"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
| Descriptor ID |
D008247
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| MeSH Number(s) |
A11.284.430.214.190.875.190.550
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in this website by year, and whether "Lysosomes" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 2 | 2 |
| 2004 | 0 | 2 | 2 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 3 | 4 |
| 2008 | 1 | 0 | 1 |
| 2009 | 2 | 3 | 5 |
| 2010 | 2 | 2 | 4 |
| 2011 | 5 | 2 | 7 |
| 2012 | 3 | 2 | 5 |
| 2013 | 5 | 6 | 11 |
| 2014 | 8 | 8 | 16 |
| 2015 | 7 | 2 | 9 |
| 2016 | 8 | 9 | 17 |
| 2017 | 7 | 6 | 13 |
| 2018 | 5 | 11 | 16 |
| 2019 | 12 | 3 | 15 |
| 2020 | 5 | 5 | 10 |
| 2021 | 2 | 7 | 9 |
| 2022 | 4 | 5 | 9 |
| 2023 | 3 | 10 | 13 |
| 2024 | 3 | 4 | 7 |
| 2025 | 7 | 3 | 10 |
| 2026 | 3 | 3 | 6 |
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click here.
Below are the most recent publications written about "Lysosomes" by people in Profiles.
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TRPML1 agonists synergize with enzyme replacement therapy in fibroblasts from Pompe disease patients. J Transl Med. 2026 Jun 11; 24(1).
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Early-onset neuroinflammation drives neurodegeneration caused by lysosomal PI(3,5)P2 insufficiency. Neurobiol Dis. 2026 Aug; 226:107467.
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TFEB degradation is regulated by an IKK/?-TrCP2 phosphorylation-ubiquitination cascade. Nat Commun. 2026 Apr 01; 17(1).
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Integration of cross-species multi-omics with in vivo experimental validation identifies Parkinson's disease therapeutic targets and novel risk factors within endolysosomal pathway subnetworks. Neurobiol Dis. 2026 May; 222:107364.
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Two lysosomal genes ATP13A2 and GBA1 interact to drive neurodegeneration. Mol Neurodegener. 2026 Jan 30; 21(1).
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Rab4 spatially and functionally converges with Rab7 in the degradative endolysosomal network. Mol Biol Cell. 2026 Mar 01; 37(3):ar18.
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Loss of the lysosomal protein CLN3 triggers c-Abl-dependent YAP1 pro-apoptotic signaling. EMBO Rep. 2025 Dec; 26(24):6096-6120.
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Lysosomes signal through the epigenome to regulate longevity across generations. Science. 2025 Sep 25; 389(6767):1353-1360.
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Nortriptyline Inhibits Lysosomal Exocytosis-Mediated SASP During Gastric Cancer Progression via Targeting HOXA1-PITX2 Phase Separation. Adv Sci (Weinh). 2025 Dec; 12(46):e12407.
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Structural basis for mTORC1 activation on the lysosomal membrane. Nature. 2025 11; 647(8089):536-543.