Chromatin Immunoprecipitation
"Chromatin Immunoprecipitation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
| Descriptor ID |
D047369
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| MeSH Number(s) |
E05.393.170 E05.478.605.160
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Chromatin Immunoprecipitation".
Below are MeSH descriptors whose meaning is more specific than "Chromatin Immunoprecipitation".
This graph shows the total number of publications written about "Chromatin Immunoprecipitation" by people in this website by year, and whether "Chromatin Immunoprecipitation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 4 | 4 |
| 2005 | 1 | 23 | 24 |
| 2006 | 0 | 17 | 17 |
| 2007 | 0 | 26 | 26 |
| 2008 | 0 | 17 | 17 |
| 2009 | 0 | 27 | 27 |
| 2010 | 0 | 27 | 27 |
| 2011 | 1 | 29 | 30 |
| 2012 | 1 | 28 | 29 |
| 2013 | 2 | 30 | 32 |
| 2014 | 0 | 20 | 20 |
| 2015 | 0 | 19 | 19 |
| 2016 | 1 | 10 | 11 |
| 2017 | 2 | 8 | 10 |
| 2018 | 1 | 5 | 6 |
| 2019 | 1 | 4 | 5 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 4 | 4 |
| 2023 | 0 | 2 | 2 |
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Below are the most recent publications written about "Chromatin Immunoprecipitation" by people in Profiles.
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Chromatin immunoprecipitation and library preparation: a powerful tool to unravel the epigenome. Biotechniques. 2023 07; 75(1):339-342.
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Therapeutic targeting of CNBP phase separation inhibits ribosome biogenesis and neuroblastoma progression via modulating SWI/SNF complex activity. Clin Transl Med. 2023 04; 13(4):e1235.
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Computational modeling of chromatin accessibility identified important epigenomic regulators. BMC Genomics. 2022 Jan 08; 23(1):19.
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Systematic identification of non-canonical transcription factor motifs. BMC Mol Cell Biol. 2021 Aug 31; 22(1):44.
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Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo. Nat Commun. 2021 05 04; 12(1):2509.
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Combinations of histone post-translational modifications. Biochem J. 2021 02 12; 478(3):511-532.
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Predicting regulatory variants using a dense epigenomic mapped CNN model elucidated the molecular basis of trait-tissue associations. Nucleic Acids Res. 2021 01 11; 49(1):53-66.
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p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23663-23673.
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Disruption of TP63-miR-27a* Feedback Loop by Mutant TP53 in Head and Neck Cancer. J Natl Cancer Inst. 2020 03 01; 112(3):266-277.
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Lats1 and Lats2 are required for the maintenance of multipotency in the M?llerian duct mesenchyme. Development. 2019 10 18; 146(20).