"Substrate Specificity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
| Descriptor ID |
D013379
|
| MeSH Number(s) |
G02.111.835
|
| Concept/Terms |
Substrate Specificity- Substrate Specificity
- Specificities, Substrate
- Specificity, Substrate
- Substrate Specificities
|
Below are MeSH descriptors whose meaning is more general than "Substrate Specificity".
Below are MeSH descriptors whose meaning is more specific than "Substrate Specificity".
This graph shows the total number of publications written about "Substrate Specificity" by people in this website by year, and whether "Substrate Specificity" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 |
| 1996 | 0 | 6 | 6 |
| 1997 | 0 | 6 | 6 |
| 1998 | 0 | 7 | 7 |
| 1999 | 0 | 6 | 6 |
| 2000 | 0 | 7 | 7 |
| 2001 | 0 | 6 | 6 |
| 2002 | 0 | 8 | 8 |
| 2003 | 0 | 11 | 11 |
| 2004 | 0 | 16 | 16 |
| 2005 | 0 | 9 | 9 |
| 2006 | 0 | 13 | 13 |
| 2007 | 0 | 9 | 9 |
| 2008 | 0 | 10 | 10 |
| 2009 | 0 | 13 | 13 |
| 2010 | 0 | 9 | 9 |
| 2011 | 0 | 11 | 11 |
| 2012 | 0 | 11 | 11 |
| 2013 | 0 | 7 | 7 |
| 2014 | 0 | 9 | 9 |
| 2015 | 0 | 13 | 13 |
| 2016 | 0 | 8 | 8 |
| 2017 | 0 | 7 | 7 |
| 2018 | 0 | 6 | 6 |
| 2019 | 0 | 4 | 4 |
| 2020 | 0 | 8 | 8 |
| 2021 | 0 | 7 | 7 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 2 | 2 |
| 2024 | 0 | 2 | 2 |
| 2025 | 0 | 2 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Substrate Specificity" by people in Profiles.
-
Deciphering the dark cancer phosphoproteome using machine-learned co-regulation of phosphosites. Nat Commun. 2025 Mar 20; 16(1):2766.
-
The DNase TREX1 is a substrate of the intramembrane protease SPP with implications for disease pathogenesis. Cell Mol Life Sci. 2025 Mar 12; 82(1):107.
-
A Gram-negative-selective antibiotic that spares the gut microbiome. Nature. 2024 Jun; 630(8016):429-436.
-
The intrinsic substrate specificity of the human tyrosine kinome. Nature. 2024 May; 629(8014):1174-1181.
-
Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor. Nature. 2024 Feb; 626(8001):1141-1148.
-
Polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) isozyme surface charge governs charge substrate preferences to modulate mucin type O-glycosylation. Glycobiology. 2023 10 30; 33(10):817-836.
-
Molecular mechanisms of SARS-CoV-2 resistance to nirmatrelvir. Nature. 2023 10; 622(7982):376-382.
-
Mapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M ?-lactamase. Commun Biol. 2023 01 12; 6(1):35.
-
Deciphering the mechanism and function of Hsp100 unfoldases from protein structure. Biochem Soc Trans. 2022 12 16; 50(6):1725-1736.
-
Engineered kinases as a tool for phosphorylation of selected targets in vivo. J Cell Biol. 2022 10 03; 221(10).