Transient Receptor Potential Channels
"Transient Receptor Potential Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
| Descriptor ID |
D050051
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| MeSH Number(s) |
D12.776.157.530.400.901 D12.776.543.585.400.901
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| Concept/Terms |
Transient Receptor Potential Channels- Transient Receptor Potential Channels
- TRP Membrane Proteins
- Membrane Proteins, TRP
- Proteins, TRP Membrane
- TRP Cation Channels
- Cation Channels, TRP
- Channels, TRP Cation
- Transient Receptor Potential Cation Channels
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Below are MeSH descriptors whose meaning is more general than "Transient Receptor Potential Channels".
Below are MeSH descriptors whose meaning is more specific than "Transient Receptor Potential Channels".
This graph shows the total number of publications written about "Transient Receptor Potential Channels" by people in this website by year, and whether "Transient Receptor Potential Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 2 | 1 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Transient Receptor Potential Channels" by people in Profiles.
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Investigation of dynamic regulation of TFEB nuclear shuttling by microfluidics and quantitative modelling. Commun Biol. 2025 Mar 15; 8(1):443.
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The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons. eNeuro. 2023 06; 10(6).
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Neuroprotective Potential of HC070, a Potent TRPC5 Channel Inhibitor in Parkinson's Disease Models: A Behavioral and Mechanistic Study. ACS Chem Neurosci. 2022 09 21; 13(18):2728-2742.
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TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKK?/VPS34 pathway. Nat Commun. 2019 12 10; 10(1):5630.
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Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol. 2019 01; 26(1):40-49.
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Lysosome signaling controls the migration of dendritic cells. Sci Immunol. 2017 10 27; 2(16).
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Lysosomal calcium signalling regulates autophagy through calcineurin and ?TFEB. Nat Cell Biol. 2015 Mar; 17(3):288-99.
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The anoctamin family channel subdued mediates thermal nociception in Drosophila. J Biol Chem. 2015 Jan 23; 290(4):2521-8.
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Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24; 289(43):29961-74.
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Intracellular two-phase Ca2+ release and apoptosis controlled by TRP-ML1 channel activity in coronary arterial myocytes. Am J Physiol Cell Physiol. 2013 Mar 01; 304(5):C458-66.