"Alkylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group.
| Descriptor ID |
D000478
|
| MeSH Number(s) |
G02.111.035 G02.607.094 G03.059
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Alkylation".
Below are MeSH descriptors whose meaning is more specific than "Alkylation".
This graph shows the total number of publications written about "Alkylation" by people in this website by year, and whether "Alkylation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
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Below are the most recent publications written about "Alkylation" by people in Profiles.
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Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. ACS Chem Biol. 2020 04 17; 15(4):1036-1049.
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Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus. Nat Commun. 2019 10 24; 10(1):4847.
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Synthesis of fused imidazoles, pyrroles, and indoles with a defined stereocenter a to nitrogen utilizing Mitsunobu alkylation followed by palladium-catalyzed cyclization. J Org Chem. 2011 Oct 21; 76(20):8477-82.
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Biofunctionalization on alkylated silicon substrate surfaces via "click" chemistry. J Am Chem Soc. 2010 Nov 24; 132(46):16432-41.
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A modified host-cell reactivation assay to measure repair of alkylating DNA damage for assessing risk of lung adenocarcinoma. Carcinogenesis. 2007 Jul; 28(7):1430-6.
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Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine. Biochemistry. 2002 Aug 13; 41(32):10262-9.
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Clinical pharmacology of melphalan and its implications for clinical resistance to anticancer agents. Cancer Treat Res. 2002; 112:305-22.
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Extracellular matrix-derived peptide binds to alpha(v)beta(3) integrin and inhibits angiogenesis. J Biol Chem. 2001 Aug 24; 276(34):31959-68.
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Structural basis of mRNA cap recognition by proteins. Curr Opin Struct Biol. 2000 Feb; 10(1):78-86.
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Relationship between DNA adduct levels, repair enzyme, and apoptosis as a function of DNA methylation by azoxymethane. Cell Growth Differ. 1999 Nov; 10(11):749-58.