Receptors, Cytoplasmic and Nuclear
"Receptors, Cytoplasmic and Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracellular receptors that can be found in the cytoplasm or in the nucleus. They bind to extracellular signaling molecules that migrate through or are transported across the CELL MEMBRANE. Many members of this class of receptors occur in the cytoplasm and are transported to the CELL NUCLEUS upon ligand-binding where they signal via DNA-binding and transcription regulation. Also included in this category are receptors found on INTRACELLULAR MEMBRANES that act via mechanisms similar to CELL SURFACE RECEPTORS.
| Descriptor ID |
D018160
|
| MeSH Number(s) |
D12.776.826
|
| Concept/Terms |
Receptors, Cytoplasmic and Nuclear- Receptors, Cytoplasmic and Nuclear
- Receptors, Cytosol and Nuclear
- Cytosolic and Nuclear Receptors
- Receptors, Nuclear and Cytoplasmic
- Cytoplasmic and Nuclear Receptors
- Cytosol and Nuclear Receptors
- Nuclear and Cytoplasmic Receptors
- Receptors, Cytosolic and Nuclear
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Cytoplasmic and Nuclear".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Cytoplasmic and Nuclear".
This graph shows the total number of publications written about "Receptors, Cytoplasmic and Nuclear" by people in this website by year, and whether "Receptors, Cytoplasmic and Nuclear" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 1 | 2 |
| 1997 | 2 | 2 | 4 |
| 1998 | 3 | 0 | 3 |
| 1999 | 6 | 1 | 7 |
| 2000 | 4 | 5 | 9 |
| 2001 | 6 | 2 | 8 |
| 2002 | 7 | 3 | 10 |
| 2003 | 11 | 3 | 14 |
| 2004 | 6 | 5 | 11 |
| 2005 | 7 | 7 | 14 |
| 2006 | 7 | 3 | 10 |
| 2007 | 10 | 2 | 12 |
| 2008 | 4 | 3 | 7 |
| 2009 | 6 | 1 | 7 |
| 2010 | 9 | 2 | 11 |
| 2011 | 5 | 1 | 6 |
| 2012 | 7 | 1 | 8 |
| 2013 | 6 | 4 | 10 |
| 2014 | 4 | 6 | 10 |
| 2015 | 7 | 2 | 9 |
| 2016 | 7 | 1 | 8 |
| 2017 | 8 | 0 | 8 |
| 2018 | 5 | 3 | 8 |
| 2019 | 3 | 3 | 6 |
| 2020 | 3 | 2 | 5 |
| 2021 | 3 | 1 | 4 |
| 2022 | 1 | 4 | 5 |
| 2023 | 0 | 3 | 3 |
| 2025 | 4 | 2 | 6 |
| 2026 | 2 | 1 | 3 |
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Below are the most recent publications written about "Receptors, Cytoplasmic and Nuclear" by people in Profiles.
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The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis. Biomed Pharmacother. 2025 Sep; 190:118427.
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Nuclear receptor SHP dampens transcription function and abrogates mitotic chromatin association of PXR and ERa via intermolecular interactions. Biochim Biophys Acta Gene Regul Mech. 2021 03; 1864(3):194683.
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XPO1 expression worsens the prognosis of unfavorable DLBCL that can be effectively targeted by selinexor in the absence of mutant p53. J Hematol Oncol. 2020 11 04; 13(1):148.
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Targeting LRH-1 in hepatoblastoma cell lines causes decreased proliferation. Oncol Rep. 2019 Jan; 41(1):143-153.
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LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 10 10; 9(1):4055.
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Nuclear localization signal region in nuclear receptor PXR governs the receptor association with mitotic chromatin. Chromosome Res. 2018 12; 26(4):255-276.
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Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. Endocrinology. 2018 06 01; 159(6):2435-2446.
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Heterodimerization of Retinoid X Receptor with Xenobiotic Receptor partners occurs in the cytoplasmic compartment: Mechanistic insights of events in living cells. Exp Cell Res. 2017 11 15; 360(2):337-346.
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Novel Application of Red Fluorescent Protein (DsRed-Express) for the Study of Functional Dynamics of Nuclear Receptors. J Fluoresc. 2017 Jul; 27(4):1225-1231.
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Nutrient-sensing nuclear receptors PPARa and FXR control liver energy balance. J Clin Invest. 2017 Apr 03; 127(4):1193-1201.