The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor ID	D015398
MeSH Number(s)	G02.111.820 G04.835
Concept/Terms	Signal Transduction Signal Transduction Signal Transductions Transduction, Signal Transductions, Signal Signal Transduction Systems Signal Transduction System System, Signal Transduction Systems, Signal Transduction Signal Pathways Signal Pathways Pathway, Signal Pathways, Signal Signal Pathway Signal Transduction Pathways Signal Transduction Pathways Pathway, Signal Transduction Pathways, Signal Transduction Signal Transduction Pathway Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transduction Receptor-Mediated Signal Transductions Signal Transduction, Receptor-Mediated Signal Transductions, Receptor-Mediated Receptor Mediated Signal Transduction

Below are MeSH descriptors whose meaning is more general than "Signal Transduction".

Below are MeSH descriptors whose meaning is related to "Signal Transduction".

Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".