Transient Receptor Potential Channels
"Transient Receptor Potential Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A broad group of eukaryotic six-transmembrane cation channels that are classified by sequence homology because their functional involvement with SENSATION is varied. They have only weak voltage sensitivity and ion selectivity. They are named after a DROSOPHILA mutant that displayed transient receptor potentials in response to light. A 25-amino-acid motif containing a TRP box (EWKFAR) just C-terminal to S6 is found in TRPC, TRPV and TRPM subgroups. ANKYRIN REPEATS are found in TRPC, TRPV & TRPN subgroups. Some are functionally associated with TYROSINE KINASE or TYPE C PHOSPHOLIPASES.
| Descriptor ID |
D050051
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| MeSH Number(s) |
D12.776.157.530.400.901 D12.776.543.585.400.901
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| Concept/Terms |
Transient Receptor Potential Channels- Transient Receptor Potential Channels
- TRP Membrane Proteins
- Membrane Proteins, TRP
- Proteins, TRP Membrane
- TRP Cation Channels
- Cation Channels, TRP
- Channels, TRP Cation
- Transient Receptor Potential Cation Channels
|
Below are MeSH descriptors whose meaning is more general than "Transient Receptor Potential Channels".
Below are MeSH descriptors whose meaning is more specific than "Transient Receptor Potential Channels".
This graph shows the total number of publications written about "Transient Receptor Potential Channels" by people in this website by year, and whether "Transient Receptor Potential Channels" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 2 | 1 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 1 | 3 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Transient Receptor Potential Channels" by people in Profiles.
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The Voltage-Gated Sodium Channel in Drosophila, Para, Localizes to Dendrites As Well As Axons in Mechanosensitive Chordotonal Neurons. eNeuro. 2023 Jun; 10(6).
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TRPML1 links lysosomal calcium to autophagosome biogenesis through the activation of the CaMKK?/VPS34 pathway. Nat Commun. 2019 12 10; 10(1):5630.
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HRAS-driven cancer cells are vulnerable to TRPML1 inhibition. EMBO Rep. 2019 04; 20(4).
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Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol. 2019 01; 26(1):40-49.
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Injury-induced cold sensitization in Drosophila larvae involves behavioral shifts that require the TRP channel Brv1. PLoS One. 2018; 13(12):e0209577.
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Lysosome signaling controls the migration of dendritic cells. Sci Immunol. 2017 10 27; 2(16).
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The TRP Channels Pkd2, NompC, and Trpm Act in Cold-Sensing Neurons to Mediate Unique Aversive Behaviors to Noxious Cold in Drosophila. Curr Biol. 2016 12 05; 26(23):3116-3128.
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A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23; 137(50):15859-64.
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Mechanisms involved in the development of chemotherapy-induced neuropathy. Pain Manag. 2015; 5(4):285-96.
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Lysosomal calcium signalling regulates autophagy through calcineurin and ?TFEB. Nat Cell Biol. 2015 Mar; 17(3):288-99.