"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Descriptor ID |
D015398
|
MeSH Number(s) |
G02.111.820 G04.835
|
Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 12 | 16 | 28 |
1995 | 21 | 30 | 51 |
1996 | 20 | 34 | 54 |
1997 | 24 | 41 | 65 |
1998 | 29 | 39 | 68 |
1999 | 36 | 63 | 99 |
2000 | 44 | 69 | 113 |
2001 | 33 | 65 | 98 |
2002 | 38 | 89 | 127 |
2003 | 71 | 153 | 224 |
2004 | 70 | 155 | 225 |
2005 | 79 | 197 | 276 |
2006 | 106 | 176 | 282 |
2007 | 104 | 191 | 295 |
2008 | 108 | 210 | 318 |
2009 | 94 | 205 | 299 |
2010 | 128 | 274 | 402 |
2011 | 137 | 272 | 409 |
2012 | 124 | 274 | 398 |
2013 | 121 | 295 | 416 |
2014 | 94 | 327 | 421 |
2015 | 88 | 279 | 367 |
2016 | 84 | 270 | 354 |
2017 | 87 | 275 | 362 |
2018 | 68 | 214 | 282 |
2019 | 61 | 217 | 278 |
2020 | 56 | 165 | 221 |
2021 | 42 | 166 | 208 |
2022 | 11 | 58 | 69 |
2023 | 5 | 66 | 71 |
2024 | 3 | 14 | 17 |
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Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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Nutrient Sensing in Macrophages Linked to Reorganized Tumor Vasculature. Cancer Res. 2024 03 04; 84(5):650-651.
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Understanding the mechanisms of diffuse midline glioma cell migration toward therapeutic targeting. Neuro Oncol. 2024 03 04; 26(3):569-570.
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Nutrient scavenging-fueled growth in pancreatic cancer depends on caveolae-mediated endocytosis under nutrient-deprived conditions. Sci Adv. 2024 Mar; 10(9):eadj3551.
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Impaired bone morphogenetic protein (BMP) signaling pathways disrupt decidualization in endometriosis. Commun Biol. 2024 Feb 24; 7(1):227.
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Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Proc Natl Acad Sci U S A. 2024 Feb 27; 121(9):e2322582121.
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Inhibition of CSF1R and KIT With Pexidartinib Reduces Inflammatory Signaling and Cell Viability in Endometriosis. Endocrinology. 2024 Feb 20; 165(4).
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Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. Sci Transl Med. 2024 Feb 14; 16(734):eadj5962.
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The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer. Nat Commun. 2024 Feb 14; 15(1):1373.
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JAK/STAT defects and immune dysregulation, and guiding therapeutic choices. Immunol Rev. 2024 Mar; 322(1):311-328.
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Regulating Androgen Receptor Function in Prostate Cancer: Exploring the Diversity of Post-Translational Modifications. Cells. 2024 01 19; 13(2).