Inositol 1,4,5-Trisphosphate Receptors
"Inositol 1,4,5-Trisphosphate Receptors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular receptors that bind to INOSITOL 1,4,5-TRISPHOSPHATE and play an important role in its intracellular signaling. Inositol 1,4,5-trisphosphate receptors are calcium channels that release CALCIUM in response to increased levels of inositol 1,4,5-trisphosphate in the CYTOPLASM.
| Descriptor ID |
D053496
|
| MeSH Number(s) |
D12.776.157.530.400.150.760 D12.776.543.550.450.150.760 D12.776.543.585.400.150.760 D12.776.826.179
|
| Concept/Terms |
Inositol 1,4,5-Trisphosphate Receptors- Inositol 1,4,5-Trisphosphate Receptors
- INSP3 Receptor
- Receptor, INSP3
- IP3 Receptor
- Receptor, IP3
- Inositol 1,4,5-Triphosphate Receptors
- Receptor, Inositol-1,4,5-triphosphate
- Inositol-1,4,5-Triphosphate Receptor
- 1,4,5-INTP Receptor
- Inositol Triphosphate Receptor
- Receptor, Inositol Triphosphate
- Triphosphate Receptor, Inositol
|
Below are MeSH descriptors whose meaning is more general than "Inositol 1,4,5-Trisphosphate Receptors".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Calcium Channels [D12.776.157.530.400.150]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.157.530.400.150.760]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.450]
- Calcium Channels [D12.776.543.550.450.150]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.550.450.150.760]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Calcium Channels [D12.776.543.585.400.150]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.543.585.400.150.760]
- Receptors, Cytoplasmic and Nuclear [D12.776.826]
- Inositol 1,4,5-Trisphosphate Receptors [D12.776.826.179]
Below are MeSH descriptors whose meaning is more specific than "Inositol 1,4,5-Trisphosphate Receptors".
This graph shows the total number of publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in this website by year, and whether "Inositol 1,4,5-Trisphosphate Receptors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 4 | 4 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
| 2023 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Inositol 1,4,5-Trisphosphate Receptors" by people in Profiles.
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Host IP3R channels are dispensable for rotavirus Ca2+ signaling but critical for intercellular Ca2+ waves that prime uninfected cells for rapid virus spread. mBio. 2024 Jan 16; 15(1):e0214523.
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Understanding IP3R channels: From structural underpinnings to ligand-dependent conformational landscape. Cell Calcium. 2023 09; 114:102770.
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Conformational motions and ligand-binding underlying gating and regulation in IP3R channel. Nat Commun. 2022 11 14; 13(1):6942.
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Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects. Cell Mol Immunol. 2023 01; 20(1):11-25.
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Functional determination of calcium-binding sites required for the activation of inositol 1,4,5-trisphosphate receptors. Proc Natl Acad Sci U S A. 2022 09 27; 119(39):e2209267119.
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Cryo-EM structure of type 1 IP3R channel in a lipid bilayer. Commun Biol. 2021 05 25; 4(1):625.
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A novel de novo intronic variant in ITPR1 causes Gillespie syndrome. Am J Med Genet A. 2021 08; 185(8):2315-2324.
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Long-term follow-up of an individual with ITPR1-related disorder. Am J Med Genet A. 2020 07; 182(7):1846-1847.
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Bcl-2-Protein Family as Modulators of IP3 Receptors and Other Organellar Ca2+ Channels. Cold Spring Harb Perspect Biol. 2020 04 01; 12(4).
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Multiple calcium sources are required for intracellular calcium mobilization during gastric organoid epithelial repair. Physiol Rep. 2020 03; 8(5):e14384.