"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.820 G04.835
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 6 | 10 | 16 |
| 1996 | 5 | 9 | 14 |
| 1997 | 7 | 10 | 17 |
| 1998 | 11 | 13 | 24 |
| 1999 | 14 | 27 | 41 |
| 2000 | 18 | 30 | 48 |
| 2001 | 13 | 30 | 43 |
| 2002 | 21 | 40 | 61 |
| 2003 | 21 | 53 | 74 |
| 2004 | 27 | 62 | 89 |
| 2005 | 24 | 77 | 101 |
| 2006 | 38 | 67 | 105 |
| 2007 | 35 | 67 | 102 |
| 2008 | 48 | 84 | 132 |
| 2009 | 40 | 77 | 117 |
| 2010 | 55 | 105 | 160 |
| 2011 | 60 | 110 | 170 |
| 2012 | 38 | 117 | 155 |
| 2013 | 64 | 134 | 198 |
| 2014 | 49 | 149 | 198 |
| 2015 | 41 | 125 | 166 |
| 2016 | 42 | 119 | 161 |
| 2017 | 46 | 130 | 176 |
| 2018 | 34 | 109 | 143 |
| 2019 | 34 | 104 | 138 |
| 2020 | 38 | 89 | 127 |
| 2021 | 18 | 95 | 113 |
| 2022 | 7 | 38 | 45 |
| 2023 | 5 | 38 | 43 |
| 2024 | 23 | 46 | 69 |
| 2025 | 3 | 10 | 13 |
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click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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The small GTPase Rap1 in POMC neurons regulates leptin actions and glucose metabolism. Mol Metab. 2025 May; 95:102117.
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The common HAQ STING allele prevents clinical penetrance of COPA syndrome. J Exp Med. 2025 Apr 07; 222(4).
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Biguanides antithetically regulate tumor properties by the dose-dependent mitochondrial reprogramming-driven c-Src pathway. Cell Rep Med. 2025 Feb 18; 6(2):101941.
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Integral Roles of the TGF? Signaling Pathway in Uterine Function and Disease. Endocrinology. 2025 Feb 05; 166(3).
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The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma. Nat Commun. 2025 Feb 02; 16(1):1267.
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KLF4 enhances transplantation-induced hematopoiesis by inhibiting TLRs and noncanonical NF?B signaling at a steady state. Exp Hematol. 2025 Apr; 144:104730.
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The dynamics of tubulogenesis in development and disease. Development. 2025 Feb 01; 152(3).
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Comparative Single-Cell Analysis Reveals Tendon Progenitor Dysfunction by Age-Associated Oxidative Stress and Its Restoration by Antioxidant Treatments. J Cell Physiol. 2025 Feb; 240(2):e70016.
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Vitronectin regulates lung tissue remodeling and emphysema in chronic obstructive pulmonary disease. Mol Ther. 2025 Mar 05; 33(3):917-932.
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Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers. Cancer Discov. 2025 Jan 13; 15(1):119-138.