Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
"Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subgroup of cyclic nucleotide-regulated ION CHANNELS of the superfamily of pore-loop cation channels that are opened by hyperpolarization rather than depolarization. The ion conducting pore passes SODIUM, CALCIUM, and POTASSIUM cations with a preference for potassium.
Descriptor ID |
D064428
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MeSH Number(s) |
D12.776.157.530.400.368 D12.776.543.550.450.476 D12.776.543.585.400.476
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Concept/Terms |
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels- Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
- Hyperpolarization Activated Cyclic Nucleotide Gated Channels
- Ih Cation Channels
- Cation Channels, Ih
- Channels, Ih Cation
- Hyperpolarization Cyclic-Nucleotide Gated Ion Channels
- Hyperpolarization Cyclic Nucleotide Gated Ion Channels
- I(h) Channels
- Hyperpolarization-Activated Cation Channel
- Cation Channel, Hyperpolarization-Activated
- Channel, Hyperpolarization-Activated Cation
- Hyperpolarization Activated Cation Channel
- HCN Pacemaker Channels
- Channels, HCN Pacemaker
- Pacemaker Channels, HCN
- I(h) Cation Channels
HCN4 Channel- HCN4 Channel
- Channel, HCN4
- Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 4
- Hyperpolarization Cyclic Nucleotide Gated Cation Channel 4
HCN3 Channel- HCN3 Channel
- Channel, HCN3
- Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 3
- Hyperpolarization Cyclic Nucleotide Gated Cation Channel 3
HCN1 Channel- HCN1 Channel
- Channel, HCN1
- Hyperpolarization Cyclic-Nucleotide Gated Cation Channel 1
- Hyperpolarization Cyclic Nucleotide Gated Cation Channel 1
HCN2 Channel- HCN2 Channel
- Channel, HCN2
- Potassium-Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2
- Potassium Sodium Hyperpolarization Activated Cyclic Nucleotide Gated Channel 2
- HCN2 Potassium Channel
- Channel, HCN2 Potassium
- Potassium Channel, HCN2
- Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2
- Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 2
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Below are MeSH descriptors whose meaning is more general than "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels".
Below are MeSH descriptors whose meaning is more specific than "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels".
This graph shows the total number of publications written about "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels" by people in this website by year, and whether "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2004 | 0 | 1 | 1 |
2005 | 0 | 1 | 1 |
2009 | 0 | 2 | 2 |
2015 | 1 | 0 | 1 |
2016 | 1 | 1 | 2 |
2018 | 1 | 0 | 1 |
2019 | 0 | 1 | 1 |
2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels" by people in Profiles.
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Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes. Cells. 2023 05 13; 12(10).
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Reduction in Junctophilin 2 Expression in Cardiac Nodal Tissue Results in Intracellular Calcium-Driven Increase in Nodal Cell Automaticity. Circ Arrhythm Electrophysiol. 2023 02; 16(2):e010858.
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Active membrane conductances and morphology of a collision detection neuron broaden its impedance profile and improve discrimination of input synchrony. J Neurophysiol. 2019 08 01; 122(2):691-706.
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Biophysics of object segmentation in a collision-detecting neuron. Elife. 2018 04 18; 7.
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Serotonin modulates spike probability in the axon initial segment through HCN channels. Nat Neurosci. 2016 06; 19(6):826-34.
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Sudden unexpected death in epilepsy genetics: Molecular diagnostics and prevention. Epilepsia. 2016 Jan; 57 Suppl 1:17-25.
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Distribution and function of HCN channels in the apical dendritic tuft of neocortical pyramidal neurons. J Neurosci. 2015 Jan 21; 35(3):1024-37.
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Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors. J Neurosci. 2009 May 06; 29(18):5841-53.
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Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5972-7.
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Mapping ligand interactions with the hyperpolarization activated cyclic nucleotide modulated (HCN) ion channel binding domain using a soluble construct. Biochemistry. 2007 Aug 21; 46(33):9417-31.