Nucleic Acid Denaturation
"Nucleic Acid Denaturation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
| Descriptor ID |
D009691
|
| MeSH Number(s) |
E05.393.640 G02.111.603 G05.627
|
| Concept/Terms |
Nucleic Acid Denaturation- Nucleic Acid Denaturation
- Acid Denaturation, Nucleic
- Denaturation, Nucleic Acid
- Nucleic Acid Denaturations
|
Below are MeSH descriptors whose meaning is more general than "Nucleic Acid Denaturation".
Below are MeSH descriptors whose meaning is more specific than "Nucleic Acid Denaturation".
This graph shows the total number of publications written about "Nucleic Acid Denaturation" by people in this website by year, and whether "Nucleic Acid Denaturation" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 3 | 3 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 1 | 3 | 4 |
| 2002 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2016 | 2 | 0 | 2 |
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Below are the most recent publications written about "Nucleic Acid Denaturation" by people in Profiles.
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COLD-PCR: Applications and Advantages. Methods Mol Biol. 2016; 1392:17-25.
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High-Resolution Melt Curve Analysis in Cancer Mutation Screen. Methods Mol Biol. 2016; 1392:63-9.
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Protected DNA strand displacement for enhanced single nucleotide discrimination in double-stranded DNA. Sci Rep. 2015 Mar 04; 5:8721.
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Real-time monitoring of DNA hybridization and melting processes using a fiber optic sensor. Nanotechnology. 2012 Feb 17; 23(6):065503.
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Diagnostic testing for IDH1 and IDH2 variants in acute myeloid leukemia an algorithmic approach using high-resolution melting curve analysis. J Mol Diagn. 2011 Nov; 13(6):678-86.
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Real-time monitoring of solid-phase PCR using fiber-optic SPR. Small. 2011 Apr 18; 7(8):1003-6.
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COLD-PCR finds hot application in mutation analysis. Clin Chem. 2009 Dec; 55(12):2077-8.
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In the absence of writhe, DNA relieves torsional stress with localized, sequence-dependent structural failure to preserve B-form. Nucleic Acids Res. 2009 Sep; 37(16):5568-77.
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Mosaicism in von Hippel-Lindau disease: an event important to recognize. J Cell Mol Med. 2007 Nov-Dec; 11(6):1408-15.
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Rapid detection of CAA/CAG repeat polymorphism in the AIB1 gene using DHPLC. J Biochem Biophys Methods. 2007 Apr 10; 70(3):511-3.