"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Descriptor ID |
D008247
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MeSH Number(s) |
A11.284.430.214.190.875.190.550
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Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in this website by year, and whether "Lysosomes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 1 | 0 | 1 |
1998 | 1 | 1 | 2 |
1999 | 2 | 1 | 3 |
2000 | 2 | 1 | 3 |
2001 | 1 | 0 | 1 |
2003 | 0 | 3 | 3 |
2004 | 0 | 3 | 3 |
2005 | 2 | 1 | 3 |
2006 | 0 | 1 | 1 |
2007 | 4 | 3 | 7 |
2008 | 2 | 0 | 2 |
2009 | 2 | 4 | 6 |
2010 | 2 | 5 | 7 |
2011 | 5 | 4 | 9 |
2012 | 3 | 4 | 7 |
2013 | 6 | 8 | 14 |
2014 | 8 | 10 | 18 |
2015 | 7 | 4 | 11 |
2016 | 10 | 10 | 20 |
2017 | 10 | 4 | 14 |
2018 | 6 | 12 | 18 |
2019 | 11 | 5 | 16 |
2020 | 8 | 9 | 17 |
2021 | 2 | 9 | 11 |
2022 | 4 | 6 | 10 |
2023 | 4 | 10 | 14 |
2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lysosomes" by people in Profiles.
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Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control. Cell Death Dis. 2024 01 22; 15(1):80.
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TFEB-vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy. Nat Neurosci. 2024 Jan; 27(1):48-62.
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Inducible tricolor reporter mouse for parallel imaging of lysosomes, mitochondria, and microtubules. J Cell Biol. 2024 01 01; 223(1).
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TFEB and TFE3 control glucose homeostasis by regulating insulin gene expression. EMBO J. 2023 11 02; 42(21):e113928.
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Lysosome-dependent FOXA1 ubiquitination contributes to luminal lineage of advanced prostate cancer. Mol Oncol. 2023 10; 17(10):2126-2146.
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Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation. Nat Commun. 2023 07 03; 14(1):3911.
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Reprogramming tumour-associated macrophages to outcompete cancer cells. Nature. 2023 Jul; 619(7970):616-623.
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Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health. Nat Commun. 2023 05 29; 14(1):3086.
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Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. PLoS Genet. 2023 05; 19(5):e1010760.
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RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nat Commun. 2023 05 15; 14(1):2775.