMP-dependent protein kinase activation and vasodilator-stimulated phosphoprotein serine-phosphorylation. Clin Exp Hypertens. 2019; 41(1):5-13.
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Synaptopodin Limits TRPC6 Podocyte Surface Expression and Attenuates Proteinuria. J Am Soc Nephrol. 2016 Nov; 27(11):3308-3319.
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Second Messenger-Operated Calcium Entry Through TRPC6. Adv Exp Med Biol. 2016; 898:201-49.
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a-Synuclein expression in the mouse cerebellum is restricted to VGluT1 excitatory terminals and is enriched in unipolar brush cells. Cerebellum. 2015 Oct; 14(5):516-27.
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Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt A):2610-20.